Wafer cartridge for biochip detection

By adding silicone gaskets and UV bioglue between the upper and lower layers of the biological wafer cassette and optimizing the microflower design, the problems of microflower leakage and blockage are solved, and the detection accuracy and reliability are improved.

CN222624596UActive Publication Date: 2025-03-18WUXI YIFU MEDICAL TECHNOLOGY CO LTD
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Patent Information

Application Number
CN202421318255.8
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-06-11
Publication Date
2025-03-18
Estimated Expiration
2034-06-11

AI Technical Summary

Technical Problem

The existing biological chip cassettes have gaps between the end surfaces of the upper and lower cassettes, causing microflow channels to leak, affecting the detection accuracy or causing the detection to be unable to advance.

Method used

Add silicone gaskets with a thickness of more than 10% of the gap between the upper and lower cassettes, and use the pressing force to prevent the leakage of the medium. At the same time, UV bioglue is used to connect the cassette layer to enhance the sealing effect. The width of the microflow channel is set to 1.5mm, and 12 holes with a depth of 1.0mm are buried to fill with the agent to avoid clogging.

Benefits of technology

Effectively prevent microflow media from leaking, improve sealing effect, avoid blockage, and ensure detection accuracy and reliability.

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Abstract

The utility model provides a wafer cartridge for biochip detection, and aims to solve the problem of leakage caused by a gap between the end surfaces of an upper-layer cartridge and a lower-layer cartridge of a traditional biochip cartridge. The device mainly comprises an upper-layer cartridge, a lower-layer cartridge, a micro-channel device and a biochip assembly, a new scheme is provided for solving the problem of cartridge micro-channel leakage, the silica gel gasket with the thickness larger than 10% of the gap is added between the upper cartridge and the lower cartridge, and medium leakage is prevented through pressing force. Meanwhile, the clamping box layer is connected through the UV biological glue so that the sealing effect can be further enhanced. In order to solve the problems of the size and blockage of the flow channel, the width of the micro-flow channel is set to be 1.5 mm, and 12 medicine containing cavities with the depth of 1.0 mm are embedded to be filled with medicine, so that compared with a traditional flow channel of dozens of microns to hundreds of microns, the micro-flow channel is wider, and the blockage of the micro-flow channel caused by molecular aggregation or blood clot aggregation can be more effectively prevented in combination with medicine pre-embedding.
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