Preparation method and application of an antibacterial and healing-promoting photosensitizer

By constructing a photosensitizer with an Ag/NH2/Br-MIL-88B@MIL-88C core-shell structure, the stability and antibacterial and healing-promoting effects of Fe-MOF materials were solved, achieving a synergistic effect of highly efficient photodynamic antibacterial activity and cell migration promotion, and overcoming the problem of drug resistance.

CN122582278APending Publication Date: 2026-08-18THE FIRST AFFILIATED HOSPITAL OF JINZHOU MEDICAL UNIV
0 Cites 0 Cited by

Patent Information

Application Number
CN202610671625.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-05-15
Publication Date
2026-08-18

AI Technical Summary

Technical Problem

Existing Fe-MOF materials suffer from poor stability, low ROS generation efficiency, and potential drug burst release problems in photodynamic therapy. Furthermore, single photosensitizers are prone to drug resistance, making it difficult to achieve the synergistic function of efficient antibacterial and repair promotion.

Method used

A photosensitizer with an Ag/NH2/Br-MIL-88B@MIL-88C core-shell structure was constructed by competitively modifying silver nanoparticles (AgNPs) with dual ligands and growing the MIL-88C shell in situ, thereby enhancing the separation and migration of photogenerated carriers.

Benefits of technology

It significantly enhances photodynamic antibacterial activity, broadly and efficiently kills bacteria, including Gram-positive bacteria, Gram-negative bacteria, and drug-resistant bacteria, and has good biocompatibility and cell migration promotion capabilities, significantly accelerating wound healing.

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

This invention discloses an antibacterial and wound-healing photosensitizer, its preparation method, and its applications. The photosensitizer of this invention has a core-shell structure, with the core being MIL-88B modified with amino / bromodiphenyl ligands embedded in silver nanoparticles, and the shell being MIL-88C grown in situ on the core surface. The photosensitizer of this invention significantly improves the photogenerated carrier separation efficiency and reactive oxygen species generation capacity through its MOF-on-MOF heterostructure. Under light irradiation, it exhibits highly efficient killing effects against Staphylococcus aureus, Escherichia coli, and methicillin-resistant Staphylococcus aureus, while also possessing good biocompatibility, promoting fibroblast migration, and showing significant hemostatic and wound-healing effects. This photosensitizer has broad application prospects in the preparation of photodynamic antibacterial drugs and wound-healing medical materials.
Need to check novelty before this filing date? Find Prior Art