Coronary coating balloon with curcumen

Abstract

The present invention relates to a curcumen coronary coated balloon catheter, which is an OTW balloon dilatation catheter, i.e. an over-the-wire design, which provides stability and overall stiffness in procedures requiring wire exchange. The balloon surface has micropores for drug release and a central portion that allows blood to pass through. The balloon uses nanotechnology to control the drug release of curcumen, which can be sustained for more than three minutes in the coronary artery without blocking blood flow, improving treatment efficacy and reducing patient discomfort.

Description

Technical Field

[0001] This invention relates to the field of medical devices, specifically a turmeric-coated balloon for coronary artery interventional therapy. Background Technology

[0002] Percutaneous coronary intervention (PCI) is an important treatment for coronary artery disease. Traditional balloon angioplasty and stent placement have achieved certain results in treating coronary artery disease, but problems such as restenosis exist. Even the most widely used and effective rapamycin-eluting stents and paclitaxel-eluting stents still result in 1.2% late in-stent thrombosis, and an effective solution has yet to be found. Late in-stent thrombosis directly causes fatal acute myocardial infarction or death, with a mortality rate as high as 45%. Furthermore, although traditional drug-eluting stents can release drugs after intravascular dilation, they cannot be retrieved, which limits their flexibility in subsequent treatments. In addition, rapid drug release may lead to excessively high drug concentrations in the blood vessel, causing side effects. To solve this problem, drug-coated balloon technology has emerged. By coating the surface of the balloon with drugs, local drug release is achieved, reducing restenosis. A greater advantage is that no foreign body is left in the body. Summary of the Invention

[0003] The purpose of this invention is to address the shortcomings of existing technologies by providing a turmeric-coated coronary artery balloon. This turmeric-coated coronary artery balloon can release medication after intravascular dilation and retrieve the stent after medication release, achieving the same therapeutic effect as a stent without leaving any foreign body in the body. Both the stent and balloon surfaces are coated with turmeric medication, which allows the medication to be released to the vessel wall after stent dilation and remain in the vessel wall for one to three months. After stent release, the central long axis of the balloon allows blood flow, maintaining unobstructed blood flow. The stent dilation time can reach more than three minutes, ensuring effective drug release.

[0004] In one aspect, the present invention provides a turmeric-coated coronary balloon, wherein the balloon is a catheter structure, the catheter being composed of a balloon, a catheter, and a guidewire; the surface of the balloon has micropores and is uniformly coated with a turmeric-coated layer; and the central portion of the balloon allows blood to pass through.

[0005] In another aspect of the invention, the turmeric alcohol coating has a thickness at the nanometer level to control drug release.

[0006] Another aspect of the invention is that the balloon design employs the latest technology, enabling the release of drugs within the coronary arteries without obstructing blood flow.

[0007] Another aspect of the invention is that the duration of drug release within the coronary artery by the balloon is approximately 3 minutes.

[0008] Another advantage of this invention is that the drug is retained in the coronary artery wall for a longer period of time before being released.

[0009] The stent prepared by this invention can also be used as a carotid artery stent, an intracranial artery stent, and other peripheral vascular stents. Detailed Implementation

[0010] Example 1

[0011] The following is a detailed implementation method for the turmeric-coated coronary artery elution balloon catheter:

[0012] Balloon catheter structure: The balloon catheter consists of a balloon, a catheter, and a guidewire. The balloon surface has micropores and is uniformly coated with turmeric alcohol at the nanometer level to control drug release. The central portion allows blood to pass through.

[0013] Nanotechnology Coating: The turmeric coating is prepared using nanotechnology to ensure uniform drug distribution and controlled release. The concentration and distribution of turmeric in the coating are precisely adjusted through nanotechnology processes to achieve optimal therapeutic effects.

[0014] Drug release control: Curcumol in the coating begins to be released as the balloon dilates, lasting approximately three minutes. This rapid release design aims to minimize obstruction of blood flow while ensuring effective drug penetration into the vessel wall.

[0015] To control drug release, a multi-layer coating technique can be used. A very small amount of drug solution is sprayed onto the capsule each time, resulting in a dense coating of drug molecules with high adhesion. The number of sprays can range from 1 to 30. Furthermore, the sprayed drug solution is supersaturated; each spray does not dissolve the existing drug coating but instead uses the existing coating as a nucleating agent to continue crystallizing, layer by layer, resulting in a tightly packed drug molecule coating with high adhesion.

[0016] Non-blocking blood flow design: The balloon catheter is designed to allow unobstructed blood flow during drug release, which is achieved through special balloon materials and design to minimize impact on the patient.

[0017] Drug retention time: Curcumol has a longer retention and release time in the coronary artery wall, about three minutes, which is superior to existing drug-coated balloons on the market.

[0018] Through the above embodiments, the turmeric-coated coronary artery balloon of the present invention can achieve rapid release of turmeric without blocking blood flow. The balloon can remain on the blood vessel wall for 3 minutes during release, which facilitates sufficient drug penetration into the blood vessel wall, thereby improving the treatment effect, reducing patient discomfort, and is expected to reduce the risk of coronary artery restenosis.

[0019] The above examples are for illustrative purposes only and are not intended to limit the scope of the invention. The scope of the invention is based on the foregoing claims.

Claims

1. A turmeric-coated coronary artery balloon, characterized in that, The balloon is a catheter structure, which consists of a balloon, a catheter, and a guidewire; the surface of the balloon has micropores and is uniformly coated with a turmeric alcohol coating. Furthermore, the central portion of the balloon allows blood to pass through.

2. The turmeric-coated coronary artery balloon according to claim 1, characterized in that, The curcumin coating is nanometer thick to control drug release.

3. The turmeric-coated coronary artery balloon according to claim 2, characterized in that... The balloon is designed with the latest technology to release drugs within the coronary arteries without blocking blood flow.

4. The turmeric-coated coronary artery balloon according to claim 3, characterized in that... The balloon releases the drug within the coronary artery for approximately 3 minutes.

5. The turmeric-coated coronary artery balloon according to claim 4, characterized in that, The drug remains within the coronary artery wall for a relatively long period of release.