A combination of monoclonal antibodies for detecting feline coronavirus NP protein and application thereof

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By developing a monoclonal antibody combination of 3C6 and 6H9 for colloidal gold immunochromatographic detection, the problems of low sensitivity and poor specificity in feline coronavirus antigen detection were solved, achieving rapid detection with high sensitivity and specificity.

CN121698997BActive Publication Date: 2026-05-12BEIJING SUBENYUANHE BIOTECHNOLOGY CO LTD

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Patent Information

Application Number: CN202610209242.4
Authority / Receiving Office: CN · China
Patent Type: Patents(China)
Current Assignee / Owner
Filing Date: 2026-02-13
Publication Date: 2026-05-12
Estimated Expiration: 2046-02-13

Application Information

Patent Timeline

13 Feb 2026

Application

CN202610209242.4

12 May 2026

Publication

CN121698997B

IPC: C07K16/102; C12N15/13; G01N33/569; G01N33/543; G01N33/577; G01N33/58

CPC: Y02A50/30

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Application Domain

Immunoglobulins Biological testing

Technology Topics

Feline coronavirusColloidal au

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AI Technical Summary

Technical Problem

Existing feline coronavirus antigen detection methods have low sensitivity and poor specificity, making them unsuitable for rapid screening at the grassroots level or on-site.

Method used

A monoclonal antibody combination, including monoclonal antibody 3C6 and monoclonal antibody 6H9, was developed for colloidal gold immunochromatographic detection to specifically recognize feline coronavirus NP protein. A colloidal gold immunochromatographic test strip was constructed.

Benefits of technology

It achieves high-sensitivity detection of FECV-NP and FIPV-NP, with a detection limit of 1 ng/mL, and no cross-reactivity with other feline pathogens, making it suitable for rapid, on-site detection.

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Abstract

The application belongs to the technical field of biological detection, and particularly relates to a combination of monoclonal antibodies for detecting feline coronavirus NP protein and application thereof. The combination is composed of monoclonal antibodies 3C6 and 6H9, 3C6 is used as a coating antibody, and 6H9 is used for colloidal gold labeling, so that efficient and specific sandwich detection of feline coronavirus NP protein can be realized. The combination of monoclonal antibodies is applied to an immunodetection platform, and a rapid detection test strip or test card based on colloidal gold immunochromatography technology is constructed. The test card has high sensitivity to FECV-NP and FIPV-NP recombinant proteins, and has no cross reaction with other proteins, and is suitable for rapid and on-site detection.

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