Application of chalcone compound in preparation of medicine for treating depression
Chalcone compounds are used to prepare antidepressants, which solves the problem of insufficient therapeutic effects of existing drugs. Compounds WR010 and WR034 significantly improve depressive symptoms, reduce side effects, and improve therapeutic efficacy.
CN121868285APending Publication Date: 2026-04-17UNIVERSITY OF HEALTH & REHABILITATION SCIENCES
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Patent Information
- Application Number
- CN202411443218.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-10-16
- Publication Date
- 2026-04-17
AI Technical Summary
Technical Problem
Existing antidepressant medications are not effective enough, with about one-third of patients experiencing unsatisfactory responses and side effects. There is a need to develop new drugs with fewer side effects and better efficacy.
Method used
Chalcone compounds and their derivatives, such as WR010 and WR034, are used to treat depression, including mild, moderate and severe depression, by oral or injectable administration.
Benefits of technology
It significantly improves depressive symptoms, increases patient response rates, and reduces side effects. The treatment effect is determined through behavioral experiments and clinical evaluation.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention provides application of a chalcone compound as well as a stereoisomer, a pharmaceutically acceptable salt or a solvate thereof in preparation of a medicament for treating depression. The depression is selected from mild depression, moderate depression, severe depression, persistent depressive disorder, depression associated with bipolar disorder, seasonal affective disorder, psychotic depression, postpartum depression, premenstrual anxiety disorder, encountering depression, pleasant sensation deficiency, melancholia, middle-year depression and late-year depression; depression caused by identifiable pressure factors, refractory depression, or a combination thereof. The compounds can treat mental symptoms of depression, such as depressive mood and loss of interest or fun in almost all activities.
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