Composition as well as preparation method and application thereof in preparation of product with hangover alleviating effect
By using specific traditional Chinese medicine compositions and extraction processes, combined with auxiliary ingredients, a composition with significant hangover relief effects has been prepared, solving the problems of large side effects and limited efficacy of existing hangover relief products, and achieving a safe and efficient hangover relief effect.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- 星馥乐(福建)生物科技有限公司
- Filing Date
- 2026-01-21
- Publication Date
- 2026-05-01
AI Technical Summary
Existing hangover remedies suffer from significant side effects and limited effectiveness, especially chemically synthesized drugs and vitamin complex preparations. The hangover remedy effects of traditional Chinese herbal extracts need to be improved.
Using Hovenia dulcis, vine tea, kudzu root, hawthorn and licorice as the main Chinese medicinal raw materials, combined with nutmeg, sophora flavescens and other ingredients, the composition is prepared by specific solvent extraction and silica gel column elution process. Yeast extract, corn peptide, oyster peptide and L-cysteine can be added to form a composition with synergistic hangover relief effect.
It significantly improves the hangover relief effect, significantly reduces the blood alcohol content in rats, and enhances the safety and efficacy of hangover relief products.
Smart Images
Figure SMS_1
Abstract
Description
A composition, its preparation method, and its application in the preparation of products with hangover-relieving effects. Technical Field
[0001] This invention relates to the field of natural product technology, specifically to a composition, its preparation method, and its application in the preparation of products with hangover-relieving effects. Background Technology
[0002] With the continuous development of social interaction and dietary culture, the consumption of alcoholic beverages in daily life and social occasions is becoming increasingly common. However, excessive or frequent drinking can easily lead to acute alcohol poisoning, hangovers, and increased metabolic burden on the liver, which can, in severe cases, cause chronic diseases such as fatty liver, alcoholic hepatitis, and even cirrhosis. Therefore, developing safe, effective, and clearly efficacious hangover remedies has become an important research direction in the field of public health.
[0003] Currently, the market offers a wide variety of hangover remedies, primarily including chemically synthesized drugs (such as metadoxine), vitamin complex preparations, amino acid supplements, and some traditional Chinese medicine extracts. While chemically synthesized drugs can accelerate ethanol metabolism to some extent, they also have potential side effects and usage limitations. Vitamin and amino acid products mainly work by assisting metabolic pathways, resulting in limited hangover relief. In contrast, active ingredients derived from traditional Chinese medicine are increasingly becoming a focus of hangover remedy development due to their high safety, low toxicity, and diverse mechanisms of action.
[0004] Therefore, developing a composition with hangover-relieving effects using traditional Chinese medicine as raw materials has significant application value. Summary of the Invention
[0005] In order to overcome one of the technical problems existing in the prior art, the present invention provides a composition and its preparation method and its application in the preparation of products with hangover relief effect.
[0006] The technical solution of the present invention to solve the above-mentioned technical problems is as follows: The present invention first provides a composition comprising the following Chinese herbal raw materials: 10-20 parts of Hovenia dulcis; 10-20 parts of vine tea; 5-15 parts of kudzu root; 5-15 parts of hawthorn; and 5-10 parts of licorice.
[0007] This invention provides a novel composition, and studies have shown that the composition has a hangover-relieving effect.
[0008] Preferably, the composition comprises the following traditional Chinese medicine ingredients: 15 parts of Hovenia dulcis fruit; 15 parts of vine tea; 10 parts of kudzu root; 10 parts of hawthorn; and 8 parts of licorice root.
[0009] Preferably, the medicinal materials also include nutmeg or sophora flavescens.
[0010] The inventors discovered in their research that by further adding nutmeg or sophora flavescens to the traditional Chinese medicine ingredients, such as Japanese raisin tree fruit, vine tea, kudzu root, hawthorn, and licorice, the composition prepared can improve the hangover-relieving effect of the prepared composition to a certain extent.
[0011] Preferably, the nutmeg in the Chinese herbal raw materials is 10-20 parts by weight.
[0012] Most preferably, the nutmeg in the Chinese herbal raw materials is 15 parts by weight.
[0013] Preferably, the weight of Sophora flavescens in the Chinese herbal raw materials is 10-20 parts.
[0014] Most preferably, the weight of Sophora flavescens in the Chinese herbal raw materials is 15 parts.
[0015] Preferably, the medicinal materials also include nutmeg and sophora flavescens.
[0016] More preferably, the weight proportions of nutmeg and sophora flavescens in the medicinal materials are: 10-20 parts nutmeg; 10-20 parts sophora flavescens. Most preferably, the weight proportions of nutmeg and sophora flavescens in the medicinal materials are: 15 parts nutmeg; 15 parts sophora flavescens.
[0017] The inventors discovered in their research that when nutmeg and sophora flavescens are added simultaneously to the traditional Chinese medicine ingredients Hovenia dulcis, vine tea, kudzu root, hawthorn, and licorice, the resulting composition can significantly improve the hangover-relieving effect compared to adding only nutmeg or only sophora flavescens.
[0018] A composition prepared by simultaneously adding nutmeg and sophora flavescens to the traditional Chinese medicine ingredients, such as jujube seed, vine tea, kudzu root, hawthorn, and licorice, can synergistically enhance the hangover-relieving effect of the prepared composition.
[0019] Preferably, the medicinal materials also include Antrodia camphorata and Pueraria lobata.
[0020] More preferably, the weight proportions of Antrodia camphorata and Pueraria lobata in the medicinal materials are: 10-20 parts Antrodia camphorata and 10-20 parts Pueraria lobata. Most preferably, the weight proportions of Antrodia camphorata and Pueraria lobata in the medicinal materials are: 15 parts Antrodia camphorata and 15 parts Pueraria lobata.
[0021] The present invention also provides a method for preparing the above composition, which includes the following steps: mixing the Chinese herbal raw materials evenly and extracting them with a solvent; after the extraction is completed, separating the extract, concentrating and drying it to obtain the Chinese herbal extract; taking the Chinese herbal extract to obtain the composition.
[0022] Preferably, the ratio of raw Chinese medicine materials to solvent is 1kg:8-15L.
[0023] The most preferred ratio of the herbal raw material to the solvent is 1 kg: 12 L.
[0024] Preferably, the solvent is an aqueous ethanol solution; the volume fraction of ethanol in the aqueous ethanol solution is 40-80%.
[0025] Most preferably, the volume fraction of ethanol in the ethanol-water solution is 65%.
[0026] Preferably, the preparation method of the composition further includes the following steps: loading the traditional Chinese medicine extract onto a silica gel column, first eluting with organic solvent A, discarding the eluent eluted with organic solvent A; then eluting with organic solvent B, collecting the eluent eluted with organic solvent B, concentrating and drying to obtain the traditional Chinese medicine silica gel column eluent; taking the traditional Chinese medicine silica gel column eluent is the composition.
[0027] Preferably, the organic solvent A is an organic solvent composed of petroleum ether and acetone in a volume ratio of 84-81:16-19.
[0028] Most preferably, the organic solvent A is an organic solvent composed of petroleum ether and acetone in a volume ratio of 83:17.
[0029] Preferably, the amount of organic solvent A is 3-5 times the column volume of the silica gel column.
[0030] Preferably, the organic solvent B is an organic solvent composed of petroleum ether and acetone in a volume ratio of 59-57:41-43.
[0031] Most preferably, the organic solvent B is an organic solvent composed of petroleum ether and acetone in a volume ratio of 58:42.
[0032] Preferably, the amount of organic solvent B is 3-5 times the column volume of the silica gel column.
[0033] The inventors discovered in their research that the preparation method of this invention is also crucial; by further eluting the Chinese herbal extract through the silica column described in this invention, the Chinese herbal composition is obtained, and its hangover-relieving effect is further and significantly improved.
[0034] Preferably, the composition further comprises yeast extract, corn peptide, oyster peptide, and L-cysteine, or a combination of one or more of these.
[0035] Preferably, the preparation method of the composition includes the following steps: mixing the Chinese herbal raw materials evenly and extracting them with a solvent; after extraction, separating the extract, concentrating and drying to obtain the Chinese herbal extract; and mixing the Chinese herbal extract with yeast extract, corn peptide, oyster peptide and / or L-cysteine evenly to obtain the composition.
[0036] Preferably, the weight ratio of the herbal extract to yeast extract, corn peptide, oyster peptide and L-cysteine is 1:8-9:0.3-1:0.3-1:0.5-1.5.
[0037] The traditional Chinese medicine raw materials described in this invention can also be compounded with yeast extract, corn peptide, oyster peptide and / or L-cysteine, etc., which have the effect of relieving or assisting in relieving alcohol, to obtain new compositions.
[0038] This invention provides an application of the above composition in the preparation of a product with hangover-relieving effects.
[0039] Preferably, the product is a medicine or health product.
[0040] Beneficial effects: This invention provides a novel composition, and studies have shown that the composition has a hangover-relieving effect; therefore, it has significant application value as an active ingredient in the preparation of drugs or health products with hangover-relieving effects. Detailed Implementation
[0041] The present invention will be further explained below with reference to the embodiments, but the embodiments do not limit the scope of protection of the present invention.
[0042] Example 1 Preparation of the Composition The weight parts of the Chinese herbal raw materials are as follows: 15 parts of Hovenia dulcis; 15 parts of vine tea; 10 parts of kudzu root; 10 parts of hawthorn; and 8 parts of licorice.
[0043] Preparation method: After the Chinese herbal raw materials are mixed evenly, they are heated to boiling with a solvent and then refluxed for 1 hour. After extraction, the extract is separated, concentrated and dried to obtain the Chinese herbal extract. The Chinese herbal extract is used to obtain the composition. The ratio of Chinese herbal raw materials to solvent is 1 kg: 12 L. The solvent is an aqueous ethanol solution. The volume fraction of ethanol in the aqueous ethanol solution is 65%.
[0044] Example 2 Preparation of the Composition The weight parts of the Chinese herbal raw materials are as follows: 15 parts of Japanese raisin tree fruit; 15 parts of vine tea; 15 parts of nutmeg; 10 parts of kudzu root; 10 parts of hawthorn; and 8 parts of licorice.
[0045] Preparation method: After the Chinese herbal raw materials are mixed evenly, they are heated to boiling with a solvent and then refluxed for 1 hour. After extraction, the extract is separated, concentrated and dried to obtain the Chinese herbal extract. The Chinese herbal extract is used to obtain the composition. The ratio of Chinese herbal raw materials to solvent is 1 kg: 12 L. The solvent is an aqueous ethanol solution. The volume fraction of ethanol in the aqueous ethanol solution is 65%.
[0046] Example 3 Preparation of the Composition The weight parts of the Chinese herbal raw materials are as follows: 15 parts of Hovenia dulcis; 15 parts of vine tea; 15 parts of Sophora flavescens; 10 parts of Pueraria lobata; 10 parts of hawthorn; and 8 parts of licorice.
[0047] Preparation method: After the Chinese herbal raw materials are mixed evenly, they are heated to boiling with a solvent and then refluxed for 1 hour. After extraction, the extract is separated, concentrated and dried to obtain the Chinese herbal extract. The Chinese herbal extract is used to obtain the composition. The ratio of Chinese herbal raw materials to solvent is 1 kg: 12 L. The solvent is an aqueous ethanol solution. The volume fraction of ethanol in the aqueous ethanol solution is 65%.
[0048] Example 4 Preparation of the Composition The weight parts of the Chinese herbal raw materials are as follows: 15 parts of Hovenia dulcis; 15 parts of vine tea; 15 parts of nutmeg; 15 parts of Sophora flavescens; 10 parts of kudzu root; 10 parts of hawthorn; and 8 parts of licorice.
[0049] Preparation method: After the Chinese herbal raw materials are mixed evenly, they are heated to boiling with a solvent and then refluxed for 1 hour. After extraction, the extract is separated, concentrated and dried to obtain the Chinese herbal extract. The Chinese herbal extract is used to obtain the composition. The ratio of Chinese herbal raw materials to solvent is 1 kg: 12 L. The solvent is an aqueous ethanol solution. The volume fraction of ethanol in the aqueous ethanol solution is 65%.
[0050] Example 5 Preparation of the Composition The weight parts of the Chinese herbal raw materials are as follows: 15 parts of Japanese raisin tree fruit; 15 parts of vine tea; 15 parts of nutmeg; 15 parts of sophora flavescens; 10 parts of kudzu root; 10 parts of hawthorn; and 8 parts of licorice.
[0051] Preparation method: (1) After mixing the Chinese herbal raw materials evenly, heat them to boiling with a solvent and then reflux for 1 hour. After extraction, separate the extract, concentrate and dry to obtain the Chinese herbal extract; wherein, the ratio of Chinese herbal raw materials to solvent is 1 kg: 12 L; the solvent is an aqueous ethanol solution; the volume fraction of ethanol in the aqueous ethanol solution is 65%; (2) Load the Chinese herbal extract onto a silica gel column, first elute with 4 column volumes of organic solvent A, discard the eluent eluted by organic solvent A; then elute with 4 column volumes of organic solvent B, collect the eluent eluted by organic solvent B, concentrate and dry to obtain the Chinese herbal silica gel column elution part; take the Chinese herbal silica gel column elution part to obtain the composition; wherein, the organic solvent A is an organic solvent composed of petroleum ether and acetone in a volume ratio of 83:17; the organic solvent B is an organic solvent composed of petroleum ether and acetone in a volume ratio of 58:42.
[0052] Preparation of the composition of Comparative Example 1: The raw materials of traditional Chinese medicine are as follows (by weight): 15 parts of Hovenia dulcis, 15 parts of vine tea, 15 parts of nutmeg, 15 parts of Sophora flavescens, 10 parts of Pueraria lobata, 10 parts of hawthorn, and 8 parts of licorice.
[0053] Preparation method: (1) After mixing the Chinese herbal raw materials evenly, heat them to boiling with a solvent and then reflux for 1 hour. After extraction, separate the extract, concentrate and dry to obtain the Chinese herbal extract; wherein, the ratio of Chinese herbal raw materials to solvent is 1 kg: 12 L; the solvent is an aqueous ethanol solution; the volume fraction of ethanol in the aqueous ethanol solution is 65%; (2) Load the Chinese herbal extract onto a silica gel column, first elute with 4 column volumes of organic solvent A, discard the eluent eluted by organic solvent A; then elute with 4 column volumes of organic solvent B, collect the eluent eluted by organic solvent B, concentrate and dry to obtain the Chinese herbal silica gel column elution part; take the Chinese herbal silica gel column elution part to obtain the composition; wherein, the organic solvent A is an organic solvent composed of petroleum ether and acetone in a volume ratio of 95:5; the organic solvent B is an organic solvent composed of petroleum ether and acetone in a volume ratio of 80:20.
[0054] Preparation of the composition of Comparative Example 2: The raw materials of traditional Chinese medicine are as follows (by weight): 15 parts of Hovenia dulcis, 15 parts of vine tea, 15 parts of nutmeg, 15 parts of Sophora flavescens, 10 parts of Pueraria lobata, 10 parts of hawthorn, and 8 parts of licorice.
[0055] Preparation method: (1) After mixing the Chinese herbal raw materials evenly, heat them to boiling with a solvent and then reflux for 1 hour. After extraction, separate the extract, concentrate and dry to obtain the Chinese herbal extract; wherein, the ratio of Chinese herbal raw materials to solvent is 1 kg: 12 L; the solvent is an aqueous ethanol solution; the volume fraction of ethanol in the aqueous ethanol solution is 65%; (2) Load the Chinese herbal extract onto a silica gel column, first elute with 4 column volumes of organic solvent A, discard the eluent eluted by organic solvent A; then elute with 4 column volumes of organic solvent B, collect the eluent eluted by organic solvent B, concentrate and dry to obtain the Chinese herbal silica gel column elution fraction; take the Chinese herbal silica gel column elution fraction to obtain the composition; wherein, the organic solvent A is an organic solvent composed of petroleum ether and acetone in a volume ratio of 50:50; the organic solvent B is an organic solvent composed of petroleum ether and acetone in a volume ratio of 30:70.
[0056] Experimental Example: In an experiment to investigate the alcohol-relieving effects of the composition of this invention, 96 male SD rats (weighing 430±20g) were randomly divided into 8 groups: one model group and seven experimental groups, with 12 rats in each group. Experimental groups 1-7 were administered the compositions prepared in Examples 1-5 and Comparative Examples 1-2 by gavage at a dosage of 15mg / kg, respectively; the compositions were suspended in distilled water before gavage. The model group was administered an equal volume of distilled water by gavage. One hour after gavage, both experimental and model groups were administered 53-degree baijiu (Chinese liquor) by gavage at a dosage of 1mL / kg. Two hours after gavage, the blood alcohol content of each group was measured; the experimental results are shown in Table 1.
[0057] Table 1. Alcohol-relieving experiments of the compositions of the present invention As can be seen from the experimental results in Table 1, the alcohol content in the blood of rats in experimental group 1 was significantly lower than that in the model group, which indicates that the composition described in this invention has an alcohol-relieving effect.
[0058] As can be seen from the experimental results in Table 1, the blood alcohol content of rats in experimental groups 2 and 3 was lower than that in experimental group 1. This indicates that the combination prepared by adding nutmeg or sophora flavescens to the Chinese herbal raw materials such as jujube seed, vine tea, kudzu root, hawthorn, and licorice can improve the alcohol-relieving effect of the prepared combination to a certain extent.
[0059] As shown in Table 1, the blood alcohol content of rats in experimental group 4 was significantly lower than that in experimental group 1, and also significantly lower than that in experimental groups 2 and 3. This indicates that the combination prepared by simultaneously adding nutmeg and sophora flavescens to the traditional Chinese medicine ingredients Hovenia dulcis, vine tea, kudzu root, hawthorn, and licorice significantly enhances the alcohol-relieving effect of the prepared composition compared to adding only nutmeg or only sophora flavescens. Furthermore, the combination prepared by simultaneously adding nutmeg and sophora flavescens to the traditional Chinese medicine ingredients Hovenia dulcis, vine tea, kudzu root, hawthorn, and licorice can synergistically enhance the alcohol-relieving effect of the prepared composition.
[0060] As can be seen from the experimental results in Table 1, the blood alcohol content of rats in experimental group 5 was significantly lower than that in experimental group 4. This indicates that the alcohol-relieving effect of the traditional Chinese medicine composition obtained by further eluting the extract of traditional Chinese medicine through the silica gel column of the present invention was further significantly improved.
[0061] As can be seen from the experimental results in Table 1, the reduction in blood alcohol content in Comparative Examples 1 and 2 rats was not significant compared to that in Experimental Group 4, and the reduction was much smaller than that in Experimental Group 5. This indicates that the silica gel column elution conditions described in this invention are crucial. Only by further eluting the herbal extracts using the silica gel column elution conditions of this invention to prepare the herbal composition can the alcohol-relieving effect be further significantly improved. However, eluting the herbal extracts using other silica gel column elution conditions to prepare the herbal composition does not result in a further significant improvement in the alcohol-relieving effect.
[0062] Example 6 Preparation of the Composition The following are the components of the Chinese herbal raw materials by weight: 15 parts of Hovenia dulcis; 15 parts of vine tea; 15 parts of Antrodia camphorata; 15 parts of Pueraria lobata; 10 parts of Pueraria lobata root; 10 parts of hawthorn; and 8 parts of licorice.
[0063] Preparation method: After the Chinese herbal raw materials are mixed evenly, they are heated to boiling with a solvent and then refluxed for 1 hour. After extraction, the extract is separated, concentrated and dried to obtain the Chinese herbal extract. The Chinese herbal extract is used to obtain the composition. The ratio of Chinese herbal raw materials to solvent is 1 kg: 12 L. The solvent is an aqueous ethanol solution. The volume fraction of ethanol in the aqueous ethanol solution is 65%.
[0064] Example 7 Preparation of the Composition: The raw materials of the traditional Chinese medicine are as follows (by weight): 15 parts of Hovenia dulcis; 15 parts of vine tea; 15 parts of Antrodia camphorata; 15 parts of Pueraria lobata; 15 parts of nutmeg; 15 parts of Sophora flavescens; 10 parts of Pueraria lobata; 10 parts of hawthorn; and 8 parts of licorice.
[0065] Preparation method: After the Chinese herbal raw materials are mixed evenly, they are heated to boiling with a solvent and then refluxed for 1 hour. After extraction, the extract is separated, concentrated and dried to obtain the Chinese herbal extract. The Chinese herbal extract is used to obtain the composition. The ratio of Chinese herbal raw materials to solvent is 1 kg: 12 L. The solvent is an aqueous ethanol solution. The volume fraction of ethanol in the aqueous ethanol solution is 65%.
[0066] Example 8 Preparation of the composition: The composition is obtained by mixing the traditional Chinese medicine extract prepared in any one of Examples 1-7 with the yeast extract; wherein the weight ratio of the traditional Chinese medicine extract to the yeast extract is 1:5.
[0067] Example 9: Preparation of the Composition. The traditional Chinese medicine extract prepared in any one of Examples 1-7 was mixed evenly with yeast extract and corn peptide to obtain the composition described above; wherein the weight ratio of the traditional Chinese medicine extract to yeast extract and corn peptide was 1:8:1. Example 10: Preparation of the Composition. The traditional Chinese medicine extract prepared in any one of Examples 1-7 was mixed evenly with yeast extract, oyster peptide and L-cysteine to obtain the composition described above; wherein the weight ratio of the traditional Chinese medicine extract to yeast extract, corn peptide and L-cysteine was 1:8:1:1.
[0068] Example 11 Preparation of the composition The traditional Chinese medicine extract prepared in any of Examples 1-7 was mixed evenly with yeast extract, corn peptide and L-cysteine to obtain the composition; wherein the weight ratio of the traditional Chinese medicine extract to yeast extract, corn peptide and L-cysteine was 1:8:1:1.
[0069] Example 12 Preparation of the composition: The traditional Chinese medicine extract prepared in any of Examples 1-7 was mixed evenly with yeast extract, corn peptide, oyster peptide and L-cysteine to obtain the composition; wherein, the weight ratio of the traditional Chinese medicine extract to yeast extract, corn peptide, oyster peptide and L-cysteine was 1:9:0.5:0.5:1.
Claims
1. A composition, characterized in that, It contains the following Chinese medicinal ingredients: 10-20 parts of Hovenia dulcis fruit; 10-20 parts of vine tea; 5-15 parts of kudzu root; 5-15 parts of hawthorn; and 5-10 parts of licorice root.
2. The composition according to claim 1, characterized in that, It contains the following Chinese medicinal ingredients: 15 parts of Japanese raisin tree fruit; 15 parts of vine tea; 10 parts of kudzu root; 10 parts of hawthorn; and 8 parts of licorice root.
3. The composition according to claim 1, characterized in that, The medicinal materials mentioned also include nutmeg or sophora flavescens.
4. The composition according to claim 1, characterized in that, The weight of nutmeg in the Chinese medicinal materials is 10-20 parts.
5. The composition according to claim 1, characterized in that, The weight of Sophora flavescens in the Chinese herbal raw materials is 10-20 parts.
6. A method for preparing the composition according to any one of claims 1-5, characterized in that, The process includes the following steps: mixing the Chinese herbal raw materials evenly and then extracting them with a solvent; after extraction, separating the extract, concentrating and drying it to obtain the Chinese herbal extract; and taking the Chinese herbal extract to obtain the composition.
7. The composition according to claim 1, characterized in that, The composition further comprises yeast extract, corn peptide, oyster peptide, and one or more of L-cysteine.
8. The method for preparing the composition according to claim 7, characterized in that, The process includes the following steps: after mixing the Chinese herbal raw materials evenly, extracting them with a solvent; after extraction, separating the extract, concentrating and drying it to obtain the Chinese herbal extract; and mixing the Chinese herbal extract with yeast extract, corn peptide, oyster peptide and / or L-cysteine evenly to obtain the composition.
9. The use of the composition according to any one of claims 1-5 and 7 in the preparation of a product having a hangover-relieving effect.
10. The application according to claim 9, characterized in that, The product in question is a medicine or health supplement.