A traditional Chinese medicine ointment composition for nourishing qi and blood, warming the meridians and beautifying the complexion, and its preparation method.

Abstract

This invention discloses a traditional Chinese medicine paste composition for nourishing qi and blood, warming the meridians, and beautifying the complexion, and its preparation method. It relates to the field of traditional Chinese medicine paste compositions and is prepared from the following raw materials: food ingredients and excipients. This traditional Chinese medicine paste composition for nourishing qi and blood, warming the meridians, and beautifying the complexion, and its preparation method, constructs a multi-dimensional and three-dimensional conditioning system based on the traditional Chinese medicine principle of "principal, assistant, adjuvant, and guide" in prescription. Red ginseng extract and donkey-hide gelatin are used as the principal ingredients to achieve the core goal of nourishing both qi and blood. The assistant ingredients are cleverly combined with cooling and moisturizing herbs such as American ginseng and rehmannia root, and warming and tonifying herbs such as astragalus and angelica root, effectively balancing the drawbacks of traditional tonifying formulas that easily cause internal heat, achieving a "warm but not drying" effect. Simultaneously, herbs such as tangerine peel, poria cocos, and peach kernel are added to regulate qi, strengthen the spleen, and promote blood circulation and remove blood stasis. This promotes the digestion and absorption of nourishing herbs such as donkey-hide gelatin and rehmannia root, solving the problem of traditional pastes being "difficult to absorb in the stomach."

Description

Technical Field

[0001] This invention relates to the technology of traditional Chinese medicine ointment composition, specifically to a traditional Chinese medicine ointment composition for nourishing qi and blood, warming the meridians and beautifying the complexion, and its preparation method. Background Technology

[0002] With the fast pace of modern life, women often face problems such as high work pressure and irregular work and rest schedules, leading to a prevalent sub-health state such as "deficiency of qi and blood, insufficiency of spleen and kidney, and cold uterus and blood stasis." Specific manifestations include dull complexion, insomnia and excessive dreaming, irregular menstruation, dysmenorrhea, difficulty conceiving, and postpartum weakness. Currently, most treatments for these problems involve single-function traditional Chinese medicine formulas or health products.

[0003] For example, while traditional Chinese medicine formulas such as "Siwu Tang" and "Danggui Buxue Tang" can nourish blood and regulate menstruation, their simple formulations and singular functions make them difficult to address the complex constitutions of modern women who often exhibit symptoms of deficiency, cold, blood stasis, and dryness. Furthermore, traditional decoctions are often unpalatable and inconvenient to take. Some commercially available herbal pastes or health products are either too strong, causing excessive heat and inflammation, making them unsuitable for long-term use; or they are too rich and greasy, hindering digestion and absorption, especially unsuitable for those with weak spleens and stomachs, such as those trying to conceive or postpartum. In addition, most existing products fail to effectively combine traditional Chinese medicine theory with modern nutrition, lacking comprehensive consideration of intestinal absorption, gentle nourishment, and precise constitution regulation. Therefore, developing a herbal paste composition that integrates nourishing qi and blood, warming the meridians and dispelling cold, strengthening the spleen and promoting digestion, calming the mind and beautifying the complexion, and is gentle, easily absorbed, and suitable for a wide range of people is of significant practical importance. Summary of the Invention

[0004] The purpose of this invention is to provide a traditional Chinese medicine ointment composition for nourishing qi and blood, warming the meridians and beautifying the complexion, and its preparation method, so as to solve the problems of single function, warming and drying, poor absorption and unsuitability for people with various constitutions in the prior art.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a traditional Chinese medicine ointment composition for nourishing qi and blood, warming the meridians, and beautifying the complexion, prepared from the following raw materials: food ingredients and excipients;

[0006] The ingredients include: American ginseng, donkey-hide gelatin, mulberry, wolfberry, jujube, rehmannia root, angelica root, red ginseng extract, cornus officinalis, peach kernel, astragalus root, poria cocos, tangerine peel, jujube seed, rose, angelica dahurica, blood protein polypeptide, and snow lotus culture.

[0007] The excipient is fructooligosaccharide;

[0008] The composition uses red ginseng extract and donkey-hide gelatin as the principal ingredients, synergistically constructing a core for replenishing both qi and blood; astragalus, angelica, American ginseng, rehmannia, blood protein polypeptide, snow lotus culture, and jujube seed as the assistant ingredients, assisting the principal ingredients in enhancing the effects of replenishing qi, nourishing blood, warming the meridians, and calming the mind; mulberry, wolfberry, jujube, cornus officinalis, peach kernel, poria cocos, tangerine peel, rose, and angelica dahurica as adjuvant ingredients, used for nourishing yin and moistening dryness, promoting blood circulation and removing blood stasis, strengthening the spleen and stomach, soothing the liver and regulating qi, nourishing the skin and balancing the properties of the principal and assistant ingredients; and fructooligosaccharides as the guiding ingredient, used to harmonize the various ingredients, promote absorption, and improve flavor, forming a combination of principal, assistant, adjuvant, and guiding ingredients.

[0009] Further, the weight parts of each raw material in the composition are as follows: American ginseng 5-15 parts, donkey-hide gelatin 10-25 parts, mulberry 8-20 parts, wolfberry 5-15 parts, jujube 8-20 parts, rehmannia root 5-15 parts, angelica root 5-15 parts, red ginseng extract 2-8 parts, cornus officinalis 3-10 parts, peach kernel 3-10 parts, astragalus root 8-20 parts, poria cocos 8-20 parts, tangerine peel 3-10 parts, jujube seed 5-15 parts, rose 3-10 parts, angelica dahurica 3-8 parts, blood protein polypeptide 1-5 parts, snow lotus culture 1-5 parts, and fructooligosaccharides 5-20 parts.

[0010] Further, the weight parts of each raw material in the composition are as follows: American ginseng 8-12 parts, donkey-hide gelatin 15-20 parts, mulberry 10-15 parts, wolfberry 8-12 parts, jujube 10-15 parts, rehmannia root 8-12 parts, angelica root 8-12 parts, red ginseng extract 3-6 parts, cornus officinalis 5-8 parts, peach kernel 5-8 parts, astragalus root 10-15 parts, poria cocos 10-15 parts, tangerine peel 5-8 parts, jujube seed 8-12 parts, rose 5-8 parts, angelica dahurica 4-6 parts, blood protein polypeptide 2-4 parts, snow lotus culture 2-4 parts, and fructooligosaccharides 8-15 parts.

[0011] A method for preparing a traditional Chinese medicine ointment composition for nourishing qi and blood, warming the meridians, and beautifying the complexion includes the following steps:

[0012] Step 1: Raw material processing: Weigh out the remaining ingredients except for donkey-hide gelatin, red ginseng extract, blood protein polypeptide, and fructooligosaccharides according to the weight proportions. After washing and drying, grind them into coarse powder for later use.

[0013] Step 2, Extraction and Concentration: Mix the coarse powder obtained in Step 1, add 8-12 times the amount of water, soak for 2-4 hours, then decoct and extract 2-3 times, each time for 1.5-2.5 hours. Combine the extracts, filter, and concentrate the filtrate under reduced pressure at 60-80℃ to a clear extract with a relative density of 1.10-1.20 (measured at 60℃).

[0014] Step 3, Concentrate the paste: Add donkey-hide gelatin, red ginseng extract, hemoglobin polypeptide and fructooligosaccharide to the clear paste obtained in Step 2, and continue to stir and concentrate at 60-80℃ until a thick paste with a relative density of 1.30-1.40 (measured at 60℃) is obtained, which is the Chinese herbal paste composition.

[0015] Furthermore, the decoction extraction in step two is performed three times: the first time, 12 times the amount of water is added and the extraction is carried out for 2 hours; the second time, 10 times the amount of water is added and the extraction is carried out for 2 hours; the third time, 8 times the amount of water is added and the extraction is carried out for 1.5 hours.

[0016] Furthermore, in step one, the method employs a low-temperature slow-cooking technique for drying to preserve the active ingredients in the raw materials. This technique involves placing the cleaned ingredients in a controlled low-temperature environment and slowly drying them through prolonged hot air circulation, vacuum, or infrared methods to maximize the preservation of the bioactivity of heat-sensitive components (such as volatile oils, glycosides, polypeptides, anthocyanins, etc.) in the raw materials. Specific process parameters are: drying temperature controlled between 40℃ and 60℃, drying time 6 to 12 hours, which can be adjusted appropriately according to the moisture content of the raw materials; a low-temperature vacuum drying oven or a hot air circulating drying oven (with a low-temperature mode) can be used, supplemented by a turning device to ensure uniform drying. Compared to traditional high-temperature (above 80℃) rapid drying, this technique effectively avoids the destruction, oxidation, or volatilization of active ingredients, thereby improving the efficacy and quality of the final paste.

[0017] Furthermore, after step three, the method further includes filling and sealing the obtained viscous paste in a GMP Class 100,000 cleanroom.

[0018] Furthermore,

[0019] Compared with the prior art, the present invention provides a traditional Chinese medicine ointment composition for nourishing qi and blood, warming the meridians and beautifying the complexion, and its preparation method, which have the following beneficial effects:

[0020] By employing the TCM principle of "principal, assistant, adjuvant, and guide" in formulating prescriptions, a multi-dimensional and comprehensive conditioning system is constructed. Red ginseng extract and donkey-hide gelatin are used as the principal ingredients to achieve the core goal of simultaneously replenishing qi and blood. The assistant ingredients are cleverly combined with cooling and moisturizing herbs such as American ginseng and rehmannia root, along with warming and tonifying herbs such as astragalus and angelica root, effectively balancing the drawbacks of traditional tonifying formulas that easily cause internal heat, achieving a "warm but not drying" effect. Simultaneously, herbs such as tangerine peel, poria cocos, and peach kernel are added to regulate qi, strengthen the spleen, and promote blood circulation. This promotes the absorption and digestion of rich and greasy herbs like donkey-hide gelatin and rehmannia root, solving the problem of "difficult absorption due to stomach upset" in traditional herbal pastes, achieving a "tonifying but not greasy" effect. Furthermore, herbs such as mulberry, wolfberry, jujube seed, and rose petals simultaneously achieve the effects of nourishing yin and moisturizing dryness, calming the mind and beautifying the complexion, and soothing the liver and relieving depression. The formula contains more than 20 medicinal herbs that work synergistically, rather than simply adding up single functions. Instead, it targets the complex constitution of modern women, which is characterized by "deficiency, cold, stagnation, and dryness," forming a multi-target closed-loop conditioning system that integrates nourishing qi and blood, warming the meridians and dispelling cold, strengthening the spleen and promoting digestion, and calming the mind and beautifying the skin, thus significantly improving the overall conditioning effect.

[0021] By decocting and extracting medicinal herbs for an extended period and then concentrating the extract into a paste, and supplementing it with fructooligosaccharides as an adjuvant, the medicinal properties of the herbs are harmonized, and the paste is given a sweet taste, greatly improving patient compliance. Secondly, fructooligosaccharides, as a high-quality prebiotic, can selectively promote the proliferation of beneficial intestinal bacteria and improve the intestinal microecological environment, thereby enhancing the absorption and utilization of nourishing components by people with weak spleen and stomach from a physiological perspective. This is especially suitable for women with weak digestive function who are trying to conceive or postpartum. In terms of preparation method, a low-temperature, reduced-pressure concentration technique is used to maximize the preservation of the activity of heat-sensitive components such as blood protein peptides and snow lotus culture. Compared with commercially available donkey-hide gelatin cakes or traditional decoctions, this invention, while ensuring strong efficacy, significantly reduces the risks of cloying and irritating the stomach, as well as causing heat and dryness, broadening the applicable population. It allows people with sensitive constitutions, weak spleen and stomach, and those requiring long-term conditioning to use it safely and effectively, embodying the modern TCM concept of combining "prevention of disease" with precise conditioning. Attached Figure Description

[0022] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in this invention. For those skilled in the art, other drawings can be obtained based on these drawings.

[0023] Figure 1 This is a flowchart illustrating the preparation method of a traditional Chinese medicine ointment composition for nourishing qi and blood, warming the meridians, and beautifying the complexion, according to the present invention. Detailed Implementation

[0024] To enable those skilled in the art to better understand the technical solution of the present invention, the present invention will be further described in detail below with reference to the accompanying drawings.

[0025] Example 1: Basic Formula of Herbal Paste and Its Effects

[0026] This embodiment provides a traditional Chinese medicine ointment composition for nourishing qi and blood, warming the meridians, and beautifying the complexion, prepared from the following raw materials in parts by weight:

[0027] American ginseng 10 parts, donkey-hide gelatin 18 parts, mulberry 12 parts, wolfberry 10 parts, jujube 12 parts, rehmannia root 10 parts, angelica root 10 parts, red ginseng extract 5 parts, cornus officinalis 6 parts, peach kernel 6 parts, astragalus root 12 parts, poria cocos 12 parts, tangerine peel 6 parts, jujube seed 10 parts, rose (double-petaled red rose) 6 parts, angelica dahurica 5 parts, blood protein polypeptide 3 parts, snow lotus culture 3 parts, fructooligosaccharides 12 parts.

[0028] Preparation method:

[0029] Step 1: Raw material processing: Weigh out the remaining raw materials except for donkey-hide gelatin, red ginseng extract, blood protein polypeptide, and fructooligosaccharides according to the above weight proportions. After washing and drying, grind them into coarse powder for later use.

[0030] Step 2, Extraction and Concentration: Mix the coarse powder obtained in Step 1, add 12 times the amount of water, soak for 2 hours, and then perform three extractions: First, add 12 times the amount of water and extract for 2 hours; second, add 10 times the amount of water and extract for 2 hours; third, add 8 times the amount of water and extract for 1.5 hours. Combine the three extracts, filter, and concentrate the filtrate under reduced pressure at 70℃ to a clear extract with a relative density of 1.15 (measured at 60℃).

[0031] Step 3, Concentrate the paste: Add donkey-hide gelatin, red ginseng extract, hemoglobin polypeptide and fructooligosaccharide to the clear paste obtained in Step 2, and continue to stir and concentrate at 70°C until a thick paste with a relative density of 1.35 (measured at 60°C) is obtained, which is the traditional Chinese medicine paste composition of this embodiment.

[0032] Effect:

[0033] Thirty female volunteers diagnosed by Traditional Chinese Medicine (TCM) with deficiency of both Qi and Blood, and mild uterine coldness (manifested as pale or sallow complexion, fatigue, scanty and pale menstrual flow, and lower abdominal pain during menstruation) were selected. They continuously took the herbal paste prepared in this example, 10g twice daily, dissolved in warm water, for two months. Results showed that 90% of the volunteers experienced significant improvement in complexion and reduced fatigue; 85% experienced increased menstrual flow and relief from lower abdominal pain during menstruation; and 80% reported improved sleep quality. No adverse reactions such as abdominal distension or heatiness were observed in any of the volunteers.

[0034] Example 2: Adjusting the proportions to enhance the qi-tonifying effect of the herbal paste and its effects

[0035] This embodiment provides a traditional Chinese medicine ointment composition for nourishing qi and blood, warming the meridians, and beautifying the complexion, prepared from the following raw materials in parts by weight:

[0036] American ginseng 8 parts, donkey-hide gelatin 15 parts, mulberry 10 parts, wolfberry 8 parts, jujube 15 parts, rehmannia root 8 parts, angelica root 8 parts, red ginseng extract 6 parts, cornus officinalis 5 parts, peach kernel 5 parts, astragalus root 15 parts, poria cocos 10 parts, tangerine peel 5 parts, jujube seed 8 parts, rose 5 parts, angelica dahurica 4 parts, blood protein polypeptide 2 parts, snow lotus culture 2 parts, fructooligosaccharide 15 parts.

[0037] Preparation method:

[0038] Step 1: Raw material processing: Weigh out the remaining raw materials except for donkey-hide gelatin, red ginseng extract, blood protein polypeptide, and fructooligosaccharides according to the above weight proportions. After washing and drying, grind them into coarse powder for later use.

[0039] Step 2, Extraction and Concentration: Mix the coarse powder obtained in Step 1, add 12 times the amount of water, soak for 2 hours, and then perform three extractions: First, add 12 times the amount of water and extract for 2 hours; second, add 10 times the amount of water and extract for 2 hours; third, add 8 times the amount of water and extract for 1.5 hours. Combine the three extracts, filter, and concentrate the filtrate under reduced pressure at 70℃ to a clear extract with a relative density of 1.20 (measured at 60℃).

[0040] Step 3, Concentrate the paste: Add donkey-hide gelatin, red ginseng extract, hemoglobin polypeptide and fructooligosaccharide to the clear paste obtained in Step 2, and continue to stir and concentrate at 70°C until a thick paste with a relative density of 1.40 (measured at 60°C) is obtained, which is the traditional Chinese medicine paste composition of this embodiment.

[0041] Effect:

[0042] Thirty women preparing for pregnancy, diagnosed by Traditional Chinese Medicine (TCM) as primarily Qi deficiency with concurrent blood deficiency (manifested as fatigue, shortness of breath, lethargy, spontaneous sweating, pale complexion, low basal body temperature, and unsuccessful attempts to conceive for over a year), were selected. They continuously took the herbal paste prepared in this example, 10g twice daily, starting after menstruation and continuing until the next menstrual period, for three consecutive menstrual cycles. Results showed that 93% of the volunteers reported significant improvement in energy and disappearance of fatigue; 87% of the volunteers experienced improvement in basal body temperature, with the high-temperature phase stabilizing; and five volunteers successfully conceived during the treatment period. No adverse reactions such as fever or dry mouth occurred during the treatment.

[0043] Example 3: Adjusting the formulation to enhance the effects of a yin-nourishing and calming herbal paste and its effects.

[0044] This embodiment provides a traditional Chinese medicine ointment composition for nourishing qi and blood, warming the meridians, and beautifying the complexion, prepared from the following raw materials in parts by weight:

[0045] American ginseng 12 parts, donkey-hide gelatin 20 parts, mulberry 15 parts, wolfberry 12 parts, jujube 10 parts, rehmannia root 12 parts, angelica root 12 parts, red ginseng extract 3 parts, cornus officinalis 8 parts, peach kernel 8 parts, astragalus root 10 parts, poria cocos 15 parts, tangerine peel 8 parts, jujube seed 12 parts, rose 8 parts, angelica dahurica 6 parts, blood protein polypeptide 4 parts, snow lotus culture 4 parts, fructooligosaccharides 8 parts.

[0046] Preparation method:

[0047] Step 1: Raw material processing: Weigh out the remaining raw materials except for donkey-hide gelatin, red ginseng extract, blood protein polypeptide, and fructooligosaccharides according to the above weight proportions. After washing and drying, grind them into coarse powder for later use.

[0048] Step 2, Extraction and Concentration: Mix the coarse powder obtained in Step 1, add 12 times the amount of water, soak for 2 hours, and then perform three extractions: first, add 12 times the amount of water and extract for 2 hours; second, add 10 times the amount of water and extract for 2 hours; third, add 10 times the amount of water and extract for 2 hours. Combine the three extracts, filter, and concentrate the filtrate under reduced pressure at 70℃ to a clear extract with a relative density of 1.15 (measured at 60℃).

[0049] Step 3, Concentrate the paste: Add donkey-hide gelatin, red ginseng extract, hemoglobin polypeptide and fructooligosaccharide to the clear paste obtained in Step 2, and continue to stir and concentrate at 70°C until a thick paste with a relative density of 1.35 (measured at 60°C) is obtained, which is the traditional Chinese medicine paste composition of this embodiment.

[0050] Effect:

[0051] Thirty female volunteers, diagnosed by Traditional Chinese Medicine (TCM) as suffering from insomnia and excessive dreaming due to Yin and Blood deficiency and malnourishment of the Heart and Spirit, along with irritability, dry mouth, and a dull complexion, were selected. They continuously took the herbal paste prepared in this example, 10g twice daily, with an additional dose one hour before bedtime, for 1.5 months. Results showed that, assessed using the Pittsburgh Sleep Quality Index (PSQI), 90% of the volunteers experienced significant improvement in sleep quality, with shorter sleep onset times, fewer nighttime awakenings, and improved dreaming. Simultaneously, 87% of the volunteers reported relief from dry mouth and irritability, and a more radiant complexion. No volunteers experienced stomach upset or discomfort due to the rich, greasy texture.

[0052] Example 4: A formula for enhancing the effects of warming the meridians and dispelling cold, and its effects.

[0053] This embodiment provides a traditional Chinese medicine ointment composition for nourishing qi and blood, warming the meridians, and beautifying the complexion, prepared from the following raw materials in parts by weight:

[0054] American ginseng 5 parts, donkey-hide gelatin 25 parts, mulberry 8 parts, wolfberry 5 parts, jujube 20 parts, rehmannia glutinosa 5 parts, angelica sinensis 15 parts, red ginseng extract 8 parts, cornus officinalis 3 parts, peach kernel 10 parts, astragalus membranaceus 20 parts, poria cocos 8 parts, tangerine peel 3 parts, jujube seed 5 parts, rose 10 parts, angelica dahurica 3 parts, blood protein polypeptide 5 parts, snow lotus culture 5 parts, fructooligosaccharide 5 parts.

[0055] Preparation method:

[0056] Step 1: Raw material processing: Weigh out the remaining raw materials except for donkey-hide gelatin, red ginseng extract, blood protein polypeptide, and fructooligosaccharides according to the above weight proportions. After washing and drying, grind them into coarse powder for later use.

[0057] Step 2, Extraction and Concentration: Mix the coarse powder obtained in Step 1, add 12 times the amount of water, soak for 2 hours, and then perform three extractions: First, add 12 times the amount of water and extract for 2 hours; second, add 10 times the amount of water and extract for 2 hours; third, add 8 times the amount of water and extract for 1.5 hours. Combine the three extracts, filter, and concentrate the filtrate under reduced pressure at 70℃ to a clear extract with a relative density of 1.15 (measured at 60℃).

[0058] Step 3, Concentrate the paste: Add donkey-hide gelatin, red ginseng extract, hemoglobin polypeptide and fructooligosaccharide to the clear paste obtained in Step 2, and continue to stir and concentrate at 70°C until a thick paste with a relative density of 1.35 (measured at 60°C) is obtained, which is the traditional Chinese medicine paste composition of this embodiment.

[0059] Effect:

[0060] Thirty female volunteers diagnosed with severe uterine cold and blood stasis (manifested as severe menstrual cramps relieved by warmth, dark menstrual blood with clots, aversion to cold, cold limbs, and weakness in the lower back and knees) according to Traditional Chinese Medicine (TCM) were selected. They continuously took the herbal paste prepared in this example, 15g twice daily, for three menstrual cycles. Results showed that 90% of the volunteers experienced a significant reduction in dysmenorrhea (using the Visual Analogue Scale, VAS) and a decrease in menstrual clots; 85% of the volunteers experienced significant improvement in their aversion to cold and cold limbs. Compared to before treatment, overall symptom improvement was significant. A few volunteers with a constitution leaning towards Yin deficiency experienced mild dry mouth at the beginning of treatment; this symptom disappeared after the dosage was reduced to 10g daily, indicating that the auxiliary herbs in the formula were effective in balancing the symptoms.

[0061] Example 5: Postpartum recovery herbal paste and its effects

[0062] This embodiment provides a traditional Chinese medicine ointment composition for nourishing qi and blood, warming the meridians, and beautifying the complexion, prepared from the following raw materials in parts by weight:

[0063] American ginseng 15 parts, donkey-hide gelatin 10 parts, mulberry 20 parts, wolfberry 15 parts, jujube 8 parts, rehmannia root 15 parts, angelica root 5 parts, red ginseng extract 2 parts, cornus officinalis 10 parts, peach kernel 3 parts, astragalus root 8 parts, poria cocos 20 parts, tangerine peel 10 parts, jujube seed 15 parts, rose 3 parts, angelica dahurica 8 parts, blood protein polypeptide 1 part, snow lotus culture 1 part, fructooligosaccharides 20 parts.

[0064] Preparation method:

[0065] Step 1: Raw material processing: Weigh out the remaining raw materials except for donkey-hide gelatin, red ginseng extract, blood protein polypeptide, and fructooligosaccharides according to the above weight proportions. After washing and drying, grind them into coarse powder for later use.

[0066] Step 2, Extraction and Concentration: Mix the coarse powder obtained in Step 1, add 12 times the amount of water, soak for 2 hours, and then perform three extractions: First, add 12 times the amount of water and extract for 2 hours; second, add 10 times the amount of water and extract for 2 hours; third, add 8 times the amount of water and extract for 1.5 hours. Combine the three extracts, filter, and concentrate the filtrate under reduced pressure at 70℃ to a clear extract with a relative density of 1.15 (measured at 60℃).

[0067] Step 3, Concentrate the paste: Add donkey-hide gelatin, red ginseng extract, hemoglobin polypeptide and fructooligosaccharide to the clear paste obtained in Step 2, and continue to stir and concentrate at 70°C until a thick paste with a relative density of 1.35 (measured at 60°C) is obtained, which is the traditional Chinese medicine paste composition of this embodiment.

[0068] Effect:

[0069] Thirty postpartum women, one month postpartum and exhibiting symptoms of severe qi and blood deficiency (sallow complexion, fatigue, insufficient breast milk, prolonged lochia, spontaneous sweating, and night sweats), were selected. They took the herbal paste prepared in this example twice daily, 15g each time, for two consecutive months. Results showed that 93% of the volunteers experienced significant recovery in physical strength, with their complexion changing from sallow to rosy; 87% reported increased breast milk production and improved milk quality; and 80% reported a shorter lochia discharge time compared to the norm. All volunteers experienced no gastrointestinal discomfort during the treatment period, and no cases of excessive heat or abnormally increased lochia occurred, indicating that this herbal paste, while replenishing qi and blood, also addresses the specific needs of postpartum women, making it safe and effective.

[0070] Comparison Example

[0071] Comparison with Example 1: Modified traditional Siwu Decoction (decoction)

[0072] 1. Formula Composition

[0073] 15g of prepared Rehmannia root

[0074] Angelica sinensis 10g

[0075] 10g of white peony root

[0076] Chuanxiong 6g

[0077] 6g of melted donkey-hide gelatin

[0078] Codonopsis pilosula 10g

[0079] 3g of prepared licorice root

[0080] 2. Preparation method

[0081] Add water to the above-mentioned medicinal materials (except for donkey-hide gelatin) and boil them over high heat. After boiling, simmer over low heat for 30 minutes and filter out the liquid. Add water again and boil for 20 minutes. Combine the two liquids, dissolve the donkey-hide gelatin and add it in. Take the liquid twice a day, morning and evening, while it is still warm.

[0082] 3. Functional Positioning

[0083] It is mainly used for gynecological blood deficiency syndromes, such as irregular menstruation, scanty menstruation, sallow complexion, dizziness, and palpitations.

[0084] It primarily focuses on replenishing blood, while also promoting blood circulation and relieving stagnation.

[0085] 4. Technical Features and Limitations

[0086] Advantages: Classic formula, clear blood-replenishing effect, and low cost.

[0087] limitation:

[0088] Single function: It mainly targets "blood deficiency" and lacks consideration for multiple complex constitutions such as "qi deficiency", "cold uterus", "insomnia" and "spleen deficiency with dampness".

[0089] Its nature is warm and dry: Chuanxiong is pungent and warm, and can easily cause dry mouth and internal heat in people with yin deficiency and fire excess or blood heat.

[0090] Rich and greasy, it can upset the stomach: Rehmannia glutinosa and donkey-hide gelatin are rich and greasy, and people with weak spleen and stomach are prone to abdominal distension, loss of appetite and loose stools after taking them.

[0091] Inconvenient to take: It needs to be decocted daily, has a bitter taste, poor patient compliance, and is not suitable for long-term treatment.

[0092] Intestinal absorption was not considered: the formula lacks spleen-strengthening and digestion-promoting properties, resulting in low utilization of the nourishing components.

[0093] Not suitable for those preparing for pregnancy or postpartum: lacks targeted conditioning of key factors in preparing for pregnancy such as "cold uterus", "kidney deficiency" and "calming the mind".

[0094] Compare with Example 2: A commercially available brand of donkey-hide gelatin cake (a type of tonic paste).

[0095] 1. Formula Composition

[0096] donkey-hide gelatin

[0097] Black sesame

[0098] Walnuts

[0099] red dates

[0100] crystal sugar

[0101] Shaoxing wine

[0102] 2. Preparation method

[0103] After melting the donkey-hide gelatin in rice wine, add roasted black sesame seeds, walnuts, red dates, etc., mix well, cool and slice to make block-shaped snacks.

[0104] 3. Functional Positioning

[0105] It is mainly used for daily blood replenishment, beauty enhancement, and immune system boosting.

[0106] With donkey-hide gelatin as the core ingredient, combined with nuts, it has a good taste and is easy to eat.

[0107] 4. Technical Features and Limitations

[0108] Advantages: Easy to carry and take, tastes good, and has certain blood-nourishing and skin-moisturizing effects.

[0109] limitation:

[0110] The formula is simple: it mainly uses donkey-hide gelatin as the main ingredient, and the auxiliary ingredients are mostly food products. It lacks the rigorous compatibility logic of traditional Chinese medicine.

[0111] Its effects are singular: it tends to nourish yin and replenish blood, but lacks the synergistic effects of replenishing qi, warming yang, promoting blood circulation, strengthening the spleen, and calming the mind.

[0112] The combination of donkey-hide gelatin, rock sugar, and rice wine is rich and heavy, which can easily cause bloating and indigestion in people with weak spleen and stomach. Long-term use will increase the burden on the spleen and stomach.

[0113] Dryness and Heatiness: Yellow wine is warm in nature. When used with donkey-hide gelatin, people with yin deficiency or heat constitution are prone to symptoms of heatiness such as dry mouth, sore throat, and constipation.

[0114] High in sugar: It has a high sugar content and a high glycemic index, making it unsuitable for diabetics, obese individuals, and women trying to conceive who need to control their sugar intake.

[0115] Lack of targeted conditioning for preconception: There is a lack of systematic conditioning for key issues in preconception preparation, such as cold uterus, kidney deficiency, insomnia, and emotional depression.

[0116] Comparative Example 3: A certain brand of ginseng and donkey-hide gelatin oral liquid

[0117] 1. Formula Composition

[0118] Ginseng extract

[0119] donkey-hide gelatin

[0120] Jujube extract

[0121] Honey

[0122] purified water

[0123] 2. Preparation method

[0124] The above raw materials are mixed in proportion, water is added for adjustment, and the mixture is filtered, filled, and sterilized to produce an oral liquid dosage form.

[0125] 3. Functional Positioning

[0126] It is used to improve fatigue, pale complexion, and low immunity caused by insufficient Qi and blood.

[0127] It focuses on "replenishing qi and nourishing blood", with ginseng and donkey-hide gelatin as its core ingredients.

[0128] 4. Technical Features and Limitations

[0129] Advantages: Oral liquid formulation, convenient to take and relatively quick to absorb; ginseng replenishes qi and donkey-hide gelatin replenishes blood, with a clear approach of simultaneously replenishing qi and blood.

[0130] limitation:

[0131] The formula is simple: it contains only three core ingredients: ginseng, donkey-hide gelatin, and jujube, and lacks comprehensive conditioning for other organs (liver, kidney, spleen) and complex constitutions.

[0132] Significantly warming and drying: Ginseng is warm in nature, and long-term use can easily cause internal heat, especially unsuitable for people with yin deficiency and excessive internal heat or those with excess heat syndrome.

[0133] Lack of balancing mechanism: There are no cooling medicinal materials (such as American ginseng, rehmannia, and mulberry) to balance the warming properties of ginseng and donkey-hide gelatin, resulting in prominent dryness and heat.

[0134] Lacks spleen-strengthening and digestive aid: It lacks ingredients such as Poria cocos and tangerine peel that regulate qi and strengthen the spleen, and its nourishing ingredients are prone to causing qi stagnation and stomach obstruction.

[0135] Lacking blood-activating ingredients: It lacks blood-activating herbs such as angelica and peach kernel, so its effect on improving dysmenorrhea and poor menstrual flow caused by blood stasis is limited.

[0136] Lacking calming components: It offers no targeted treatment for symptoms of restlessness such as insomnia, excessive dreaming, irritability, and anxiety.

[0137] Not suitable for those with cold uterus preparing for pregnancy: It lacks warming and dispersing ingredients such as snow lotus and rose, which can soothe the liver and regulate qi. It also lacks effective intervention for fertility problems such as cold uterus and emotional depression.

[0138] The effects of a traditional Chinese medicine ointment composition for nourishing qi and blood, warming the meridians and beautifying the complexion, as described in Examples 1 to 3, and its preparation method were compared with those of a control example, as shown in the table below.

[0139]

[0140]

[0141] Compared with Comparative Examples 1-3, the traditional Chinese medicine ointment compositions of Examples 1-3 of this invention exhibit significant beneficial effects in several aspects. First, in terms of formulation theory, the examples strictly follow the principle of "principal, assistant, adjuvant, and guide," constructing a multi-target synergistic closed loop of "nourishing qi and blood, warming the meridians and dispelling cold, nourishing blood and calming the mind, and strengthening the spleen and promoting digestion." In contrast, the formulations of Comparative Examples 1-3 are simple and have single functions, making it difficult to address the complex constitution of modern women with the coexistence of "deficiency, cold, blood stasis, dryness, dampness, and stagnation." Second, in terms of the balance of medicinal properties, the examples balance the warming properties of red ginseng, angelica, and snow lotus by using cooling herbs such as American ginseng, rehmannia, and mulberry, achieving "warming without drying." They balance the nourishing properties of donkey-hide gelatin and rehmannia by using qi-regulating and blood-activating herbs such as tangerine peel, poria, and peach kernel, achieving "nourishing without being greasy," effectively avoiding the problems of greasy feeling in the stomach and excessive heat that are common in the comparative examples. Third, in terms of functional coverage, the embodiments simultaneously address the needs of replenishing Qi, nourishing blood, warming the meridians, calming the mind, strengthening the spleen, beautifying the complexion, and promoting absorption. In contrast, Control Example 1 focuses primarily on replenishing blood, Control Example 2 on replenishing blood and moisturizing the skin, and Control Example 3 on replenishing both Qi and blood. All lack a systematic approach to addressing key issues such as uterine coldness, insomnia, spleen deficiency, and blood stasis. Fourth, regarding the target population, the embodiments significantly improve absorption rate and safety through the use of fructooligosaccharides for flavoring, spleen-strengthening and digestion-aiding ingredients, and a balanced formula. This makes them widely applicable to individuals with Qi and blood deficiency, uterine coldness and blood stasis, insomnia, those preparing for pregnancy, postpartum recovery, and those requiring blood sugar control. Control Examples 1-3, due to their cloying, warming, and high-sugar content, have limited applicability. Finally, in terms of clinical efficacy, volunteers in the embodiments achieved improvements of over 90% in areas such as improved complexion, restored energy, menstrual regulation, dysmenorrhea relief, improved sleep quality, and increased success rate in conceiving, with no adverse reactions. Their comprehensive conditioning effect is significantly superior to that of the control examples.

[0142] Application examples

[0143] Patient Zhang, female, 32 years old, married, has been trying to conceive for 2 years without success. Chief complaint: Irregular menstruation for over 2 years, cycle 35-45 days, menstrual period 5-7 days, scanty and pale flow, accompanied by lower abdominal pain, aversion to cold, and cold hands and feet. She usually has a sallow complexion, fatigue, insomnia with vivid dreams, and loose stools. Her tongue is pale and swollen with teeth marks on the edges, thin white coating, and a deep, thready, and weak pulse. Western medicine diagnosis: Primary infertility, oligomenorrhea. Traditional Chinese medicine diagnosis: Qi and blood deficiency, spleen and kidney insufficiency, uterine cold and blood stasis.

[0144] Treatment plan: Administer the herbal paste prepared according to Example 1 of this invention for conditioning. Dosage and administration: Begin after menstruation ends, take 10g twice daily, dissolved in warm water one hour after breakfast and dinner. Continue taking until the next menstrual period. Instruct the patient to avoid raw, cold, and cooling foods during medication, maintain a regular sleep schedule, and keep a cheerful mood.

[0145] Therapeutic effect observation:

[0146] First month: The patient reported significant improvement in sleep quality, reduced dreaming, restored daytime energy, and gradually formed stools. Menstruation resumed with a 38-day cycle, slightly increased menstrual flow, and reduced abdominal pain.

[0147] Second month: Complexion changed from dull to radiant, cold hands and feet improved, and fatigue basically disappeared. Menstrual cycle was 35 days, menstrual flow was moderate, menstrual color turned red, no blood clots, and abdominal pain disappeared.

[0148] Third month: The menstrual cycle returned to 32 days, with normal flow, color, and consistency. At the follow-up examination, the patient was in good spirits, with a pale red tongue, thin white coating, and a stronger pulse than before. Medication was discontinued after another month of continued treatment to consolidate the results.

[0149] Follow-up: Three months after stopping the medication, the patient confirmed her pregnancy and subsequently gave birth to a healthy baby at full term.

[0150] Effects: This application example fully demonstrates that the herbal paste of the present invention has a significant comprehensive conditioning effect on symptoms such as infertility, irregular menstruation, insomnia, and fatigue caused by "deficiency of qi and blood, insufficiency of spleen and kidney, and cold uterus and blood stasis". It can fundamentally improve the physical condition for preparing for pregnancy and reflects its advantages of multi-target synergistic effect of "nourishing qi and blood, warming the meridians and dispelling cold, nourishing blood and calming the mind, and strengthening the spleen and promoting digestion".

[0151] The foregoing has only described certain exemplary embodiments of the present invention by way of illustration. Undoubtedly, those skilled in the art can modify the described embodiments in various ways without departing from the spirit and scope of the present invention. Therefore, the foregoing drawings and descriptions are illustrative in nature and should not be construed as limiting the scope of protection of the claims of the present invention.

Claims

1. A traditional Chinese medicine ointment composition for tonifying qi and blood, warming meridians and nourishing the complexion, characterized in that, It is prepared from the following raw materials: food ingredients and auxiliary materials; The ingredients include: American ginseng, donkey-hide gelatin, mulberry, wolfberry, jujube, rehmannia root, angelica root, red ginseng extract, cornus officinalis, peach kernel, astragalus root, poria cocos, tangerine peel, jujube seed, rose, angelica dahurica, blood protein polypeptide, and snow lotus culture. The excipient is fructooligosaccharide.

2. The traditional Chinese medicine ointment composition for tonifying qi and blood, warming meridians, and preserving youthfulness according to claim 1, characterized in that, The weight parts of each raw material in the composition are as follows: American ginseng 5-15 parts, donkey-hide gelatin 10-25 parts, mulberry 8-20 parts, wolfberry 5-15 parts, jujube 8-20 parts, rehmannia root 5-15 parts, angelica root 5-15 parts, red ginseng extract 2-8 parts, cornus officinalis 3-10 parts, peach kernel 3-10 parts, astragalus root 8-20 parts, poria cocos 8-20 parts, tangerine peel 3-10 parts, jujube seed 5-15 parts, rose 3-10 parts, angelica dahurica 3-8 parts, blood protein polypeptide 1-5 parts, snow lotus culture 1-5 parts, and fructooligosaccharides 5-20 parts.

3. The traditional Chinese medicine ointment composition for tonifying qi and blood, warming meridians, and preserving youthfulness according to claim 1, characterized in that, The weight parts of each raw material in the composition are as follows: American ginseng 8-12 parts, donkey-hide gelatin 15-20 parts, mulberry 10-15 parts, wolfberry 8-12 parts, jujube 10-15 parts, rehmannia root 8-12 parts, angelica root 8-12 parts, red ginseng extract 3-6 parts, cornus officinalis 5-8 parts, peach kernel 5-8 parts, astragalus root 10-15 parts, poria cocos 10-15 parts, tangerine peel 5-8 parts, jujube seed 8-12 parts, rose 5-8 parts, angelica dahurica 4-6 parts, blood protein polypeptide 2-4 parts, snow lotus culture 2-4 parts, and fructooligosaccharides 8-15 parts.

4. The preparation method of the traditional Chinese medicine paste composition for tonifying qi and blood, warming meridians, and nourishing the face according to any one of claims 1-3, characterized in that, Includes the following steps: Step 1: Raw material processing: Weigh out the remaining ingredients except for donkey-hide gelatin, red ginseng extract, blood protein polypeptide, and fructooligosaccharides according to the weight proportions. After washing and drying, grind them into coarse powder for later use. Step 2, Extraction and Concentration: Mix the coarse powder obtained in Step 1, add 8-12 times the amount of water, soak for 2-4 hours, then decoct and extract 2-3 times, each time for 1.5-2.5 hours. Combine the extracts, filter, and concentrate the filtrate under reduced pressure at 60-80℃ to a clear extract with a relative density of 1.10-1.

20. Step 3, Concentrate the paste: Add donkey-hide gelatin, red ginseng extract, hemoglobin polypeptide and fructooligosaccharide to the clear paste obtained in Step 2, and continue to stir and concentrate at 60-80℃ until a thick paste with a relative density of 1.30-1.40 is obtained, which is the Chinese herbal paste composition.

5. The method for preparing a traditional Chinese medicine ointment composition for nourishing qi and blood, warming the meridians, and beautifying the complexion according to claim 4, characterized in that, The decoction and extraction described in step two is performed three times. The first time, 12 times the amount of water is added and the extraction is carried out for 2 hours. The second time, 10 times the amount of water is added and the extraction is carried out for 2 hours. The third time, 8 times the amount of water is added and the extraction is carried out for 1.5 hours.

6. The method for preparing a traditional Chinese medicine ointment composition for nourishing qi and blood, warming the meridians, and beautifying the complexion according to claim 4, characterized in that, In step one of the method, a low-temperature slow-cooking technique is used for drying to retain the active ingredients in the raw materials.

7. The method of claim 4, wherein the Chinese medicine paste composition is prepared by the following steps: a. mixing the Chinese medicine paste composition of claim 4; b. heating the mixture to 60-80°C; c. stirring the mixture until the Chinese medicine paste composition is formed; d. cooling the Chinese medicine paste composition; and e. packaging the Chinese medicine paste composition. After step three, the method further includes filling and sealing the obtained viscous paste in a GMP Class 100,000 cleanroom.

8. The traditional Chinese medicine paste composition for tonifying qi and blood, warming meridians, and preserving youthfulness according to claim 1, characterized in that, The roses mentioned are double-petaled red roses.

Images