Capillary electrophoresis analysis device with preheating function

Abstract

The utility model discloses a capillary electrophoresis analysis device with a preheating function, which comprises a main machine, a capillary is fixedly mounted through a fixing plate, and the fixing plate is mounted on the main machine through a support table; a lifting support frame is arranged on the support table, a heating module is mounted on the lifting support frame, the heating module is connected with a control system of the host, and the capillary tube is in contact with the heating module; a lifting driving mechanism is mounted on the lifting support frame, and the heating module is connected with the lifting driving mechanism to form a structure capable of lifting along the lifting support frame. According to the utility model, the heating module is arranged and is in close contact with the capillary tube, the capillary tube is heated by the heating module, so that the temperature of the capillary tube reaches a set temperature, and the temperature balance of the capillary tube and an electrophoresis reagent in the capillary tube and the temperature of the heating module is ensured; and the electrophoresis separation characteristic of gel in the electrophoresis reagent is changed to influence the test effect.

Description

Technical Field

[0001] This utility model relates to the field of trace sample analysis and detection technology, and in particular to a device for detecting trace samples by capillary electrophoresis. Background Technology

[0002] Capillary electrophoresis is a commonly used method for chemical and biomolecular analysis, widely applied in drug analysis, environmental monitoring, bioengineering research, DNA, oligonucleotide, protein molecule, and organic chemical composition analysis. Automated capillary electrophoresis instruments include an automated sample introduction system, a capillary, a sample detection system, and a gel tank. The inlet and outlet of the capillary are the negative and positive terminals of a high-voltage power supply, respectively. Negatively charged samples migrate from the negative terminal (capillary inlet) to the positive terminal under a high-voltage electric field. Because smaller molecules migrate faster than larger molecules, different components are separated due to their different migration speeds. Each component is detected and recorded in the detector area, achieving the purpose of analysis. For example, Chinese Utility Model Patent CN2020224449314 discloses a multi-channel rapid capillary electrophoresis analysis device. This device enables automated operation of the multi-channel capillary electrophoresis inlet, greatly improving the sample introduction speed and efficiency of the capillary electrophoresis instrument. However, the capillary tube and the electrophoretic separation reagent inside the capillary tube are directly exposed to ambient temperature, making the electrophoretic separation reagent susceptible to the influence of ambient temperature. In environments without temperature control, the gel electrophoretic separation characteristics of the electrophoretic reagent will change under excessively low temperatures, affecting the test results. Utility Model Content

[0003] This invention addresses the shortcomings of existing technologies by providing a capillary electrophoresis analysis device with a preheating function that features a simple structure, a more rational design, avoids the influence of ambient temperature on electrophoresis reagents, and improves processing results.

[0004] To solve the above-mentioned technical problems, the present invention adopts the following technical solution: a capillary electrophoresis analysis device with preheating function, comprising a main unit, a capillary tube fixed by a fixing plate, the fixing plate being mounted on the main unit by a support platform; a lifting support frame is provided on the support platform, a heating module is installed on the lifting support frame, the heating module is connected to the control system of the main unit, and the capillary tube is in contact with the heating module; a lifting drive mechanism is installed on the lifting support frame, and the heating module is connected to the lifting drive mechanism to form a structure that can move up and down along the lifting support frame.

[0005] Furthermore, the heating module adopts a cylindrical structure, with each capillary tube closely abutting the circumferential surface of the heating module to achieve contact with the heating module.

[0006] Furthermore, it also includes a protection module, which is connected to each capillary to form a temperature monitoring structure for each capillary, and the protection module is connected to the control system of the host.

[0007] Furthermore, the protection module is installed at the bottom of the lifting support frame near the capillary tube.

[0008] Furthermore, the lifting drive mechanism includes a motor, which is connected to the heating module via a pulley and belt. The motor is mounted on the upper part of the main unit and located above the lifting support frame, while the belt and pulley are located on one outer side of the lifting support frame.

[0009] This invention incorporates a heating module that is in close contact with the capillary. The heating module heats the capillary to a set temperature, ensuring that the temperature of the capillary and the electrophoresis reagents inside are balanced with the temperature of the heating module. This solves the problem that the gel electrophoresis separation characteristics of the electrophoresis reagents change and affect the test results when the working environment is too low. Attached Figure Description

[0010] Figure 1 This is a schematic diagram of the structure of this utility model;

[0011] Figure 2 This is a structural schematic diagram of the main body of the present invention (heating module in the lowered state);

[0012] Figure 3 This is another structural schematic diagram of the main body of this utility model (heating module in raised state).

[0013] In the diagram, 1 is the main unit, 2 is the support platform, 3 is the fixing plate, 4 is the capillary tube, 5 is the heating module, 6 is the lifting support frame, 7 is the motor, 8 is the belt, and 9 is the protection module. Detailed Implementation

[0014] In this embodiment, refer to Figures 1-3The capillary electrophoresis analysis device with preheating function includes a main unit 1, and a row of multiple (e.g., 12) capillary tubes 4 fixed by a fixing plate 3. The capillary tubes 4 extend below the fixing plate to align with the liquid-filling plate below. The fixing plate 3 is mounted on the main unit 1 via a support platform 2. A lifting support frame 6 is provided on the support platform 2, and a heating module 5 is installed on the lifting support frame 6. The heating module 5 is connected to the control system of the main unit 1, and the capillary tubes 4 are in contact with the heating module 5. A lifting drive mechanism is installed on the lifting support frame 6, and the heating module 5 is connected to the lifting drive mechanism to form a structure that can move up and down along the lifting support frame 6. The heating module 5 can use PTC, NTC, or other heating methods. The specific control of heating is existing technology and will not be described in detail here. The heating module 5 can raise the surface metal temperature to a set temperature, and then heat the capillary tubes through thermal radiation.

[0015] The heating module 5 adopts a cylindrical structure, and each capillary tube 4 is in close contact with the heating module 5 on the circumference surface. This can avoid the heating effect being affected by poor contact between the capillary tube 4 and the heating module 5.

[0016] It also includes a protection module 9, which is connected to each capillary tube 4 to form a temperature monitoring structure for each capillary tube 4, and is also connected to the control system of the main unit 1. The protection module 9 is essentially a temperature monitoring system. When the temperature control device of the heating module 5 malfunctions, potentially causing the capillary tube 4 to overheat, the protection module 9 can detect the temperature exceeding the set value and control the heating module 5 to stop heating via the main unit 1, thereby protecting the capillary tube 4 from overheating damage. The specific methods of temperature monitoring and control are existing technology and will not be elaborated upon here.

[0017] The protection module 9 is installed on the bottom of the lifting support frame 6 near the capillary tube 4 so that it can be monitored in a timely manner.

[0018] The lifting drive mechanism includes a motor 7, which is connected to the heating module 5 via a pulley and a belt 8. The motor 7 is mounted on the upper part of the main unit 1 and located above the lifting support frame 6, while the belt 8 and pulley are located on one side of the lifting support frame 6. By controlling the distance between the heating module 5 and the capillary tube 4 through the motor 7, the heating effect can be better adjusted.

[0019] The present invention has been described in detail above. The above description is only a preferred embodiment of the present invention and should not be construed as limiting the scope of the present invention. All equivalent changes and modifications made in accordance with the scope of this application should still fall within the scope of the present invention.

Claims

1. A capillary electrophoresis analysis device with preheating function, comprising a main unit, a capillary tube fixed by a fixing plate, the fixing plate being mounted on the main unit by a support platform, characterized in that: A lifting support frame is installed on the support platform, and a heating module is installed on the lifting support frame. The heating module is connected to the control system of the main unit, and the capillary tube is in contact with the heating module. A lifting drive mechanism is installed on the lifting support frame, and the heating module is connected to the lifting drive mechanism to form a structure that can move up and down along the lifting support frame.

2. The capillary electrophoresis analysis device with a preheating function according to claim 1, characterized in that: The heating module adopts a cylindrical structure, and each capillary tube is in close contact with the heating module on its circumference.

3. The capillary electrophoresis analysis device with a preheating function according to claim 1, characterized in that: It also includes a protection module, which is connected to each capillary to form a temperature monitoring structure for each capillary, and the protection module is connected to the control system of the host.

4. The capillary electrophoresis analysis device with a preheating function according to claim 3, characterized in that: The protection module is installed at the bottom of the lifting support frame near the capillary tube.

5. The capillary electrophoresis analysis device with preheating function according to claim 1, characterized in that: The lifting drive mechanism includes a motor, which is connected to the heating module via a pulley and belt.

6. The capillary electrophoresis analysis device with a preheating function according to claim 5, characterized in that: The motor is mounted on the upper part of the main unit and above the lifting support frame, while the belt and pulley are located on the outer side of the lifting support frame.

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