Nano material for treating uveal melanoma as well as preparation method, application and medicine thereof

By utilizing a zinc/copper bimetallic organic framework and a hyaluronic acid-coated nanomaterial, highly selective targeted therapy for uveal melanoma has been achieved, overcoming the problem of poor efficacy in treating metastatic uveal melanoma in existing technologies and providing effective therapeutic activity and metastasis inhibition at low doses.

CN122440591AActive Publication Date: 2026-07-24XIANGYA HOSPITAL CENT SOUTH UNIV
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Patent Information

Application Number
CN202610924451.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-06-25
Publication Date
2026-07-24
Estimated Expiration
2046-06-25

AI Technical Summary

Technical Problem

Current technologies lack efficient, universal, and well-validated treatment options for metastatic uveal melanoma. Traditional treatments have little effect on UM, and the effects of immune checkpoint inhibitors and targeted inhibitors are limited.

Method used

Nanomaterials composed of a zinc/copper bimetallic organic framework and a hyaluronic acid coating layer can achieve highly selective targeted inhibition of uveal melanoma cells through the synergistic effect of the zinc/copper bimetallic organic framework and the compound of formula 1. This blocks the energy acquisition of cancer cells and induces copper death, thereby inhibiting tumor growth and metastasis through a multi-mechanism strategy.

Benefits of technology

It exhibits excellent therapeutic activity at low doses, effectively inhibiting cancer cells of uveal melanoma, significantly suppressing its metastasis, while maintaining biocompatibility and providing a broad therapeutic window.

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Abstract

The invention belongs to the field of medicine, and particularly relates to a nanometer material for treating uveal melanoma, a preparation method and application of the nanometer material and a medicine, and the nanometer material for treating uveal melanoma comprises a core and a hyaluronic acid coating layer coating the core; the core comprises a zinc / copper bimetal organic framework and a compound shown in a formula 1, and the formula 1 is shown in the specification. Aiming at ophthalmic UM pathogenic mechanisms, characteristics and treatment problems, the invention provides a brand-new nano material which is based on combination and synergy of a zinc / copper bimetal organic framework, a compound as shown in a formula 1 and an HA component and structure, so that synergy can be realized, cancer cells of uveal melanoma can be inhibited in a targeted manner based on multi-mechanism combination and synergy and high selectivity; according to the present invention, the nano-material can provide excellent treatment activity under the condition of low administration dosage, can effectively inhibit the transfer of the nano-material, and further has excellent biological safety.
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