Rumen bypass choline chloride particle and preparation method thereof

By combining hydrophobic materials and an outer protective layer, the stability and release rate of choline chloride in the rumen of ruminants were solved, improving bioavailability and maintaining feed intake in dairy cows, thus achieving efficient preparation of choline chloride granules.

CN121867332APending Publication Date: 2026-04-17SHANGHAI MEINONG FEED CO LTD
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Patent Information

Application Number
CN202610126549.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-01-29
Publication Date
2026-04-17

AI Technical Summary

Technical Problem

Existing technologies are insufficient to effectively protect choline chloride from being released through the rumen of ruminants and into the small intestine, resulting in low bioavailability. In addition, traditional coating methods suffer from low production efficiency, complex solvent recovery, and unpleasant odors that affect feed intake.

Method used

A drug-loaded core of crystalline choline chloride is made by encapsulating crystalline choline chloride with hydrophobic materials, and an outer protective layer mainly composed of fatty acids, hydrogenated oils and pH-sensitive materials. Combined with fragrance raw materials with fruity, grassy or fermented aromas, rumen-protected choline chloride granules are prepared to improve toughness and fit, and avoid degradation and odor.

Benefits of technology

It significantly improved the rumen clearance rate and small intestinal release rate of choline chloride, avoided the impact of unpleasant odor on feed intake, and ensured the stability of the particles in the rumen environment and rapid release in the small intestine.

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Abstract

The invention discloses rumen bypass choline chloride particles and a preparation method thereof, and belongs to the technical field of feed additives. The rumen bypass choline chloride particle comprises a drug-loading inner core and an outer protective layer coating the drug-loading inner core, the drug-loading inner core is obtained by mixing hydrophobic particles with a melt, extruding and granulating; wherein the hydrophobic particles are obtained by wrapping crystal form choline chloride with a hydrophobic material; the molten liquid is obtained by melting and mixing stearic acid, magnesium stearate and oleophylic cellulose; the oleophylic cellulose adopts ethyl cellulose; the outer protective layer is obtained by mixing fatty acid, hydrogenated grease, a pH sensitive material and a fragrant raw material with fruit fragrance, green grass fragrance or fermentation fragrance; the outer protective layer of the rumen bypass choline chloride particle is good in toughness and fitness, the rumen bypass choline chloride particle is good in rumen bypass effect and good in small intestine release rate, the food intake of dairy cows is not affected, the risk of metabolic diseases is effectively reduced, and the health level of the dairy cows is improved.
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