A therapeutic drug monitoring kit and methods and systems thereof
By combining magnetic bead method with LC-MS/MS detection, the matrix effect and automation challenges of sample pretreatment in TDM have been solved, enabling efficient and accurate multi-drug monitoring and supporting personalized treatment.
CN122409898APending Publication Date: 2026-07-17CALIBRA SCIENTIFIC INC
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Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- CALIBRA SCIENTIFIC INC
- Filing Date
- 2026-05-07
- Publication Date
- 2026-07-17
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Figure CN122409898A_ABST
Abstract
本发明提供了一种治疗药物监测试剂盒及其方法和系统，将磁珠提取法结合LC‑MS / MS检测应用于人血药物浓度监测，利用含有除磷脂磁珠和吸附待测药物磁珠的混合磁珠溶液，对样本中的待测药物进行吸附和提取前处理，搭配自动化处理设备，前处理效率高，上清液中磷脂含量低，大大降低了基质效应和色谱柱冲洗压力。本发明提供的治疗药物监测方法使用统一的前处理流程，实现对多种药物的同时提取，且通过磁珠自动化提取方法，可快速完成样本的前处理步骤，快速出治疗药物监测结果，缩短整体的检测时间，从而为实现个体化治疗提供可靠的实验室检查依据。
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