Traditional Chinese medicine application product with effects of tonifying spleen and nourishing stomach and preparation method of traditional Chinese medicine application product

Abstract

The invention discloses a traditional Chinese medicine application product with spleen-tonifying and stomach-nourishing effects and a preparation method thereof. The product comprises a traditional Chinese medicine powder application and traditional Chinese medicine essential oil, the traditional Chinese medicine powder patch is prepared from 65-75 parts of folium artemisiae argyi, 1-5 parts of herba cistanche, 2-10 parts of radix et rhizoma rhei, 1-8 parts of fructus aurantii immaturus, 1-8 parts of radix angelicae sinensis, 1-10 parts of semen raphani, 1-8 parts of flos caryophylli, 1-10 parts of radix aucklandiae, non-woven fabric and a heating bag. The traditional Chinese medicine essential oil comprises 70-80 parts of base oil, 1-10 parts of blumea oil, 1-5 parts of aloe oil, 1-7 parts of immature bitter orange oil, 1-5 parts of mangnolia officinalis oil, 1-7 parts of clove oil, 1-8 parts of butter, 1-5 parts of astragalus membranaceus oil, 1-5 parts of hemp seed oil and 1-5 parts of borneol. When the product is prepared, the medicinal powder application is subjected to the steps of screening, weighing, grinding, sieving, coating, forming, fixed packaging and the like. The traditional Chinese medicine essential oil is prepared by screening, weighing, mixing and stirring, filtering to remove impurities, filling and sealing, and the traditional Chinese medicine essential oil and the traditional Chinese medicine essential oil are integrated to prepare a traditional Chinese medicine application product. The product is applied to acupoints, so that side effects of oral medicines are avoided, the transdermal absorption efficiency is improved, and the symptom of weakness of spleen and stomach is effectively improved.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine preparation technology, specifically to a traditional Chinese medicine patch product with spleen-strengthening and stomach-nourishing effects and its preparation method. Guided by traditional Chinese medicine theory, this invention selects traditional Chinese medicinal materials with spleen-strengthening, qi-regulating, digestion-aiding, and bowel-regulating effects, and formulates them according to the principles of monarch, minister, assistant, and guide in traditional Chinese medicine formulation. This results in a traditional Chinese medicine patch product with specific spleen-strengthening and stomach-nourishing effects. The drug is absorbed transdermally through skin application, combining with the theory of meridians and acupoints in traditional Chinese medicine to exert its therapeutic effect. The preparation process involves the processing, formulation combination, and processing technology of various traditional Chinese medicinal materials. The patch dosage form is a combination of medicinal powder and essential oil, with an integrated design of the powder pack and heating pack, and the combined use of traditional Chinese medicine essential oils. This improves the transdermal absorption efficiency of the drug, enhances the spleen-strengthening and stomach-nourishing effects of the product, and avoids the gastrointestinal irritation and other side effects of oral medications. Background Technology

[0002] Spleen and stomach weakness manifests differently in different groups of people, causing many adverse effects on health. In children, it easily leads to food stagnation, affecting nutrient absorption and causing problems such as stunted growth and weakened immunity. Adults often suffer from bloating, constipation, loose or sticky stools, and a thick, greasy tongue coating. Bloating causes abdominal discomfort and pain, affecting daily life and work; constipation leads to the accumulation of toxins in the body, causing skin problems, bad breath, etc., and long-term constipation increases the risk of intestinal diseases; abnormal stools reflect digestive system dysfunction and are also related to factors such as intestinal flora imbalance; a thick, greasy tongue coating is one of the external manifestations of spleen and stomach dysfunction, often accompanied by loss of appetite; in the elderly, due to the decline in bodily functions, spleen and stomach weakness manifests as decreased digestive capacity, easily leading to indigestion, which in turn affects nutrient absorption, increases the burden on other organs, reduces quality of life, and increases the risk of disease.

[0003] Meanwhile, many factors in modern society contribute to spleen and stomach weakness, such as poor eating habits and unhealthy lifestyles. In daily life, an overly oily diet burdens the spleen and stomach, overloading their fat-transforming functions and affecting normal digestion and absorption. Excessively salty foods damage the spleen and stomach's yang energy, leading to weakened spleen and stomach function. Overly sweet foods easily generate phlegm and dampness, obstructing the spleen and stomach's qi flow and affecting their digestive function. Cold foods such as ice cream and cooling fruits and vegetables can expose the spleen and stomach to cold pathogens, causing stagnation and hindering the smooth flow of qi and blood, thus leading to spleen and stomach weakness. Failure to keep warm, especially in the abdomen, allows cold pathogens to easily invade the body, affecting the spleen and stomach's yang energy. Poor sleep is also closely related to spleen and stomach weakness; spleen and stomach dysfunction affects sleep quality, and insufficient or poor sleep quality further affects the repair and normal function of the spleen and stomach, creating a vicious cycle. People who frequently stay up late often experience spleen and stomach problems such as loss of appetite and indigestion.

[0004] While oral medications for regulating the spleen and stomach on the market are relatively quick to take effect, they also have certain side effects. After oral administration, the drug needs to undergo absorption in the gastrointestinal tract, metabolism in the liver, and excretion in the kidneys, which puts a burden on organs such as the kidneys, liver, spleen, and stomach. Long-term or high-dose use of certain oral spleen-strengthening and stomach-nourishing medications can affect the liver's detoxification function, the kidney's excretory function, and even irritate the spleen and stomach themselves, leading to further damage to their function. Some oral medications containing chemical ingredients can also cause adverse reactions such as gastrointestinal discomfort, nausea, and vomiting, which can worsen the condition of people with already weak spleens and stomachs. Existing topical patch products on the market generally have the problems of slow onset and unclear effects in regulating the spleen and stomach. These products fail to quickly and effectively improve symptoms of spleen and stomach weakness due to reasons such as unreasonable formulas, low content of active ingredients, and poor transdermal absorption. Some herbal ingredients in some patch products have not been finely processed, resulting in large particles that are not easily absorbed through the skin to exert their effects. Alternatively, the dosage form of the products may be poorly designed, failing to ensure continuous and stable release of the medication, leading to poor therapeutic effects and failing to meet patients' needs for rapid symptom relief and effective regulation of the spleen and stomach. Summary of the Invention

[0005] The purpose of this invention is to provide a traditional Chinese medicine patch with spleen-strengthening and stomach-nourishing effects and its preparation method. The product combines a traditional Chinese medicine powder patch with a traditional Chinese medicine essential oil. The formula is optimized, using a variety of carefully selected and proportioned traditional Chinese medicinal materials, such as mugwort, cistanche, rhubarb, immature bitter orange, and angelica. These materials undergo a series of strict processes including screening, weighing, grinding, and mixing to produce an extremely fine powder, which is then integrally molded with a heating pack and adhered to the center of a non-woven fabric using adhesive, forming a convenient patch. A base oil is mixed with various volatile oils from traditional Chinese medicine, such as mugwort oil, immature bitter orange oil, and clove oil, in a specific ratio to form a traditional Chinese medicine essential oil. This essential oil is poured into the center of the powder patch and then applied to acupoints such as Zhongwan, Jizhong, or Pishu, achieving acupoint application and transdermal drug delivery. This addresses the problems of side effects from existing oral spleen-strengthening and stomach-nourishing drugs and the slow onset and unclear effects of external patch products. It achieves targeted drug delivery, improves the specificity and effectiveness of treatment, reduces adverse reactions, and meets patients' needs for regulating the spleen and stomach.

[0006] The herbal patch product provided by this invention consists of two parts: a herbal powder patch and a herbal essential oil. The herbal powder patch contains a variety of carefully selected and proportioned Chinese medicinal herbs, such as mugwort, cistanche, rhubarb, immature bitter orange, and angelica. These herbs undergo a series of rigorous processes including screening, weighing, grinding, and mixing to produce an extremely fine powder, which is then integrally molded with a heating pack and adhered to the center of a non-woven fabric using adhesive, forming a convenient patch. The herbal essential oil is a unique formula composed of a base oil mixed with various volatile oils from Chinese herbs, such as mugwort oil, immature bitter orange oil, and clove oil. By pouring the herbal essential oil into the center of the powder patch and then applying it to acupoints such as Zhongwan, Jizhong, or Pishu, transdermal drug delivery and absorption are achieved. This method of drug delivery avoids the complex metabolic processes of oral medications involving the gastrointestinal tract, liver, and kidneys, reducing the potential burden and damage to these organs. Simultaneously, by utilizing the special physiological functions of acupoints, it improves the absorption efficiency and therapeutic effect of the drug.

[0007] Oral medications for strengthening the spleen and stomach, during treatment, require the drug components to undergo a series of metabolic transformations in the body, which can burden vital organs such as the kidneys and liver. Long-term use can also affect the function of the spleen and stomach themselves. The herbal patch product of this invention acts directly on the skin surface, allowing the drug to be absorbed transdermally into the local bloodstream, bypassing the first-pass effect of the gastrointestinal tract and liver. This significantly reduces the potential risks to the kidneys and liver, while avoiding direct stimulation of the spleen and stomach, providing a safer conditioning method for patients with weak spleen and stomach. Existing external patch products on the market often suffer from slow onset and insignificant effects. This invention improves the transdermal absorption speed and effectiveness of the drug through optimized formulation, increased content and variety of effective ingredients in the powder, and innovative designs such as the use of a heating pack to promote drug penetration. The addition of herbal essential oils not only acts as a guide, allowing the drug to better act on the spleen, stomach, and large intestine meridians, but also enhances the drug's activity and penetration ability. Through these measures, the herbal patch product of the present invention can more effectively improve symptoms such as food stagnation, indigestion, constipation, sticky stools, and thick tongue coating caused by spleen and stomach weakness. It takes effect in a shorter time, improving the effectiveness and practicality of the product and meeting patients' needs for rapid and significant improvement of spleen and stomach function.

[0008] This invention provides a traditional Chinese medicine patch with spleen-strengthening and stomach-nourishing effects. The patch comprises a traditional Chinese medicine powder patch and traditional Chinese medicine essential oils. The traditional Chinese medicine powder patch includes: 65-75 parts Artemisia argyi, 1-5 parts Cistanche deserticola, 2-10 parts Rheum palmatum, 1-8 parts Citrus aurantium, 1-8 parts Angelica sinensis, 1-10 parts Raphanus sativus, 1-8 parts Clove, 1-10 parts Aucklandia lappa, non-woven fabric, and a heating pack. The traditional Chinese medicine essential oils include: 70-80 parts base oil, 1-10 parts Artemisia argyi oil, 1-5 parts Aloe vera oil, 1-7 parts Citrus aurantium oil, 1-5 parts Magnolia officinalis oil, 1-7 parts Clove oil, 1-8 parts Yellow glutinous rice oil, 1-5 parts Astragalus membranaceus oil, 1-5 parts Cannabis sativa seed oil, and 1-5 parts Borneol.

[0009] In this traditional Chinese medicine powder plaster, mugwort is warm in nature and has the effects of warming the meridians and stopping bleeding, dispelling cold and relieving pain, and removing dampness and relieving itching. In this invention, it is used as a major ingredient in a relatively large quantity. Its warming properties help to dispel cold pathogens from the spleen and stomach, improving symptoms of spleen and stomach deficiency caused by cold invasion, such as abdominal pain and diarrhea. Simultaneously, the aromatic scent of mugwort also has a certain effect of opening the orifices and invigorating the spleen, promoting the digestive function of the spleen and stomach, and enhancing appetite. Cistanche deserticola has the effects of tonifying kidney yang, nourishing essence and blood, and moistening the intestines and promoting bowel movements. In the spleen-strengthening and stomach-nourishing formula, its kidney-yang tonifying effect can indirectly warm the spleen and stomach, enhance spleen and stomach yang qi, and promote the digestive function of the spleen and stomach. For the elderly or those whose spleen and stomach function declines due to kidney yang deficiency, Cistanche deserticola can fundamentally regulate bodily functions and enhance spleen and stomach motility. Furthermore, its moistening properties... The laxative effect helps improve constipation caused by spleen and stomach weakness. Rhubarb has the effects of purging, clearing heat and purging fire, cooling blood and detoxifying, and removing blood stasis and promoting menstruation. In this formula, rhubarb mainly plays the role of purging, which can clear the stagnation in the intestines, promote defecation, help expel toxins from the body, and reduce the burden on the spleen and stomach. It has a good effect on improving symptoms such as constipation and difficulty in defecation caused by spleen and stomach weakness. However, because its purgative power is strong, the dosage should be carefully controlled to avoid excessive damage to the body's vital energy. Fructus Aurantii Immaturus is bitter, pungent, and sour in taste, and slightly cold in nature. It has the effects of breaking up qi stagnation, eliminating stagnation, resolving phlegm and dispersing masses. It promotes qi circulation and breaks up stagnation, enhances the qi movement of the spleen and stomach, promotes digestion, and eliminates symptoms such as bloating and pain caused by qi stagnation in the spleen and stomach. When combined with other drugs, it can synergistically enhance the overall formula's ability to regulate the qi of the spleen and stomach. The function of Angelica sinensis is to restore the normal digestive function of the spleen and stomach. Angelica sinensis has the effects of nourishing blood, promoting blood circulation, regulating menstruation, relieving pain, and moistening the intestines to relieve constipation. In terms of strengthening the spleen and stomach, its blood-nourishing effect helps nourish the qi and blood of the spleen and stomach, promoting the recovery and maintenance of spleen and stomach function. Its laxative effect also helps improve problems such as slowed intestinal peristalsis and constipation caused by spleen and stomach weakness. Simultaneously, its blood-activating effect promotes local blood circulation in the spleen and stomach, which is beneficial for drug absorption and the repair of spleen and stomach function. Radish seed is pungent and sweet in taste, and neutral in nature. It has the effects of relieving indigestion and bloating, and reducing phlegm. It is mainly used to treat symptoms such as food stagnation, abdominal distension and pain, and constipation. In this formula, radish seed can promote the digestion and absorption of food, eliminate food stagnation, relieve abdominal distension and discomfort caused by food stagnation, and strengthen the spleen and stomach. Its digestive function is particularly suitable for spleen and stomach dysfunction caused by improper diet. Clove warms the middle and relieves nausea, tonifies the kidneys and assists yang. Its warming effect can warm the spleen and stomach, relieve symptoms such as vomiting and hiccups caused by spleen and stomach deficiency and cold, and enhance the digestive function of the spleen and stomach. At the same time, the rich aroma of clove can stimulate the olfactory receptors of the spleen and stomach, promote the peristalsis and secretion of digestive juices, and improve the digestive efficiency of the spleen and stomach. Together with other drugs, it can play a role in strengthening the spleen and stomach. Costus root promotes qi circulation, relieves pain, strengthens the spleen and promotes digestion. It is good at clearing the qi stagnation of the spleen and stomach. It is an important drug for promoting qi circulation and relieving pain. It can effectively relieve symptoms such as abdominal distension, belching and toothache caused by qi stagnation of the spleen and stomach. In the prescription, costus root can be combined with other drugs to enhance the qi circulation and spleen strengthening effect of the whole prescription, so that the qi of the spleen and stomach is unobstructed and the digestive function is normal.

[0010] Non-woven fabric, used as the coating material for the medicinal powder, is soft, breathable, and lightweight, allowing the powder to fully contact the skin without hindering normal skin respiration. The heating pack generates heat during use, stimulating acupoints to promote local blood circulation, accelerate drug absorption and penetration, and enable the medication to take effect more quickly. Simultaneously, the warmth further enhances the medication's effects of warming the meridians, dispelling cold, and relieving pain, working synergistically with the herbal powder to better regulate spleen and stomach function, improve therapeutic efficacy, and provide patients with a comfortable application experience.

[0011] In traditional Chinese medicine (TCM) essential oils, the carrier oil is the main transporter, diluting and dissolving various volatile oils from the herbs, ensuring even mixing and easy application and absorption. Simultaneously, the carrier oil itself moisturizes the skin and protects the skin barrier, preventing excessive irritation from the volatile oils and providing a favorable environment for transdermal absorption of the herbal components, thus enhancing the overall efficacy and safety of the TCM essential oil. Artemisia oil retains some of the medicinal properties of Artemisia, including warming the meridians, dispelling cold and relieving pain, and antibacterial and anti-inflammatory effects. In TCM essential oils, Artemisia oil works synergistically with Artemisia in herbal powder plasters to further enhance the warming and dispelling effects, and regulate the spleen and stomach. Its meridian-warming properties help promote drug transmission through the meridians, allowing the drugs to better act on the spleen. It benefits the stomach and related organs, improving treatment efficacy. Its antibacterial and anti-inflammatory effects help prevent and improve local inflammatory reactions caused by spleen and stomach weakness. Aloe vera oil has moisturizing, hydrating, anti-inflammatory, and wound-healing properties. In traditional Chinese medicine essential oils, aloe vera oil can moisturize the skin, preventing dryness and irritation caused by heat from the heating pack or the ingredients of traditional Chinese medicine. Its anti-inflammatory effect helps reduce allergic or inflammatory reactions on the skin, creating a favorable skin environment for the transdermal absorption of traditional Chinese medicine essential oils. It also plays a certain auxiliary role in improving the inflammatory state within the spleen and stomach, promoting the recovery of spleen and stomach function. Fructus Aurantii Immaturus (Zhishi) oil inherits some of the pharmacological properties of Zhishi, mainly playing a role in regulating qi and eliminating stagnation. In traditional Chinese medicine essential oils, Zhishi oil works synergistically with Zhishi in the herbal powder application, increasing... It strengthens the spleen and stomach's Qi circulation, promotes digestion and absorption, and eliminates stagnation and accumulation in the spleen and stomach. Its volatile oil components can penetrate the skin more quickly and enter the body more effectively, working synergistically with other medications to improve various symptoms caused by spleen and stomach Qi stagnation, such as bloating, pain, and indigestion. Magnolia officinalis oil has the effects of drying dampness and resolving phlegm, and relieving bloating. In the formula, Magnolia officinalis oil can enhance the effect of drying dampness and resolving phlegm, helping to improve symptoms of internal phlegm and dampness caused by spleen and stomach weakness, such as thick and greasy tongue coating and heaviness in the body. At the same time, its effect of relieving bloating, along with other Qi-regulating medications, further promotes the smooth flow of spleen and stomach Qi, relieves abdominal distension and other discomforts, and improves the spleen and stomach's digestive function and ability. Clove oil has the effects of warming the middle and relieving nausea, dispelling cold and relieving pain, and warming the kidneys and assisting Yang. In traditional Chinese medicine essential oils, clove oil is combined with other herbs to promote the smooth flow of spleen and stomach Qi, relieve bloating and other discomforts, and improve the spleen and stomach's digestive function and ability. Clove complements the other ingredients, enhancing the warming and dispersing effects of the spleen and stomach, effectively relieving symptoms such as vomiting, hiccups, and abdominal pain caused by spleen and stomach deficiency and cold. Its rich aroma can stimulate the olfactory nerves, promote the secretion of digestive juices, and enhance appetite. At the same time, its kidney-warming and yang-tonifying effects also help to improve the body's overall yang energy, indirectly promoting the recovery of spleen and stomach function. Rhubarb oil has the effects of purging and clearing heat and fire, similar to the effects of rhubarb in traditional Chinese medicine powder plasters. It mainly targets intestinal stagnation and heat evil, promotes defecation, and clears turbid toxins from the intestines. In traditional Chinese medicine essential oils, the presence of rhubarb oil further enhances the overall product's ability to cleanse the intestines, and has a good effect on improving symptoms such as constipation and dry stools caused by spleen and stomach heat accumulation or intestinal stagnation. Together with other drugs, it maintains the health of the spleen, stomach, and intestines.Astragalus oil has the effects of invigorating qi and strengthening the exterior, promoting diuresis and reducing swelling, and promoting tissue regeneration and detoxification. In terms of strengthening the spleen and stomach, astragalus oil mainly plays a role in invigorating qi, replenishing the qi of the spleen and stomach, enhancing their digestive function and the body's resistance. It has a good conditioning effect on symptoms such as weak digestion, loss of appetite, and fatigue caused by spleen and stomach qi deficiency. When combined with other drugs, it promotes the recovery and maintenance of spleen and stomach function from the perspective of replenishing qi. Hemp seed oil has the effect of moistening the intestines and promoting bowel movements, relieving constipation caused by spleen and stomach weakness. In traditional Chinese medicine essential oils, hemp seed oil works synergistically with other drugs with laxative effects (such as rhubarb and immature bitter orange). Its functions include enhancing intestinal excretion, facilitating the smooth elimination of waste from the body, reducing the burden on the spleen, stomach, and intestines, and aiding in the recovery and adjustment of spleen and stomach function. Borneol is pungent and bitter in taste, and slightly cold in nature. It has the effects of opening the orifices and refreshing the mind, clearing heat and relieving pain. In traditional Chinese medicine essential oils, borneol mainly plays a role in guiding the medicine upwards and promoting transdermal absorption. Its cold nature can, to a certain extent, restrain the warming properties of other medicines, preventing excessive heat from damaging yin. Simultaneously, its effect of opening the orifices and refreshing the mind helps improve the digestive function of the spleen and stomach, enhancing their ability to absorb and utilize nutrients, promoting the effects of the medicine in the body, and improving the overall therapeutic effect of the traditional Chinese medicine patch.

[0012] This invention provides a method for preparing a traditional Chinese medicine patch with spleen-strengthening and stomach-nourishing effects. This method not only inherits and innovates traditional Chinese medicine therapies, but also improves the stability, uniformity, and absorption efficiency of the medicine through rigorous screening, precise proportioning, fine grinding, and a unique combination of powder and heating packs with essential oil blending. This ensures the accuracy and reliability of product quality and efficacy. Furthermore, it provides a safe, effective, and convenient new approach to treating spleen and stomach diseases, reducing the side effects of oral medications, meeting market demand for green and healthy products, and promoting the development of the traditional Chinese medicine industry. It has undeniable value and positive impact in medical treatment, the inheritance and innovation of traditional Chinese medicine, and the socio-economic field.

[0013] This invention provides a method for preparing a traditional Chinese medicine patch product with spleen-strengthening and stomach-nourishing effects, specifically including the following steps: Preparation of S1 Traditional Chinese Medicine Powder Plaster: 65-75 parts of Artemisia argyi, 1-5 parts of Cistanche deserticola, 2-10 parts of Rheum palmatum, 1-8 parts of Citrus aurantium, 1-8 parts of Angelica sinensis, 1-10 parts of Raphanus sativus, 1-8 parts of Syzygium aromaticum, and 1-10 parts of Aucklandia lappa are screened, weighed according to proportions, and mixed. The mixture is then ground and sieved 2-4 times to obtain an extremely fine powder of 80-120 mesh. This powder is then wrapped in non-woven fabric to form a powder packet with a diameter of 60-100 mm, containing a total powder content of 1.2 ± 0.35 g. This packet is then combined with a heating pad, also with a diameter of 60-100 mm and containing 11 g ± 2 g of heating powder. The one-piece molded medicine pack is adhered to the center of the non-woven fabric with adhesive backing, forming a complete traditional Chinese medicine patch. It is then sealed in a bag for later use. Screening removes impurities and inferior products, ensuring the purity and quality of the medicinal materials used, laying the foundation for the product's effectiveness and safety. Proportional weighing accurately controls the dosage of each herb, ensuring optimal compatibility between ingredients and guaranteeing stable and expected efficacy. Grinding the herbs into an extremely fine powder of 80-120 mesh significantly increases the surface area of ​​the medicine, allowing for faster and more complete contact and absorption with the skin during application. This improves the bioavailability and therapeutic effect of the drug; multiple grinding and sieving ensures thorough and uniform mixing of the various Chinese herbs, avoiding differences in efficacy caused by uneven particle size or incomplete mixing, and ensuring that each powder contains the same proportion of active ingredients; the integrated structure of the powder pack and heating pack promotes drug penetration. The heating pack generates heat during use, raising the local skin temperature, which dilates skin capillaries and increases skin permeability, thereby promoting better penetration of the active ingredients in the powder into the body, enhancing drug absorption and therapeutic effects; combining the powder pack and heating pack into one... The entire package is integrated and adhered to the center of the non-woven fabric with adhesive backing, forming a complete herbal patch. This not only facilitates patient use but also ensures that the powder packet stays firmly on the skin during application, preventing displacement or detachment and guaranteeing the continuous action of the medication on the specific area. The sealed packaging prevents the powder from being contaminated by dust, microorganisms, or other external environmental contaminants, maintaining its cleanliness and hygiene, ensuring product quality and safety, and preventing oxidation or deliquescence of the active ingredients due to contact with air and moisture. This extends the product's shelf life and ensures stable efficacy during storage and transportation.

[0014] Preparation of S2 Traditional Chinese Medicine Essential Oil: 70-80 parts base oil, 1-10 parts Artemisia argyi oil, 1-5 parts Aloe vera oil, 1-7 parts Citrus aurantium oil, 1-5 parts Magnolia officinalis oil, 1-7 parts Clove oil, 1-8 parts Butternut oil, 1-5 parts Astragalus membranaceus oil, 1-5 parts Cannabis sativa seed oil, and 1-5 parts Borneol are screened and weighed according to the specified proportions. The ingredients are then mixed and stirred at room temperature for 15-30 minutes until homogeneous. The mixture is then bottled, sealed, and stored for later use. Screening the base oil and various herbal oils removes impurities and undesirable components, ensuring the purity and quality of the raw materials and guaranteeing the preparation of high-quality herbal essential oils. Weighing each component according to the specified proportions allows for precise control of the herbal essential oil formula, enabling synergistic effects between the components to maximize their spleen-strengthening and stomach-nourishing effects, thus ensuring the product's effectiveness. Stability and efficacy are ensured by mixing all oil components at room temperature for 10-20 minutes to ensure thorough mixing and a homogeneous system. This guarantees that each drop of essential oil contains a balanced amount of active ingredients, avoiding differences in efficacy due to uneven composition. During mixing, the components come into contact with and blend, resulting in synergistic effects or physicochemical changes that help improve the overall quality and efficacy of the herbal essential oil. The mixed herbal essential oil is then bottled and sealed to effectively prevent volatile components from evaporating into the air, avoiding loss of active ingredients and maintaining the concentration and efficacy of the essential oil. Sealed packaging prevents external dust and microorganisms from entering the bottle, avoiding contamination, ensuring cleanliness and hygiene, and extending its shelf life.

[0015] The integrated preparation of S3 traditional Chinese medicine patch products: Pour 2-5 ml of herbal essential oil evenly onto the center of two herbal powder patches, allowing them to stand for 1-2 minutes to form a homogeneous herbal mixture system, resulting in a herbal patch product with spleen-strengthening and stomach-nourishing effects. Alternatively, pour the herbal essential oil evenly onto the center of the herbal powder patch and allow it to stand, enabling the essential oil and powder to fully mix and form a homogeneous herbal mixture system. In this system, the effective components of the powder and essential oil can work synergistically, exerting a more significant spleen-strengthening and stomach-nourishing effect than a single dosage form, achieving a synergistic effect greater than the sum of its parts. This mixing method allows for a slower and more sustained release of the drug, continuously providing the body with effective components during the application process, maintaining an effective blood drug concentration, and thus improving therapeutic efficacy. Through this step, the advantages of herbal powder patches and herbal essential oils are organically combined to create a herbal patch product with unique therapeutic effects. This product combines the long-lasting, sustained-release effect of medicated powder patches with the rapid penetration and aromatic properties of traditional Chinese medicine essential oils, thus leveraging the spleen-strengthening and stomach-nourishing effects of various Chinese medicine ingredients. The resulting herbal patch is easy to use; patients simply need to apply it to the corresponding acupoints or areas without requiring complicated procedures or professional medical knowledge, making it convenient for patients to use themselves and improving patient compliance and the convenience of treatment.

[0016] In the preparation method of this invention, the preparation steps of the traditional Chinese medicine powder patch include: raw material processing and weighing: screening ensures the purity and absence of impurities in the medicinal materials; precise weighing ensures accurate proportions of each component, laying the foundation for stable product efficacy; mixing, grinding, and sieving steps: these steps ensure thorough mixing of the medicinal materials and produce an extremely fine powder, promoting uniform distribution of drug components for synergistic effects, increasing the surface area of ​​the drug, facilitating the release and absorption of active ingredients, and improving skin adhesion, thus enhancing therapeutic efficacy and user comfort; powder packaging and molding: non-woven fabric wrapping of specific powder packets facilitates control of dosage and application area, and the integrated molding with a heating pack promotes transdermal absorption of the drug through heating, enhancing practicality; fixing and packaging steps: fixing the powder packets to prevent displacement, and sealing the packaging to isolate adverse external factors, ensuring the stability and quality of the product during storage and transportation, and ensuring its safety, effectiveness, and convenience in spleen-strengthening and stomach-nourishing applications.

[0017] Preferably, the preparation of the herbal powder plaster in step S1 specifically includes the following steps: S11 Raw Material Processing and Weighing: The medicinal materials, including Artemisia argyi, Cistanche deserticola, rhubarb, Citrus aurantium, Angelica sinensis, radish seed, clove, and Costus root, are screened to remove impurities and substandard products. Then, 65-75 parts of Artemisia argyi, 1-5 parts of Cistanche deserticola, 2-10 parts of rhubarb, 1-8 parts of Citrus aurantium, 1-8 parts of Angelica sinensis, 1-10 parts of radish seed, 1-8 parts of clove, and 1-10 parts of Costus root are accurately weighed. Removing impurities and substandard products ensures the purity and quality of the medicinal materials, preventing impurities from adversely affecting the efficacy and ensuring the effectiveness and safety of the final product. Precise measurement of each medicinal material allows for strict control of the proportions of each component, making the drug formulation more precise, thereby ensuring the stability and consistency of the product's efficacy and ensuring the accurate exertion of its spleen-strengthening and stomach-nourishing effects.

[0018] S12 Mixing, Grinding, and Sieving: After thoroughly mixing the weighed medicinal materials, perform 2-4 grinding and sieving operations, sieving after each grinding, until the medicinal materials are ground into an extremely fine powder of 80-120 mesh. This ensures that all the medicinal materials are fully mixed, guaranteeing a uniform distribution of the powder components. This allows the various drugs to work synergistically during use, comprehensively regulating spleen and stomach function and enhancing the overall effect of strengthening the spleen and nourishing the stomach. Grinding the medicinal materials into an extremely fine powder of 80-120 mesh increases the surface area of ​​the medicine, which not only facilitates the release and absorption of the active ingredients but also makes the powder finer, allowing it to adhere better to the skin, improving the comfort of application and the penetration of the medicine. Multiple grinding and sieving processes further ensure the fineness and uniformity of the powder.

[0019] S13 Powder Packaging and Molding: The ground powder is wrapped in non-woven fabric to form powder packets with a diameter of 60-100mm, controlling the total powder content within the range of 1.2±0.35g. The powder packets and heating packs are integrally molded, with the heating pack having the same diameter and a heating powder content of 11g±2g. Wrapping the powder in non-woven fabric into powder packets of specific diameter and content facilitates control over the amount of powder used and the application area, ensuring accurate dosage and effective coverage of the target area each time. The non-woven fabric also has good breathability and softness, reducing skin irritation. The heating pack and powder packets are integrally molded to the same size. The heat generated by the heating pack promotes blood circulation in the skin, dilates pores, and enhances the transdermal absorption of the drug, better exerting the effects of the spleen-strengthening and stomach-nourishing drugs. This also facilitates use and improves the product's practicality.

[0020] S14 Fixing and Packaging: The one-piece molded medicine packet is adhered to the center of the non-woven fabric using adhesive backing, forming a complete Chinese herbal medicine powder patch. It is then sealed in a bag for later use. Adheding the medicine packet to the center of the non-woven fabric securely fixes the powder packet in the center of the patch, preventing the powder from shifting or scattering during use and ensuring the medicine accurately acts on the corresponding acupoints or areas. Sealing in the bag effectively isolates the powder from external air, moisture, and microorganisms, preventing it from becoming damp, deteriorating, or contaminated, extending the product's shelf life, and ensuring its stability and quality during storage and transportation.

[0021] The integrated molding of the powder pack and heating pack plays a crucial role in enhancing product performance, user experience, and therapeutic efficacy. Firstly, the heating pack generates heat during use, raising the local skin temperature, dilating pores, and increasing skin permeability. This allows the drug molecules in the powder pack to penetrate the skin more quickly and effectively, improving absorption efficiency. The effective components of traditional Chinese medicines such as Artemisia argyi, Cistanche deserticola, and rhubarb can better penetrate acupoints and surrounding tissues with the aid of heating, exerting effects such as strengthening the spleen and stomach, and regulating the intestines. Compared to ordinary non-heating patches, the integrated design allows the drug and heat to work synergistically, accelerating the movement and diffusion of drug molecules, increasing the concentration gradient of the drug in skin tissue, further enhancing transdermal absorption, and enabling the drug to reach the target site more quickly to exert its therapeutic effect. Secondly, the warmth generated by the heating pack can alleviate discomfort such as abdominal coldness and bloating caused by spleen and stomach upset, providing a comfortable experience. The warm stimulation can also promote local blood circulation, improve tissue metabolism, help relieve muscle tension, and reduce fatigue, allowing users to feel relaxed and comfortable while receiving treatment. The one-piece design ensures a tight fit between the powder pack and the heating pack, preventing separation or displacement during use. This guarantees that the medicine and heat can continuously and stably act on the acupoints, eliminating the need for frequent adjustments to the application position and improving convenience and comfort. Thirdly, the one-piece structure of the powder pack and heating pack helps maintain the stability of the powder, preventing deterioration or reduced efficacy due to moisture, oxidation, or other factors during storage and use. The heating pack provides moisture protection and insulation, creating a relatively stable storage environment and extending the product's shelf life. During use, the continuous heating keeps the powder in a suitable temperature environment, facilitating the slow release and sustained action of the medicine, ensuring long-lasting efficacy. Compared to traditional separate powder and heating devices, the one-piece design reduces heat loss and drug loss, allowing the medication to work more stably and continuously, thus improving therapeutic efficacy. Simultaneously, the one-piece structure is more compact and efficient, reducing product size and weight, making it easier to carry and store. Users can easily place it in their pockets or backpacks for convenient application anytime, anywhere, without disrupting daily life or work. This design simplifies usage; users simply remove the one-piece patch, peel off the release paper, and apply it directly to the acupoint, eliminating the need to separately handle the powder and heating packs. This reduces the difficulty of use, improves ease of use, and better meets the modern consumer demand for convenient and efficient products.

[0022] Furthermore, the specific method for integrally molding the powder pack and the heating pack includes the following operations: placing the prepared powder pack in the center and flat on the mold, taking the heating pack and placing it correspondingly to the powder pack to ensure that the centers of the two are aligned, the heating powder of the heating pack is evenly distributed without accumulation or gaps, and using hot pressing molding with a temperature range of 120-150℃, a pressure of 0.3-0.5MPa, and a time of 10-15 seconds to form a complete assembly. After cooling, the integrally molded powder pack is obtained.

[0023] The powder pack is placed evenly in the center to ensure accurate and stable positioning within the mold. This lays the foundation for precise assembly with the heating pack, ensuring even stress distribution during molding and guaranteeing consistent quality after one-piece molding. It prevents molding problems caused by powder pack misalignment, avoiding areas of excessive thickness or thinness, thus ensuring stable drug release and heating effect during use. Center alignment ensures even stress distribution throughout the powder pack and heating pack during thermoforming, resulting in a tight and secure bond and preventing separation during use. The heat generated by the heating pack can be evenly transferred to the powder pack, promoting the uniform penetration and absorption of the active ingredients in the powder, improving the transdermal absorption effect of the drug, and thus enhancing its spleen-strengthening and stomach-nourishing effects. The even distribution of the heating powder avoids local overheating or insufficient heat in the heating pack, ensuring that the entire powder pack receives a stable and uniform heat supply during use. This causes the skin surface temperature to rise evenly, resulting in a consistent effect of dilating skin capillaries. This facilitates the continuous and stable penetration of the active ingredients in the powder into the body through the skin, improving drug absorption efficiency. At the same time, it also enhances user comfort and avoids discomfort such as burns caused by local overheating.

[0024] Hot pressing, performed at 120-150℃, softens the materials of both the powder pack and the heating pack to a certain extent, facilitating a tight bond under pressure to form a stable, integrated structure. This process prevents excessive deformation or damage due to high temperatures, ensuring the performance of both the powder and the heating pack remains unaffected and guaranteeing product quality. Simultaneously, it activates some of the active ingredients in the powder, enhancing their bioactivity, promoting transdermal absorption, and strengthening the spleen and stomach-nourishing effects. A pressure of 0.3-0.5 MPa ensures the powder pack and heating pack adhere fully, compacting the contact surfaces, reducing gaps, and further strengthening the bond. This prevents delamination or loosening during use. Appropriate pressure... The pressure also allows the powder to be more densely distributed within the pack, which helps control the release rate, enabling slow and continuous drug release, prolonging the duration of action, and improving therapeutic efficacy. The 10-15 second hot-pressing time ensures the powder pack and heating pack effectively combine under the specified temperature and pressure, forming a stable, integrated structure. It also avoids the adverse effects of prolonged hot pressing on materials and drug components, such as material aging and drug component damage. Precise control of the hot-pressing time ensures the product's quality and performance remain unaffected during the molding process, allowing the final herbal patch to consistently exert its spleen-strengthening and stomach-nourishing effects, while guaranteeing product safety and reliability. Simultaneously, cooling lowers the temperature of the hot-pressed assembly to room temperature, fixing the integrated structure and shape of the powder pack and heating pack. This prevents structural deformation or loosening due to temperature changes during subsequent operations or storage, ensuring product stability and integrity. This guarantees good performance during storage and transportation, allowing patients to use the product effectively and achieve the therapeutic goal of strengthening the spleen and stomach.

[0025] Traditional Chinese medicine essential oils have multiple benefits. As an adjuvant, they guide the various herbs in a powder packet to the spleen, stomach, and large intestine meridians. Ingredients such as immature bitter orange oil and magnolia bark oil have qi-regulating and stagnation-relieving effects, helping other herbs to better act on the spleen, stomach, and intestines, enhancing their effects on specific meridians and organs. When used in combination with herbal powders that strengthen the spleen, they promote the absorption and distribution of the herbs in the spleen and stomach meridians, making the spleen-strengthening and stomach-nourishing effects more significant. This helps regulate the digestive function of the spleen and stomach, improving indigestion and loss of appetite caused by spleen and stomach weakness. The combined effects of various Chinese herbal essential oils strengthen the spleen and regulate qi. Clove oil has the effects of warming the middle jiao and relieving nausea, tonifying the kidneys and assisting yang, which can warm the spleen and stomach and promote the flow of qi in the spleen and stomach. Astragalus oil has the effects of invigorating qi and consolidating the exterior, strengthening the spleen and replenishing the middle jiao, which can enhance the digestive function of the spleen and stomach and improve the body's ability to absorb nutrients. Artemisia oil has the effects of regulating qi and blood and dispelling cold and dampness, which can improve the state of spleen and stomach deficiency and cold, promote the flow of qi and blood in the spleen and stomach, relieve discomfort symptoms such as abdominal distension and pain caused by qi stagnation and blood stasis, and make the qi of the spleen and stomach smooth and restore normal function. Ingredients such as lard and aloe vera oil have purgative and heat-clearing effects, promoting intestinal peristalsis and helping to expel accumulated stool, toxins, and other waste from the intestines. Hemp seed oil has a laxative effect, moisturizing the intestines, promoting smooth bowel movements, and preventing constipation. These herbal essential oils work synergistically to help cleanse the intestinal environment, reduce the absorption of harmful substances in the intestines, and alleviate the burden on the intestines, thereby improving spleen and stomach function. They have a good effect on improving symptoms such as abdominal distension, constipation, and sticky stools caused by intestinal stagnation. By regulating the ascending and descending of Qi and the transformation and transportation of fluids in the spleen and stomach, herbal essential oils can promote the digestion of food and the absorption of nutrients by the spleen and stomach, while expelling metabolic waste from the body. When the ascending function of the spleen and stomach is normal, nutrients such as the essence of food can be transported upward to the heart, lungs, and other organs to nourish the whole body; while the descending function is normal, ensuring that waste products are smoothly expelled from the body. The various components in herbal essential oils work together to help restore the normal physiological function of the spleen and stomach, maintain the balance of digestion, absorption, and metabolism, and have a positive effect on improving a series of symptoms caused by spleen and stomach weakness, such as thick and greasy tongue coating and heaviness in the body.

[0026] Preferably, the preparation of the herbal essential oil in step S2 specifically includes the following steps: S21 Raw Material Pretreatment: The base oil, mugwort oil, aloe vera oil, immature bitter orange oil, magnolia bark oil, clove oil, ghee, astragalus oil, and hemp seed oil are screened. Borneol is dissolved by heating and stirring in a 40-50℃ water bath. 70-80 parts of base oil, 1-10 parts of mugwort oil, 1-5 parts of aloe vera oil, 1-7 parts of immature bitter orange oil, 1-5 parts of magnolia bark oil, 1-7 parts of clove oil, 1-8 parts of ghee, 1-5 parts of astragalus oil, 1-5 parts of hemp seed oil, and 1- Five portions of borneol were used. The base oils, mugwort oil, aloe vera oil, immature bitter orange oil, magnolia bark oil, clove oil, lard oil, astragalus oil, and hemp seed oil were screened to remove impurities, foreign matter, and deteriorated components, ensuring the purity and quality of the raw materials. This provides a guarantee for preparing high-quality Chinese herbal essential oils. Pure raw materials help improve the stability, safety, and efficacy of the essential oils, avoiding adverse reactions caused by impurities or affecting the efficacy of the essential oils. The borneol was then subjected to a 40-50℃ water bath. Heating and stirring to dissolve borneol is necessary because borneol is solid at room temperature and is difficult to mix evenly with other oil components when added directly. Heating it in a water bath ensures that borneol is fully dispersed in the essential oil system during subsequent mixing, allowing it to exert its effects such as guiding the medicine upwards, promoting transdermal absorption, and clearing the mind. At the same time, it works synergistically with other components to improve the overall therapeutic effect of the herbal essential oil. Precisely weighing 70-80 parts of base oil, 1-10 parts of Artemisia argyi oil, 1-5 parts of aloe vera oil, 1-7 parts of Citrus aurantium oil, 1-5 parts of Magnolia officinalis oil, 1-7 parts of clove oil, 1-8 parts of lard oil, 1-5 parts of Astragalus membranaceus oil, 1-5 parts of hemp seed oil, and 1-5 parts of borneol allows for precise control of the herbal essential oil formula, enabling the components to work synergistically to exert the best spleen-strengthening and stomach-nourishing effects, ensuring the effectiveness and stability of the product. The accuracy of the proportions of each component directly affects the overall performance and therapeutic effect of the essential oil, and precise proportions help ensure the consistency of quality in each batch of product.

[0027] S22 Mixing and Stirring: Weigh out the base oil, mugwort oil, aloe vera oil, immature bitter orange oil, magnolia bark oil, clove oil, lard, astragalus oil, and hemp seed oil, and put them into a container. Use a stirring device to stir at room temperature for 50-100 rpm for 10-20 minutes to form a uniform preliminary mixture. This ensures that all oils are thoroughly mixed and form a homogeneous system, guaranteeing that each drop of essential oil contains a balanced amount of effective components. This avoids differences in efficacy due to uneven component distribution and lays the foundation for subsequent mixing with borneol and the quality stability of the final product. Slowly add the completely dissolved borneol and continue stirring for 5-10 minutes to obtain a mixture of Chinese herbal essential oils. This allows the borneol to be evenly dispersed throughout the mixture. During the stirring process, the components come into contact with and fuse with each other, producing synergistic effects or physicochemical changes. This helps improve the overall quality and efficacy of the Chinese herbal essential oils, ensuring that borneol can work synergistically with other components, such as promoting transdermal absorption and regulating the direction of drug action, allowing the Chinese herbal essential oils to exert better effects in strengthening the spleen and stomach.

[0028] S23 Filtration and Impurity Removal: The mixed herbal essential oils are filtered through a filtration device at room temperature under a pressure of -0.06MPa to -0.07MPa, passing through a polyethersulfone filter membrane with a pore size of 0.2-0.8 microns for 1-3 hours. This effectively removes tiny impurities and insoluble substances from the essential oils. These impurities can affect the appearance, stability, and transdermal absorption of the essential oils. Filtration and impurity removal can improve the purity of the essential oils, ensure product quality, make the essential oils safer and more effective when used, reduce skin irritation, and help maintain the stability of the essential oils, extending their shelf life.

[0029] S24 Filling and Sealing: After the filtered herbal essential oil mixture is filled into essential oil bottles by a filling machine, the bottles are immediately sealed for later use. Filling the essential oil mixture into bottles ensures quantitative packaging, facilitating product storage, transportation, and use. This ensures accurate and consistent oil content in each bottle, allowing patients to use it according to the prescribed dosage, guaranteeing the stability and repeatability of therapeutic effects. Immediate sealing effectively prevents volatile components from evaporating into the air, avoiding loss of active ingredients and maintaining the concentration and efficacy of the essential oil. Simultaneously, the sealed packaging prevents external dust and microorganisms from entering the bottles, preventing contamination and ensuring cleanliness and hygiene. This extends the shelf life and ensures the product maintains good quality and performance throughout storage and use, providing patients with safe and effective herbal essential oil products and guaranteeing the continued effectiveness of its spleen-strengthening and stomach-nourishing effects.

[0030] This invention provides a traditional Chinese medicine patch product with spleen-strengthening and stomach-nourishing effects. The specific method of using the product includes the following operations: the integrated and prepared traditional Chinese medicine patch product is applied to specific acupoints such as Zhongwan, Jizhong, and Pishu, with two patches applied at a time.

[0031] This invention relates to a method of applying a traditional Chinese medicine patch with spleen-strengthening and stomach-nourishing effects to acupoints. It embodies the specific application of the theory of meridians and acupoints in traditional Chinese medicine in disease treatment, and provides a safe and effective non-oral treatment method to improve various symptoms caused by spleen and stomach weakness and enhance quality of life.

[0032] In Traditional Chinese Medicine (TCM), acupoints such as Zhongwan (CV12), Jizhong (SI11), and Pishu (BL20) are closely related to the function of the spleen and stomach. Applying herbal patches to these acupoints follows the TCM principle of "treating internal diseases externally," allowing the medicine to be delivered directly to the affected area via the meridians, regulating the balance of Qi, blood, Yin, and Yang in the spleen and stomach. This represents a continuation and inheritance of traditional TCM theories and treatment methods, contributing to the further development and application of TCM theory in modern medical practice. Simultaneously, it avoids the side effects of oral medications, such as gastrointestinal irritation, first-pass effect in the liver, and metabolic burden on the kidneys. For patients with weak spleen and stomach, especially children, the elderly, and those with weak gastrointestinal function or poor tolerance to oral medications, this external application method is particularly beneficial. Safer and gentler, reducing the risk of adverse drug reactions and improving patient adherence; this invention's herbal patch product has a significant improving effect on various symptoms caused by spleen and stomach weakness, such as food stagnation, indigestion, bloating, constipation, abnormal bowel movements, and thick, greasy tongue coating. By regulating spleen and stomach function, it promotes digestion and absorption, relieves gastrointestinal discomfort, and improves the body's nutritional status, thereby improving the patient's quality of life. It improves symptoms of food stagnation and indigestion, allowing patients to restore normal appetite and take in sufficient nutrients; it relieves constipation and abnormal bowel movements, helps to expel toxins from the body, improves intestinal health, and reduces other health risks caused by spleen and stomach problems. Personalized acupoint application adjusts the combination or key acupoints based on the patient's different symptoms and physical differences, achieving individualized treatment that is more precise and effective. This meets the individualized needs of different patients, reflecting the trend of modern medicine towards precision and personalization, which helps improve medical outcomes and reduce the blindness of treatment. This innovative Chinese medicine patch product and its usage method enrich the product types and treatment methods of traditional Chinese medicine in the field of spleen and stomach regulation. In addition to treating diseases related to spleen and stomach weakness, this method can also be applied to daily health care and management of the spleen and stomach. In daily life, for people with poor eating habits, irregular lifestyles, or those in a sub-healthy state, regular use of Chinese medicine patch products for acupoint application can help prevent spleen and stomach diseases, enhance spleen and stomach function, and regulate bodily functions.

[0033] Preferably, the traditional Chinese medicine powder patch includes a powder pack, a heating pack, an adhesive backing, and a third non-woven fabric. The powder pack is made by covering the ground powder with a first non-woven fabric, and has a diameter of 60-100mm. The heating pack is made by covering the heating powder with a second non-woven fabric, and has the same diameter as the powder pack. The powder pack and the heating pack are integrally formed and then adhered to the center of the third non-woven fabric with an adhesive backing to form a complete traditional Chinese medicine powder patch.

[0034] The soft, breathable, and lightweight non-woven fabric in the powder pack allows the powder to fully contact the skin, facilitating transdermal absorption of the medication. It also ensures normal skin respiration, reduces skin burden, and improves patient comfort. The powder is carefully blended and ground from various Chinese medicinal herbs, including mugwort, cistanche, and rhubarb. Each herb exerts its unique effects, working synergistically to comprehensively regulate spleen and stomach function. Mugwort warms and dispels cold, cistanche tonifies the kidneys and warms the spleen, and rhubarb purges and detoxifies, thus improving symptoms of spleen and stomach weakness from multiple perspectives.

[0035] The second non-woven fabric in the heating pack serves to encapsulate the heating powder, preventing leakage while maintaining breathability to ensure proper heating function. When used, the heating powder generates heat, stimulating acupoints, dilating skin capillaries, accelerating the absorption and penetration of the active ingredients in the powder, and enhancing the therapeutic effect. Its warming properties also synergize with the warming medicinal herbs in the powder, better promoting the functions of warming and unblocking meridians, dispelling cold and relieving pain, and promoting the recovery of spleen and stomach function.

[0036] The adhesive backing firmly bonds the one-piece molded powder pack and heating pack to the center of the third non-woven fabric, ensuring the stability of the powder pack and heating pack during use, preventing displacement or detachment, and ensuring that the medicine can continuously and accurately act on specific acupoints or areas, maintaining the effectiveness and stability of the treatment. The third non-woven fabric provides support and adhesion for the entire Chinese medicine powder patch, making the patch easy to use and fix on the skin, facilitating patient operation, and ensuring the overall stability of the powder pack and heating pack during the application process.

[0037] The adhesive backing is placed on the inside of the herbal powder pack, while the heating pack is placed on the outside. When the herbal powder patch is applied to the skin, one side of the powder pack is in direct contact with the skin. The adhesive backing ensures that the powder pack adheres firmly to the skin, preventing it from easily shifting or falling off during use (especially in daily activities). Simultaneously, the active ingredients in the powder pack can act more directly on the skin surface, allowing for transdermal absorption and enhancing the spleen and stomach's health benefits. The heating pack primarily promotes drug penetration and absorption. Placed on the outside of the powder pack, it allows for better heat exchange with the external environment, generating a suitable temperature to accelerate the movement and penetration of drug molecules, improving absorption efficiency and thus enhancing the therapeutic effect of the herbal patch. Furthermore, it avoids the discomfort or potential risks associated with direct skin contact of the heating pack.

[0038] As a preferred embodiment, the traditional Chinese medicine patch product with spleen-strengthening and stomach-nourishing effects also includes active auxiliary ingredients such as Bifidobacterium metabolites.

[0039] Adding Bifidobacterium metabolites to traditional Chinese medicine plasters with spleen-strengthening and stomach-nourishing effects can regulate the intestinal microecology, enhance gastrointestinal motility, promote nutrient absorption, and synergize with the effects of the herbal ingredients. Bifidobacterium metabolites contain short-chain fatty acids such as acetic acid, propionic acid, and butyric acid, which lower the pH value in the intestines, creating an acidic environment unfavorable to the growth of harmful bacteria, while providing suitable conditions for the survival and reproduction of beneficial bacteria such as Bifidobacterium, thus promoting the establishment and maintenance of intestinal flora balance. In cases of spleen and stomach weakness related to intestinal flora imbalance, supplementing with Bifidobacterium metabolites can improve the intestinal microecology, alleviate symptoms such as diarrhea and bloating, and promote the recovery of digestive and absorptive functions. Some metabolites have the effect of stimulating intestinal smooth muscle contraction, which can promote gastrointestinal motility, accelerate the propulsion of food in the gastrointestinal tract, and prevent food from staying in the gastrointestinal tract for too long, thus preventing fermentation, putrefaction, and the production of gas and harmful substances. This has a positive effect on improving common symptoms of spleen and stomach weakness such as indigestion and constipation. Bifidobacterium metabolites affect the metabolism and function of intestinal mucosal cells, increasing the absorption area and carrier protein activity on the surface of intestinal mucosal cells. This improves the absorption efficiency of nutrients such as glucose, amino acids, vitamins, and minerals, helping to maintain the normal function of the spleen and stomach and the body's overall health, providing a sufficient material basis for the repair and conditioning of the spleen and stomach. Simultaneously, they work synergistically with other ingredients in traditional Chinese medicine patches (such as Artemisia argyi, Cistanche deserticola, Rheum palmatum, and Citrus aurantium). On one hand, Bifidobacterium metabolites can enhance the regulatory effect of traditional Chinese medicine components on the gastrointestinal tract, promoting the absorption and transport of effective components in the intestines, allowing them to better act on the spleen, stomach, and related organs. On the other hand, traditional Chinese medicine components also provide a favorable environment and nutritional support for the growth and metabolism of Bifidobacterium in the intestines. The two work together to comprehensively regulate spleen and stomach function from multiple perspectives, enhancing the product's spleen-strengthening and stomach-nourishing effects, and improving symptoms of spleen and stomach weakness (such as thick tongue coating, indigestion, and constipation).

[0040] The present invention relates to the preparation and integration process of Bifidobacterium metabolites in a traditional Chinese medicine patch product. In the cultivation and collection stage, aseptic conditions, specific temperatures, pH values, and anaerobic environments ensure the activation and proliferation of Bifidobacterium, producing active metabolites. Centrifugation is used to obtain a crude extract. Ultrafiltration concentration utilizes specific molecular weight cutoffs and pressure to precisely separate impurities and small-molecule active ingredients, concentrating them. Freeze-drying, using low temperature, low pressure, and precise temperature and time control parameters, dries the product into powder while preserving its activity. In the integration stage, the metabolites are evenly dispersed in the traditional Chinese medicine powder according to a specific ratio and mixing method. Each step works closely together to fully utilize the functions of Bifidobacterium metabolites in regulating intestinal microecology and synergistically strengthening the spleen and stomach with traditional Chinese medicine, thereby improving the overall efficacy and quality of the product.

[0041] Preferably, the preparation and integration process of the active auxiliary ingredient, Bifidobacterium metabolites, included in the traditional Chinese medicine patch product of the present invention specifically includes the following steps: Culture and Metabolite Collection of Bifidobacterium S41: Under aseptic conditions, Bifidobacterium strains were inoculated into a dedicated culture medium and cultured in an anaerobic incubator for 24-48 hours to activate the bacteria, avoiding contamination and ensuring normal growth and activity, laying the foundation for subsequent large-scale fermentation. The activated Bifidobacterium was then transferred to a fermenter at a volume ratio of 5-10%, maintaining a temperature of 37℃ and a pH of 6.5-7.0, with continuous purging of sterile nitrogen to maintain an anaerobic environment. Large-scale fermentation was carried out for 48-72 hours, conditions close to the physiological growth environment of Bifidobacterium, allowing for its proliferation and the production of metabolites. After fermentation, the culture medium was centrifuged at 3-6℃ and 8000-10000 rpm for 20-30 minutes, and the supernatant was collected. This supernatant is the crude extract rich in Bifidobacterium metabolites. Low temperature prevents degradation or denaturation of metabolites, while high-speed centrifugation effectively separates metabolites from bacterial cells and other macromolecular impurities, yielding a crude extract rich in metabolites.

[0042] Concentration and Drying of S42 Metabolites: The crude extract was concentrated using an ultrafiltration membrane with a molecular weight cutoff of 1000-5000 Da. At a pressure of 0.1-0.3 MPa, small-molecule metabolites permeated through the ultrafiltration membrane, while large-molecule impurities were retained, concentrating the metabolite solution to 1 / 5-1 / 10 of its original volume. This increased product concentration and reduced subsequent processing volume and costs. The concentrated metabolite solution was transferred to a pre-freezing tray in a freeze dryer and pre-frozen at -40℃ to -50℃ for 2-3 hours until completely frozen. Then, a vacuum system was activated, and freeze-drying was performed under a vacuum of 80-100 Pa. The sublimation temperature was controlled at -20℃ to -30℃, and the desorption drying temperature was 30℃-40℃ for 24-48 hours. Moisture was removed under low temperature and low pressure to avoid damaging the metabolite activity at high temperatures, resulting in a dry powder with well-preserved activity. This powder is easy to store and can be mixed with traditional Chinese medicine powders to obtain dried Bifidobacterium metabolite powder.

[0043] Integration of S43 metabolites with traditional Chinese medicine patch products: In the preparation of traditional Chinese medicine powder patches, after completing the preliminary steps of screening, weighing, grinding, and sieving the traditional Chinese medicine materials such as Artemisia argyi, Cistanche deserticola, rhubarb, Citrus aurantium, Angelica sinensis, radish seed, clove, and Aucklandia lappa to obtain an 80-120 mesh ultra-fine powder, take an appropriate amount of dried Bifidobacterium metabolite powder and mix it with the traditional Chinese medicine powder at a ratio of 5-10% of the total powder mass. First, grind and mix the metabolite powder with a small amount of the powder in a mortar, and then gradually add the mixed powder to the remaining powder. Continue stirring in a mixer for 10-20 minutes at a speed of 50-80 rpm to ensure uniform mixing. Then continue the preparation of the traditional Chinese medicine powder patch to ensure that the metabolites are evenly dispersed in the powder, so that they can stably play their role in regulating the intestinal microecology and synergistically strengthening the spleen and stomach of traditional Chinese medicine when applied, ensuring the consistency of product quality and efficacy.

[0044] In summary, the present invention has the following beneficial effects: 1. This invention, a traditional Chinese medicine patch product with spleen-strengthening and stomach-nourishing effects, exhibits a unique formula of Chinese herbal ingredients that demonstrates significant advantages compared to traditional product formulas. Traditional products focus on single effects or simple combinations of a few herbs, making it difficult to comprehensively address the complex and diverse symptoms of spleen and stomach weakness. This invention, however, carefully selects a variety of herbs such as Artemisia argyi, Cistanche deserticola, Rheum palmatum, Citrus aurantium, Angelica sinensis, Raphanus sativus, Clove, and Aucklandia lappa, which work synergistically from multiple dimensions, including warming yang and dispelling cold, tonifying the kidneys and strengthening the spleen, purging and eliminating stagnation, promoting qi circulation and relieving stagnation, nourishing blood and promoting blood circulation, eliminating food stagnation, and warming the middle jiao and relieving nausea. The large quantity of Artemisia argyi warms yang and dispels cold, and opens the orifices and awakens the spirit. The formula combines the following ingredients: Cistanche deserticola tonifies kidney yang, indirectly warms the spleen and stomach, and moistens the intestines to relieve constipation; rhubarb, when used in appropriate dosage, purges stagnation and detoxifies without harming the body's vital energy; immature bitter orange and other qi-regulating herbs enhance the movement of qi in the spleen and stomach; angelica sinensis nourishes qi and blood and promotes blood circulation; radish seed eliminates food stagnation and promotes digestion; clove warms the middle jiao, relieves nausea, and stimulates digestion; and costus root regulates qi, relieves pain, and aids digestion. This comprehensive and precise combination can more effectively improve various symptoms caused by spleen and stomach weakness, such as food stagnation, indigestion, constipation, abnormal bowel movements, and thick, greasy tongue coating. It provides a more comprehensive, efficient, and targeted conditioning solution for patients with spleen and stomach weakness, making up for the shortcomings of traditional products with single formulas and limited efficacy. 2. The herbal patch of this invention uses a combination of medicinal powder and essential oils, which has significant advantages over traditional dosage forms. Traditional dosage forms are mostly single powders or ointments, which have problems such as unstable drug release and low absorption efficiency. In the herbal patch of this invention, the Chinese medicinal materials are made into an extremely fine powder and integrated with a heating pack. The powder has a delicate texture and can adhere tightly to the skin, increasing the contact area between the drug and the skin and promoting transdermal absorption. The heating pack further facilitates drug penetration. The herbal essential oils are mixed with various volatile oils using a base oil as a carrier. The base oil moisturizes the skin and helps the volatile oils absorb. The volatile oils each exert their unique effects and have a significant synergistic effect, such as regulating the spleen and stomach qi, promoting digestion, and lubricating the intestines to relieve constipation. When the two are combined, the essential oils and the powder form a uniform mixture system, which makes the drug release slow and long-lasting, with both long-acting sustained release and rapid penetration characteristics, effectively improving the therapeutic effect and overcoming many drawbacks of traditional dosage forms, providing a better solution for strengthening the spleen and stomach. 3. Unlike traditional or conventional patch products that either lack heating function or have limitations due to the separation of the powder and heating device, this invention features an integrated powder pack and heating pack. During use, the heating pack generates heat, effectively expanding skin pores and increasing skin permeability. This greatly promotes the transdermal absorption of the active ingredients in the powder, enhancing the speed of drug onset and therapeutic effect—achievements difficult to attain with traditional methods. Simultaneously, the warmth of the heating pack not only relieves gastrointestinal discomfort but also improves local blood circulation and tissue metabolism, providing a comfortable experience. Traditional products cannot offer such comprehensive benefits. Furthermore, the integrated structure maintains the stability of the powder, preventing moisture absorption and deterioration, extending shelf life, and reducing heat loss and drug loss, ensuring the drug's continuous and stable effect. Traditional separate application methods have significant shortcomings in these aspects. This invention is designed to better meet the modern consumer's demand for convenient, efficient, and stable products. 4. The preparation method of the traditional Chinese medicine patch product with spleen-strengthening and stomach-nourishing effects provided by this invention overcomes the problems of insufficient fineness in raw material processing and difficulty in ensuring the purity and precise ratio of medicinal materials in traditional preparation processes. In the preparation of the medicinal powder patch, this invention strictly screens the raw materials to remove impurities and accurately weighs each medicinal material to ensure accurate drug compatibility and lay the foundation for stable efficacy. In the grinding stage, the medicinal powder produced by traditional methods has large particles and poor uniformity. This invention grinds the medicinal materials into an 80-120 mesh ultra-fine powder and sieves it multiple times, greatly increasing the surface area of ​​the medicine, which is conducive to the release and absorption of effective ingredients, making the powder fine in texture and with good adhesion, thus improving the therapeutic effect and user comfort. The medicinal powder is packaged into... In terms of design, traditional methods struggle to effectively combine the powder pack and the heating pack. This invention integrates them into a single unit, using heat to promote transdermal drug absorption and enhance practicality. Regarding the preparation of traditional Chinese medicine essential oils, traditional processes neglect raw material screening and impurity removal. This invention screens both base oils and medicinal oils to ensure raw material quality and provides special treatment for borneol to ensure uniform dispersion. Furthermore, traditional methods lack rigorous standards in mixing, filtration, filling, and sealing. This invention, through scientific operation, improves the purity, stability, and effectiveness of the essential oils. Each step is closely integrated to ensure product quality and efficacy. The overall preparation method is more scientific, rigorous, and efficient, overcoming many drawbacks of traditional methods. 5. The herbal patch of this invention acts directly on the skin surface. Although commercially available oral spleen-strengthening and stomach-nourishing products are relatively fast-acting, the drugs are absorbed through the gastrointestinal tract, metabolized by the liver, and excreted by the kidneys, which can burden organs such as the liver, kidneys, spleen, and stomach. Long-term use can affect their function, and some products can cause adverse reactions such as gastrointestinal discomfort. The patch of this invention avoids these problems. It is absorbed directly into the local blood circulation through the skin, reducing the burden on the liver and kidneys and reducing stimulation to the spleen and stomach, making it safer and especially suitable for special groups such as children and the elderly. Commercially available external patch products generally have the problems of slow onset of action and unclear effects. They are often poorly formulated, have low content of effective ingredients, and poor transdermal absorption. This invention, through acupoint application, follows the TCM concept of "treating internal diseases externally" and uses meridian conduction to directly reach the affected area, regulating the balance of Qi, blood, Yin, and Yang in the spleen and stomach. It is precise and efficient, and can quickly improve various symptoms of spleen and stomach weakness. Acupoints can also be adjusted according to individual patient differences to achieve personalized treatment. It is also suitable for daily health care and prevention of spleen and stomach diseases. Commercially available products cannot match these advantages. 6. Unlike traditional and conventional spleen-strengthening and stomach-nourishing products that only focus on the direct effects of drugs, the herbal patch product of this invention adds Bifidobacterium metabolites, an active auxiliary ingredient, to regulate the intestinal microecology. Its short-chain fatty acids can lower the intestinal pH, creating an environment conducive to the growth of beneficial bacteria and improving the balance of intestinal flora—a function not found in traditional products. Furthermore, the Bifidobacterium metabolites in this herbal patch product enhance gastrointestinal motility, stimulate intestinal smooth muscle contraction, and promote food propulsion, effectively relieving problems such as indigestion and constipation. Compared to conventional technologies, it is more direct and effective in promoting gastrointestinal motility. Moreover, it can promote nutrient absorption, increase the absorption area of ​​intestinal mucosal cells and the activity of carrier proteins, and synergistically enhance the effects with the herbal ingredients, providing more sufficient nutritional support for the recovery of spleen and stomach function. This comprehensive mechanism of action in improving spleen and stomach weakness is significantly different from conventional technologies, further enhancing the product's conditioning effect on symptoms of spleen and stomach weakness. Attached Figure Description

[0045] Figure 1 This is a schematic diagram of the herbal powder patch structure in the herbal patch product of the present invention; In the diagram: 1. Powder packet; 2. Heating pack; 3. Adhesive backing; 4. Third non-woven fabric; 11. First non-woven fabric; 12. Powder; 21. Second non-woven fabric; 22. Heating powder. Detailed Implementation

[0046] This specific embodiment is merely an explanation of the present invention and is not intended to limit the invention. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but such modifications are protected by patent law as long as they are within the scope of the claims of the present invention.

[0047] Example 1

[0048] Preparation of S1 Traditional Chinese Medicine Powder Patch: 70 parts Artemisia argyi, 2 parts Cistanche deserticola, 6 parts Rheum palmatum, 4 parts Citrus aurantium, 4 parts Angelica sinensis, 5 parts Raphanus sativus, 4 parts Clove, and 5 parts Aucklandia lappa were screened, weighed according to proportions, mixed, ground and sieved three times to obtain a 100-mesh ultrafine powder; an appropriate amount of dried Bifidobacterium metabolite powder was taken and mixed with the traditional Chinese medicine powder at a ratio of 8% of the total powder mass, wrapped in non-woven fabric to form a powder pack with a diameter of 80mm, and then combined with a heating pack with the same diameter of 80mm; the integrated powder pack was glued to the center of the non-woven fabric with adhesive backing to form a complete traditional Chinese medicine powder patch, sealed in a bag, and ready for use; Preparation of S2 Traditional Chinese Medicine Essential Oil: 75 parts base oil, 5 parts mugwort oil, 2 parts aloe vera oil, 3 parts immature bitter orange oil, 2 parts magnolia bark oil, 3 parts clove oil, 4 parts lard, 2 parts astragalus oil, 2 parts hemp seed oil, and 2 parts borneol were screened and weighed according to the proportions. The weighed base oil, mugwort oil, aloe vera oil, immature bitter orange oil, magnolia bark oil, clove oil, lard, astragalus oil, and hemp seed oil were added and mixed. The mixture was stirred at 75 rpm for 15 minutes at room temperature to form a uniform preliminary mixture. The completely dissolved borneol was slowly added and the mixture was stirred for another 7 minutes to obtain the traditional Chinese medicine essential oil mixture. The mixed traditional Chinese medicine essential oil was filtered through a filter device. After being filtered under reduced pressure for 2 hours at room temperature through a polyethersulfone filter membrane with a pore size of 0.5 micrometers under a pressure of -0.065 MPa, the mixture was bottled, sealed, and stored for later use. Preparation of S3 Traditional Chinese Medicine Patch Product: Pour 3 ml of traditional Chinese medicine essential oil evenly onto the center of two traditional Chinese medicine powder patches, let the patches stand for 2 minutes to form a uniform traditional Chinese medicine mixture system, and obtain a traditional Chinese medicine patch product with spleen-strengthening and stomach-nourishing effects.

[0049] The traditional Chinese medicine powder patch includes a powder pack 1, a heating pack 2, an adhesive backing 3, and a third non-woven fabric 4. The powder pack 1 is made by covering the ground powder 12 with a first non-woven fabric 11. The heating pack 2 is made by covering the heating powder 22 with a second non-woven fabric 21, and its diameter is the same as that of the powder pack 1. After the powder pack 1 and the heating pack 2 are integrally formed, they are attached to the center of the third non-woven fabric 4 with the adhesive backing 3 to form a complete traditional Chinese medicine powder patch.

[0050] Example 2

[0051] Preparation of S1 Traditional Chinese Medicine Powder Plaster: 75 parts Artemisia argyi, 5 parts Cistanche deserticola, 10 parts Rheum palmatum, 8 parts Citrus aurantium, 8 parts Angelica sinensis, 10 parts Raphanus sativus, 8 parts Clove, and 10 parts Aucklandia lappa were screened, weighed according to proportions, mixed, ground and sieved four times to obtain a 120-mesh ultrafine powder; an appropriate amount of dried Bifidobacterium metabolite powder was taken and mixed with the traditional Chinese medicine powder at a ratio of 10% of the total powder mass, wrapped in non-woven fabric to form a powder pack with a diameter of 80mm, and then combined with a heating pack with the same diameter of 80mm; the integrated powder pack was glued to the center of the non-woven fabric with adhesive backing to form a complete traditional Chinese medicine plaster, sealed in a bag, and ready for use; Preparation of S2 Traditional Chinese Medicine Essential Oil: 80 parts base oil, 10 parts mugwort oil, 5 parts aloe vera oil, 7 parts immature bitter orange oil, 5 parts magnolia bark oil, 7 parts clove oil, 8 parts lard, 5 parts astragalus oil, 5 parts hemp seed oil, and 5 parts borneol were screened and weighed according to the proportions. The weighed base oil, mugwort oil, aloe vera oil, immature bitter orange oil, magnolia bark oil, clove oil, lard, astragalus oil, and hemp seed oil were added and mixed. The mixture was stirred at 100 rpm for 20 minutes at room temperature to form a uniform preliminary mixture. The completely dissolved borneol was slowly added and the mixture was stirred for another 10 minutes to obtain the traditional Chinese medicine essential oil mixture. The mixed traditional Chinese medicine essential oil was filtered through a filter device. After being filtered under reduced pressure at -0.07 MPa and room temperature through a polyethersulfone filter membrane with a pore size of 0.8 microns for 3 hours, the mixture was bottled, sealed, and stored for later use. Preparation of S3 Traditional Chinese Medicine Patch Product: Pour 5 ml of traditional Chinese medicine essential oil evenly onto the center of two traditional Chinese medicine powder patches, let the patches stand for 3 minutes to form a uniform traditional Chinese medicine mixture system, and obtain a traditional Chinese medicine patch product with spleen-strengthening and stomach-nourishing effects.

[0052] Example 3

[0053] Preparation of S1 Traditional Chinese Medicine Powder Plaster: 65 parts of Artemisia argyi, 1 part of Cistanche deserticola, 2 parts of rhubarb, 1 part of Citrus aurantium, 1 part of Angelica sinensis, 1 part of radish seed, 1 part of clove, and 1 part of Aucklandia lappa were screened, weighed according to proportions, mixed, ground twice, and sieved to form an 80-mesh ultrafine powder; an appropriate amount of dried Bifidobacterium metabolite powder was taken and mixed with the traditional Chinese medicine powder at a ratio of 5% of the total powder mass, wrapped in non-woven fabric to form a powder pack with a diameter of 60mm, and then combined with a heating pack with the same diameter of 60mm; the integrated powder pack was glued to the center of the non-woven fabric with adhesive backing to form a complete traditional Chinese medicine plaster, sealed in a bag, and ready for use; Preparation of S2 Traditional Chinese Medicine Essential Oil: 70 parts base oil, 1 part Artemisia argyi oil, 1 part aloe vera oil, 1 part Citrus aurantium oil, 1 part Magnolia officinalis oil, 1 part clove oil, 1 part lard, 1 part Astragalus membranaceus oil, 1 part hemp seed oil, and 1 part borneol were screened and weighed according to the proportions. The weighed base oil, Artemisia argyi oil, aloe vera oil, Citrus aurantium oil, Magnolia officinalis oil, clove oil, lard, Astragalus membranaceus oil, and hemp seed oil were added and mixed. The mixture was stirred at 50 rpm for 10 minutes at room temperature to form a uniform preliminary mixture. The completely dissolved borneol was slowly added and the mixture was stirred for another 5 minutes to obtain the traditional Chinese medicine essential oil mixture. The mixed traditional Chinese medicine essential oil was filtered through a filter device. After being filtered under reduced pressure for 1 hour at room temperature through a polyethersulfone filter membrane with a pore size of 0.2 microns under -0.06 MPa pressure, the mixture was bottled, sealed, and stored for later use. Preparation of S3 Traditional Chinese Medicine Patch Product: Pour 2 ml of traditional Chinese medicine essential oil evenly onto the center of two traditional Chinese medicine powder patches, let the patches stand for 1 minute to form a uniform traditional Chinese medicine mixture system, and obtain a traditional Chinese medicine patch product with spleen-strengthening and stomach-nourishing effects.

[0054] Comparative Example 1 Traditional oral products for strengthening the spleen and stomach, such as commercially available digestive tablets, mainly contain ingredients such as Codonopsis pilosula, dried tangerine peel, yam, roasted malt, and hawthorn, with excipients such as sucrose, dextrin, and magnesium stearate.

[0055] Comparative Example 2 Commercially available external spleen-strengthening and stomach-nourishing patch products mainly contain ingredients such as cloves, cinnamon, and long pepper. They use ordinary non-woven fabric backing, do not have a heating pack design, and the medicinal powder is not finely ground, resulting in relatively coarse particles.

[0056] Comparative Example 3 According to the formula and process of the traditional Chinese medicine powder patch of the present invention, a traditional Chinese medicine patch product without a heating pack is prepared. The traditional Chinese medicine patch product is a traditional Chinese medicine powder patch product without a heating pack, traditional Chinese medicine essential oil, and active auxiliary ingredient Bifidobacterium metabolites. The specific operation includes the following steps: S11 Raw material processing and weighing: 70 parts of Artemisia argyi, 2 parts of Cistanche deserticola, 6 parts of rhubarb, 4 parts of Citrus aurantium, 4 parts of Angelica sinensis, 5 parts of radish seed, 4 parts of clove, and 5 parts of Aucklandia lappa are screened and weighed according to the proportions. S12 Mixing, Grinding and Sieving: After thoroughly mixing the weighed medicinal materials, perform three grinding and sieving operations, sieving after each grinding, until the medicinal materials are ground into 100-mesh ultra-fine powder; S13 Powder Packaging and Molding: The ground powder is wrapped in non-woven fabric to form a powder bag with a diameter of 80mm; the powder bag and the heating pack are integrally molded, with the heating pack having the same diameter. S14 Fixing and Packaging: The one-piece molded medicine pack is glued to the center of the non-woven fabric with adhesive backing to form a complete Chinese medicine powder patch product.

[0057] 1. Experimental Methods Three hundred subjects with weak spleen and stomach were selected to voluntarily undergo treatment. Their symptoms mainly included one or more of the following: food stagnation, indigestion, constipation, sticky stools, and thick tongue coating. Before treatment, the symptoms of each subject were recorded and the number of people with each symptom was counted.

[0058] The subjects were divided into 6 groups of 50 people each. Each group used one of the following: the herbal patch products prepared in Examples 1-3 (each with spleen-strengthening and stomach-nourishing effects); Comparative Example 1: commercially available digestive tablets; Comparative Example 2: commercially available external spleen-strengthening and stomach-nourishing patch; and Comparative Example 3: a herbal patch without a heating pack. For Examples 1-3, two patches were applied to acupoints such as Zhongwan, Jizhong, or Pishu, depending on the specific treatment needs, for 6 hours each time, with a 7-day course of treatment. For Comparative Example 1, adults took commercially available digestive tablets orally according to the recommended dosage in the drug's instructions. The digestive tablets were taken 3 tablets three times a day before meals. The dosage for children was reduced according to age and weight. One course of treatment consisted of 7 consecutive days. In control group 2, after cleansing the skin, commercially available external spleen-strengthening and stomach-nourishing patches were applied to the Shenque acupoint, one patch at a time, for 24 hours each time, for 7 consecutive days as one course of treatment. In control group 3, two self-made herbal patches (without heating packs) were applied to the Zhongwan and Jizhong acupoints, two patches at a time, for 6 hours each time, for 7 consecutive days as one course of treatment. Changes in symptoms and skin condition were observed in each group. The treatment was continued for one month, and the therapeutic effect was evaluated. The evaluation criteria are shown in Table 1.

[0059] Table 1 Evaluation Criteria for Therapeutic Effects

[0060] 2. Experimental Results (1) The improvement rate of spleen and stomach weakness of subjects in the Example Group and the Comparative Group after the product was evaluated. The conditioning effects of the Chinese herbal patch products with spleen-strengthening and stomach-nourishing effects prepared in Examples 1-3 and the commercially available stomach-strengthening and digestive tablets in Comparative Example 1, the commercially available external spleen-strengthening and stomach-nourishing patch product in Comparative Example 2, and the Chinese herbal patch product without heat pack in Comparative Example 3 are shown in Table 2.

[0061] Table 2. Therapeutic effects on subjects with spleen and stomach deficiency (unit: cases)

[0062] Results analysis: From the evaluation results of the therapeutic effect, the total effective rate of the traditional Chinese medicine patch products of the present invention in the groups of Examples 1-3 was 98%, which was significantly higher than the total effective rate of 88% of the commercially available digestive tablets in Comparative Example 1, the total effective rate of 90% of the commercially available external spleen-nourishing and stomach-strengthening patch products in Comparative Example 2, and the total effective rate of 88% of the traditional Chinese medicine patch products without heating packs in Comparative Example 3.

[0063] Regarding the cure rate, the cure rates of Examples 1-3 were 30% (15 / 50), 28% (14 / 50), and 28% (14 / 50), respectively, which were also higher than those of the comparative example group. This indicates that the herbal patch product of the present invention has a significant advantage in improving the overall symptoms of spleen and stomach weakness.

[0064] The herbal patch product of this invention adopts a unique formula, with multiple herbal ingredients working synergistically. The dosage form of combining herbal powder and essential oil, as well as the integrated design of the herbal powder pack and the heating pack, promotes transdermal absorption of the medicine and improves the bioavailability of the medicine, thereby more effectively exerting the effects of strengthening the spleen and nourishing the stomach.

[0065] (2) Further verification of the therapeutic effects of the traditional Chinese medicine patch products with spleen-strengthening and stomach-nourishing effects prepared in Examples 1-3, the commercially available digestive tablets of Comparative Example 1, the commercially available external spleen-strengthening and stomach-nourishing patch product of Comparative Example 2, and the traditional Chinese medicine patch product without heat pack of Comparative Example 3 on each symptom. The results are shown in Table 3.

[0066] Table 3. Treatment efficacy (effective rate, %) for different symptoms in subjects with spleen and stomach deficiency.

[0067] Results Analysis: The effectiveness rates of the three groups in Examples 1-3 for thick tongue coating symptoms were all 96% or higher, with the Example 1 group reaching 98%, significantly higher than the 88% of Comparative Example 1 and 94% of Comparative Example 3. The commercially available external spleen-strengthening and stomach-nourishing patch in Comparative Example 2 had an effectiveness rate of 96% in improving thick tongue coating symptoms, which was close to that of the Example groups, but still lower than that of Example 1. This indicates that the Chinese herbal ingredients in the patch of this invention, such as Artemisia argyi and clove, have the effects of warming yang and dispelling cold, warming the middle and descending rebellious qi, which can regulate spleen and stomach function and improve thick and greasy tongue coating symptoms. At the same time, the synergistic effect of multiple components in the Chinese herbal essential oil helps to restore the normal physiological function of the spleen and stomach, thus having a positive impact on thick tongue coating symptoms. Compared with the comparative product, the Example groups have advantages in formulation and dosage form design, making them perform better in improving thick tongue coating.

[0068] The efficacy rates of Examples 1-3 for symptoms of food stagnation and indigestion were all 96% or higher, with Examples 1 and 2 reaching 98%, which was higher than Comparative Example 1 (92%), Comparative Example 2 (94%), and Comparative Example 3 (90%). This indicates that the Chinese herbal ingredients such as radish seed and costus root in this invention have the effects of relieving indigestion and bloating, promoting qi circulation and relieving pain, and strengthening the spleen and promoting digestion. They can promote food digestion and absorption, enhance the spleen and stomach's digestive capacity, and the combination of powder and essential oil makes the drug release slower and longer, continuously acting on the spleen and stomach, effectively relieving symptoms of food stagnation and indigestion. The shortcomings of the comparative products in terms of formulation or dosage form resulted in their relatively weaker effects in improving symptoms of food stagnation and indigestion.

[0069] The efficacy rate of Examples 1-3 for treating constipation symptoms reached 98%, which was higher than that of Comparative Example 1 (90%), Comparative Example 2 (90%), and Comparative Example 3 (88%). This indicates that the rhubarb, immature bitter orange, and hemp seed oil in the formula of this invention have the effects of purging and relieving constipation, effectively promoting intestinal peristalsis, and helping to expel accumulated stool and toxins. The integrated design of the powder pack and the heating pack promotes drug absorption and enhances the regulatory effect on the intestines, thereby improving constipation symptoms. The comparative products, due to the lack of a heating pack to promote absorption or limitations in drug components and dosage forms, were not as significant as the Example groups in improving constipation.

[0070] The efficacy rates of Examples 1-3 for treating the symptom of sticky stools on the toilet bowl were all 98%, higher than those of Comparative Example 1 (88%), Comparative Example 2 (90%), and Comparative Example 3 (88%). This indicates that the rhubarb and lard oil in the Chinese herbal ingredients of this invention have the effects of clearing heat and purging fire, and purging accumulations, which can clear intestinal stagnation and improve stool consistency. The aloe vera oil and other components in the Chinese herbal essential oils play a certain regulatory role in the intestinal environment and reduce the stickiness of stools. The comparative products were relatively less effective in solving the problem of sticky stools on the toilet bowl, which is related to their formula and dosage form not being able to effectively regulate this symptom.

[0071] (3) Further, the number of people whose symptoms improved after using the traditional Chinese medicine patch products with spleen-strengthening and stomach-nourishing effects prepared in Examples 1-3 at different times was verified. The results are shown in Table 4.

[0072] Table 4 shows the improvement of various symptoms after different numbers of uses of the traditional Chinese medicine patch product with spleen-strengthening and stomach-nourishing effects prepared in the examples.

[0073] Results Analysis: The data shows that as the number of uses increased, the number of people with significant improvement in various symptoms gradually increased. During the first 1-3 uses, symptoms such as thick tongue coating, indigestion, constipation, and sticky stools showed significant improvement in a certain number of people, with 48, 43, 50, and 43 people respectively. During the 4-6 uses, the symptoms improved further, with the number of people increasing to 43, 46, 45, and 47 respectively. During the 7-9 uses, the number of people with improvement continued to increase, indicating that the effect of the herbal patch product of this invention on improving symptoms of spleen and stomach weakness continued to increase with the number of uses.

[0074] Among the results, 50 people experienced significant improvement in bowel movement symptoms after 1-3 uses, indicating that the product has a relatively rapid effect on improving bowel movement. This is related to the laxative ingredients such as rhubarb and immature bitter orange, as well as the heat pack that promotes drug absorption and acts quickly on the intestines. The number of people experiencing improvement in symptoms such as thick tongue coating, indigestion, and sticky stools also steadily increased during use, reflecting the product's comprehensive regulatory effect on spleen and stomach function. By continuously adjusting the spleen and stomach's digestive and absorptive functions and the ascending and descending of Qi, these symptoms are gradually improved.

[0075] Overall, the herbal patch product of this invention has significant effects in regulating spleen and stomach weakness. Whether it is the overall improvement rate of spleen and stomach weakness or the conditioning effect on specific symptoms such as food stagnation, indigestion, constipation, sticky stools, and thick tongue coating, it is superior to the traditional oral spleen and stomach strengthening product of Comparative Example 1, the commercially available external spleen and stomach strengthening patch product of Comparative Example 2, and the similar product without a heating pack of Comparative Example 3.

[0076] This invention provides a traditional Chinese medicine patch product with spleen-strengthening and stomach-nourishing effects. The herbal ingredients are carefully formulated, working synergistically to comprehensively regulate spleen and stomach function from multiple aspects. The combination of powder and essential oil, along with the integrated design of the powder pack and heating pack, effectively improves transdermal absorption efficiency, allowing the medicine to exert its effects continuously and stably. The addition of Bifidobacterium metabolites, an active auxiliary ingredient, synergistically enhances the effects of the herbal ingredients, resulting in better therapeutic outcomes. This herbal patch product is applied to acupoints, following the theory of meridians and acupoints in Traditional Chinese Medicine. The combination of acupoints can be adjusted according to the patient's different symptoms and constitution, achieving personalized treatment. This not only improves the precision and effectiveness of treatment but also reflects the trend of modern medicine towards personalization, better meeting the needs of different patients. Furthermore, this product can not only be used to treat diseases related to spleen and stomach weakness but is also suitable for daily health maintenance and management of the spleen and stomach. For individuals with poor eating habits, irregular lifestyles, or those in a sub-healthy state, regular use can help prevent spleen and stomach diseases, enhance spleen and stomach function, and regulate bodily functions, showing broad application prospects.

Claims

1. A traditional Chinese medicine patch product with spleen-strengthening and stomach-nourishing effects, characterized in that, Its product composition includes traditional Chinese medicine powder plasters and traditional Chinese medicine essential oils; The herbal powder plaster includes: 65-75 parts Artemisia argyi, 1-5 parts Cistanche deserticola, 2-10 parts Rheum palmatum, 1-8 parts Citrus aurantium, 1-8 parts Angelica sinensis, 1-10 parts Raphanus sativus, 1-8 parts Clove, 1-10 parts Aucklandia lappa, non-woven fabric, and a heating pack; the herbal essential oil includes: 70-80 parts base oil, 1-10 parts Artemisia argyi oil, 1-5 parts Aloe vera oil, 1-7 parts Citrus aurantium oil, 1-5 parts Magnolia officinalis oil, 1-7 parts Clove oil, 1-8 parts Yellow glutinous rice oil, 1-5 parts Astragalus membranaceus oil, 1-5 parts Cannabis sativa seed oil, and 1-5 parts Borneol.

2. A method for preparing a traditional Chinese medicine patch product with spleen-strengthening and stomach-nourishing effects, characterized in that, Specifically, the following steps are included: Preparation of S1 Traditional Chinese Medicine Powder Plaster: 65-75 parts of Artemisia argyi, 1-5 parts of Cistanche deserticola, 2-10 parts of Rheum palmatum, 1-8 parts of Citrus aurantium, 1-8 parts of Angelica sinensis, 1-10 parts of Raphanus sativus, 1-8 parts of Clove, and 1-10 parts of Aucklandia lappa are screened, weighed according to proportions, mixed, and ground and sieved 2-4 times to obtain an extremely fine powder of 80-120 mesh. The powder is then wrapped in non-woven fabric to form a powder packet with a diameter of 60-100 mm and a total powder content of 1.2 ± 0.35 g. This packet is then combined with a heating pack, also with a diameter of 60-100 mm and containing 11 g ± 2 g of heating powder. The integrated powder packet is then glued to the center of the non-woven fabric with adhesive backing to form a complete traditional Chinese medicine plaster. It is then sealed in a bag for later use. Preparation of S2 Chinese Herbal Essential Oils: 70-80 parts base oil, 1-10 parts Artemisia argyi oil, 1-5 parts aloe vera oil, 1-7 parts Citrus aurantium oil, 1-5 parts Magnolia officinalis oil, 1-7 parts clove oil, 1-8 parts lard, 1-5 parts Astragalus membranaceus oil, 1-5 parts hemp seed oil, and 1-5 parts borneol are screened and weighed according to the proportions. The ingredients are added and mixed, and stirred at room temperature for 15-30 minutes until evenly mixed. The mixture is then bottled, sealed, and stored for later use. Preparation of S3 Traditional Chinese Medicine Patch Products: Pour 2-5 ml of traditional Chinese medicine essential oil evenly onto the center of two traditional Chinese medicine powder patches, let the patches stand for 1-2 minutes to form a uniform traditional Chinese medicine mixture system, and obtain a traditional Chinese medicine patch product with spleen-strengthening and stomach-nourishing effects.

3. The method for preparing a traditional Chinese medicine patch product with spleen-strengthening and stomach-nourishing effects according to claim 2, characterized in that, The preparation of the herbal powder plaster in step S1 specifically includes the following steps: S11 Raw Material Processing and Weighing: The medicinal materials, including Artemisia argyi, Cistanche deserticola, rhubarb, Citrus aurantium, Angelica sinensis, radish seeds, cloves, and Aucklandia lappa, are screened to remove impurities and substandard products. Then, 65-75 parts of Artemisia argyi, 1-5 parts of Cistanche deserticola, 2-10 parts of rhubarb, 1-8 parts of Citrus aurantium, 1-8 parts of Angelica sinensis, 1-10 parts of radish seeds, 1-8 parts of cloves, and 1-10 parts of Aucklandia lappa are accurately weighed. S12 Mixing, Grinding and Sieving: After thoroughly mixing the weighed medicinal materials, perform 2-4 grinding and sieving operations, sieving after each grinding, until the medicinal materials are ground into an extremely fine powder of 80-120 mesh; S13 Powder Packaging and Molding: The ground powder is wrapped in non-woven fabric to form a powder bag with a diameter of 60-100mm, and the total powder content is controlled within the range of 1.2±0.35g; the powder bag and the heating pack are integrally molded, with the heating pack having the same diameter and the heating powder content being 11g±2g. S14 Fixing and Packaging: The one-piece molded medicine pack is glued to the center of the non-woven fabric with adhesive backing to form a complete Chinese medicine powder patch. It is then sealed in a bag for later use.

4. The preparation method of the traditional Chinese medicine patch product with spleen-strengthening and stomach-nourishing effects according to claim 2 or 3, characterized in that, The specific method for integrally molding the powder pack and the heating pack includes the following operations: the prepared powder pack is placed flat and centered on the mold; the heating pack is taken and placed correspondingly to the powder pack, ensuring that the centers of the two are aligned; the heating powder of the heating pack is evenly distributed without accumulation or gaps; hot pressing is used, with a temperature range of 120-150℃, a pressure of 0.3-0.5MPa, and a duration of 10-15 seconds, to form a complete assembly; after cooling, the integrally molded powder pack is obtained.

5. The preparation method of the traditional Chinese medicine patch product with spleen-strengthening and stomach-nourishing effects according to claim 2, characterized in that, The preparation of the herbal essential oil in step S2 specifically includes the following steps: S21 Raw Material Pretreatment: The base oil, mugwort oil, aloe vera oil, immature bitter orange oil, magnolia bark oil, clove oil, lard, astragalus oil, and hemp seed oil are screened. Borneol is dissolved by heating and stirring in a water bath at 40-50℃. 70-80 parts of base oil, 1-10 parts of mugwort oil, 1-5 parts of aloe vera oil, 1-7 parts of immature bitter orange oil, 1-5 parts of magnolia bark oil, 1-7 parts of clove oil, 1-8 parts of lard, 1-5 parts of astragalus oil, 1-5 parts of hemp seed oil, and 1-5 parts of borneol are accurately weighed. S22 Mixing and Stirring: Weigh the base oil, mugwort oil, aloe vera oil, immature bitter orange oil, magnolia bark oil, clove oil, lard, astragalus oil, and hemp seed oil into a container. Use a stirring device to stir at room temperature for 50-100 rpm for 10-20 minutes to form a uniform preliminary mixture. Slowly add the completely dissolved borneol and continue stirring for 5-10 minutes to obtain a mixture of Chinese herbal essential oils. S23 Filtration and Impurity Removal: The mixed Chinese herbal essential oils are filtered through a filtration device at room temperature under pressure of -0.06MPa to -0.07MPa, using a polyethersulfone filter membrane with a pore size of 0.2-0.8 micrometers for 1-3 hours. S24 Filling and Sealing: After the filtered herbal essential oil mixture is filled into essential oil bottles through the filling machine, the essential oil bottles are immediately sealed for later use.

6. The traditional Chinese medicine patch product with spleen-strengthening and stomach-nourishing effects according to claim 1, characterized in that, The specific method of using the product includes the following steps: apply the integrated and prepared Chinese herbal patch to specific acupoints such as Zhongwan, Jizhong, and Pishu, applying two patches at a time.

7. The traditional Chinese medicine patch product with spleen-strengthening and stomach-nourishing effects according to claim 1, characterized in that, The traditional Chinese medicine powder patch includes a powder pack (1), a heating pack (2), an adhesive backing (3), and a third non-woven fabric (4). The powder pack (1) is made by covering the ground powder (12) with a first non-woven fabric (11), and has a diameter of 60-100mm. The heating pack (2) is made by covering the heating powder (22) with a second non-woven fabric (21), and has the same diameter as the powder pack (1). After the powder pack (1) and the heating pack (2) are integrally formed, they are attached to the center of the third non-woven fabric (4) with an adhesive backing (3) to form a complete traditional Chinese medicine powder patch.

8. A traditional Chinese medicine patch product with spleen-strengthening and stomach-nourishing effects according to claim 1, characterized in that, The product composition also includes active auxiliary ingredients, Bifidobacterium metabolites.

9. A traditional Chinese medicine patch product with spleen-strengthening and stomach-nourishing effects according to claim 8, characterized in that, The preparation and integration process of the active auxiliary ingredient, Bifidobacterium metabolites, specifically includes the following steps: Culture and Metabolite Collection of Bifidobacterium S41: Under aseptic conditions, Bifidobacterium strains were inoculated into a special culture medium and activated by 24-48 hours in an anaerobic incubator. The activated Bifidobacterium was then transferred to a fermenter at a volume ratio of 5-10%, maintaining a temperature of 37℃ and a pH of 6.5-7.0, with sterile nitrogen continuously purging to maintain an anaerobic environment. Large-scale fermentation was carried out for 48-72 hours to allow Bifidobacterium to proliferate and produce metabolites. After fermentation, the culture medium was centrifuged at 3-6℃ and 8000-10000 rpm for 20-30 minutes, and the supernatant was collected. This supernatant is the crude extract rich in Bifidobacterium metabolites. Concentration and drying of S42 metabolites: The crude extract was concentrated by ultrafiltration using an ultrafiltration membrane with a molecular weight cutoff of 1000-5000 Da. Small molecule metabolites were allowed to pass through the ultrafiltration membrane under a pressure of 0.1-0.3 MPa, while large molecule impurities were retained. The metabolite solution was concentrated to 1 / 5-1 / 10 of its original volume. The concentrated metabolite solution was then transferred to a pre-freezing tray of a freeze dryer and pre-frozen at -40℃ to -50℃ for 2-3 hours to ensure complete freezing. Subsequently, the vacuum system was activated, and freeze-drying was carried out under a vacuum of 80-100 Pa. The sublimation temperature was controlled at -20℃ to -30℃, the desorption drying temperature was 30℃-40℃, and the drying time was 24-48 hours to obtain dried Bifidobacterium metabolite powder. Integration of S43 metabolites with traditional Chinese medicine patch products: In the preparation of traditional Chinese medicine powder patches, after completing the preliminary steps such as screening, weighing, grinding, and sieving of the traditional Chinese medicine materials Artemisia argyi, Cistanche deserticola, rhubarb, Citrus aurantium, Angelica sinensis, radish seed, clove, and Aucklandia lappa to obtain an 80-120 mesh ultra-fine powder, take an appropriate amount of dried Bifidobacterium metabolite powder and mix it with the traditional Chinese medicine powder at a ratio of 5-10% of the total mass of the powder. First, grind and mix the metabolite powder with a small amount of the powder in a mortar, and then gradually add the mixed powder to the remaining powder. Continue stirring in a stirrer for 10-20 minutes at a speed of 50-80 rpm to ensure uniform mixing before continuing the preparation of the traditional Chinese medicine powder patch.

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