A russia color leaf exosome-like nanoparticle, and a preparation method and use thereof

Exosome-like nanoparticles were extracted and purified from *Lespedeza rubra* using differential and ultra-high speed centrifugation methods. This solved the problem of unclear efficacy of *Lespedeza rubra* exosome-like nanoparticles in improving glucose and lipid metabolism disorders. The results showed significant reduction in fasting blood glucose, improvement in glucose tolerance and insulin sensitivity, reduction in serum TC and TG levels, and reduction in hepatic lipid accumulation.

CN122214238BActive Publication Date: 2026-07-24SICHUAN CENT FOR TRANSLATIONAL MEDICINE OF TRADITIONAL CHINESE MEDICINE
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Patent Information

Application Number
CN202610693245.X
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2026-05-20
Publication Date
2026-07-24
Estimated Expiration
2046-05-20

AI Technical Summary

Technical Problem

Currently, there is a lack of literature reports on Russian serovar exosome-like nanoparticles, and their chemical composition and effectiveness are unclear, making them unable to effectively improve glucose and lipid metabolism disorders.

Method used

Exosome-like nanoparticles were extracted from *Lespedeza rubra* using differential centrifugation and ultra-high speed centrifugation. After purification, *Lespedeza rubra* exosome-like nanoparticles with specific potentials and particle sizes were prepared and used to prepare pharmaceutically acceptable formulations for improving glucose and lipid metabolism.

Benefits of technology

Russian serotonin exosome-like nanoparticles significantly reduced fasting blood glucose, improved glucose tolerance and insulin sensitivity, reduced serum TC and TG levels, and reduced hepatic lipid accumulation, with effects superior to rosiglitazone, while without the risk of weight gain or liver damage.

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Abstract

This invention relates to a *Malus toringo* exosome-like nanoparticle, its preparation method, and its uses, belonging to the pharmaceutical field. The *Malus toringo* exosome-like nanoparticles of this invention are derived from the plant *Malus toringo*, belonging to the Rosaceae family. Malus toringoides (Rehd.) Hughes and Begonia variegated Malus transitoria Using fresh leaves of *Batal.* Schneid. as raw material, exosome-like nanoparticles were extracted from *Batal.* Schneid. using differential centrifugation and ultra-high speed centrifugation. The *Batal.* Schneid. exosome-like nanoparticles of this invention exhibit significant hypoglycemic and lipid-regulating effects, significantly reducing fasting blood glucose, improving glucose tolerance, increasing insulin sensitivity, and lowering serum TC and TG levels; they also improve liver pathological damage, significantly reducing hepatic lipid accumulation and steatosis, with effects superior to rosiglitazone; while lowering blood glucose and regulating lipids, the *Batal.* Schneid. exosome-like nanoparticles of this invention also inhibit weight gain without the risk of liver damage, demonstrating good comprehensive therapeutic potential.
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