Collagen-exosome composite membrane material for uterine cavity repair as well as preparation method and application of collagen-exosome composite membrane material

The collagen-exosome composite membrane material solves the problem of limited repair effect on endometrial damage and intrauterine adhesions, realizes long-term sustained release of exosomes and endometrial regeneration, provides stable physical support and safe degradation products, promotes angiogenesis, and is easy to operate.

CN122440908APending Publication Date: 2026-07-24YANTAI ZHENGHAI BIO TECH
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Patent Information

Application Number
CN202610909347.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-06-23
Publication Date
2026-07-24

AI Technical Summary

Technical Problem

Existing treatments for endometrial damage and intrauterine adhesions have limited effectiveness. Mesenchymal stem cell-derived exosomes have short retention times and low local concentrations in the uterine cavity, and thermosensitive collagen exosome hydrogels have unstable morphology and limited in situ maintenance effects.

Method used

A collagen-exosome composite membrane material is used. By combining type I collagen with mesenchymal stem cell-derived exosomes to form a porous structure, a stable spatial network structure is constructed using the cross-linking agent 1-ethyl-3-(3-dimethylpropyl)carbodiimide hydrochloride/N-hydroxysuccinimide, thereby achieving long-term sustained release and physical isolation of exosomes.

Benefits of technology

It significantly prolongs the retention time of exosomes in the uterine cavity, promotes endometrial regeneration and angiogenesis, provides stable physical support, and the degradation products are amino acids or small molecule peptides. It is highly safe and easy to operate.

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Abstract

The invention discloses a collagen-exosome composite membrane material for uterine cavity repair as well as a preparation method and application thereof. The collagen-exosome composite membrane material is prepared by compounding type I collagen and mesenchymal stem cell source exosome, the I-type collagen is obtained by carrying out cross-linking reaction on animal tissues and a cross-linking agent; the mesenchymal stem cell source exosome expresses one or more of exosome marker proteins of CD9, CD63 and TSG101. The mesenchymal stem cell source exosome can be used for expressing one or more of the exosome marker proteins of CD9, CD63 and TSG101. The collagen-exosome composite membrane material disclosed by the invention keeps flexibility at body temperature, can be attached to an endometrial wound surface, realizes exosome slow release and uterine cavity physical isolation effects, has good biological activity, and can promote endometrial regeneration and angiogenesis.
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