A rectification device for reducing impurity generation for 4,6-pyrimidine production

Abstract

This utility model relates to the field of 4,6-pyrimidine production technology, specifically a distillation apparatus for reducing impurity formation in 4,6-pyrimidine production. It includes a reaction vessel and a mounting frame. The reaction vessel is mounted on the right side of the mounting frame. An inlet pipe is mounted on the top left side of the reaction vessel, and a condenser pipe is mounted on the top right side of the reaction vessel. An outlet port is installed at the bottom of the reaction vessel, and a flow divider is installed at the bottom of the outlet port. The flow divider includes a flow divider pipe and a drain pipe. The drain pipe is installed on the center left side of the flow divider pipe. A mixing mechanism is mounted on the top left side of the mounting frame. A semi-circular baffle installed on the inner wall of the drain pipe allows for timely drainage during cleaning of the reaction vessel, preventing water accumulation from affecting subsequent reactions and saving time. The added catalyst is rapidly mixed and added to the reaction vessel together. Rapid mixing reduces impurity production and improves the applicability of the apparatus.

Description

Technical Field

[0001] This utility model relates to the field of 4,6-pyrimidine production technology, specifically to a distillation apparatus for reducing impurity generation in the production of 4,6-pyrimidine. Background Technology

[0002] 4,6-Dichloropyrimidine is a grayish-white needle-like crystal with a melting point of 64.66℃. It is poorly soluble in water, has some solubility in 1,2-dichloroethane, and is readily soluble in solvents such as dichloromethane and DMF. It is mainly used as a pharmaceutical intermediate in the production of sulfamethoxypyrimidine and as an intermediate in the synthesis of the fungicide azoxystrobin.

[0003] For example, CN218222373U discloses a purification system for 4,6-dichloropyrimidine, including purification components, which include a reaction vessel, a hydrolysis vessel, a layering vessel, a feed pipe, and an exhaust pipe; and a recovery mechanism, which includes a first gas supply pipe, a first condenser, a first water return pipe, a dropper, a second gas supply pipe, a second condenser, and a second water return pipe; the top of the outer wall of the reaction vessel is connected to an exhaust pipe. This invention introduces the gas generated by chlorination in the reactor into the interior of the first condenser through a first gas supply pipe. The gas is then condensed in the first condenser, allowing the dichloroethane carried in the gas to return to the reactor through the first water return pipe, thereby improving resource utilization and avoiding waste. The chlorination solution is then added dropwise to the interior of the hydrolysis reactor using a dropper, where chilled water is used for hydrolysis and purification, thus improving the purification effect on 4,6-dichloropyrimidine. However, existing devices only add 4,6-pyrimidine raw materials and catalysts to the reactor for reaction, and the lack of internal stirring results in different reaction zones and incomplete impurity removal. Furthermore, the reactor cannot be quickly cleaned after the reaction, affecting production efficiency. Therefore, there is an urgent need to design a distillation device for 4,6-pyrimidine production that reduces impurity formation to solve these problems. Utility Model Content

[0004] The purpose of this invention is to provide a distillation apparatus for reducing impurity generation in the production of 4,6-pyrimidine, in order to solve the problems mentioned in the background art. The existing apparatus only adds 4,6-pyrimidine raw material and catalyst into the reactor for reaction, but the internal addition cannot be stirred, resulting in different reaction zones and incomplete removal of impurities. At the same time, the reactor cannot be quickly cleaned after the reaction, which affects the production efficiency.

[0005] To achieve the above objectives, this utility model provides the following technical solution: a distillation apparatus for reducing impurity generation in the production of pyrimidine, comprising a reaction vessel and a mounting frame. The reaction vessel is mounted on the right side of the mounting frame. An inlet pipe is mounted on the left side of the top of the reaction vessel. A condenser pipe is mounted on the right side of the top of the reaction vessel. An outlet is mounted at the bottom of the interior of the reaction vessel. A flow divider is mounted at the bottom of the outlet. The flow divider includes a flow divider pipe and a drain pipe. A drain pipe is mounted on the left side of the center of the flow divider pipe. A mixing mechanism is mounted on the top left side of the mounting frame. The mixing mechanism includes a mixing chamber and a stirring component. The stirring component is mounted inside the mixing chamber. A conveying component is horizontally mounted at the bottom of the mixing chamber. The right end of the conveying component injects material into the inlet pipe through a connecting pipe.

[0006] Preferably, the diversion pipe is equipped with an upper solenoid valve and a lower solenoid valve, respectively. The upper solenoid valve is installed at the connection between the diversion pipe and the bottom side of the reactor, and the lower solenoid valve is installed on the bottom side of the diversion pipe.

[0007] Preferably, the drain pipe is installed at the center of the upper solenoid valve and the lower solenoid valve, and a semi-circular baffle is installed on the upper side of the inner wall of the contact surface between the drain pipe and the diversion pipe.

[0008] Preferably, the bottom of the mixing tank has a horizontal through hole, the center of the horizontal through hole has a vertical through hole, the top of the mixing tank has a liquid collection tank, the upper right side of the liquid collection tank has a feeding port, and the center of the mixing tank has a stirring component.

[0009] Preferably, the stirring component includes a second servo motor and a limiting bearing. The second servo motor is installed at the top of the liquid collection tank, and the limiting bearing is installed at the center of the top of the liquid collection tank. The second servo motor drives the second auger to rotate through the limiting bearing. The second auger rotates in the vertical through hole, and the side of the second auger is attached to the inner wall of the vertical through hole.

[0010] Preferably, the conveying component includes an extension plate and a first servo motor. The first servo motor is mounted on the top of the extension plate, and a conveying pipe is connected to the right side of the first servo motor. The conveying pipe is installed in a transverse through hole.

[0011] Preferably, a fixed bearing is installed on the inner left wall of the conveying pipe, a first auger is installed inside the conveying pipe, the left end of the first auger is connected to a first servo motor through the fixed bearing, a vertical through hole is connected to the center of the top end of the conveying pipe, and a feed pipe is installed on the rear side of the left end of the conveying pipe.

[0012] Compared with the prior art, the beneficial effects of this utility model are:

[0013] This distillation apparatus for reducing impurity formation in the production of 4,6-pyrimidine features an upper and lower solenoid valve installed in the split pipe, allowing for flexible control of the feed material in the reactor. It is easy to operate. The semi-circular baffle installed on the inner wall of the drain pipe allows for timely drainage during cleaning of the reactor, preventing water accumulation from affecting subsequent reactions and saving time.

[0014] This distillation apparatus for reducing impurity generation in the production of 4,6-pyrimidine features a collection tank at the top of a mixing chamber where a catalyst can be placed. The catalyst is then gradually added downwards via an internally installed agitator, saving manual addition time and labor. A vertical through-hole is connected to a conveying pipe, facilitating rapid mixing of the 4,6-pyrimidine feedstock fed into the feed pipe and the catalyst added through the vertical through-hole by a first auger before being fed into the reactor. This rapid mixing reduces impurities and improves the apparatus's applicability. Attached Figure Description

[0015] Figure 1 This is a front view structural diagram of the present invention;

[0016] Figure 2 This is a schematic cross-sectional view of the reactor structure of this utility model;

[0017] Figure 3 This is a schematic cross-sectional view of the internal structure of the diversion tube of this utility model;

[0018] Figure 4 This is a cross-sectional schematic diagram of the conveyor component of this utility model.

[0019] In the diagram: 1. Reactor; 11. Inlet pipe; 12. Condenser pipe; 13. Outlet; 2. Mounting bracket; 3. Diverter; 31. Diverter pipe; 32. Upper solenoid valve; 33. Lower solenoid valve; 34. Drain pipe; 341. Semi-arc baffle; 4. Mixing mechanism; 41. Mixing box; 411. Horizontal through hole; 412. Vertical through hole; 413. Collection box; 414. Feed port; 42. Stirring component; 421. Second servo motor; 422. Limit bearing; 423. Second auger; 5. Conveying component; 51. Extension plate; 52. First servo motor; 53. Conveying pipe; 531. Fixed bearing; 532. First auger; 533. Feed pipe. Detailed Implementation

[0020] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0021] Please see Figures 1-4 One embodiment provided by this utility model:

[0022] A distillation apparatus for reducing impurity formation in the production of 4,6-pyrimidine is disclosed in this application. The reactor 1, upper solenoid valve 32, and lower solenoid valve 33 used in this application are commercially available products, and their principles and connection methods are existing technologies well known to those skilled in the art. The apparatus includes a reactor 1 and a mounting frame 2. The reactor 1 is mounted on the right side of the mounting frame 2. An inlet pipe 11 is mounted on the top left side of the reactor 1. A condenser pipe 12 is mounted on the top right side of the reactor 1. An outlet port 13 is mounted at the bottom of the reactor 1. A flow divider 3 is mounted at the bottom of the outlet port 13. The flow divider 3 includes a flow divider pipe 31 and a drain pipe 34. The drain pipe 34 is mounted on the center left side of the flow divider pipe 31. A mixing mechanism 4 is mounted on the top left side of the mounting frame 2. The mixing mechanism 4 includes a mixing chamber 41 and a stirring element 42. The stirring element 42 is mounted inside the mixing chamber 41. A conveying element 5 is mounted laterally at the bottom of the mixing chamber 41. The right end of the conveying element 5 injects material into the inlet pipe 11 through a connecting pipe.

[0023] As a further feature of this invention, an upper solenoid valve 32 and a lower solenoid valve 33 are respectively installed on the diversion pipe 31. The upper solenoid valve 32 is installed at the connection between the diversion pipe 31 and the bottom side of the reactor 1, and the lower solenoid valve 33 is installed on the bottom side of the diversion pipe 31. The drain pipe 34 is installed at the center of the upper solenoid valve 32 and the lower solenoid valve 33. A semi-arc baffle 341 is installed on the upper side of the inner wall of the contact surface between the drain pipe 34 and the diversion pipe 31, which is beneficial for flexibly controlling the feeding of raw materials in the reactor and is simple to operate.

[0024] Furthermore, a horizontal through hole 411 is provided at the bottom of the mixing tank 41, and a vertical through hole 412 is provided at the center of the horizontal through hole 411. A liquid collection tank 413 is provided at the top of the mixing tank 411, and a feeding port 414 is provided on the upper right side of the liquid collection tank 413. A stirring component 42 is installed at the center of the mixing tank 41. The stirring component 42 includes a second servo motor 421 and a limiting bearing 422. The second servo motor 421 is installed at the top of the liquid collection tank 413, and the limiting bearing 422 is installed at the center of the top of the liquid collection tank 413. The second servo motor 421 drives the second auger 423 to rotate through the limiting bearing 422. The second auger 423 rotates in the vertical through hole 412, and the side of the second auger 423 is attached to the inner wall of the vertical through hole 412, which is beneficial for adding the catalyst, facilitating subsequent mixing and improving efficiency.

[0025] As a further improvement of this utility model, the conveying component 5 includes an extension plate 51 and a first servo motor 52. The first servo motor 52 is installed at the top of the extension plate 51. The right side of the first servo motor 52 is connected to the conveying pipe 53. The conveying pipe 53 is installed in the transverse through hole 411. A fixed bearing 531 is installed on the inner left wall of the conveying pipe 53. A first auger 532 is installed inside the conveying pipe 53. The left end of the first auger 532 is connected to the first servo motor 52 through the fixed bearing 531. The top center of the conveying pipe 53 is connected to the vertical through hole 412. A feed pipe 533 is installed on the rear side of the left end of the conveying pipe 53. This facilitates the rapid mixing of the 4,6-pyrimidine raw material put into the feed pipe and the catalyst put into the vertical through hole by the first auger, and then puts them into the reactor together. The rapid mixing reduces impurities and improves the applicability of the device.

[0026] Working principle: In use, the user first connects the conveying pipe 53 to the air inlet pipe 11 on the left side of the top of the reactor 1 using the connecting pipe. Then, the first servo motor 52 is powered on to drive the first auger 532 inside the conveying pipe 53 to rotate. The 4,6-pyrimidine raw material is fed in through the feed pipe 533 on the rear left side of the conveying pipe 53, and then transported into the reactor 1 through the first auger 532. When it is necessary to mix the catalyst, the second servo motor 421 is powered on to drive the second auger 423 on the bottom side to rotate in the vertical through hole 412. The rotation of the second auger 423 can send the catalyst in the collection tank 413 into the conveying pipe 53 for mixing and then into the reactor 1. After mixing, the upper solenoid valve 32 and the lower solenoid valve 33 need to be opened simultaneously. After cleaning, the upper solenoid valve 32 needs to be opened to discharge the cleaning water through the feed port 414. The above is the complete working principle of this utility model.

[0027] It will be apparent to those skilled in the art that this invention is not limited to the details of the exemplary embodiments described above, and that it can be implemented in other specific forms without departing from the spirit or essential characteristics of this invention. Therefore, the embodiments should be considered illustrative and non-limiting in all respects, and the scope of this invention is defined by the appended claims rather than the foregoing description. Thus, it is intended that all variations falling within the meaning and scope of equivalents of the claims be included within this invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

Claims

1. A distillation apparatus for reducing impurity formation in the production of 4,6-pyrimidine, comprising a reaction vessel (1) and a mounting frame (2), characterized in that: A reactor (1) is installed on the right side of the mounting frame (2). An air inlet pipe (11) is installed on the left side of the top of the reactor (1). A condenser pipe (12) is installed on the right side of the top of the reactor (1). An outlet port (13) is installed at the bottom of the reactor (1). A flow divider (3) is installed at the bottom of the outlet port (13). The flow divider (3) includes a flow divider pipe (31) and a drain pipe (34). A drain pipe (34) is installed on the left side of the center of the flow divider pipe (31). A mixing mechanism (4) is installed on the top side of the left end of the mounting frame (2). The mixing mechanism (4) includes a mixing box (41) and a stirring component (42). A stirring component (42) is installed inside the mixing box (41). A conveying component (5) is installed horizontally at the bottom of the mixing box (41). The right end of the conveying component (5) injects material into the air inlet pipe (11) through a connecting pipe.

2. A distillation apparatus for reducing impurity generation in the production of 4,6-pyrimidine according to claim 1, characterized in that: The diversion pipe (31) is equipped with an upper solenoid valve (32) and a lower solenoid valve (33). The upper solenoid valve (32) is installed at the connection between the diversion pipe (31) and the bottom side of the reactor (1), and the lower solenoid valve (33) is installed on the bottom side of the diversion pipe (31).

3. A distillation apparatus for reducing impurity generation in the production of 4,6-pyrimidine according to claim 1, characterized in that: The drain pipe (34) is installed at the center of the upper solenoid valve (32) and the lower solenoid valve (33), and a semi-arc baffle (341) is installed on the upper side of the inner wall of the contact surface between the drain pipe (34) and the diversion pipe (31).

4. A distillation apparatus for reducing impurity generation in the production of 4,6-pyrimidine according to claim 1, characterized in that: A horizontal through hole (411) is provided at the bottom of the mixing tank (41), and a vertical through hole (412) is provided at the center of the horizontal through hole (411). A liquid collection tank (413) is provided at the top of the mixing tank (41), and a feeding port (414) is provided on the upper right side of the liquid collection tank (413). A stirring component (42) is installed at the center of the mixing tank (41).

5. A distillation apparatus for reducing impurity generation in the production of 4,6-pyrimidine according to claim 1, characterized in that: The stirring component (42) includes a second servo motor (421) and a limiting bearing (422). The second servo motor (421) is installed at the top of the liquid collection tank (413). The limiting bearing (422) is installed at the center of the top of the liquid collection tank (413). The second servo motor (421) drives the second auger (423) to rotate through the limiting bearing (422). The second auger (423) rotates in the vertical through hole (412). The side of the second auger (423) is attached to the inner wall of the vertical through hole (412).

6. A distillation apparatus for reducing impurity generation in the production of 4,6-pyrimidine according to claim 1, characterized in that: The conveying component (5) includes an extension plate (51) and a first servo motor (52). The first servo motor (52) is installed at the top of the extension plate (51). The right side of the first servo motor (52) is connected to a conveying pipe (53). The conveying pipe (53) is installed in a transverse through hole (411).

7. A distillation apparatus for reducing impurity generation in the production of 4,6-pyrimidine according to claim 6, characterized in that: A fixed bearing (531) is installed on the inner left wall of the conveying pipe (53). A first auger (532) is installed inside the conveying pipe (53). The left end of the first auger (532) is connected to a first servo motor (52) through the fixed bearing (531). A vertical through hole (412) is connected to the center of the top end of the conveying pipe (53). A feed pipe (533) is installed on the rear side of the left end of the conveying pipe (53).

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