A method for one-step synthesis of vanillin and o-vanillin based on microchannel continuous flow reactor
The synthesis process of vanillin and ortho-vanillin was optimized by using a microchannel continuous flow reactor, which solved the problems of low efficiency and poor safety in traditional synthesis, and achieved efficient and green one-step synthesis, reducing raw material consumption and improving safety.
CN122212905APending Publication Date: 2026-06-16CHONGQING THRIVE CHEM
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- CHONGQING THRIVE CHEM
- Filing Date
- 2026-04-21
- Publication Date
- 2026-06-16
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Figure CN122212905A_ABST
Abstract
The present application relates to the synthetic technical field of vanillin and ortho-vanillin, and discloses a one-step synthesis method of vanillin and ortho-vanillin based on a micro-channel continuous flow reactor, which comprises the following steps: S1, mixing guaiacol, alkali and solvent I, stirring and dissolving to prepare a uniform guaiacol sodium lye as a first feed; chloroform or a mixture of chloroform and solvent II is used as a second feed; S2, pumping the first feed and the second feed into a micro-channel continuous flow reactor at the same time for mixing and reaction to obtain a reaction liquid; S3, pumping the reaction liquid, an acid solution and an extraction solvent into the micro-channel continuous flow reactor at the same time for mixing and reaction to obtain a two-phase solution; S4, layering the two-phase solution to obtain vanillin and ortho-vanillin in sequence through rectification purification. By using a micro-channel continuous flow reaction container and optimizing the reaction conditions, the time consumption of the RT reaction is shortened from 30 min to 2-3 min, the space-time yield is increased by 7-10 times, and the process is extremely intensified.
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