Candida vesiensis and application thereof
The *Candida viride* strain CATH2402, obtained through screening and adaptive evolution, solves the problems of azelaic acid product tolerance and metabolic flux regulation difficulties in microbial synthesis, achieving efficient fermentation production of azelaic acid. It is suitable for various fermentation substrates and different pH conditions, and has significant potential for industrial production.
Patent Information
- Application Number
- CN202411765768.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-04
- Publication Date
- 2026-06-05
AI Technical Summary
In existing technologies, engineered strains used for microbial synthesis of azelaic acid generally suffer from low product tolerance and difficulty in regulating metabolic flux. Furthermore, there is limited research on the synthesis of azelaic acid through whole-biofermentation, resulting in a lack of effective industrial production solutions.
A strain of Candida virescens, CATH2402, was screened using a laboratory adaptive evolution method. By gradually improving nonane tolerance and optimizing fermentation conditions, efficient fermentation production of azelaic acid was achieved, which is suitable for various fermentation substrates and different pH conditions.
It significantly improves the yield and fermentation efficiency of azelaic acid, shortens the fermentation time, expands the potential for industrial production, is suitable for petroleum-based and bio-based fermentation substrates, and the fermentation process can be carried out under acidic or alkaline conditions.