Venous sinus thrombus multi-side-hole intervention catheter and venous sinus thrombus thrombolysis device

Abstract

The utility model relates to the field of mechanical thrombus extraction devices, in particular to a venous sinus thrombus multi-side-hole intervention catheter and a venous sinus thrombus thrombolysis device. The venous sinus thrombus multi-side-hole intervention catheter comprises a catheter body and a plurality of micro-tubes, a plurality of open holes are formed in the catheter body, the micro-tubes are all arranged in the catheter body, a plurality of medicine flowing holes are formed in each micro-tube, and the medicine flowing holes in the micro-tubes correspond to the open holes in a one-to-one mode. The medicine can be released at multiple parts in the thrombus, so that the thrombolytic medicine is in full contact with the multiple parts of the thrombus, and the contact area of the thrombolytic medicine and the thrombus is greatly increased.

Description

Technical Field

[0001] The utility model relates to the field of mechanical thrombus removal devices, in particular to a venous sinus thrombosis multi-side hole interventional catheter and a venous sinus thrombosis thrombolytic device. Background Art

[0002] Cerebral venous thrombosis (CVT) is a special type of cerebrovascular disease caused by thrombosis of the cerebral venous system, such as the dural sinus, cortical vein, and deep vein, due to various reasons. It is characterized by obstruction of cerebral venous return and intracranial hypertension, and clinical manifestations include headache, blurred vision, epilepsy, and focal neurological dysfunction. It is more common in young people, with a female predominance, with a male-to-female ratio of 1:3.5. The incidence of CVT in postpartum women can be as high as 10 / 100,000, accounting for about 5%-20% of all CVT. With the advancement of imaging technology, the use of oral contraceptives / hormone replacement, and the implementation of the "two-child policy", the incidence of CVT has shown a significant upward trend in recent years. In addition, with the promotion of various vaccinations, vaccine-induced CVT cases have also been frequently reported, bringing new challenges to the prevention and treatment of CVT. In the context of first-line anticoagulant treatment, even if CVT survivors have achieved neurological independence, residual symptoms are high, including headache, epilepsy, memory loss, and impaired work ability, which seriously endanger the quality of life of CVT patients and bring serious economic burdens to CVT patients, their families, and even society.

[0003] Although anticoagulation is currently the first-line treatment for CVT, some CVT patients still cannot control the progression of the disease after standardized anticoagulation treatment, resulting in disability or even death. The ISCVT study reported that even with standardized anticoagulation treatment, some patients still had poor clinical outcomes, such as patients unable to achieve functional independence or even death. As a treatment for CVT, endovascular treatment is widely used worldwide, but it is limited by interventional materials and interventional techniques. In addition, the widespread presence of arachnoid granulations, trabeculae, cords and septa in the venous sinus can cause repeated operations to break or damage the venous sinus, causing damage to the cerebral venous sinus wall and cerebral veins, perforation, tearing and bleeding, and even endangering the patient's life. The TO-ACT (Thrombolysis or Anticoagulation for Cerebral Venous Thrombosis) study is currently the only randomized controlled clinical trial exploring the safety and effectiveness of mechanical thrombectomy for severe CVT, but it was terminated early due to ineffectiveness.

[0004] Although the effectiveness of endovascular treatment has not been confirmed, the data from the TO-ACT study provides a lot of experience in the treatment of CVT, and also provides a lot of references for the redesign and initiation of subsequent clinical trials of endovascular treatment for severe CVT. The development of cerebral vein-specific endovascular treatment devices is a difficult problem that needs to be solved in the field of cerebral venous thrombosis treatment worldwide.

[0005] Endovascular treatment represented by mechanical thrombectomy has become the standard treatment for acute ischemic stroke caused by anterior circulation large vessel occlusion. At present, the most commonly used CVT interventional treatment devices in clinical practice include plastic guidewires, thrombus protection devices, balloon dilatation, thrombus aspiration, and arterial retrievable thrombectomy stents, all of which are designed for intra-arterial operations. The use of arterial thrombectomy devices does not conform to the anatomical characteristics of the venous sinus and the need for large-load thrombus fragmentation. The operation time is long, and it is difficult to quickly and effectively remove large-load thrombi to achieve recanalization of the venous sinus. For patients with severe CVT whose condition is still difficult to control after adequate anticoagulation treatment, there are currently more and more clinical case reports internationally showing that traditional intra-arterial treatment methods such as local drug thrombolysis can be used to quickly remove thrombi and improve blood flow, thereby saving the lives of critically ill patients and improving the prognosis of critically ill patients.

[0006] However, cerebral veins and venous sinuses have unique anatomical structures and drainage patterns. The lumen of the cerebral venous sinuses is relatively large, the thrombus load is large, and in the presence of thrombotic pathological conditions, blood flow is stagnant. Traditional single-hole catheters at the tip cannot release thrombolytic drugs evenly and fully around the thrombus. The contact area between thrombolytic drugs and thrombus is small, and the clinical efficacy is unsatisfactory.

[0007] Up to now, there is a lack of side-hole catheters specifically used for contact thrombolysis in the cerebral venous system at home and abroad. Compared with intra-arterial thrombosis, intracranial venous thrombosis often forms over a wider range and with a larger load, often involving multiple venous sinuses at the same time. Therefore, the development of multi-side-hole catheters specifically suitable for the cerebral venous system to quickly remove thrombi, improve blood flow, and restore venous recanalization has become an urgent problem to be solved in the treatment of patients with severe cerebral venous thrombosis.

[0008] Based on this, the technical solution of the utility model is proposed. Utility Model Content

[0009] The objectives of the utility model include, for example, providing a venous sinus thrombosis multi-side hole interventional catheter and a venous sinus thrombosis thrombolytic device, which can release drugs at multiple locations in the thrombus, so that the thrombolytic drugs can fully contact with multiple locations of the thrombus, greatly increasing the contact area between the thrombolytic drugs and the thrombus.

[0010] The embodiments of the present invention can be implemented as follows:

[0011] In the first aspect, the utility model provides a multi-side hole interventional catheter for venous sinus thrombosis, comprising a catheter body and a plurality of microtubes, wherein the catheter body is provided with a plurality of openings, the plurality of microtubes are arranged in the catheter body, each of the microtubes is provided with a plurality of drug flow holes, and the plurality of drug flow holes on the plurality of microtubes correspond one-to-one to the plurality of openings.

[0012] In an optional embodiment, two adjacent drug flow holes on two adjacent microtubes are staggered.

[0013] In an optional embodiment, in a cross section of a location where the catheter body is provided with a plurality of openings, the plurality of drug flow holes are arranged along the circumference of the catheter body.

[0014] In an optional embodiment, a plurality of the microtubes are arranged in a circumferential ring around the catheter body and form a guidewire lumen for accommodating a guidewire.

[0015] In an optional embodiment, the catheter body includes a pressure sensing section, a drug dissolution section and a drug injection section connected in sequence, and the drug dissolution section is provided with a plurality of openings, and the plurality of openings correspond one-to-one to the plurality of drug flow holes on the plurality of microtubes.

[0016] In an optional embodiment, the pressure sensing segment is provided with a pressure sensor.

[0017] In a second aspect, the utility model provides a venous sinus thrombosis lytic device, which includes the venous sinus thrombosis multi-side hole interventional catheter described in the aforementioned embodiment.

[0018] In an optional embodiment, it also includes an automatic control system, which is electrically connected to the pressure sensor.

[0019] In an optional embodiment, it further includes a pressure pump and a flow meter, wherein the pressure pump and the flow meter are both connected to the drug injection section of the catheter body and electrically connected to the automatic control system.

[0020] In an optional embodiment, it further comprises a valve, wherein the valve is connected to the drug injection section of the catheter body.

[0021] The beneficial effects of the embodiment of the utility model include that the embodiment of the utility model provides a plurality of microtubes, and the plurality of drug flow holes on each microtube correspond one-to-one with the plurality of openings on the catheter body, so that the intervention can release drugs at a plurality of sites, and the speed and content of the drug released at each site are substantially the same, thereby improving the thrombolytic effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] In order to more clearly illustrate the technical solutions of the embodiments of the utility model, the drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the utility model and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other relevant drawings can be obtained based on these drawings without paying creative work.

[0023] Figure 1 A schematic diagram of the structure of a multi-side hole interventional catheter for venous sinus thrombosis provided in an embodiment of the utility model;

[0024] Figure 2 A schematic diagram of a microtube provided by an embodiment of the utility model;

[0025] Figure 3 A schematic diagram of microtubule expansion provided by an embodiment of the utility model;

[0026] Figure 4 A schematic diagram of the structure of a venous sinus thrombosis lytic device provided in an embodiment of the utility model.

[0027] Icons: 100- multi-side hole interventional catheter for venous sinus thrombosis; 110- catheter body; 111- pressure sensing section; 112- drug dissolution section; 113- drug injection section; 114- opening; 115- pressure sensor; 116- guidewire cavity; 120- microtube; 121- drug flow hole; 200- venous sinus thrombosis lytic device; 210- automatic control system. DETAILED DESCRIPTION

[0028] In order to make the purpose, technical scheme and advantages of the embodiments of the utility model clearer, the technical scheme in the embodiments of the utility model will be clearly and completely described below in conjunction with the drawings in the embodiments of the utility model. Obviously, the described embodiments are part of the embodiments of the utility model, not all of the embodiments. Generally, the components of the embodiments of the utility model described and shown in the drawings here can be arranged and designed in various different configurations.

[0029] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the present invention to be protected, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0030] It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, further definition and explanation thereof is not required in subsequent drawings.

[0031] In the description of the present utility model, it should be noted that if the terms "upper", "lower", "inside", "outside", etc. appear, the orientation or position relationship indicated is based on the orientation or position relationship shown in the accompanying drawings, or is the orientation or position relationship in which the utility model product is usually placed when used. It is only for the convenience of describing the utility model and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation. Therefore, it cannot be understood as a limitation on the present utility model.

[0032] In addition, the terms “first”, “second”, etc., if used, are merely used to distinguish between the descriptions and should not be understood as indicating or implying relative importance.

[0033] It should be noted that, in the absence of conflict, the features in the embodiments of the present invention may be combined with each other.

[0034] Please refer to Figure 1 The present embodiment provides a venous sinus thrombosis multi-side hole interventional catheter 100, which includes a catheter body 110. The catheter body 110 is a tubular structure with a hollow interior, and can be used to place subsequent multiple microtubes 120 and guide wires.

[0035] The catheter body 110 is divided into three parts, including a pressure sensing section 111, a drug dissolution section 112 and a drug injection section 113, which are connected in sequence. The pressure sensing section 111 is provided with a pressure sensor 115, which can monitor the intracranial pressure and determine whether the thrombolytic drug has a therapeutic effect and what effect it has.

[0036] The drug dissolution section 112 is provided with a plurality of openings 114 . The plurality of openings 114 can release the drug at multiple locations in the thrombus, so that the thrombolytic drug contacts multiple locations of the thrombus, thereby increasing the contact area between the thrombolytic drug and the thrombus.

[0037] The thrombolytic drug is injected from the drug injection section 113 and then flows out through the opening 114 on the drug dissolution section 112, and then reacts with the thrombus to dissolve the thrombus.

[0038] A plurality of openings 114 are provided on the drug dissolution section 112. The openings 114 closer to the drug injection section 113 are subjected to greater pressure after the injection of the thrombolytic drug, and more thrombolytic drug can flow out. The openings 114 relatively far from the drug injection section 113 are subjected to relatively less pressure, and thus less thrombolytic drug flows out.

[0039] See also Figure 2 and Figure 3In order to make each opening 114 on the drug dissolution section 112 release the same amount of thrombolytic drugs, the embodiment of the utility model is provided with a plurality of microtubes 120, each of which is arranged in the catheter body 110, and each of which is provided with a plurality of drug flow holes 121, and the plurality of drug flow holes 121 on the plurality of microtubes 120 correspond to the plurality of openings 114 one by one. That is to say, one opening 114 corresponds to one drug flow hole 121, and then the thrombolytic drugs passing through the microtube 120 can enter the thrombus through the drug flow hole 121 and the opening 114.

[0040] Specifically, the number of the microtubes 120 may be 2, 3, 4 or more. In the embodiment of the present invention, the number of the microtubes 120 is 4.

[0041] The shape of the microtube 120 can be circular or other shapes. For example, in the embodiment of the present invention, the shape of the cross section of the microtube 120 is the same as one quarter of the cross-sectional area of ​​the catheter body 110 .

[0042] Furthermore, the two adjacent drug flow holes 121 on the two adjacent microtubes 120 are staggered. That is, the drug flow holes 121 of the two adjacent microtubes 120 are not on the same horizontal plane, but are alternated up and down and staggered left and right, so that the pressures received by the two adjacent openings 114 are almost the same, and then the release of equal amounts of drugs can be achieved. In the embodiment of the utility model, 3-4 drug flow holes 121 are opened on each microtube 120. Of course, it can be understood that the number of drug flow holes 121 on each microtube 120 can be appropriately adjusted according to actual conditions.

[0043] Furthermore, the microtube 120 may be connected to the pressure sensing segment 111 or not, that is, the side of the microtube 120 closer to the pressure sensing segment 111 may be closed or open, and this side may be located inside the pressure sensing segment 111 or not.

[0044] More specifically, in a cross section of the catheter body 110 at a location where the plurality of openings 114 are formed, the plurality of drug flow holes 121 are arranged along the circumference of the catheter body 110 .

[0045] The plurality of microtubes 120 are arranged in a circumferential ring around the catheter body 110 , thereby forming a guidewire lumen 116 for accommodating a guidewire in the center of the catheter body 110 .

[0046] Further, see Figure 4 The embodiment of the utility model further provides a venous sinus thrombosis lytic device 200, which includes the venous sinus thrombosis multi-side hole interventional catheter 100 described in the aforementioned embodiment.

[0047] It also includes an automatic control system 210, which can receive signals, process signals, output different signals according to the processed signals, and control the start or stop of other devices or other actions of the devices. The automatic control system 210 can be an integrated circuit chip with signal processing capabilities. The above-mentioned processor can be a general-purpose processor, including a central processing unit (CPU), a network processor (NP), etc.; it can also be a digital signal processor (DSP), an application specific integrated circuit (ASIC), a field programmable gate array (FPGA) or other programmable logic devices, discrete gates or transistor logic devices, discrete hardware components. The general-purpose processor can be a microprocessor or the processor can also be any conventional processor, etc.

[0048] Specifically, the automatic control system 210 is electrically connected to the pressure sensor 115, that is, the pressure sensor 115 transmits the monitored pressure to the automatic control system 210, and the automatic control system 210 displays the relevant numerical value or converts it into a relevant signal. Then the operator can observe the numerical value or signal on the automatic control system 210 and then determine whether to continue to introduce thrombolytic drugs.

[0049] Furthermore, it also includes a pressure pump and a flow meter, the pressure pump is used to pump thrombolytic drugs into the microtube 120, and the flow meter is used to monitor the amount of thrombolytic drugs pumped into the microtube 120. Specifically, the pressure pump and the flow meter are both connected to the drug injection section 113 of the catheter body 110, and are electrically connected to the automatic control system 210. The automatic control system 210 controls the amount of thrombolytic drugs pumped in by the pressure pump.

[0050] Furthermore, the venous sinus thrombolysis device 200 further includes a valve, which is connected to the drug injection section 113 of the catheter body 110. The valve is a medical Y-type valve.

[0051] Specifically, the working process of the venous sinus thrombosis lytic device 200 is as follows:

[0052] The drug injection section 113 is connected to a medical Y-type valve, and an angiographic guide wire is inserted through the main hole of the Y-type valve. Under the guidance of the guide wire, the venous sinus thrombosis multi-side hole interventional catheter 100 is placed in the anterior part of the superior sagittal sinus, and the guide wire is removed. The pressure pump pumps thrombolytic drugs into the microtube 120 to implement drug pumping therapy and sinus pressure monitoring.

[0053] The above is only a specific implementation of the utility model, but the protection scope of the utility model is not limited thereto. Any changes or substitutions that can be easily thought of by a person skilled in the art within the technical scope disclosed by the utility model should be included in the protection scope of the utility model. Therefore, the protection scope of the utility model should be based on the protection scope of the claims.

Claims

1. A multi-side hole interventional catheter for venous sinus thrombosis, characterized in that: It includes a catheter body and multiple microtubes. The catheter body is provided with multiple openings. The multiple microtubes are arranged in the catheter body. Each of the microtubes is provided with multiple drug flow holes. The multiple drug flow holes on the multiple microtubes correspond to the multiple openings one by one.

2. The multi-side hole interventional catheter for venous sinus thrombosis according to claim 1, characterized in that: Two adjacent drug flow holes on two adjacent microtubes are arranged in a staggered manner.

3. The multi-side hole interventional catheter for venous sinus thrombosis according to claim 1, characterized in that: In a cross section of a position where the catheter body is provided with a plurality of openings, the plurality of drug flow holes are arranged along a circumferential direction of the catheter body.

4. The multi-side hole interventional catheter for venous sinus thrombosis according to claim 1, characterized in that: A plurality of microtubes are arranged in a circumferential ring around the catheter body and form a guidewire cavity for accommodating a guidewire.

5. The venous sinus thrombosis multi-side hole interventional catheter according to any one of claims 1 to 4, characterized in that: The catheter body comprises a pressure sensing section, a drug dissolution section and a drug injection section which are connected in sequence. The drug dissolution section is provided with a plurality of openings, and the plurality of openings correspond one-to-one to the plurality of drug flow holes on the plurality of microtubes.

6. The multi-side hole interventional catheter for venous sinus thrombosis according to claim 5, characterized in that: The pressure sensing section is provided with a pressure sensor.

7. A thrombolytic device for venous sinus thrombosis, characterized in that: It includes the venous sinus thrombosis multi-side hole interventional catheter according to claim 1.

8. The venous sinus thrombosis lytic device according to claim 7, characterized in that: It also includes an automatic control system, which is electrically connected to the pressure sensor.

9. The venous sinus thrombosis lytic device according to claim 8, characterized in that: It also includes a pressure pump and a flow meter. The pressure pump and the flow meter are both connected to the drug injection section of the catheter body and are electrically connected to the automatic control system.

10. The venous sinus thrombosis lytic device according to claim 8, characterized in that: It also includes a valve, which is connected to the drug injection section of the catheter body.

Images