Method for preparing diethyl hydroxymethylphosphonate
By using sodium carbonate or potassium carbonate catalysts to react with DEPI and formaldehyde aqueous solution in the synthesis of DEHMP, the problems of long reaction time, high cost and difficult purification were solved, achieving high yield of high-purity DEHMP and simplifying purification, thus reducing production costs.
Patent Information
- Application Number
- CN202480069474.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Priority Date
- 2023-11-06
- Filing Date
- 2024-10-31
- Publication Date
- 2026-05-26
AI Technical Summary
The synthesis of DEHMP in the existing technology has problems such as long reaction time, high cost of using paraformaldehyde and trialkylamine, difficult product purification, and many by-products that are difficult to remove. In particular, the saponification and hydrolysis of DEPI lead to low yield, complicated purification and toxicity.
Sodium carbonate or potassium carbonate is used as a catalyst to react with DEPI and formaldehyde aqueous solution at a certain molar ratio, avoiding the use of phase transfer catalysts. The reaction temperature is controlled between 5°C and 85°C, preferably between 25°C and 65°C. The conversion rate is monitored by 31P NMR spectroscopy, simplifying the purification process.
This method achieves high yield of high-purity DEHMP, simplifies purification steps, reduces production costs, minimizes the use of toxic substances and the formation of byproducts, and improves production efficiency.