Online cleaning system for multi-dimensional chromatographic trapping column

By introducing an online cleaning unit and switching valve assembly into the multi-dimensional chromatographic capture column system, multiple capture columns are realized simultaneously, and the problem of low cleaning efficiency of the capture column in the prior art is solved, which significantly improves the cleaning efficiency and reduces the time cost.

CN222657833UActive Publication Date: 2025-03-25SOOCHOW HIGH TECH CHROMATOGRAPHY
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Patent Information

Application Number
CN202420176377.1
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-01-24
Publication Date
2025-03-25
Estimated Expiration
2034-01-24

AI Technical Summary

Technical Problem

The cleaning method of existing multidimensional chromatography capture columns is inefficient. It takes 10 minutes to clean a single capture column, while 10 capture columns take about 2 hours, resulting in high time costs.

Method used

A multi-dimensional chromatographic capture column online cleaning system is designed, using an online cleaning unit and a switching valve assembly. Through the switching valve assembly, the capture columns in adjacent online cleaning units can be connected, and multiple capture columns can be cleaned simultaneously, improving cleaning efficiency.

Benefits of technology

Through this system, the efficiency of the capture column cleaning can be significantly improved, the cleaning time can be reduced, the time cost can be reduced, and the waste liquid can be easily processed to ensure the cleaning effect.

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Abstract

The utility model relates to an online cleaning system for a multi-dimensional chromatographic trapping column. The technical problem that an existing trapping column is low in cleaning efficiency is solved. Comprising a plurality of on-line cleaning units distributed in sequence, a cleaning pump system and a waste liquid pool system, each on-line cleaning unit is provided with a trapping column, the cleaning pump system is connected with one on-line cleaning unit, and the waste liquid pool system is connected with each on-line cleaning unit. Each online cleaning unit is internally provided with a switching valve assembly which can enable the trapping columns in all the online cleaning units to be sequentially connected in series and communicate with the cleaning pump system or enable the trapping columns in any one or more online cleaning units to communicate with the cleaning pump system. The cleaning device has the advantages that by switching the two working positions of the valve body, a user can clean the trapping column according to requirements, and the cleaning efficiency is effectively improved. And the multiple trapping columns can be communicated with one another through the switching valve assembly, so that the cleaning efficiency is further improved.
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