4-phenoxy quinoline compound containing dihydropicolinamide and dihydropyridazinamide and application of 4-phenoxy quinoline compound

By designing and synthesizing 4-phenoxyquinoline compounds containing dihydropyridine amide and dihydropyridazinamide, the shortcomings of existing c-Met kinase inhibitors in clinical practice have been overcome, achieving effective inhibition of c-Met kinase and anti-cancer activity, especially therapeutic effects on gastric cancer and breast cancer.

CN122103091APending Publication Date: 2026-05-29LIAONING UNIVERSITY
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Patent Information

Application Number
CN202610276668.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-03-09
Publication Date
2026-05-29

AI Technical Summary

Technical Problem

Existing c-Met kinase inhibitors have poor efficacy in clinical treatment, unsatisfactory pharmacokinetic parameters, low oral bioavailability, and significant toxic side effects. There is a lack of novel inhibitors that are structurally sound, safe, and effective.

Method used

A series of 4-phenoxyquinoline compounds containing dihydropyridine amide and dihydropyridazinamide were designed and synthesized. By optimizing the molecular structure to improve the inhibitory activity against c-Met kinase, these compounds can be used to prepare drugs for the treatment and prevention of cancer.

Benefits of technology

These compounds significantly inhibit c-Met kinase activity and exhibit remarkable antitumor activity, particularly in vitro against gastric and breast cancer cells, making them suitable for the preparation of drugs for the treatment and prevention of cancer.

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Abstract

The invention belongs to the field of medicines, and particularly relates to a 4-phenoxy quinoline compound containing dihydropicolinamide and dihydropyridazinamide and application of the 4-phenoxy quinoline compound. The 4-phenoxy quinoline compound containing dihydropicolinamide and dihydropyridazinamide and the pharmaceutically acceptable salt of the 4-phenoxy quinoline compound have a structure as shown in a general formula (I). The invention also relates to a strong c-Met kinase inhibition effect of the compound shown in the general formula (I), and also relates to an application of the compound in preparation of drugs for treating and / or preventing diseases caused by abnormal high expression of c-Met kinase, especially an application in preparation of drugs for treating and / or preventing cancers. The compound is especially suitable for preparing drugs for treating and / or preventing gastric cancer and breast cancer. .
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