Condensation specimen collection multi-element dispersing device

Abstract

The utility model discloses a condensation sample collection multi-element dispersing device. Comprising a main shell, a water temperature control unit, a specimen shaking unit, a diluent filling unit and a control mainboard. Through a multi-element condensation set sample dispersion method integrating warm bath, shaking and warm bath diluent injection, the dispersion efficiency of the condensation set is greatly improved, and the dispersion time is saved; meanwhile, a swinging and rotating mode is adopted to replace a traditional centrifugal method, the structural design is simplified, the design cost is reduced, in addition, alternate magnetic pole ring spaced transmission is adopted, and the waterproof problem caused by dynamic sealing inside and outside the warm bath cavity is solved. Besides, the conduit passes through the warm bath chamber, so that before the condensation sample is loaded, the conduit diluent reaches the temperature in the warm bath chamber, the temperature-containing diluent is controlled to be injected at the beginning of starting of the device, direct contact heat transfer of the condensation sample can be realized in advance, the temperature rise speed in the condensation sample is further improved, and the dispersion efficiency is improved.

Description

A condensation and collection device for multi-element dispersion of specimens Technical Field

[0001] The embodiments of this utility model belong to the field of condensation and dispersion technology, and more specifically, relate to a condensation and dispersion device for multiple components of a sample. Background Technology

[0002] High-titer cold agglutinins are heterophilic cold antibodies produced in the body against the patient's own red blood cells. These antibodies are mainly IgM class and can undergo non-specific agglutination reactions with the patient's own red blood cells under in vitro conditions of 4°C or room temperature. Healthy human serum generally contains a small amount of agglutinin with a titer below 16 and is inactive under normal body temperature conditions, which is physiological cold agglutination. Under pathological conditions, the content increases significantly, which is common clinically, and the reaction temperature also increases accordingly. Excessively high cold agglutinin titers make blood typing and crossmatching difficult, leading to inconsistencies in forward and reverse typing, and agglutination on both major and minor sides in crossmatching, resulting in crossmatch incompatibility and difficulty in blood typing. Cold agglutination of specimens directly affects laboratory tests that rely on the dispersion state of red blood cells. In routine blood tests, specific effects include: falsely decreasing red blood cell count (RBC) and hematocrit (HCT), and falsely increasing mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH). Therefore, agglutinated blood needs to be dispersed to ensure the accuracy of test results. Existing methods for condensation and dispersion treatment are inefficient and cannot meet the demands of future large-scale operations. Therefore, it is of great significance to propose a device that can improve the efficiency of zero condensation and dispersion.

[0003] To address the aforementioned technical problems, Chinese invention patent CN108772209A discloses a blood analysis equipment technology, particularly a constant temperature blood typing centrifuge. The centrifuge includes a main body, a cap mounted on top of the main body, and a heating chamber mounted on the back of the main body. The main body contains an incubation chamber and a centrifugation chamber. The incubation chamber contains a gel card holder and a test tube holder. The centrifugation chamber contains a centrifuge. The cap has a sealing ring on its surface. The heating chamber contains an electric heating rod that generates heat to maintain a suitable temperature inside the incubation and centrifugation chambers, facilitating the rapid dispersal of agglomerated red blood cells. By using the test tube holder and gel card holder for pre-treatment of the blood and then centrifuging it, agglomeration can be completely eliminated, facilitating blood typing and crossmatching.

[0004] The above-mentioned patented method uses warm bath centrifugation to achieve the dispersion treatment of condensate specimens to a certain extent, but there are the following technical problems and directions for improvement: (1) The manufacturing cost and maintenance cost of existing centrifugation equipment are high, which limits its promotion and application in medical institutions with limited resources; (2) It is possible to consider using slight shaking to replace the centrifugation operation scheme, so as to achieve the dispersion operation of condensate while making the equipment lighter and reducing the equipment cost; (3) Based on the shaking and warm bath method, it is possible to add a diluent injection unit, reduce the concentration of condensate agglutinin to reduce red blood cell agglutination, and further improve the dispersion efficiency of condensate. Summary of the Invention

[0005] To address the aforementioned deficiencies or improvement needs of existing technologies, this invention provides a multi-element dispersion device for condensate specimens. By integrating a warm bath, shaking, and the addition of a warm bath diluent, this multi-element condensate sample dispersion method significantly improves dispersion efficiency and saves dispersion time. Simultaneously, this invention replaces the traditional centrifugation method with oscillation and rotation, simplifying the structural design and reducing design costs. Furthermore, the use of alternating magnetic pole rings for air-locked transmission avoids waterproofing issues caused by dynamic sealing between the warm bath chamber and its interior / exterior. Moreover, since the conduit is installed within the warm bath chamber, the diluent in the conduit has already reached the temperature within the warm bath chamber before the condensate sample is inserted into the device. Therefore, by controlling the diluent to reach the standard temperature and adding it to the condensate specimen at the beginning of device startup, direct contact heat transfer to the condensate specimen can be achieved, further increasing the internal heating rate of the condensate specimen and improving dispersion efficiency.

[0006] To achieve the above objective, a condensation and dispersion device for collecting specimens includes:

[0007] The main housing includes a box body, a cover that rotates and is provided with an opening on the top of the box body, a middle partition layer that is horizontally fixed inside the box body, a warm bath chamber and a back stage chamber that are formed on both sides of the middle partition layer, and a water-insulating layer that is tightly attached to the periphery of the warm bath chamber.

[0008] A water temperature control unit located in the warm bath chamber includes a heating tube and a temperature sensor; a specimen shaking unit located in the warm bath chamber for mounting and shaking the condensed specimen; a diluent filling unit for adding diluent to the specimen shaking unit; and a control main board.

[0009] Preferably, the diluent dispensing unit includes:

[0010] The following components are provided in the background chamber: a storage chamber, a liquid inlet connected to the storage chamber, a peristaltic pump for pumping the diluent from the storage chamber to the outside, a conduit connected to the output end of the peristaltic pump, and a liquid inlet connected to the output end of the conduit.

[0011] The peristaltic pump input is connected to the injection chamber, and the liquid dispensing head is positioned directly above the specimen shaking unit on the inner surface of the cap.

[0012] Preferably, the conduit passes through the warm bath chamber and directly contacts the warm water inside for heat transfer.

[0013] Preferably, the specimen shaking unit includes:

[0014] A universal connecting ball fixed at the center of the upper surface of the intermediate spacer layer, a sample mounting cylinder, a universal connecting groove located at the bottom of the sample mounting cylinder and used for rotatable connection with the universal connecting ball, and a shaking drive unit for driving the sample mounting cylinder to shake.

[0015] Preferably, the rocking drive unit includes:

[0016] A permanent magnet array is provided on the lower surface of the sample mounting cylinder, and the permanent magnet array is a ring array with opposite magnetic poles arranged alternately.

[0017] A magnetic attraction drive unit is provided in the backstage chamber, the magnetic attraction drive unit is located directly below the permanent magnet array, and the magnetic attraction drive unit is arranged in a magnetic pole ring array;

[0018] The lower surface of the sample mounting cylinder is at a higher level than the upper surface of the intermediate spacer layer.

[0019] Preferably, the sample mounting tube includes:

[0020] The side holes are uniformly opened through the wall of the sample mounting cylinder for heat conduction inside and outside the sample mounting cylinder.

[0021] Preferably, the water temperature control unit further includes:

[0022] The agitator, located on the outer wall of the sample mounting cylinder, is used to agitate and homogenize the temperature field inside the temperature bath chamber.

[0023] Preferably, the main housing includes: a cover handle disposed on the cover.

[0024] In summary, compared with the prior art, the above-described technical solution conceived by this utility model can achieve the following beneficial effects:

[0025] This invention discloses a multi-element dispersion device for condensate specimens. By integrating a warm bath, shaking, and the addition of a warm bath diluent, this multi-element dispersion method significantly improves the dispersion efficiency of condensate and saves dispersion time. Simultaneously, this invention uses oscillation and rotation instead of traditional centrifugation, simplifying the structural design and reducing design costs. Furthermore, the use of alternating magnetic pole rings for air-locked transmission avoids waterproofing issues caused by dynamic sealing between the warm bath chamber and its interior / exterior. Moreover, since the conduit is installed within the warm bath chamber, the diluent in the conduit has already reached the temperature within the warm bath chamber before the condensate specimen is inserted into the device. Therefore, the diluent, having reached the standard temperature, is added to the condensate specimen at the beginning of device startup, enabling direct contact heat transfer to the condensate specimen and further increasing the internal heating rate and dispersion efficiency. Attached Figure Description

[0026] Figure 1 is a schematic diagram of the overall structure of a multi-element dispersion device for condensing and collecting specimens according to an embodiment of the present invention;

[0027] Figure 2 is a schematic diagram of the working state structure of a multi-element dispersion device for condensing and collecting specimens according to an embodiment of the present invention.

[0028] In all the accompanying drawings, the same reference numerals denote the same technical features, specifically: 1-main shell, 101-box body, 102-lid body, 103-lid handle, 104-insulated water layer, 105-intermediate partition, 110-warm bath chamber, 120-backstage chamber, 2-diluent filling unit, 201-storage chamber, 202-peristaltic pump, 203-conduit, 204-liquid filling head, 205-liquid filling port, 3-specimen shaking unit, 301-universal connecting ball, 302-sample mounting cylinder, 303-side hole, 304-universal connecting groove, 305-permanent magnet array, 306-magnetic drive unit, 307-electromagnetic array, 4-water temperature control unit, 401-heating tube, 402-stirring paddle, 5-control main board, 6-condensed specimen. Detailed Implementation

[0029] In the description of this application, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", etc., indicating the orientation or positional relationship are based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this utility model and simplifying the description, and are not intended to indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model.

[0030] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this utility model, "a plurality of" means two or more, unless otherwise explicitly specified.

[0031] In this application, unless otherwise expressly specified and limited, the terms "installation," "connection," "linking," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0032] To make the objectives, technical solutions, and advantages of this utility model clearer, the present utility model will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only for explaining the present utility model and are not intended to limit the present utility model. Furthermore, the technical features involved in the various embodiments of the present utility model described below can be combined with each other as long as they do not conflict with each other.

[0033] As shown in Figures 1 and 2, in this embodiment of the present invention, the multi-element dispersion device for condensing and collecting specimens includes:

[0034] The main housing 1 includes a box body 101, a cover 102 that is rotatably covered by the opening above the box body 101, a middle partition 105 that is horizontally fixed inside the box body 101, a warm bath chamber 110 and a back stage chamber 120 that are formed on both sides of the middle partition 105, and a water-insulating layer 104 that is tightly attached to the periphery of the warm bath chamber 110.

[0035] The water temperature control unit 4, located in the warm bath chamber 110, includes a heating tube 401 and a temperature sensor; the specimen shaking unit 3, located in the warm bath chamber 110, is used to install and shake the cold agglomerated specimen 6; the diluent filling unit 2 adds diluent to the specimen shaking unit 3; and the control main board 5.

[0036] As shown in Figure 1, in this embodiment of the present invention, the diluent dispensing unit 2 includes:

[0037] The following components are provided in the background chamber 120: a storage chamber 201, a liquid inlet 205 connected to the storage chamber 201, a peristaltic pump 202 for pumping the diluent in the storage chamber 201 outward, a conduit 203 connected to the output end of the peristaltic pump 202, and a liquid inlet head 204 connected to the output end of the conduit 203.

[0038] The input end of the peristaltic pump 202 is connected to the injection chamber 201, and the liquid dispensing head 204 is located directly above the specimen shaking unit 3 on the inner surface of the cover 102.

[0039] As shown in Figure 1, in this embodiment of the present invention, the conduit 203 passes through the warm bath chamber 110 and directly contacts the warm water inside for heat transfer.

[0040] As shown in Figure 1, in this embodiment of the present invention, the specimen shaking unit 3 includes a universal connecting ball 301 fixed at the center of the upper surface of the intermediate spacer layer 105, a sample mounting cylinder 302, a universal connecting groove 304 disposed at the bottom of the sample mounting cylinder 302 and used for rotatably connecting with the universal connecting ball 301, and a shaking drive unit for driving the sample mounting cylinder 302 to shake.

[0041] As shown in Figure 1. In this embodiment of the present invention, the shaking drive unit includes:

[0042] A permanent magnet array 305 is provided on the lower surface of the sample mounting cylinder 302, and the permanent magnet array 305 is a ring array with opposite magnetic poles alternating.

[0043] The magnetic drive unit 306 is located in the background chamber 120. The magnetic drive unit 306 is located directly below the permanent magnet array 305. The magnetic drive unit 306 is arranged in a magnetic pole ring array.

[0044] The lower surface of the sample mounting cylinder 302 is at a higher level than the upper surface of the intermediate spacer layer 105.

[0045] As shown in Figure 1, in this embodiment of the present invention, the sample mounting cylinder 302 includes:

[0046] The side holes 303 are uniformly opened through the wall of the sample mounting cylinder 302 for heat conduction inside and outside the sample mounting cylinder 302.

[0047] As shown in Figure 1, in this embodiment of the present invention, the water temperature control unit 4 further includes:

[0048] The agitator 402, which is disposed on the side wall of the sample mounting cylinder 302, is used to agitate and homogenize the temperature field inside the temperature bath chamber 110.

[0049] As shown in Figure 1, in this embodiment of the present invention, the main housing 1 includes: a cover handle 103 disposed on the cover 102.

[0050] As shown in Figure 2, the working principle of this utility model embodiment is as follows:

[0051] S100: First, pull the lid handle 103 to open the lid 103, insert the cold agglomerated sample 6 into the sample mounting tube 302, and then close the lid 103.

[0052] S200: Start the equipment. The heating tube 401 continuously heats up. Under the closed-loop detection of the temperature sensor, the internal temperature of the temperature bath chamber 110 is controlled by constant temperature to process the condensed sample 6 in the temperature bath.

[0053] S300: During the warm bath treatment, the electromagnetic array 307 is controlled to generate dynamic alternating magnetic poles, which in turn attract the alternating magnetic poles of the permanent magnet array 305. Since the lower surface of the sample mounting cylinder 302 is at a higher level than the upper surface of the intermediate spacer layer 105, the sample mounting cylinder 302 swings and rotates, causing the condensed sample 6 to shake. The shaking also drives the stirring paddle 402 to stir, thereby homogenizing the internal temperature field and improving the uniformity of the warm bath for the condensed sample 6.

[0054] S400: At the moment of device startup, the peristaltic pump 202 is controlled to pump the solution in the storage chamber 201 to the liquid dispensing head 204, thereby adding it into the condensate sample 6 to achieve condensate dilution treatment. During this process, since the conduit 203 is installed in the warm bath chamber 110, the diluent in the conduit 203 has reached the temperature inside the warm bath chamber 110 before the condensate sample 6 is inserted into the device. Therefore, the diluent that has reached the standard temperature is added into the condensate sample 6 at the beginning of device startup, which can achieve direct contact heat transfer to the condensate sample 6, further improving the internal heating rate of the condensate sample 6 and improving the dissipation efficiency.

[0055] In this embodiment of the invention, the multi-component condensate sample 6 dispersion method, which integrates a warm bath, shaking, and the addition of a warm bath diluent, greatly improves the dispersion efficiency of condensate and saves dispersion time. Simultaneously, this invention uses oscillation and rotation instead of the traditional centrifugation method, simplifying the structural design and reducing design costs. Furthermore, the use of alternating magnetic pole rings for air-locked transmission avoids waterproofing issues caused by dynamic sealing inside and outside the warm bath chamber 110. Moreover, since the conduit 203 is installed inside the warm bath chamber 110, the diluent in the conduit 203 has already reached the temperature inside the warm bath chamber 110 before the condensate sample 6 is inserted into the device. Therefore, by controlling the diluent to reach the standard temperature and adding it to the condensate sample 6 at the beginning of device startup, direct contact heat transfer to the condensate sample 6 can be achieved, further improving the internal heating rate of the condensate sample 6 and increasing dispersion efficiency.

[0056] The above are merely preferred embodiments of this application and are not intended to limit this application. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of this application should be included within the protection scope of this application. The above are merely preferred embodiments of this application. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the technical principles of this application, and these improvements and modifications should also be considered within the protection scope of this application.

Claims

1. A device for condensing and dispersing multiple components of a specimen, characterized in that, include: The main housing (1) includes a box body (101), a cover (102) with a rotating cover located above the opening of the box body (101), a middle partition (105) horizontally fixed inside the box body (101), a warm bath chamber (110) and a backstage chamber (120) formed on both sides of the middle partition (105), and a water-insulating layer (104) tightly attached to the periphery of the warm bath chamber (110); a water temperature control unit (4) located in the warm bath chamber (110), including a heating tube (401) and a temperature sensor; a specimen shaking unit (3) located in the warm bath chamber (110) for installing and shaking the cold agglomerated specimen (6); a diluent filling unit (2) for adding diluent to the specimen shaking unit (3); and a control main board (5).

2. The condensation and dispersion device for collecting specimens according to claim 1, characterized in that, The diluent filling unit (2) includes: a filling chamber (201) disposed in the background chamber (120), a filling port (205) connected to the filling chamber (201), a peristaltic pump (202) for pumping the diluent in the filling chamber (201) outward, a conduit (203) connected to the output end of the peristaltic pump (202), and a filling head (204) connected to the output end of the conduit (203); the input end of the peristaltic pump (202) is connected to the filling chamber (201), and the filling head (204) is disposed directly above the specimen shaking unit (3) on the inner surface of the cover (102).

3. The condensation and collection specimen dispersion device according to claim 2, characterized in that, The conduit (203) passes through the warm bath chamber (110) and directly contacts the warm water inside for heat transfer.

4. The condensation and dispersion device for collecting multiple samples according to claim 1, characterized in that, The specimen shaking unit (3) includes: a universal connecting ball (301) fixed at the center of the upper surface of the intermediate spacer layer (105), a sample mounting cylinder (302), a universal connecting groove (304) located at the bottom of the sample mounting cylinder (302) and used for rotatably connecting with the universal connecting ball (301), and a shaking drive unit for driving the sample mounting cylinder (302) to shake.

5. The condensation and dispersion device for collecting specimens according to claim 4, characterized in that, The shaking drive unit includes: a permanent magnet array (305) disposed on the lower surface of the sample mounting cylinder (302), wherein the permanent magnet array (305) is arranged in a ring array with opposite magnetic poles interlaced; and a magnetic attraction drive part (306) disposed in the back stage chamber (120), wherein the magnetic attraction drive part (306) is located directly below the permanent magnet array (305), and the magnetic attraction drive part (306) is arranged in a ring array with magnetic poles; the horizontal height of the lower surface of the sample mounting cylinder (302) is higher than the height of the upper surface of the intermediate spacer layer (105).

6. The condensation and dispersion device for collecting specimens according to claim 4, characterized in that, The sample mounting cylinder (302) includes: a side hole (303) uniformly opened through the wall of the sample mounting cylinder (302) for heat conduction inside and outside the sample mounting cylinder (302).

7. The condensation and collection specimen dispersion device according to claim 4, characterized in that, The water temperature control unit (4) further includes: an agitator (402) disposed on the outer wall of the sample mounting cylinder (302) for agitating and homogenizing the temperature field inside the temperature bath chamber (110).

8. The condensation and dispersion device for collecting specimens according to claim 1, characterized in that, The main housing (1) includes: a cover handle (103) disposed on the cover (102).

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