Method for preparing astaxanthin-loaded ovomucin-pectin-epsilon-polylysine hydrochloride complex nanogel

By employing the self-assembly technology of ovomucin-pectin-ε-polylysine hydrochloride composite nanogels, the stability and bioavailability of astaxanthin in food have been addressed, achieving efficient astaxanthin encapsulation and stable delivery, thus enhancing its application potential in functional foods.

CN122139942BActive Publication Date: 2026-08-04SHANDONG UNIV OF TECH
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Patent Information

Application Number
CN202610615267.4
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2026-05-07
Publication Date
2026-08-04
Estimated Expiration
2046-05-07

AI Technical Summary

Technical Problem

Astaxanthin is easily degraded during processing and storage, has poor water solubility, and low oral bioavailability, which limits its application in functional foods and beverages.

Method used

An ovomucoid-pectin-ε-polylysine hydrochloride composite nanogel system was adopted to form a nanogel through electrostatic interaction, which encapsulates astaxanthin and forms a stable core-shell structure to improve its water solubility and bioavailability.

Benefits of technology

It significantly improves the water solubility and dispersion stability of astaxanthin, enhances its photothermal stability and antioxidant activity, achieves controllable release, and exhibits good intestinal delivery ability in a simulated gastrointestinal fluid environment. Moreover, the preparation method is simple, the raw materials are widely available, and the price is low.

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Abstract

This invention belongs to the field of polymer technology, specifically relating to a method for preparing an astaxanthin-loaded ovomucoid-pectin-ε-polylysine hydrochloride composite nanogel. Under stirring conditions, a pectin solution is added to an ovomucoid solution; then an astaxanthin solution is added, followed by ultrasonic treatment to obtain a mixed solution; an ε-polylysine hydrochloride solution is added to the mixed solution, and the mixture is stirred to obtain a further mixture; the mixture is centrifuged to obtain a dispersion and a precipitate. After separation, the dispersion is dialyzed to obtain the astaxanthin-loaded ovomucoid-pectin-ε-polylysine hydrochloride composite nanogel. This invention uses naturally sourced ovomucoid, pectin, and ε-polylysine hydrochloride as raw materials, effectively avoiding the use of organic solvents and reducing the risk of organic residues. The preparation method is mild, simple to operate, uses widely available and inexpensive raw materials, requires no complex equipment or organic solvents, and has good prospects for large-scale production and application.
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