Separation and purification device for aminoglycoside antibiotics

Abstract

The utility model relates to the technical field of pharmaceutical engineering, and discloses an aminoglycoside antibiotic separation and purification device which comprises a filtering device, a separation device is arranged on the outer wall of the filtering device, a fixing frame is fixedly connected to the outer wall of the separation device, an alcohol lamp is arranged in the fixing frame, a safety bottle is arranged in the fixing frame, and the safety bottle is connected with the filtering device. A fixing rod is fixedly connected to the top of the fixing frame, a support is arranged on the outer wall of the fixing rod, a purification assembly is arranged in the support, a clamping assembly is arranged in the fixing frame, and the clamping assembly comprises a clamping block. According to the utility model, the clamping blocks are extruded by the alcohol lamp and the safety bottle, and the spring I moves towards the interior of the hollow column through the extrusion of the clamping blocks, so that the effect of clamping the alcohol lamp and the safety bottle is achieved, and the problem that the alcohol lamp and the safety bottle are separated from the original positions due to vibration or touch in the use process is solved; the problems that the alcohol lamp is broken and the purification effect is invalid are solved, and the safety is improved.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical engineering technology, and in particular to a separation and purification device for aminoglycoside antibiotics. Background Technology

[0002] With the development of the pharmaceutical industry, aminoglycoside antibiotics are widely used clinically to treat various bacterial infections. The separation and purification of aminoglycoside antibiotics are key steps in the production process, directly affecting the purity and therapeutic effect of the drug. To improve purification efficiency and product quality, suitable heating equipment is usually needed to provide a uniform heat supply. Existing purification devices mostly use heat sources such as alcohol lamps and heat the drug through a flask. To ensure uniform heat transfer and prevent the alcohol lamp and flask from detaching or shifting position, a new separation and purification device has been designed. This device aims to solve the common safety hazards and poor purification effects of existing equipment. It combines a precise clamping structure and an adjustable position adjustment mechanism, effectively improving operational stability and purification effect.

[0003] Currently, the separation and purification of aminoglycoside antibiotics mostly employs traditional heating devices. These devices typically rely on a fixing device to secure the alcohol lamp to a base, and a simple bracket to hold the flask above the alcohol lamp. The working principle of this device is to use the flame generated by the alcohol lamp to heat the flask, and purify the substance through heat transfer. Most traditional devices use simple clamps and brackets to maintain the flask at a certain distance or position from the heat source. However, due to their simple structure, they cannot effectively adapt to the vibration and positional changes of the alcohol lamp or flask during operation. Therefore, existing equipment largely relies on manual adjustments by the operator to ensure the stability of the heating process.

[0004] In existing technologies, the alcohol lamp and safety bottle often shift position due to vibration or contact, which affects the heating effect. When the contact position between the alcohol lamp and the flask is unstable, the alcohol lamp may break or the flask may be heated unevenly, thus affecting the efficiency of the purification process or even causing purification failure. This problem seriously affects the purification efficiency and increases the safety hazards during operation. Therefore, a device that can stably fix the position of the alcohol lamp and flask is needed to avoid position shift caused by vibration or contact, thereby improving purification efficiency and safety. To this end, a separation and purification device for aminoglycoside antibiotics is proposed to solve the above problems. Utility Model Content

[0005] To overcome the above deficiencies, this utility model provides a separation and purification device for aminoglycoside antibiotics, which aims to improve the problem in the prior art where the alcohol lamp and safety bottle are dislodged from their original positions due to vibration or contact during use, resulting in the alcohol lamp breaking and the purification effect failing.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: a separation and purification device for aminoglycoside antibiotics, comprising a filtration device, a separation device disposed on the outer wall of the filtration device, a fixed frame fixedly connected to the outer wall of the separation device, an alcohol lamp disposed inside the fixed frame, a safety bottle disposed inside the fixed frame, a fixed rod fixedly connected to the top of the fixed frame, a support disposed on the outer wall of the fixed rod, a purification component disposed inside the support, and a clamping component disposed inside the fixed frame;

[0007] The clamping assembly includes a clamping block, the outer wall of which is attached to an alcohol lamp and a safety bottle. A hollow block is fixedly connected inside the fixing frame, and a hollow column is fixedly connected inside the hollow block. A spring is installed inside the hollow column, one end of which is fixedly connected to the outer wall of the clamping block, and the other end of which is fixedly connected to the inside of the hollow column. An adjustment assembly is installed inside the bracket.

[0008] As a further description of the above technical solution:

[0009] The purification assembly includes a flask, the outer wall of which is fixedly connected to the inside of the support, a rubber conduit fixedly connected to the outer wall of the flask, a connecting tube provided at one end of the rubber conduit, and one end of the connecting tube fixedly connected to the outer wall of the safety bottle.

[0010] As a further description of the above technical solution:

[0011] The adjustment assembly includes a fixed column and a sliding column. The outer wall of the sliding column is slidably connected to the inside of the fixed column. The fixed column is fixedly connected to the inside of the bracket. A slot is provided inside the fixed column.

[0012] As a further description of the above technical solution:

[0013] The outer wall of the sliding column is slidably connected to the inside of the fixed rod, and the fixed rod has a locking hole inside, which engages with the sliding column;

[0014] As a further description of the above technical solution:

[0015] A pull rod is fixedly connected to the outer wall of the sliding column, and the outer wall of the pull rod is slidably connected inside the fixed column. The pull rod and the slot are engaged.

[0016] As a further description of the above technical solution:

[0017] A limiting ring is fixedly connected to the outer wall of the sliding column, and the limiting ring is slidably connected inside the fixed column.

[0018] As a further description of the above technical solution:

[0019] A limiting disc is slidably connected to the outer wall of the sliding column, and the outer wall of the limiting disc is rotatably connected inside the fixed column.

[0020] As a further description of the above technical solution:

[0021] A second spring is installed inside the fixed column. One end of the second spring is fixedly connected to the outer wall of the limiting disc, and the other end of the second spring is fixedly connected to the outer wall of the limiting ring.

[0022] This utility model has the following beneficial effects:

[0023] 1. In this utility model, by squeezing the alcohol lamp and safety bottle against the clamping block, the spring moves into the hollow column through the squeezing of the clamping block, thereby achieving the effect of clamping the alcohol lamp and safety bottle. This solves the problem that the alcohol lamp and safety bottle may fall out of their original position due to vibration or contact during use, resulting in the alcohol lamp breaking and the purification effect failing, thus improving safety.

[0024] 2. In this utility model, by pulling the pull rod, the sliding column slides inside the fixed column. At this time, the sliding column is released from the restriction of the fixed rod. The pull rod is then moved to make it engage in the slot. Subsequently, the position of the bracket is adjusted to release the elastic potential energy of the spring two to reset the pull rod and re-engage it into the slot, thereby achieving the effect of adjusting the position of the flask. This solves the problem of better contact between the bottom of the flask and the alcohol lamp, ensuring uniform heat transfer, avoiding local overheating or insufficient heating, and improving the purification efficiency. Attached Figure Description

[0025] Figure 1 This is a three-dimensional schematic diagram of an apparatus for separating and purifying aminoglycoside antibiotics according to the present invention.

[0026] Figure 2 This is a schematic diagram of the fixing frame structure of the separation and purification device for aminoglycoside antibiotics proposed in this utility model;

[0027] Figure 3 for Figure 2 Enlarged view of point A in the middle;

[0028] Figure 4 This is a schematic diagram of the support structure of an aminoglycoside antibiotic separation and purification device proposed in this utility model;

[0029] Figure 5 for Figure 4 Enlarged view of point B in the middle.

[0030] Legend:

[0031] 1. Filtration equipment; 2. Separation equipment; 3. Fixing frame; 4. Alcohol lamp; 5. Safety bottle; 6. Hollow block; 7. Hollow column; 8. Clamping block; 9. Spring 1; 10. Connecting pipe; 11. Rubber conduit; 12. Fixing rod; 13. Support; 14. Flask; 15. Fixing column; 16. Sliding column; 17. Limiting disc; 18. Limiting ring; 19. Pull rod; 20. Slot; 21. Spring 2; 22. Locking hole. Detailed Implementation

[0032] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0033] Reference Figures 1-3 An embodiment of this utility model provides: a separation and purification device for aminoglycoside antibiotics, including a filtration device 1, which is used to initially remove insoluble impurities from the fermentation broth; a separation device 2 is provided on the outer wall of the filtration device 1, which is used to separate the target antibiotic from the filtrate; a fixing frame 3 is fixedly connected to the outer wall of the separation device 2, which is used to support and fix other components; an alcohol lamp 4 is provided inside the fixing frame 3, which is used to provide a heating source to promote the separation process; a safety bottle 5 is provided inside the fixing frame 3, which is used to collect volatile substances or prevent backflow; a fixing rod 12 is fixedly connected to the top of the fixing frame 3, which is used to support a bracket 13; a bracket 13 is provided on the outer wall of the fixing rod 12, which is used to fix a purification component; a purification component is provided inside the bracket 13, which is used to further purify the target antibiotic; and a clamping component is provided inside the fixing frame 3.

[0034] The clamping assembly includes a clamping block 8, which is used to fix the position of the alcohol lamp 4 and the safety bottle 5. The outer wall of the clamping block 8 is in contact with the alcohol lamp 4 and the safety bottle 5. A hollow block 6 is fixedly connected inside the fixing frame 3. The hollow block 6 is used to fix a hollow column 7. The hollow column 7 is fixedly connected inside the hollow block 6. The hollow column 7 is used to accommodate a spring 9 and guide the movement of the clamping block 8. The spring 9 is provided inside the hollow column 7. The spring 9 is used to provide elastic force to make the clamping block 8 clamp the alcohol lamp 4 and the safety bottle 5. One end of the spring 9 is fixedly connected to the outer wall of the clamping block 8, and the other end of the spring 9 is fixedly connected to the inside of the hollow column 7. The bracket 1 3. An adjustment component is provided inside to adjust the position or angle of the purification component. The purification component includes a flask 14, which is used to hold the antibiotic solution to be purified. The outer wall of the flask 14 is fixedly connected to the inside of the support 13, which provides stable support. A rubber conduit 11 is fixedly connected to the outer wall of the flask 14. The rubber conduit 11 is used to connect the flask 14 and the safety bottle 5. A connecting tube 10 is provided at one end of the rubber conduit 11. The connecting tube 10 is used to guide steam or liquid into the safety bottle 5. One end of the connecting tube 10 is fixedly connected to the outer wall of the safety bottle 5 to ensure airtightness and liquid transmission.

[0035] Reference Figures 4-5 The adjustment assembly includes a fixed column 15 and a sliding column 16. The fixed column 15 provides a sliding track, and the outer wall of the sliding column 16 is slidably connected to the inside of the fixed column 15 to achieve height adjustment. The fixed column 15 is fixedly connected to the inside of the bracket 13. A slot 20 is provided inside the fixed column 15 to limit the movement range of the pull rod 19. The outer wall of the sliding column 16 is slidably connected to the inside of the fixed rod 12, which provides a guiding function. A locking hole 22 is provided inside the fixed rod 12 to fix the position of the sliding column 16. The sliding column 16 and the locking hole 22 engage to ensure stability after adjustment. A pull rod 19 is fixedly connected to the outer wall of the sliding column 16 for manually adjusting the position of the sliding column 16. The sliding column 16 is movably connected inside the fixed column 15. The pull rod 19 and the slot 20 engage to prevent the pull rod 19 from disengaging from the fixed column 15. The outer wall of the sliding column 16 is fixedly connected to a limit ring 18, which limits the sliding range of the sliding column 16. The limit ring 18 is slidably connected inside the fixed column 15. The outer wall of the sliding column 16 is slidably connected to a limiting disc 17, which assists in fixing the sliding column 16. The outer wall of the limiting disc 17 is rotatably connected inside the fixed column 15. The fixed column 15 is equipped with a second spring 21, which provides a restoring force. One end of the second spring 21 is fixedly connected to the outer wall of the limiting disc 17, and the other end of the second spring 21 is fixedly connected to the outer wall of the limit ring 18 to ensure the stability and adjustability of the sliding column 16.

[0036] Working principle: When fixing the alcohol lamp 4 and safety bottle 5, the alcohol lamp 4 and safety bottle 5 are placed in the groove on the surface of the fixing frame 3, and the clamping block 8 is pressed to adapt the alcohol lamp 4 and safety bottle 5 to the appropriate clamping space. The spring 9 moves into the hollow column 7 as it is pressed, preventing the alcohol lamp 4 and safety bottle 5 from being touched or vibrated during use, which could cause them to fall out of their original position and affect the purification effect.

[0037] When adjusting the height of flask 14, the sliding column 16 slides inside the fixed column 15 by pulling the lever 19. At this time, the sliding column 16 drives the limiting ring 18 to slide inside the fixed column 15, so that the sliding column 16 is freed from the restriction of the fixed rod 12. Then, the lever 19 is pushed down and rotated so that the lever 19 is engaged in the slot 20. When rotating, the limiting disk 17 rotates inside the fixed column 15. When the lever 19 and the limiting ring 18 are pulled, they apply a pulling force to the second spring 21. At this time, the bracket 13 is adjusted downward so that the sliding column 16 is adapted to the appropriate position. The lever 19 is reset, and the second spring 21 releases its elastic potential energy and re-engages in the slot 22, thereby achieving the purpose of adjusting the height.

[0038] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A device for separating and purifying aminoglycoside antibiotics, comprising a filtration device (1), characterized in that: The filtration device (1) has a separation device (2) on its outer wall. The separation device (2) has a fixed frame (3) fixedly connected to its outer wall. The fixed frame (3) has an alcohol lamp (4) inside its interior. The fixed frame (3) has a safety bottle (5) inside its interior. The fixed frame (3) has a fixed rod (12) fixedly connected to its top. The fixed rod (12) has a support (13) on its outer wall. The support (13) has a purification component inside its interior. The fixed frame (3) has a clamping component inside its interior. The clamping assembly includes a clamping block (8), the outer wall of which is attached to an alcohol lamp (4) and a safety bottle (5). A hollow block (6) is fixedly connected inside the fixing frame (3), and a hollow column (7) is fixedly connected inside the hollow block (6). A spring (9) is provided inside the hollow column (7). One end of the spring (9) is fixedly connected to the outer wall of the clamping block (8), and the other end of the spring (9) is fixedly connected to the inside of the hollow column (7). An adjustment assembly is provided inside the bracket (13).

2. The apparatus for separating and purifying aminoglycoside antibiotics according to claim 1, characterized in that: The purification assembly includes a flask (14), the outer wall of which is fixedly connected to the inside of the support (13), and a rubber conduit (11) is fixedly connected to the outer wall of the flask (14). One end of the rubber conduit (11) is provided with a connecting tube (10), and one end of the connecting tube (10) is fixedly connected to the outer wall of the safety bottle (5).

3. The apparatus for separating and purifying aminoglycoside antibiotics according to claim 1, characterized in that: The adjustment assembly includes a fixed column (15) and a sliding column (16). The outer wall of the sliding column (16) is slidably connected to the inside of the fixed column (15). The fixed column (15) is fixedly connected to the inside of the bracket (13). A slot (20) is provided inside the fixed column (15).

4. The apparatus for separating and purifying aminoglycoside antibiotics according to claim 3, characterized in that: The outer wall of the sliding column (16) is slidably connected to the inside of the fixed rod (12), and the fixed rod (12) has a locking hole (22) inside, and the sliding column (16) and the locking hole (22) are engaged.

5. The apparatus for separating and purifying aminoglycoside antibiotics according to claim 3, characterized in that: A pull rod (19) is fixedly connected to the outer wall of the sliding column (16). The outer wall of the pull rod (19) is slidably connected inside the fixed column (15). The pull rod (19) and the slot (20) engage with each other.

6. The apparatus for separating and purifying aminoglycoside antibiotics according to claim 3, characterized in that: The outer wall of the sliding column (16) is fixedly connected to a limiting ring (18), and the limiting ring (18) is slidably connected inside the fixed column (15).

7. The apparatus for separating and purifying aminoglycoside antibiotics according to claim 3, characterized in that: The outer wall of the sliding column (16) is slidably connected to a limiting disk (17), and the outer wall of the limiting disk (17) is rotatably connected inside the fixed column (15).

8. The apparatus for separating and purifying aminoglycoside antibiotics according to claim 3, characterized in that: The fixed column (15) is provided with a second spring (21). One end of the second spring (21) is fixedly connected to the outer wall of the limiting disk (17), and the other end of the second spring (21) is fixedly connected to the outer wall of the limiting ring (18).

Images