Antibacterial hydrogel as well as preparation method and application thereof

By constructing a dual-response hydrogel triggered by the infection microenvironment, and utilizing multiple synergistic antibacterial mechanisms and visualization monitoring functions, the problems of drug resistance, cytotoxicity, and single function of existing antibacterial hydrogels are solved, achieving on-demand antibacterial, dynamic regulation, and efficient bactericidal effects.

CN122080446AActive Publication Date: 2026-05-26烟台市飞马医疗科技有限公司
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Patent Information

Application Number
CN202610525381.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-04-21
Publication Date
2026-05-26
Estimated Expiration
2046-04-21

AI Technical Summary

Technical Problem

Existing antibacterial hydrogels rely on exogenous antibacterial agents, which can easily lead to drug resistance and cytotoxicity. They also have limited functionality, cannot be dynamically adjusted according to the degree of infection, and are difficult to balance efficient sterilization and removal of oxidative stress damage. Furthermore, their preparation processes are complex and their functional components are prone to aggregation.

Method used

Using materials such as methacrylamide gelatin, mercapto-tannic acid, copper-doped Prussian blue nanozyme, horseradish peroxidase, and trehalose, a covalent cross-linked network is formed through photo-initiated polymerization to construct a dual-response hydrogel based on the infection microenvironment triggering, combining multiple synergistic antibacterial mechanisms and visual monitoring functions.

Benefits of technology

It achieves on-demand antibacterial action, multi-mechanism synergistic sterilization, dynamic control of mechanical properties, and visualized infection monitoring, avoiding drug resistance problems, improving sterilization efficiency and material stability, and adapting to the needs of different stages of wound healing.

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Abstract

The invention relates to the field of biomedical materials, in particular to antibacterial hydrogel as well as a preparation method and application thereof. The method comprises the following steps: preparing sulfhydrylated tannic acid and copper-doped Prussian blue nano-enzyme (CuPB), mixing methacrylated gelatin with the sulfhydrylated tannic acid, sequentially adding CuPB, epsilon-polylysine, trehalose, horse radish peroxidase and a photoinitiator, uniformly stirring to prepare a photosensitive prepolymer solution, and carrying out photocuring by visible light to obtain the antibacterial hydrogel. The antibacterial hydrogel prepared by the invention can respond to H2O2 concentration change of a wound surface: during infection, CuPB and HRP are subjected to cascade catalysis to generate active oxygen, and multi-mechanism efficient antibiosis is realized in cooperation with epsilon-polylysine and copper ions; meanwhile, thiolated tannic acid is triggered to be oxidized and crosslinked, the mechanical property is enhanced, and along with color change, the infection state is monitored in an auxiliary manner; the composite material has excellent biocompatibility, antibacterial property and mechanical property, and can be used in the fields of wound dressings, biosensors and the like.
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