A purification device for extracting paclitaxel

Abstract

The utility model discloses a kind of for extracting paclitaxel purification device, belong to purification device field, including purification tank, the inner chamber of purification tank is provided with frame, the inner chamber of frame is provided with placing frame, the top of purification tank Both sides are provided with structure groove, the inner chamber of purification tank Both sides are provided with through slot, the upper portion of purification tank is provided with two round rods, one end of the round rod is fixedly connected with connecting handle, the side of connecting handle is rotatably connected with connecting rod by rotating shaft;Through the cooperation between above each device, improve adsorption efficiency and purification speed, effectively shorten the entire purification cycle, not only can improve production efficiency, reduce production cost, but also can ensure the purity and quality of paclitaxel product, by optimizing adsorption process, effectively avoid the paclitaxel product in which more impurities are left due to insufficient adsorption and inefficiency, to ensure its efficacy and safety.

Description

Technical Field

[0001] This utility model relates to the field of purification equipment technology, specifically a purification device for extracting paclitaxel. Background Technology

[0002] Purification equipment is used to remove impurities from mixtures to obtain high-purity substances. Purification equipment plays an important role in many fields. Through purification, high-purity target substances can be obtained, improving product quality and performance and meeting market and customer demands. Purification equipment used to extract paclitaxel occupies an important position in the pharmaceutical manufacturing industry. As a key link in the paclitaxel production process, its purification efficiency and quality have a decisive impact on the overall efficacy and safety of paclitaxel products.

[0003] Existing purification equipment faces problems of slow adsorption and low efficiency when using adsorbents to adsorb paclitaxel from solution. Although the pretreated raw material solution and paclitaxel solution can be separated to a certain extent during the separation of adsorbent and paclitaxel solution, the adsorption process of paclitaxel molecules by silica gel adsorbent is relatively slow, which prolongs the entire purification cycle and reduces production efficiency. Insufficient or inefficient adsorption can also result in more impurities remaining in the paclitaxel product, affecting its efficacy and safety.

[0004] Therefore, this invention provides a purification apparatus for extracting paclitaxel to solve the above-mentioned problems. Utility Model Content

[0005] (a) Technical problems to be solved

[0006] This invention provides a purification apparatus for extracting paclitaxel, aiming to solve the problems mentioned in the background art.

[0007] (II) Technical Solution

[0008] To achieve the above objectives, this utility model provides the following technical solution: a purification device for extracting paclitaxel, comprising a purification box, a frame provided in the inner cavity of the purification box, a placement frame provided in the inner cavity of the frame, structural grooves on both sides of the top of the purification box, through grooves on both sides of the inner cavity of the purification box, two round rods provided above the purification box, a connecting handle fixedly connected to one end of each round rod, a connecting rod rotatably connected to one side of the connecting handle via a rotating shaft, a structural block slidably connected to the inner cavity of the structural groove, a fixed seat fixedly connected to the top of the structural block, both sides of the connecting rod rotatably connected to the inner wall of the corresponding fixed seat via a rotating shaft, an L-shaped rod penetrating the corresponding through groove fixedly connected to one side of the structural block, and the top of the frame fixedly connected to one end of the corresponding L-shaped rod.

[0009] As a preferred technical solution of this application, both sides of the purification box are fixedly connected to mounting side plates, and one end of the round rod extends through one side of the corresponding mounting side plate to the other side.

[0010] As a preferred technical solution of this application, a motor is fixedly installed on one side of the mounting side plate, and the output end of the motor is fixedly connected to the extension end of the corresponding round rod.

[0011] As a preferred technical solution of this application, the top of the frame has two grooves, and the two sides of the placement frame are fixedly connected with limit blocks.

[0012] As a preferred technical solution of this application, the outer surface of the limiting block is engaged with the inner cavity of the groove, and a handle is fixedly connected to the top of the limiting block.

[0013] As a preferred technical solution of this application, a drain pipe is fixedly connected to one side of the purification box, and a valve is fixedly installed on the outer ring of the drain pipe.

[0014] As a preferred technical solution of this application, a sealing plate is hinged to one side of the purification box, and a handle is fixedly connected to one side of the sealing plate.

[0015] (III) Beneficial Effects

[0016] This allows for better separation of the adsorbent from the paclitaxel solution, improving adsorption efficiency and purification speed, and effectively shortening the entire purification cycle. This not only improves production efficiency and reduces production costs but also ensures the purity and quality of the paclitaxel product. By optimizing the adsorption process, it effectively avoids the presence of excessive impurities in the paclitaxel product due to insufficient adsorption and low efficiency, thereby guaranteeing its efficacy and safety.

[0017] The handle allows for easy removal of the placement box, facilitating subsequent elution processing. This design not only improves work efficiency but also reduces the workload of operators. The drain pipe facilitates the discharge and treatment of waste liquid inside the purification tank. The handle allows for opening or closing of the sealing plate, making it convenient to load, unload, or maintain the contents of the purification tank. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the overall structure of a purification device for extracting paclitaxel;

[0019] Figure 2 This is a schematic diagram of the structure of a sealing plate in a purification device for extracting paclitaxel;

[0020] Figure 3This is a schematic diagram of the connecting handle in a purification device for extracting paclitaxel;

[0021] Figure 4 This is a schematic diagram of the structure of a frame in a purification apparatus for extracting paclitaxel;

[0022] Figure 5 This is a schematic diagram of the L-shaped rod in a purification device for extracting paclitaxel.

[0023] In the picture:

[0024] 1. Purification box; 2. Sealing plate; 3. Mounting side plate; 4. Motor; 5. Structural groove; 6. Drain pipe; 7. Connecting handle; 8. Frame; 9. Placement frame; 10. Round rod; 11. Handle; 12. Groove; 13. Limiting block; 14. Connecting rod; 15. Fixing base; 16. L-shaped rod; 17. Structural block; 18. Through groove; 19. Grip. Detailed Implementation

[0025] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present utility model without creative effort are within the protection scope of the present utility model.

[0026] This invention provides a purification apparatus for extracting paclitaxel, such as... Figures 1-5 As shown, the technical solution includes a purification box 1, an inner cavity of which is provided with a frame 8, an inner cavity of which is provided with a placement frame 9, structural grooves 5 are provided on both sides of the top of the purification box 1, through grooves 18 are provided on both sides of the inner cavity of the purification box 1, two round rods 10 are provided on the top of the purification box 1, one end of the round rod 10 is fixedly connected to a connecting handle 7, one side of the connecting handle 7 is rotatably connected to a connecting rod 14 via a rotating shaft, a structural block 17 is slidably connected to the inner cavity of the structural groove 5, a fixing seat 15 is fixedly connected to the top of the structural block 17, both sides of the connecting rod 14 are rotatably connected to the inner wall of the corresponding fixing seat 15 via a rotating shaft, one side of the structural block 17 is fixedly connected to an L-shaped rod 16 that passes through the corresponding through groove 18, and the top of the frame 8 is fixedly connected to one end of the corresponding L-shaped rod 16.

[0027] Both sides of the purification box 1 are fixedly connected with mounting side plates 3. One end of the round rod 10 extends through one side of the corresponding mounting side plate 3 to the other side. The mounting side plates 3 ensure the stable installation and smooth rotation of the round rod 10, providing a reliable foundation for the transmission of the motor 4 during the purification process.

[0028] A motor 4 is fixedly installed on one side of the mounting side plate 3. The output end of the motor 4 is fixedly connected to the extension end of the corresponding round rod 10. The motor 4 serves as a power source, and its output end is tightly connected to the round rod 10. After the motor 4 is started, the power is transmitted to the subsequent connection structure through the round rod 10.

[0029] Specifically: In the process of purifying paclitaxel using this purification device, firstly, the adsorbent is loaded into the placement frame 9, and the pretreated raw material solution flows into the purification chamber 1 through the placement frame 9. The operator controls the two motors 4 to start via a synchronizer. The start of the motors 4 drives the round rod 10 to rotate, and the rotation of the round rod 10 further drives the connecting handle 7 to rotate. The rotation of the connecting handle 7 is transmitted to the fixed seat 15 through the connecting rod 14, allowing it to slide in the inner cavity of the structural groove 5. The structural block 17 connected to the fixed seat 15 can drive the frame 8 to move back and forth in the inner cavity of the purification chamber 1 via the L-shaped rod 16. At this time, the limiting block 13 and the groove 12 are engaged, and the placement frame 9 is located inside the frame 8. Therefore, when the frame 8 moves back and forth in the inner cavity of the purification chamber 1, the placement frame 9 also moves back and forth in the inner cavity of the purification chamber 1, so that the adsorbent and the solution in the inner cavity of the purification chamber 1 can make full contact, thereby improving the adsorption efficiency. During the full contact process, the paclitaxel molecules in the solution are adsorbed by the adsorbent.

[0030] Two grooves 12 are provided on the top of the frame 8, and limit blocks 13 are fixedly connected to both sides of the placement frame 9. The setting of limit blocks 13 and grooves 12 ensures the stable displacement of the placement frame 9.

[0031] The outer surface of the limiting block 13 engages with the inner cavity of the groove 12, and a handle 11 is fixedly connected to the top of the limiting block 13. The handle 11 allows the operator to easily and quickly remove the placement frame 9.

[0032] A drain pipe 6 is fixedly connected to one side of the purification box 1. A valve is fixedly installed on the outer ring of the drain pipe 6. After the personnel open the valve, the waste liquid can be discharged through the drain pipe 6.

[0033] A sealing plate 2 is hinged to one side of the purification box 1. A handle 19 is fixedly connected to one side of the sealing plate 2, allowing the operator to easily and quickly open or close the sealing plate 2 to perform necessary operations and maintenance.

[0034] Specifically: When a person pulls the handle 11 upwards, the placement frame 9 is moved upwards. This action causes the limiting block 13 to disengage from the inner cavity of the groove 12, so that the placement frame 9 can be taken out. The removed placement frame 9 contains an adsorbent that has adsorbed paclitaxel molecules. After eluting these adsorbents, pure paclitaxel can be extracted.

[0035] The above description is only a preferred embodiment of the present utility model, but the protection scope of the present utility model is not limited thereto. Any equivalent substitutions or changes made by those skilled in the art within the technical scope disclosed in the present utility model, based on the technical solution and the inventive concept of the present utility model, should be included within the protection scope of the present utility model.

Claims

1. A purification apparatus for extracting paclitaxel, comprising a purification chamber (1), characterized in that: The purification box (1) has a frame (8) in its inner cavity, and a placement frame (9) in the inner cavity of the frame (8). The purification box (1) has structural grooves (5) on both sides of its top, and through grooves (18) on both sides of its inner cavity. The purification box (1) has two round rods (10) on its top. One end of the round rod (10) is fixedly connected to a connecting handle (7). One side of the connecting handle (7) is rotatably connected to a connecting rod (14) via a rotating shaft. The inner cavity of the structural groove (5) is slidably connected to a structural block (17). The top of the structural block (17) is fixedly connected to a fixing seat (15). Both sides of the connecting rod (14) are rotatably connected to the inner wall of the corresponding fixing seat (15) via a rotating shaft. One side of the structural block (17) is fixedly connected to an L-shaped rod (16) that passes through the corresponding through groove (18). The top of the frame (8) is fixedly connected to one end of the corresponding L-shaped rod (16).

2. The purification apparatus for extracting paclitaxel according to claim 1, characterized in that: Both sides of the purification box (1) are fixedly connected to mounting side plates (3), and one end of the round rod (10) extends through one side of the corresponding mounting side plate (3) to the other side.

3. The purification apparatus for extracting paclitaxel according to claim 2, characterized in that: A motor (4) is fixedly installed on one side of the mounting side plate (3), and the output end of the motor (4) is fixedly connected to the extension end of the corresponding round rod (10).

4. The purification apparatus for extracting paclitaxel according to claim 1, characterized in that: The top of the frame (8) has two grooves (12), and the two sides of the placement frame (9) are fixedly connected with limit blocks (13).

5. The purification apparatus for extracting paclitaxel according to claim 4, characterized in that: The outer surface of the limiting block (13) engages with the inner cavity of the groove (12), and a handle (11) is fixedly connected to the top of the limiting block (13).

6. The purification apparatus for extracting paclitaxel according to claim 1, characterized in that: A drain pipe (6) is fixedly connected to one side of the purification box (1), and a valve is fixedly installed on the outer ring of the drain pipe (6).

7. The purification apparatus for extracting paclitaxel according to claim 1, characterized in that: A sealing plate (2) is hinged to one side of the purification box (1), and a handle (19) is fixedly connected to one side of the sealing plate (2).

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