Recombinant collagen nasal spray and method of making same

By optimizing the formula of the recombinant collagen nasal spray, the problems of unstable efficacy and mucosal irritation in the treatment of allergic rhinitis of existing nasal sprays have been solved. The synergistic effect of nasal mucosal repair and preservatives has been achieved, extending the product's shelf life.

CN122398728APending Publication Date: 2026-07-17JIANGSU JUYUAN MEDICAL TECH CO LTD
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Patent Information

Application Number
CN202610731500.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-05-26
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing nasal sprays have unstable efficacy in treating allergic rhinitis, and long-term use can easily cause irritation and damage to the nasal mucosa. Furthermore, the physicochemical properties of nasal irrigation solutions are not compatible and can aggravate mucosal inflammation.

Method used

This nasal spray uses recombinant collagen and contains ingredients such as trehalose, glycerin, sodium hyaluronate, recombinant type III collagen, p-hydroxyacetophenone, chlorphenesin, and 1,2-hexanediol. It adjusts the pH and osmotic pressure to create a suitable environment for the nasal cavity, promotes mucosal repair, and uses mild preservatives to extend its shelf life.

Benefits of technology

The recombinant collagen nasal spray, through its optimized formula, promotes the restoration of the nasal mucosal barrier function, reduces damage from external stimuli, and extends the shelf life after opening with mild preservatives, making it suitable for use in the human nasal cavity.

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Abstract

本发明公开了一种重组胶原蛋白鼻腔喷雾剂及其制备方法。所述方法先将海藻糖、甘油、氯化钠和磷酸氢二钠用纯化水溶解完全并混合均匀,加入透明质酸钠待其溶胀并溶解完全后,加入重组III型胶原蛋白,搅拌并混合均匀,再加入对羟基苯乙酮、氯苯甘醚、1,2‑己二醇并搅拌混合均匀,纯化水定重后,得到重组胶原蛋白鼻腔喷雾剂。本发明的重组胶原蛋白鼻腔喷雾剂流动性好、成膜快,紧密贴合鼻腔黏膜,对羟基苯乙酮、氯苯甘醚和1,2‑己二醇作为弱防腐剂使用,延长了室温下的开封有效期。
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Citation Information

Patent Citations

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