Broad-spectrum antibacterial peptide as well as preparation method and application thereof

By developing antimicrobial peptides and their chemical modifications and fusion proteins, the problems of antibiotic resistance and dysbiosis in oral microbial infections have been solved, achieving efficient and safe pathogen inhibition and microecological stability.

CN121673374APending Publication Date: 2026-03-17SHENZHEN WEIZHI BIOTECHNOLOGY CO LTD
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Patent Information

Application Number
CN202511628214.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-11-07
Publication Date
2026-03-17

AI Technical Summary

Technical Problem

Current antibiotic treatments for oral microbial infections are prone to causing bacterial resistance and dysbiosis, and there is a lack of effective alternative drugs.

Method used

Develop an antimicrobial peptide or its salt that disrupts bacterial cell membranes through electrostatic interactions or physical actions, and combine chemical modifications and fusion protein design to prolong half-life, increase water solubility, and reduce toxic side effects.

Benefits of technology

Antimicrobial peptides effectively inhibit the growth of pathogens, reduce drug resistance, maintain the balance of the microecology, have high safety, no significant side effects, and have the potential to replace antibiotics.

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Abstract

The invention belongs to the technical field of biology, and discloses a broad-spectrum antibacterial peptide as well as a preparation method and application thereof. The antibacterial peptide or the salt thereof is disclosed for the first time, the antibacterial peptide has a good antibacterial effect on common pathogenic bacteria (such as staphylococcus aureus, escherichia coli, salmonella enteritidis and streptococcus suis) and oral pathogenic bacteria (such as fusobacterium nucleatum and porphyromonas gingivalis), and the antibacterial peptide shows slight cytotoxicity on mammalian cells only under high concentration; and the safety is relatively high.
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