Use of exercise-induced sweat extract for the preparation of a medicament for the treatment, prevention or alleviation of depression, anxiety

By preparing exercise-induced sweat extract and utilizing its multi-target synergistic effect, the problems of slow onset of action, large side effects and high cost of existing antidepressants are solved, providing a safe and effective treatment for depression and anxiety, which is suitable for functional foods or health products.

CN122376622APending Publication Date: 2026-07-14WUHAN SPORTS UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
WUHAN SPORTS UNIV
Filing Date
2026-05-26
Publication Date
2026-07-14

AI Technical Summary

Technical Problem

Existing antidepressants suffer from slow onset of action, significant side effects, high cost, and poor accessibility in areas with scarce medical resources. There is a lack of innovative drugs or interventions that can effectively inhibit neuroinflammation.

Method used

Using exercise-induced sweat extracts, drugs or health products are prepared through specific exercise intensities and collection methods. These products contain a variety of cytokines and bioactive peptides and are used to treat and prevent depression and anxiety. They also utilize their multi-target synergistic effects to exert anti-neuroinflammatory and neuromodulatory functions.

Benefits of technology

Exercise-induced sweat extracts have shown significant antidepressant and anti-anxiety activities, with efficacy comparable to first-line clinical drugs. They are safe, low-cost, suitable for public health interventions, and applicable to functional foods or health products, thus overcoming the shortcomings of traditional drugs.

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Abstract

The application provides an application of a motion-induced sweat extract in preparation of a medicine for treating, relieving or preventing depression and / or anxiety, and belongs to the field of biological medicine. Specifically, sweat is induced by making a healthy subject perform aerobic exercise of a specific intensity (such as 60%-80% of maximum heart rate), the sweat is collected and eluted by physiological saline, centrifuged and filtered to obtain a biologically active sweat extract. The extract is analyzed by transcriptomics and reverse transcription method to predict the anti-depression potential, and it is proved by in-vivo animal experiments that the extract can significantly improve the anhedonia, behavioral despair and anxiety-like behavior of a depression model mouse, and the effect of a high dose is equivalent to that of a first-line drug fluoxetine. The preparation raw material provided by the application is natural and safe, the preparation process is simple and the cost is low, and a new, easy-to-promote alternative strategy is provided for the prevention and treatment of depression.
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