Membranes, methods of making and use thereof, capsules and implantable medical devices comprising the same
The membrane, which combines a freeze-dried hydrogel layer and an electrospun layer, solves the problems of infection, inflammation, and displacement in implantable medical devices, achieving a comprehensive effect of antibacterial, sustained release, and hemostasis, and improving biocompatibility and safety.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- PEKING UNIVERSITY FIRST HOSPITAL (PEKING UNIVERSITY FIRST CLINICAL MEDICAL COLLEGE)
- Filing Date
- 2026-04-15
- Publication Date
- 2026-07-10
AI Technical Summary
Existing implantable medical devices present problems such as infection, aseptic inflammation, tissue fibrosis, and device displacement during implantation. Current solutions suffer from insufficient material compatibility, are prone to causing inflammation, pose risks of biological disease transmission, and have antibiotic resistance issues, and cannot effectively stop bleeding.
The membrane, which combines a freeze-dried hydrogel layer and an electrospun layer, utilizes electrospun technology to create an electrospun layer on the freeze-dried hydrogel layer. It achieves antibacterial and sustained-release functions by using polylysine and (lactide-glycolic acid) copolymer, and provides hemostasis and anti-migration effects by combining the water absorption of the freeze-dried hydrogel with the mechanical properties of the electrospun layer.
It achieves a comprehensive effect of antibacterial, sustained release, hemostasis and anti-transfer, reduces the risk of infection, improves biocompatibility and safety, avoids the spread of biological diseases and drug resistance, and provides good mechanical properties.
Smart Images
Figure CN122031785B_ABST