Nicotine-filled granules with improved component retention rate, their preparation method, and nicotine bags

Abstract

This patent discloses a method for preparing nicotine-filled granules with improved component retention, as well as nicotine pouches. The method involves dry premixing nicotine source, filler, pH adjuster, humectant, and flavoring in a mixer to obtain a premixed dry material. This material is then placed in an extruder, where it agglomerates into a dense sheet or block shape through the recrystallization water and mechanical extrusion. The material is then crushed using a crusher and sieved using a screen to obtain nicotine-filled granules. This method achieves a nicotine source retention rate greater than 94% and a flavoring retention rate greater than 87%. Nicotine-filled granules can be directly prepared from premixed dry materials without the addition of additional moisture, improving the uniformity of the granules and the retention rate of flavor substances. This significantly enhances the effectiveness and duration of the physiological satisfaction provided by nicotine pouches, improves the overall taste experience for users, and shortens the production cycle of nicotine-filled granules, reducing energy consumption and production costs.

Description

Technical Field

[0001] This patent belongs to the field of new tobacco product technology, specifically relating to a nicotine filling granule with improved component retention rate, its preparation method, and a nicotine bag. Background Technology

[0002] Nicotine pouches, as a novel type of oral tobacco product, have gained widespread attention globally in recent years. This product absorbs nicotine through the oral mucosa, utilizing controlled-release technology to achieve a stable delivery of nicotine while balancing taste comfort and dosage accuracy, providing users with an alternative to traditional tobacco.

[0003] The filler granules, as the core contents of nicotine pouches, mainly consist of nicotine, flavorings, fillers, and flavoring agents. Their physical properties (such as particle size distribution, porosity, and flowability) and chemical properties (flavor substances) directly determine the release rate, palatability, flavor, and stability during storage of the nicotine pouch. However, existing preparation processes typically employ a heat-drying step. Nicotine and flavorings are highly volatile, and heat-drying accelerates their volatilization, oxidation, and decomposition. This results in a lower retention rate of flavor substances in the final filler granules compared to the original set value. Users may experience insufficient aroma, a bland taste, or even off-flavors (such as a burnt taste). Furthermore, uneven localized heating can cause surface hardening of the filler granules, damaging the internal porous structure and leading to significant variations in nicotine content. This reduces granule uniformity, affecting nicotine solubility and release stability, thus diminishing the effectiveness of the nicotine pouch and directly impacting the user experience.

[0004] For example, patent document CN119185163A discloses a nicotine pouch for oral mucosal absorption and its preparation method, wherein the granulated particles are dried using a drying oven or fluidized bed. Patent document CN120864032A discloses a post-processing method and a manufacturing process for oral nicotine products, and patent document CN121081397A discloses a synthetic nicotine composition and its preparation method, all of which involve wet granulation followed by drying of the granulated particles using a fluidized bed dryer.

[0005] In the emerging tobacco sector, current technologies have not fully recognized the crucial impact of nicotine and flavoring substances retention in filler granules on taste consistency and aftertaste longevity. This results in taste fluctuations between batches or within individual bags, making it difficult to meet the high-end market's demand for quality stability. Furthermore, current technologies cannot directly use nicotine powder as a raw material to prepare filler granules.

[0006] Therefore, it is necessary to develop a novel method for preparing nicotine-filled granules that can improve the retention rate of flavor substances. This method would allow nicotine powder to be used directly as a raw material for the preparation of nicotine-filled granules. While ensuring the high stability of nicotine during processing, it would improve the uniformity of the filling granules and the retention rate of flavor substances, thereby enhancing the effectiveness and duration of the physiological satisfaction provided by nicotine packets, improving the overall taste experience for users, shortening the production cycle of nicotine-filled granules, and reducing energy consumption and production costs. Summary of the Invention

[0007] The purpose of this patent is to provide a nicotine-filled granule with improved component retention rate, its preparation method, and a nicotine pouch. This allows for the preparation of nicotine-filled granules using nicotine powder as a raw material without the need for other cores. While ensuring high nicotine stability during processing, it improves the uniformity of the filling granules and the retention rate of flavor substances, thereby significantly enhancing the onset and duration of physiological satisfaction from the nicotine pouch. Furthermore, the fusion of nicotine and fruit aroma reduces the irritation of nicotine release, improves the user's overall taste experience, shortens the production cycle of nicotine-filled granules, and reduces energy consumption and production costs.

[0008] Meanwhile, although extrusion spheronization has been used in wet granulation to improve uniformity and retain aroma, the art is accustomed to assuming the uniformity of nicotine powder and the stability of flavor substances. However, the inventors were surprised to find that even so, in the process of remanufacturing nicotine powder from raw materials, the original uniformity is destroyed due to the reorganization of particles. Furthermore, after wet granulation and drying, the retention rate of nicotine and flavor substances such as fragrances and flavorings is still significantly reduced. Therefore, this invention is needed to solve the problems of precipitous changes in taste and low retention rate of flavor substances.

[0009] To solve the above-mentioned technical problems, this patent provides the following technical solution: A nicotine-filled granule with improved component retention rate is prepared by the following method: Step A: Place the nicotine source, filler, pH adjuster, humectant, and flavoring in a mixer for dry premixing to obtain premixed dry material; Step B: Place the premixed dry material in an extruder. The premixed dry material's own water of crystallization and mechanical extrusion work together to cause the premixed dry material to aggregate into flakes or blocks, which is a dense body. Step C: The dense material is crushed using a crusher and then sieved through screens of different mesh sizes to obtain nicotine-filled granules; the retention rate of nicotine source components in the nicotine-filled granules is greater than 94%, and the retention rate of fragrance and flavor is greater than 87%.

[0010] Furthermore, in step A, the nicotine source, filler, pH adjuster, and fragrance are all in powder form.

[0011] Furthermore, based on the mass percentage of nicotine-filled particles of 100%, it includes 1-4% nicotine source, 65-75% filler, 2-5% pH adjuster, 8-12% humectant, and 15-20% flavoring.

[0012] Furthermore, the nicotine source includes one or more combinations of free nicotine salts, tobacco extracts, or elemental nicotine, and the free nicotine salt includes one or more combinations of nicotine hydrochloride, nicotine dihydrochloride, nicotine citrate, nicotine tartrate, nicotine hydrogen tartrate, nicotine hydrogen tartrate dihydrate, nicotine sulfate, nicotine resinate, or nicotine salicylate.

[0013] Furthermore, the filler includes one or more combinations of microcrystalline cellulose, hydroxypropyl methylcellulose, sodium carboxymethyl cellulose, methylcellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, or ethyl cellulose.

[0014] Furthermore, the wetting agent includes one or more combinations of glycerin, ethylene glycol, propylene glycol, sodium polyacrylate, polyvinylpyrrolidone, carboxylic acid type amino acid type zwitterionic wetting agents, or sulfonic acid type amino acid type zwitterionic wetting agents.

[0015] Furthermore, pH adjusters include one or more combinations of monocarbonates, bicarbonates and carbonates, acetates, lactates, glycine salts, gluconates, borates, sulfates, glycerophosphates, and citrates.

[0016] Furthermore, the flavorings and fragrances are non-exhaustive examples, including coconut, coffee, chocolate, vanilla, citrus (e.g., grapefruit, orange, lime, bergamot, or lemon), mint, licorice, caramel, honey, peanut, walnut, cashew, hazelnut, almond, pineapple, strawberry, raspberry, tropical fruit, cherry, cinnamon, cumin, peppermint, deer antler, spearmint, eucalyptus, mint, and fruit flavorings (e.g., from green apple, blueberry, mango, watermelon, pear, peach, strawberry, apricot, raspberry, cherry, pineapple, lemongrass, lime, chili (capsaicin), citrus, tobacco flavor, bergamot, and plum). Preferably, the flavorings and fragrances also comprise essential oils, including any one or more combinations of peppermint, spearmint, menthol, eucalyptus, clove oil, laurel oil, fennel, thyme, cedarwood oil, nutmeg, and oils from the aforementioned fruits.

[0017] Alternatively, 1-3% of sweeteners may be added. Non-limiting examples of sweeteners include aspartame, acesulfame potassium, cyclamate, saccharin, sodium saccharin, sucralose, neotame, sodium cyclohexylsulfamate, steviol glycosides, licorice, disodium glycyrrhizate, tripotassium and trisodium glycyrrhizate, glucose, fructose, sucrose, maltose, corn syrup, starch sugars and lactose, sorbitol, maltitol, isomaltitol, palaginitol, xylitol, lactitol, mannitol, erythritol and dextran.

[0018] Alternatively, to improve the binding effect of the premixed dry material, one or more combinations of hydroxypropyl methylcellulose, carrageenan, gum arabic, xanthan gum, pectin, chitosan, hydroxypropyl starch, or polyvinyl alcohol may be added.

[0019] Furthermore, in step B, the extrusion method is dry extrusion, which includes single-screw extrusion, twin-screw extrusion, pressure roller extrusion, or flat die extrusion; the extrusion temperature is <40℃.

[0020] Furthermore, the screw speed of single-screw extrusion and twin-screw extrusion is 50~150 rpm / min, and the extrusion pressure is 4~6 MPa.

[0021] Furthermore, the pressure applied by the pressure rollers is 6~8 MPa.

[0022] Furthermore, the pressure per unit area of ​​the flat die extrusion is 80~120 MPa, and the holding time is 4~10 s.

[0023] Furthermore, in step C, the crushing methods include toothed roller crushing and hammer crushing.

[0024] Furthermore, the roller spacing of the toothed roller crusher is 1.0~2.0 mm; the rotation speed of the hammer crusher is 2500~3000 rpm / min.

[0025] Furthermore, the size of the nicotine filling particles is 10-12 mesh, 12-14 mesh, 14-16 mesh, 16-20 mesh, 20-50 mesh, or 50-80 mesh.

[0026] Another aspect of this patent provides a nicotine pouch, comprising a saliva-permeable pouch and the aforementioned nicotine filling particles.

[0027] Furthermore, the amount of nicotine filling particles added to each nicotine bag is 300~400 mg, 400~600 mg, 600~800 mg, or 800~1000 mg.

[0028] Furthermore, the saliva-permeable pouch is made of medical-grade nonwoven fabric, lyocell, modal, or Tencel; the medical-grade nonwoven fabric is one or more combinations of polypropylene fiber, polyester fiber, polyamide fiber, polytetrafluoroethylene fiber, and glass fiber.

[0029] This patent provides a nicotine-filled granule with improved component retention rate, its preparation method, and a nicotine pouch. Without other cores or additional moisture, nicotine powder can be directly used as a raw material to prepare nicotine-filled granules. While ensuring high nicotine stability during processing, it improves the uniformity of the filling granules and the retention rate of flavor substances, resulting in a flavor and fragrance component retention rate >87% and a nicotine retention rate >94%. This significantly improves the onset and duration of physiological satisfaction from the nicotine pouch, without strong irritation. Simultaneously, the high degree of integration between nicotine and fruit aroma significantly improves the user's overall taste experience, shortens the production cycle of nicotine-filled granules, and reduces energy consumption and production costs. Attached Figure Description

[0030] The above content of this patent and the following detailed embodiments will be better understood when read in conjunction with the accompanying drawings. It should be noted that the drawings are merely examples of the claimed technical solution.

[0031] Figure 1 This is a finished product image of the nicotine-filled particles in Embodiment 1 of this patent; Figure 2 This is a finished product image of the nicotine-filled particles in Embodiment 2 of this patent; Figure 3 This is a finished product image of the nicotine-filled particles in Embodiment 4 of this patent; Figure 4 This is a finished product image of the nicotine-filled particles in Embodiment 6 of this patent. Detailed Implementation

[0032] The detailed features and advantages of this application are described below in the specific embodiments. The content of this description is sufficient to enable any person skilled in the art to understand the technical content of this application and implement it accordingly. Based on the specification, claims and drawings disclosed in this specification, a person skilled in the art can easily understand the related objectives and advantages of this application.

[0033] In this specification and claims, several terms will be used, and unless otherwise indicated, these terms will be defined to have the following meanings: All numbers used to represent component quantities, properties (such as weight-average molecular weight), reaction conditions, etc. shall be considered to be modified by the term "within inevitable error ranges" or "about" in all cases. Therefore, the numerical values set forth herein are approximate values, which may vary depending on the desired properties sought to be obtained in this patent. Without limiting the application of the doctrine of equivalents to the scope of the claims to the minimum extent, each numerical value should be interpreted, for example, at least according to the reported significant digits and by applying conventional rounding techniques.

[0034] All other terms used herein that are not specifically defined in this patent are intended to have the ordinary meaning as understood by those of ordinary skill in the art, particularly the meaning that those of ordinary skill in the art can directly and unambiguously determine how to implement the technical solution of this patent after reading the claims, the specification, and the drawings of this patent.

[0035] Even if there are descriptions that are not detailed, omissions, or ambiguities in the grammar, words, punctuation, graphics, symbols, etc. in the claims, the specification, and the drawings of this patent, those of ordinary skill in the art can still obtain the only correct understanding by starting from reading the claims, the specification, and the drawings as a whole without excessive reasoning or experimentation, and effectively exclude various incorrect understanding methods that are not aimed at achieving the purpose of this patent.

[0036] The "ranges" disclosed herein are defined in the form of a lower limit and an upper limit. A given range is defined by selecting a lower limit and an upper limit, and the selected lower limit and upper limit define the boundaries of a particular range. The ranges defined in this way can include the end values or not include the end values, and can be combined arbitrarily, that is, any lower limit can be combined with any upper limit to form a range. For example, if ranges of 60 - 120 and 80 - 110 are listed for a specific parameter, ranges of 60 - 110 and 80 - 120 are understood to be contemplated. In addition, if the smallest range values 1 and 2 are listed, and if the largest range values 3, 4, and 5 are listed, then the following ranges are all contemplated: 1 - 3, 1 - 4, 1 - 5, 2 - 3, 2 - 4, and 2 - 5. In this application, unless otherwise specified, the numerical range "a - b" represents an abbreviated representation of any real number combination between a and b, where a and b are both real numbers. For example, the numerical range "0 - 5" represents that all real numbers between "0 - 5" have been fully listed herein, and "0 - 5" is only an abbreviated representation of these numerical combinations. Additionally, when stating that a certain parameter is an integer ≥2, it is equivalent to disclosing that the parameter is, for example, the integers 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, etc.

[0037] In this article, if there is no special instruction, all the embodiments and preferred embodiments mentioned herein can be combined with each other to form a new technical solution.

[0038] Unless otherwise specified, all the technical features and preferred features mentioned herein can be combined to form new technical solutions.

[0039] Unless otherwise specified, all steps mentioned herein may be performed sequentially or randomly, but are preferably performed sequentially. For example, the method includes steps (a) and (b), indicating that the method may include steps (a) and (b) performed sequentially, or it may include steps (b) and (a) performed sequentially. For example, the mention that the method may also include step (c) indicates that step (c) may be added to the method in any order; for example, the method may include steps (a), (b), and (c), or it may include steps (a), (c), and (b), or it may include steps (c), (a), and (b), etc.

[0040] Unless otherwise specified, the terms "comprising" and "including" as used herein can be open-ended or closed-ended. For example, "comprising" and "including" may mean that other components not listed may also be included, or that only the listed components may be included.

[0041] In the description of this article, it should be noted that, unless otherwise stated, "above" and "below" include the number itself, and "several" in "one or more" means two or more.

[0042] In this description, unless otherwise stated, the term "or" is inclusive. For example, the phrase "A or B" means "A, B, or both A and B". More specifically, the condition "A or B" is satisfied by any of the following conditions: A is true (or exists) and B is false (or does not exist); A is false (or does not exist) and B is true (or exists); or both A and B are true (or exist).

[0043] Unless otherwise specified, percentages (%) in this document refer to percentages by mass relative to the composition.

[0044] Unless otherwise stated herein, the sum of the contents of the components in the composition is 100%.

[0045] In this document, unless otherwise stated, “combination of” means a multi-component mixture of the elements, such as two, three, four, and up to the maximum possible multi-component mixture.

[0046] Unless otherwise specified, the term "a" as used in this specification means "at least one".

[0047] The terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of that feature. In the description of this invention, "a plurality of" means at least two, such as two, three, etc., unless otherwise explicitly specified.

[0048] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.

[0049] To make the objectives, technical solutions, and advantages of the present invention clearer, the embodiments of the present invention will be further described in detail below with reference to the accompanying drawings. Unless otherwise specified, the experimental methods described in the embodiments of the present invention are conventional methods, and the materials and reagents used in the following embodiments are commercially available unless otherwise specified.

[0050] This patent provides a nicotine-filled granule with improved component retention rate, a method for preparing the same, and a nicotine bag, comprising the following steps: S1. Preparation of nicotine-filled particles, the specific steps are as follows: (1) The nicotine source, filler, pH adjuster, low volatile wetting agent and fragrance are placed in a mixer for dry premixing to obtain a mixed powder, which is the premixed dry material.

[0051] The premixed dry material contains no added water or binders. Based on the mass percentage of the mixed powder as 100%, it includes 1-4% nicotine source, 65-75% filler, 2-5% pH adjuster, 8-12% low-volatile wetting agent, and 15-20% fragrance and flavoring.

[0052] Nicotine sources include one or more combinations of free nicotine salt powder, tobacco extract powder, or elemental nicotine powder. Free nicotine salts include one or more combinations of nicotine hydrochloride, nicotine dihydrochloride, nicotine citrate, nicotine tartrate, nicotine hydrogen tartrate, nicotine hydrogen tartrate dihydrate, nicotine sulfate, nicotine resinate, or nicotine salicylate.

[0053] The filler includes one or more combinations of microcrystalline cellulose, hydroxypropyl methylcellulose, sodium carboxymethyl cellulose, methylcellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, or ethyl cellulose.

[0054] pH adjusters include one or more combinations of monocarbonates, bicarbonates and carbonates, acetates, lactates, glycine salts, gluconates, borates, sulfates, glycerophosphates, and citrates.

[0055] Low-volatility wetting agents include one or more combinations of glycerin, ethylene glycol, propylene glycol, sodium polyacrylate, polyvinylpyrrolidone, carboxylic acid-type amino acid-type zwitterionic wetting agents, or sulfonic acid-type amino acid-type zwitterionic wetting agents.

[0056] Flavorings and fragrances are a non-exhaustive list, including coconut, coffee, chocolate, vanilla, citrus fruits (e.g., grapefruit, orange, lime, bergamot, or lemon), mint, licorice, caramel, honey, peanut, walnut, cashew, hazelnut, almond, pineapple, strawberry, raspberry, tropical fruit, cherry, cinnamon, cumin, peppermint, deer antler, spearmint, eucalyptus, mint, and fruit flavorings (e.g., from green apple, blueberry, mango, watermelon, pear, peach, strawberry, apricot, raspberry, cherry, pineapple, lemongrass, lime, chili (capsaicin), citrus, tobacco flavor, bergamot, and plum). Preferably, the flavorings and fragrances also comprise essential oils, including any one or more combinations of peppermint, spearmint, menthol, eucalyptus, clove oil, laurel oil, fennel, thyme, cedarwood oil, nutmeg, and oils from the aforementioned fruits.

[0057] The mixer includes a three-dimensional mixer or a V-type mixer. In some other specific embodiments, any mixer capable of dry premixing the above components to ensure uniform dispersion of the components can be used.

[0058] In other specific embodiments, the amount of filler added can be reduced by adding 1-3% of a sweetener. Non-limiting examples of sweeteners include aspartame, acesulfame potassium, cyclamate, saccharin, sodium saccharin, sucralose, neotame, sodium cyclohexylsulfamate, steviol glycosides, licorice, disodium glycyrrhizate, tripotassium and trisodium glycyrrhizate, glucose, fructose, sucrose, maltose, corn syrup, starch sugar and lactose, sorbitol, maltitol, isomaltitol, palaginitol, xylitol, lactitol, mannitol, erythritol and dextran.

[0059] (2) The premixed dry material obtained in step (1) is placed in an extruder. Under the combined action of the crystal water of the premixed dry material itself and the pressure of mechanical extrusion, the premixed dry material is compacted and aggregated to form a high-density block or sheet-like dense body. This process does not add liquid binder or additional water, and mainly relies on: a. Mechanical interlocking: Particles deform, break, or flow plastically under pressure, interlocking with each other; b. Van der Waals forces and intermolecular forces: As the distance between particles decreases, the surface force increases; c. Cold welding or solid bridging: Under high pressure and frictional heat, local plastic deformation or slight melting may occur at the particle contact points, forming a solid bridge after cooling.

[0060] The principle of the transformation of premixed dry materials into dense materials is as follows: When premixed dry materials are extruded, the particles undergo elastic deformation, plastic deformation or brittle fracture under high pressure, and the new surfaces are exposed and in close contact. Frictional heat may slightly increase the temperature (usually <100℃), reduce the yield strength of the material, promote plastic flow, and the particles are combined through mechanical interlocking, molecular forces and local solid diffusion, and finally compacted into a dense material (such as flakes or blocks). The strength mainly depends on the material properties, the pressure and the roller gap design.

[0061] Meanwhile, extruders are typically designed with specific screw structures or die shapes to ensure effective pressure transmission within the material. During extrusion, pressure is gradually transmitted from the feed end to the discharge end of the extruder, and through the rotation of the screw or the constraint of the die, the pressure is evenly applied to all parts of the material. This uniform pressure transmission ensures that the material experiences similar forces throughout the entire extrusion zone, avoiding uneven compaction caused by excessive or insufficient local pressure. Uniform compaction results in dense blocks or sheets of material with a more consistent density and structure, improving product quality and stability.

[0062] Further crushing is performed by a crusher, and the crushed primary particles are conveyed to a screening device. A vibrating screen with multiple layers of screens of different mesh sizes is used. Under the action of vibration, the particles pass through or remain in each layer of screen according to their particle size, separating the finished particles that meet the target particle size range (e.g., 10~80 mesh). Overly coarse particles are returned to the crushing process, and overly fine powder is returned to the premixing or extrusion process, which are the nicotine-filled particles.

[0063] For example, premixed dry material is fed into a twin-screw or single-screw extruder through a hopper. The screws rotate inside the barrel, conveying, compressing, and kneading the material, which is then extruded through a die (which can be a strip or plate-shaped opening) at the die head to form a continuous, dense extrudate with a specific cross-sectional shape (such as a cylindrical strip or thick strip). The screw speed is adjusted to 50~150 rpm / min, the barrel isolation temperature is controlled between 30~40℃, the die head is a circular perforated plate with a diameter of 2 mm or a flat strip die with a width of 15~20 mm and a thickness of 1.5 mm, and the extrusion pressure is 4~6 MPa. After being air-cooled, the extruded strips are fed into a toothed roller crusher (roller spacing 1.5 mm) for primary crushing or a hammer crusher for further crushing. Then, they are screened by a vibrating screen (upper layer 14 mesh, lower layer 60 mesh; or upper layer 16 mesh, lower layer 80 mesh). Particles with a mesh size between 14 and 60 mesh or between 16 and 80 mesh are nicotine-filled particles.

[0064] In some other embodiments, the premixed dry material can be fed between two counter-rotating pressure rollers via a feeder. The roller surfaces can be smooth or grooved. The premixed dry material is compressed into dense flakes or strips (sheets) under high pressure at the roller gap. The roller pressure is set to 6~8 MPa, the roller surface has shallow grooves, the roller gap is 1 mm, and the extruded material is an irregular sheet about 1 mm thick. Cooling water is circulated through the rollers, and the temperature is <35℃. After cooling, the sheet is crushed by a hammer crusher (rotor speed 2500~3000 rpm / min, equipped with a 2 mm aperture screen plate at the bottom) and then enters a rotary screen (16 mesh and 80 mesh). The particles between 16 and 80 mesh are the nicotine-filled particles.

[0065] In other specific embodiments, a measured amount of premixed dry material can be evenly spread in a flat die cavity, and high pressure is applied by an upper punch or plate to compress the material into large, uniformly thick, dense tablets in one step. The unit area pressure is set to 80-120 MPa, and the holding time is 4-8 seconds, compressing large, dense tablets with a diameter of 80-120 mm and a thickness of 4-8 mm. The tableting process is carried out at room temperature. The resulting large, dense tablets are first coarsely crushed, then finely crushed using a toothed roller crusher (roller spacing 2 mm), and finally screened by vibrating sieves (12 mesh and 50 mesh). Particles between 12 and 50 mesh are taken as nicotine-filled granules.

[0066] S2. Prepare the nicotine pouch, the specific steps of which are as follows: The nicotine-filled granules prepared in step S1 above are placed in a saliva-permeable pouch as the contents, and then cut, sealed, heat-pressed and sterilized with ultraviolet light to obtain a nicotine pouch. Each nicotine pouch contains 300-1000 mg of contents, and each pouch contains 0.1-1.0 mg of nicotine.

[0067] Saliva-permeable sachets can be made of medical-grade nonwoven fabric, lyocell, modal, or tencel. The quantitative dosage of saliva-permeable sachets can be 25-35 g / m³. 2 Among them, medical-grade nonwoven fabric is one or more combinations of polypropylene fiber, polyester fiber, polyamide fiber, polytetrafluoroethylene fiber and glass fiber.

[0068] Example 1

[0069] (1) 2.0% by mass of nicotine tartrate powder, 67.5% by mass of microcrystalline cellulose powder (commercially available, MCC PH-102), 3.0% by mass of sodium bicarbonate powder, 10.0% by mass of glycerol and 17.5% by mass of peppermint flavoring powder were placed in a three-dimensional motion mixer and mixed at room temperature (25±3℃) for 30 min. After uniform mixing, a premixed dry material was obtained. Menthol accounts for 85% of the mass of peppermint flavoring, which translates to 14.875% of the mass of the premixed dry material.

[0070] (2) Place the premixed dry material prepared in step (1) into a co-rotating twin-screw extruder, adjust the screw speed to 120 rpm / min, control the barrel temperature between 30 and 35°C, use a 2.0 mm diameter circular perforated plate for the die head, and set the extrusion pressure to 4 MPa to obtain extruded strips.

[0071] (3) After the extruded strip obtained in step (2) is cooled by air, it is crushed in a toothed roller crusher. The roller spacing is adjusted to 1.5 mm to obtain the crushed material.

[0072] (4) The crushed material obtained in step (3) above is then subjected to vibratory screening. The upper screen is set to 14 mesh and the lower screen to 60 mesh, thus obtaining 14-60 mesh finished particles, which are nicotine-filled particles. The finished product is shown in the figure. Figure 1 As shown.

[0073] (5) The nicotine filling particles obtained in step (4) above are placed in a saliva-permeable pouch as the contents, and the pouch is obtained by cutting, sealing, hot pressing and ultraviolet sterilization. Each nicotine pouch contains 300 mg of contents and 0.1 mg of nicotine.

[0074] Example 2

[0075] (1) 2.0% by mass of nicotine citrate powder, 69.5% by mass of carboxymethyl cellulose powder, 3.0% by mass of sodium bicarbonate powder, 10.0% by mass of glycerol and 15.5% by mass of blueberry flavor powder were placed in a three-dimensional motion mixer and mixed at room temperature (25±3℃) for 30 min. After uniform mixing, a premixed dry material was obtained. Among them, raspberry ketone accounts for 8% of the blueberry flavor mass and vanillin accounts for 2% of the blueberry flavor mass. After conversion, the content of raspberry ketone accounts for 1.24% of the mass of the premixed dry material and the content of vanillin accounts for 0.31% of the mass of the premixed dry material.

[0076] (2) Place the premixed dry material prepared in step (1) above into a single screw extruder, adjust the screw speed to 60 rpm / min, use a deep groove screw to reduce shear heat generation, the die head temperature is <40℃, the die is a flat strip die with a width of 20mm and a thickness of 1.5mm, and the extrusion pressure is 6 MPa to obtain extruded strips.

[0077] (3) After the extruded strip obtained in step (2) is cooled by air, it is crushed in a hammer crusher. The rotor speed is adjusted to 2800 rpm / min and a 2.0 mm aperture screen plate is provided at the bottom to obtain crushed material.

[0078] (4) The crushed material obtained in step (3) is then subjected to a vibrating sieve. The upper sieve is set to 16 mesh and the lower sieve to 80 mesh, which yields 16-80 mesh finished particles, which are nicotine-filled particles. The finished product is shown in the figure. Figure 2 As shown.

[0079] (5) The nicotine filling particles obtained in step (4) above are placed in a saliva-permeable pouch as the contents, and the pouch is obtained by cutting, sealing, hot pressing and ultraviolet sterilization. Each nicotine pouch contains 300 mg of contents and 0.1 mg of nicotine.

[0080] Example 3

[0081] (1) 3.0% by mass of nicotine salicylate powder, 69.5% by mass of hydroxypropyl cellulose powder, 4.0% by mass of sodium carbonate powder, 8.0% by mass of glycerol and 15.5% by mass of blueberry flavor powder were placed in a three-dimensional motion mixer and mixed at room temperature (25±3℃) for 30 min. After uniform mixing, a premixed dry material was obtained. Among them, raspberry ketone accounts for 8% of the blueberry flavor mass and vanillin accounts for 2% of the blueberry flavor mass. After conversion, the content of raspberry ketone accounts for 1.24% of the mass of the premixed dry material and the content of vanillin accounts for 0.31% of the mass of the premixed dry material.

[0082] (2) Place the premixed dry material prepared in step (1) above into a single screw extruder, adjust the screw speed to 60 rpm / min, use a deep groove screw to reduce shear heat generation, the die head temperature is <40℃, the die is a flat strip die with a width of 20mm and a thickness of 1.5mm, and the extrusion pressure is 6 MPa to obtain extruded strips.

[0083] (3) After the extruded strip obtained in step (2) is cooled by air, it is crushed in a hammer crusher. The rotor speed is adjusted to 2800 rpm / min and a 2.0 mm aperture screen plate is provided at the bottom to obtain crushed material.

[0084] (4) The crushed material obtained in step (3) is then subjected to vibration screening. The upper screen is set to 16 mesh and the lower screen to 80 mesh, thus obtaining 16-80 mesh finished particles, which are nicotine-filled particles.

[0085] (5) The nicotine filling particles obtained in step (4) above are placed in a saliva-permeable pouch as the contents, and the pouch is obtained by cutting, sealing, hot pressing and ultraviolet sterilization. Each nicotine pouch contains 300 mg of contents and 0.1 mg of nicotine.

[0086] Example 4

[0087] (1) 2.0% by mass of nicotine tartrate powder, 69.5% by mass of microcrystalline cellulose powder, 3.0% by mass of sodium bicarbonate powder, 10.0% by mass of glycerol and 15.5% by mass of blueberry flavor powder were placed in a three-dimensional motion mixer and mixed at room temperature (25±3℃) for 30 min. After uniform mixing, a premixed dry material was obtained. Among them, raspberry ketone accounts for 8% of the blueberry flavor mass and vanillin accounts for 2% of the blueberry flavor mass. After conversion, the content of raspberry ketone accounts for 1.24% of the mass of the premixed dry material and the content of vanillin accounts for 0.31% of the mass of the premixed dry material.

[0088] (2) Place the premixed dry material prepared in step (1) into a roller press, adjust the roller pressure to 8MPa, the roller surface to shallow groove, and set the roller surface spacing to 1.0 mm to obtain an irregular sheet with a thickness of about 1.0 mm, which is the extruded material.

[0089] (3) Cooling water is passed through the roller to a temperature of <35℃. The extruded material obtained in step (2) is cooled and then placed in a hammer crusher for crushing. The rotor speed is adjusted to 2800 rpm / min and a 2.0 mm aperture screen plate is provided at the bottom to obtain crushed material.

[0090] (4) The crushed material obtained in step (3) is then subjected to a vibrating sieve. The upper sieve is set to 16 mesh and the lower sieve to 80 mesh, which yields 16-80 mesh finished particles, which are nicotine-filled particles. The finished product is shown in the figure. Figure 3 As shown.

[0091] (5) The nicotine filling particles obtained in step (4) above are placed in a saliva-permeable pouch as the contents, and the pouch is obtained by cutting, sealing, hot pressing and ultraviolet sterilization. Each nicotine pouch contains 300 mg of contents and 0.1 mg of nicotine.

[0092] Example 5

[0093] (1) 1.0% by mass of nicotine tartrate powder, 68.5% by mass of microcrystalline cellulose powder, 3.0% by mass of sodium bicarbonate powder, 12.0% by mass of glycerol and 15.5% by mass of blueberry flavor powder were placed in a three-dimensional motion mixer and mixed at room temperature (25±3℃) for 30 min. After uniform mixing, a premixed dry material was obtained. Among them, raspberry ketone accounts for 8% of the blueberry flavor mass and vanillin accounts for 2% of the blueberry flavor mass. After conversion, the content of raspberry ketone accounts for 1.24% of the mass of the premixed dry material and the content of vanillin accounts for 0.31% of the mass of the premixed dry material.

[0094] (2) Place the premixed dry material prepared in step (1) into a roller press, adjust the roller pressure to 6MPa, the roller surface to shallow groove, and set the roller surface spacing to 1.0 mm to obtain an irregular sheet with a thickness of about 1.0 mm, which is the extruded material.

[0095] (3) Cooling water is passed through the roller to a temperature of <35℃. The extruded material obtained in step (2) is cooled and then placed in a hammer crusher for crushing. The rotor speed is adjusted to 2800 rpm / min and a 2.0 mm aperture screen plate is provided at the bottom to obtain crushed material.

[0096] (4) The crushed material obtained in step (3) is then subjected to vibration screening. The upper screen is set to 16 mesh and the lower screen to 80 mesh, thus obtaining 16-80 mesh finished particles, which are nicotine-filled particles.

[0097] (5) The nicotine filling particles obtained in step (4) above are placed in a saliva-permeable pouch as the contents, and the pouch is obtained by cutting, sealing, hot pressing and ultraviolet sterilization. Each nicotine pouch contains 300 mg of contents and 0.1 mg of nicotine.

[0098] Example 6

[0099] (1) 2.0% by mass of nicotine tartrate powder, 67.5% by mass of microcrystalline cellulose powder, 3.0% by mass of sodium bicarbonate powder, 10.0% by mass of glycerol and 17.5% by mass of peppermint flavoring powder were placed in a three-dimensional motion mixer and mixed at room temperature (25±3℃) for 30 min. After uniform mixing, a premixed dry material was obtained. Menthol accounts for 85% of the mass of peppermint flavoring, which translates to 14.875% of the mass of the premixed dry material.

[0100] (2) Place the premixed dry material prepared in step (1) into a flat film tablet press, adjust the unit area pressure to 100 MPa, maintain the pressure for 5 seconds, and press it into a large dense tablet blank with a diameter of 100 mm and a thickness of 5 mm.

[0101] (3) The large dense blank obtained in step (2) above is first coarsely crushed to obtain primary crushed material.

[0102] (4) Place the primary crushed material obtained in step (3) above into a toothed roller crusher for fine crushing, and adjust the roller spacing to 2.0 mm to obtain the crushed material.

[0103] (5) The crushed material obtained in step (4) above is then subjected to vibratory screening. The upper screen is set to 12 mesh and the lower screen to 20 mesh, which yields 12-50 mesh finished particles, which are nicotine-filled particles. The finished product is shown in the figure. Figure 4 As shown.

[0104] (6) The nicotine filling particles obtained in step (5) above are placed in a saliva-permeable pouch as the contents, and the pouch is obtained by cutting, sealing, hot pressing and ultraviolet sterilization. Each nicotine pouch contains 300 mg of contents and 0.1 mg of nicotine.

[0105] Example 7

[0106] (1) 2.0% by mass of nicotine hydrochloride powder, 69.5% by mass of microcrystalline cellulose powder, 3.0% by mass of sodium bicarbonate powder, 8.0% by mass of glycerol and 17.5% by mass of peppermint flavoring powder were placed in a three-dimensional motion mixer and mixed at room temperature (25±3℃) for 30 min. After uniform mixing, a premixed dry material was obtained. Menthol accounts for 85% of the mass of peppermint flavoring, which translates to 14.875% of the mass of the premixed dry material.

[0107] (2) Place the premixed dry material prepared in step (1) into a flat film tablet press, adjust the unit area pressure to 100 MPa, maintain the pressure for 5 seconds, and press into a large dense tablet blank with a diameter of 120 mm and a thickness of 5 mm.

[0108] (3) The large dense blank obtained in step (2) above is first coarsely crushed to obtain primary crushed material.

[0109] (4) Place the primary crushed material obtained in step (3) above into a toothed roller crusher for fine crushing, and adjust the roller spacing to 2.0 mm to obtain the crushed material.

[0110] (5) The crushed material obtained in step (4) above is subjected to vibration screening. The upper screen is set to 12 mesh and the lower screen is set to 20 mesh to obtain 12~50 mesh finished particles, which are nicotine filled particles.

[0111] (6) The nicotine filling particles obtained in step (5) above are placed in a saliva-permeable pouch as the contents, and the pouch is obtained by cutting, sealing, hot pressing and ultraviolet sterilization. Each nicotine pouch contains 300 mg of contents and 0.1 mg of nicotine.

[0112] Comparative Example 1

[0113] Compared with Example 1, the difference is that this comparative example uses a traditional wet process to prepare nicotine-filled particles, and the specific steps are as follows: (1) Dissolve glycerin and peppermint flavor powder in an ethanol aqueous solution with a mass percentage of 70% and mix evenly to obtain an adhesive solution; mix microcrystalline cellulose powder, nicotine tartrate powder and sodium bicarbonate powder evenly to obtain a dry powder mixture.

[0114] (2) The adhesive solution and the dry powder mixture are placed in a high-speed shear granulation agent, and the dry powder mixture is coated by spraying the adhesive solution to prepare wet granules.

[0115] (3) Place the wet granules in a 60℃ hot air circulating oven and dry for 2 hours to make the moisture content of the wet granules <5%.

[0116] (4) The dried granules from step (3) are granulated by a gyratory pellet mill and sieved using a 20-mesh sieve to obtain nicotine-filled granules.

[0117] (5) The nicotine filling particles prepared in step (4) above are placed in a saliva-permeable pouch with the same filling amount as in Example 1. The nicotine pouch is obtained by cutting, sealing, hot pressing and ultraviolet sterilization.

[0118] Comparative Example 2

[0119] Compared with Example 4, the difference is that this comparative example uses a traditional wet process to prepare nicotine-filled particles, and the specific steps are as follows: (1) Dissolve glycerin and blueberry flavor powder in a 70% pure aqueous solution and mix evenly to obtain an adhesive solution; mix microcrystalline cellulose powder, nicotine tartrate powder and sodium bicarbonate powder evenly to obtain a dry powder mixture.

[0120] (2) The adhesive solution and the dry powder mixture are placed in a high-speed shear granulation agent, and the dry powder mixture is coated by spraying the adhesive solution to prepare wet granules.

[0121] (3) Place the wet granules in a 55°C hot air circulating oven and dry for 2.5 hours to make the moisture content of the wet granules <5%.

[0122] (4) The dried granules from step (3) are granulated by a gyratory pellet mill and sieved using a 20-mesh sieve to obtain nicotine-filled granules.

[0123] (5) The nicotine filling particles prepared in step (4) above are placed in a saliva-permeable pouch with the same filling amount as in Example 1. The nicotine pouch is obtained by cutting, sealing, hot pressing and ultraviolet sterilization.

[0124] Comparative Example 3

[0125] This comparative example uses the extrusion and spheronization pelletizing process of composition 4 shown in patent document CN119185163A to prepare nicotine-filled granules. The prepared nicotine-filled granules are then placed in saliva-permeable pouches with the same filling amount as in Example 2. The pouches are then sheared, packaged, hot-pressed, and sterilized with ultraviolet light to obtain nicotine pouches.

[0126] Test Example 1: Determination of Component Retention Rate

[0127] To further illustrate the advantages of the preparation method described in the embodiments of this application, the nicotine-filled particles prepared in Examples 1-7 and Comparative Examples 1-3 were used to determine the retention rate of flavor substances.

[0128] Nicotine-filled particle samples prepared in the different examples and comparative examples described above were subjected to ultrasonic-assisted extraction with methanol to obtain an extract. The extract was filtered through a 0.22 μm filter membrane, and the contents of menthol, raspberry ketone, and vanillin were determined using gas chromatography-mass spectrometry (GC-MS, commercially available) in SIM mode. The nicotine content was determined using high-performance liquid chromatography (HPLC, commercially available) equipped with a UV detector. The internal standard method was used to determine the components, and the actual content of each component was calculated based on the standard curve. The retention rate was calculated using the following formula: Retention rate (%) = Content of detected ingredient / Original added content; The results showed that Example 3 had similar results to Example 2, Example 5 had similar results to Example 4, and Example 7 had similar results to Example 6. Therefore, the nicotine-filled particles in Examples 1, 2, 4 and 6 were used as examples to statistically analyze the component retention rate. The results are shown in Table 1. The nicotine retention rates of the nicotine-filled particles prepared using the methods described in Examples 1, 2, 4, and 6 of this application are all above 94%, and even reach above 96%. In contrast, the nicotine retention rate of the nicotine-filled particles prepared using the methods described in Comparative Examples 1-3 is only 82.8% at most. The nicotine retention rates of the nicotine-filled particles prepared using the methods described in Examples 1 and 6 of this application are all above 87%, which are all significantly higher than the menthol retention rates of the nicotine-filled particles prepared using Comparative Examples 1-3. The raspberry ketone retention rates of the nicotine-filled particles prepared using the methods described in Examples 2 and 4 of this application are all above 87.5%, which are all significantly higher than the raspberry ketone retention rates of the nicotine-filled particles prepared using Comparative Examples 1-3.

[0129] Table 1. Statistical table of flavor component retention rates in nicotine-filled particles of different embodiments and comparative examples.

[0130] Note:" "When performing statistical analysis on the proportions and examples, the component retention rates showed a highly significant difference."

[0131] Test Example 2: Taste Test

[0132] The taste test method is as follows: a professional evaluation team (n=5) conducts the evaluation, and the nicotine pouches prepared in Examples 1 to 7 and Comparative Examples 1 to 3 are placed directly between the upper lip and the upper teeth, with a standard consumption time of 10 minutes.

[0133] (1) Since the same peppermint flavoring was used in Examples 1 and 6 and Comparative Example 1, a sensory evaluation analysis of the peppermint flavor was conducted.

[0134] The results are shown in Table 2. The overall scores of the cooling intensity, mint flavor intensity and overall pleasantness of the nicotine bags prepared by the methods shown in Examples 1 and 6 are significantly higher than those of the nicotine bags prepared in Comparative Example 1. Furthermore, the nicotine release of the nicotine bags in Examples 1 and 6 is stable and without strong irritation, while the nicotine bag in Comparative Example 1 has a strong irritation and insufficient mint flavor, further highlighting the irritation of nicotine release.

[0135] Table 2. Sensory evaluation statistics of nicotine bags in different embodiments and comparative examples.

[0136] Note:" "When performing statistical analysis on the proportions and examples, the scores showed a highly significant difference."

[0137] (2) Since the same blueberry flavoring was used in Examples 2 and 4, as well as Comparative Examples 1 and 2, a sensory evaluation analysis of the blueberry flavor was conducted.

[0138] The results are shown in Table 3. The overall scores of blueberry flavor intensity, flavor fullness, and overall pleasantness of the nicotine bags prepared by the methods shown in Examples 2 and 4 are significantly higher than those of the nicotine bags prepared in Comparative Examples 2 and 3. Furthermore, the nicotine release of the nicotine bags in Examples 2 and 4 is mild, with a high degree of integration with the fruit aroma and no strong irritation. In contrast, the nicotine bags in Comparative Examples 2 and 3 have a stronger irritation and release the fruit aroma too quickly, further highlighting the irritation of nicotine release.

[0139] Table 3. Sensory evaluation statistics of nicotine bags in different embodiments and comparative examples.

[0140] Note:" "When performing statistical analysis on the proportions and examples, the scores showed a highly significant difference."

[0141] Therefore, it can be concluded that this patent provides a nicotine filling granule with improved component retention rate, its preparation method, and a nicotine bag. Under the condition of no other core and no additional moisture addition, nicotine powder can be directly used as raw material to prepare nicotine filling granules. While ensuring the high stability of nicotine during processing, it improves the uniformity of the filling granules and the retention rate of flavor substances, resulting in a flavor and fragrance component retention rate of >87% and a nicotine retention rate of >94%. This significantly improves the onset and duration of physiological satisfaction of the nicotine bag, without strong irritation. At the same time, the high degree of integration between nicotine and fruit aroma significantly improves the user's overall taste experience, shortens the production cycle of nicotine filling granules, and reduces energy consumption and production costs.

[0142] In the foregoing description of exemplary embodiments / specific implementations of this patent, various features of this patent are sometimes combined in a single embodiment / specific implementation or its figures and description, with the aim of simplifying the disclosure and aiding in the understanding of one or more of the various aspects of the invention. However, unless expressly stated otherwise or in obvious technical contradiction or exclusion, the descriptive method of this patent should not be construed as reflecting an intention that the claimed features of the invention are more than expressly stated in each claim. Rather, the inventive aspect reflected in the claims lies in not all the features of a single foregoing disclosed embodiment / specific implementation. Therefore, the claims following the detailed description are hereby expressly incorporated into this detailed description, each claim existing independently as a separate embodiment / specific implementation of this patent.

[0143] The terms and expressions used in this specification are for illustrative purposes and not for limitation. Their use is not intended to exclude any equivalents of the shown and described features or portions thereof, but rather to facilitate the understanding that various modifications may be possible within the scope of this patent claim. Therefore, it should be understood that while this patent has been specifically disclosed through preferred embodiments, exemplary embodiments, and optional features, variations or modifications of the concepts disclosed herein may be adopted by those skilled in the art, and such variations and modifications are therefore considered to be within the scope of this patent as defined by the appended claims. The specific embodiments given in this specification are examples of useful embodiments of this patent, and it will be apparent to those skilled in the art that this patent can be implemented using many variations of the devices, device components, and method steps disclosed herein.

[0144] The foregoing description of specific embodiments fully discloses the general features of this patent, enabling others to easily modify and / or adapt such embodiments for various applications by applying knowledge within the scope of the art, without excessive experimentation or deviation from the general concept of this patent. Therefore, based on the teachings and guidance provided herein, it is intended that such modifications and alterations be included within the meaning and scope of equivalents of the disclosed embodiments. It should be understood that the wording or terminology used herein is for descriptive purposes and not intended to be limiting; thus, the wording or terminology in this specification will be interpreted by those skilled in the art based on the foregoing teachings and guidance.

[0145] Furthermore, the scope of this patent should not be limited to any of the exemplary embodiments described above, but only to the appended claims and their equivalents.

Claims

1. A nicotine filler granule with improved component retention rate, characterized in that, It is prepared by the following method: Step A: Place the nicotine source, filler, pH adjuster, humectant, and flavoring in a mixer for dry premixing to obtain premixed dry material; Step B: Place the premixed dry material in an extruder. The premixed dry material agglomerates into flakes or blocks through the combined action of its own water of crystallization and mechanical extrusion, which is a dense body. Step C: The dense body is crushed using a crusher and then sieved through screens of different mesh sizes to obtain the nicotine-filled particles; the retention rate of the nicotine source component in the nicotine-filled particles is greater than 94%, and the retention rate of the flavoring and fragrance is greater than 87%.

2. The nicotine filler particles with improved component retention rate according to claim 1, characterized in that, In step A, the nicotine source, the filler, the pH adjuster, and the fragrance are all in powder form.

3. The nicotine filler particles with improved component retention rate according to claim 2, characterized in that, The nicotine-filled particles comprise 1-4% of the nicotine source, 65-75% of the filler, 2-5% of the pH adjuster, 8-12% of the humectant, and 15-20% of the flavoring.

4. The nicotine filler particles with improved component retention rate according to claim 3, characterized in that, The nicotine source includes one or more combinations of free nicotine salts, tobacco extracts, or elemental nicotine. Free nicotine salts include one or more combinations of nicotine hydrochloride, nicotine dihydrochloride, nicotine citrate, nicotine tartrate, nicotine hydrogen tartrate, nicotine hydrogen tartrate dihydrate, nicotine sulfate, nicotine resin salt, or nicotine salicylate. The filler includes one or more combinations of microcrystalline cellulose, hydroxypropyl methylcellulose, sodium carboxymethyl cellulose, methylcellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, or ethyl cellulose; The wetting agent includes one or more combinations of glycerin, ethylene glycol, propylene glycol, sodium polyacrylate, polyvinylpyrrolidone, carboxylic acid type amino acid type zwitterionic wetting agents, or sulfonic acid type amino acid type zwitterionic wetting agents.

5. The nicotine filler particles for improving component retention rate according to claim 1, characterized in that, In step B, the extrusion method is dry extrusion, which includes single-screw extrusion, twin-screw extrusion, pressure roller extrusion, or flat die extrusion; the extrusion temperature is <40℃. The screw speed of the single-screw extrusion and the twin-screw extrusion is 50~150 rpm / min, and the extrusion pressure is 4~6MPa; The pressure applied by the pressure roller is 6~8 MPa; The pressure per unit area of ​​the flat die extrusion is 80~120 MPa, and the holding time is 4~10 s.

6. The nicotine filler particles with improved component retention rate according to claim 5, characterized in that, In step C, the crushing method includes toothed roller crushing and hammer crushing; The toothed roller crusher has a roller spacing of 1.0~2.0 mm; the hammer crusher has a rotation speed of 2500~3000 rpm / min.

7. Nicotine-filled particles with improved component retention rate according to any one of claims 1 to 6, characterized in that, The size of the nicotine filling particles is 10-12 mesh, 12-14 mesh, 14-16 mesh, 16-20 mesh, 20-50 mesh, or 50-80 mesh.

8. A nicotine bag, characterized in that, Includes saliva-permeable pouches and nicotine-filled particles as described in claim 7.

9. The nicotine bag according to claim 8, characterized in that, The amount of nicotine-filling particles added to each nicotine bag is 300-400 mg, 400-600 mg, 600-800 mg, or 800-1000 mg.

10. The nicotine bag according to claim 8, characterized in that, The saliva-permeable pouch is made of medical-grade nonwoven fabric, lyocell, modal, or Tencel; the medical-grade nonwoven fabric is one or more combinations of polypropylene fiber, polyester fiber, polyamide fiber, polytetrafluoroethylene fiber, and glass fiber.

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