A reagent bottle suitable for high throughput immunohistochemistry

Abstract

This utility model discloses a reagent bottle suitable for high-throughput immunohistochemistry, relating to the field of medical testing equipment. It includes a bottle body, a screw cap, and a sealing assembly. The bottle body is integrally molded, the screw cap is rotatably connected to the bottle body, and the sealing assembly is installed on the bottle body. The sealing assembly is used to prevent reagent leakage and is compatible with the automatic sample dispensing system of a high-throughput immunohistochemistry instrument. In practical use, this invention, with its increased capacity integrally molded reagent bottle and sealing assembly, adapts to the needs of high-throughput immunohistochemistry detection, significantly reducing the frequency of reagent addition. It solves the problem in the prior art where existing reagent bottles have small capacities, requiring frequent reagent replacement and addition, which may introduce contamination risks and affect the accuracy and validity of test results.

Description

Technical Field

[0001] This utility model relates to the field of medical testing equipment, specifically to a reagent bottle suitable for high-throughput immunohistochemistry. Background Technology

[0002] Immunohistochemistry (IHCC) is a technique for detecting the distribution and expression of specific proteins in tissues or cells. It combines antigen-antibody specific binding with a colorimetric reaction to visualize the target protein. Based on antigen-antibody specific binding, the antibody is labeled with a marker, and after color development, the location and expression of the target protein in the tissue or cell can be seen. IHCC is mainly used in pathological diagnosis and disease research. In pathological diagnosis, it can differentiate between benign and malignant tumors, determine tumor type and origin, and assess grade and prognosis. In disease research, it can be used to study the cellular and molecular mechanisms related to diseases. Currently, most of the immunohistochemistry instruments used in hospital pathology departments are still imported brands, with Roche and Leica being common. However, with the development of medical technology and the increasing demands for diagnostic accuracy, the clinical demand for immunohistochemistry testing has exploded. Existing imported equipment is gradually revealing problems such as insufficient high throughput and high maintenance costs when dealing with the ever-increasing testing volume, and is increasingly unable to meet the volume of immunohistochemistry orders placed clinically.

[0003] However, in the current technology, due to the large number of testing indicators and the limited space in the department, it is impossible to add more instruments. The only way to complete the testing indicators is to increase the number of testing rounds. Currently, the capacity of existing reagent bottles is small. Small-capacity reagent bottles require frequent replacement and addition of reagents, which may introduce the risk of contamination, leading to a longer testing time and affecting the accuracy and timeliness of the test results. The use of small reagent bottles increases the workload of reagent management, resulting in unnecessary waste and increased testing costs. Utility Model Content

[0004] In view of the problems in the related technologies, this utility model proposes a reagent bottle suitable for high-throughput immunohistochemistry to overcome the above-mentioned technical problems existing in the existing related technologies.

[0005] Therefore, the specific technical solution adopted by this utility model is as follows:

[0006] A reagent bottle suitable for high-throughput immunohistochemistry includes a bottle body, a screw cap, and a sealing assembly. The bottle body is integrally molded, with the screw cap rotatably connected to the bottle body. The sealing assembly is installed on the bottle body and is used to prevent reagent leakage and is compatible with the automated sample dispensing system of the high-throughput immunohistochemistry instrument. The integrally molded design of the bottle body ensures the stability of the overall structure, giving the reagent bottle good pressure resistance and deformation resistance, increasing the bottle capacity, and solving the problem of high-throughput detection needs. The screw cap rotatably connects to the bottle body, making the opening and closing of the reagent bottle very convenient and quick, saving time and effort during operation and improving work efficiency. The sealing assembly effectively prevents reagent leakage. Good sealing performance ensures that the reagent will not be lost due to leakage during storage and transportation, avoiding contamination and deterioration problems that may be caused by contact with the external environment such as air, moisture, and microorganisms, thereby ensuring the stability and reliability of the reagent. The reagent bottle is widened and enlarged in its overall design to adapt to the high-throughput immunohistochemistry instrument, improving the versatility of laboratory equipment and reagent bottles, and enhancing its practical value.

[0007] Furthermore, the screw cap has a stepped structure with openings at both ends. The inner diameter of the upper opening is smaller than that of the lower opening. The inner wall of the lower opening has internal threads, and the outer circumference of the cap has anti-slip textures. The internal threads can tightly engage with the external threads on the bottle body to achieve a threaded seal. The anti-slip textures on the outer circumference of the cap increase friction between the hand and the cap, allowing the operator to easily rotate the cap, facilitating quick opening and closing of the reagent bottle, saving time, and improving work efficiency.

[0008] Furthermore, a top cap is provided at the upper opening of the screw cap, and the top cap and screw cap are detachably connected by a press-sealing structure. The top cap is installed at the upper opening of the screw cap, which can further prevent external contaminants from entering the reagent bottle. The press-sealing structure ensures that the top cap and screw cap fit tightly together, forming a reliable seal, which enhances the overall sealing performance of the reagent bottle and ensures that the reagent will not deteriorate or be lost due to poor sealing during long-term storage or transportation, thus extending the shelf life of the reagent.

[0009] Furthermore, the bottle body includes a mouth, body, and bottom, with an interface for the high-throughput immunohistochemistry analyzer on the body. The integrated design of the bottle body and the interface allows the high-throughput immunohistochemistry analyzer to quickly and accurately identify and connect to the reagent bottle, enabling automated reagent dispensing and sample addition, significantly improving experimental efficiency and throughput.

[0010] Furthermore, the reagent bottle also includes an interface, which can be a threaded interface or a magnetic interface, for quick connection and disconnection. The threaded interface achieves a secure connection to the high-throughput immunohistochemistry analyzer by rotating and tightening the threads, ensuring that the reagent bottle will not loosen or fall off during the experiment, thus guaranteeing the stability and accuracy of the experiment. The magnetic interface utilizes the principle of magnetic adsorption, allowing for quick connection and disconnection of the reagent bottle to the high-throughput immunohistochemistry analyzer. The magnetic interface is simple and intuitive to operate, reducing operational difficulty and error rate.

[0011] Furthermore, the sealing assembly includes a sealing frame and a sealing ring. The sealing ring is located at the opening of the sealing frame, and the sealing assembly is used to seal the connection between the bottle body and the interface. The sealing frame provides stable and reliable support for the sealing ring, ensuring that the sealing ring maintains the correct installation position and shape during use, thereby achieving optimal sealing performance. The sealing ring, located at the opening of the sealing frame, can tightly fit the contact surface between the bottle body and the interface, forming an efficient sealing barrier, effectively preventing reagent leakage from the connection, and ensuring reagent stability and experimental accuracy.

[0012] Furthermore, the interface surface is coated with an anti-corrosion coating. This coating effectively resists the erosion of the interface surface by chemical reagents, moisture, etc., slows down the aging and damage rate of the interface material, extends the service life of the interface, and reduces the labor and material costs of equipment maintenance in the laboratory.

[0013] Furthermore, the bottle is equipped with a handle for easy gripping. In high-throughput immunohistochemistry experiments, reagent bottles often need to be frequently accessed and replaced. The handle design allows researchers to quickly remove or attach the reagent bottles to the holder, reducing experimental delays caused by prolonged gripping and handling, and greatly improving the smoothness and efficiency of experimental operations.

[0014] Furthermore, the bottle body is equipped with a transparent observation window for observing the reagent's condition. Researchers can check the reagent's level, color, clarity, and whether there is any precipitation or stratification without opening the cap. This facilitates timely detection of reagent deterioration, replenishment, or replacement, ensuring that the reagents used in experiments meet requirements and allowing for convenient recording and monitoring of reagent conditions.

[0015] Furthermore, the transparent observation window is made of corrosion-resistant glass or polycarbonate. Corrosion-resistant glass can resist the erosion of most chemical reagents and remains stable in both acidic and alkaline environments, ensuring that the transparent observation window remains clear and usable for a long time. Corrosion-resistant glass usually has high mechanical strength and can withstand a certain amount of external impact, reducing the risk of damage due to collisions during experimental operations or transportation, and extending the service life of the observation window.

[0016] The beneficial effects of this utility model are as follows:

[0017] 1. In practical use, the reagent bottle of this utility model can meet the needs of 10 rounds of 50 slides of immunohistochemistry instrument. The increased capacity of the reagent bottle is adapted to the needs of high-throughput immunohistochemistry detection, significantly reduces the frequency of reagent addition, and can effectively improve detection capacity without increasing the number of instruments. It greatly reduces the frequency of manpower and time spent on adding reagents and meets the ever-increasing clinical testing tasks.

[0018] 2. In practical use, this utility model, through the one-piece molding of the bottle and the sealing components, keeps the reagent in a sealed state for a long time, maintaining a more stable chemical property and concentration. It effectively reduces reagent loss caused by frequent opening and closing of the reagent bottle, such as evaporation, oxidation, or deterioration caused by external environmental factors, thereby reducing reagent loss and saving testing costs.

[0019] 3. In practical use, the bottle is equipped with a transparent observation window, allowing laboratory personnel to check the reagent level, color, clarity, and other statuses at any time without opening the cap. This facilitates timely detection of reagent deterioration, replenishment, or replacement, reducing operational errors and unexpected situations that may be caused by frequent reagent additions. It also makes the immunohistochemistry experimental process more coherent and smooth, improves the accuracy and reliability of test results, and provides more precise evidence for clinical diagnosis.

[0020] 4. In practical use, the bottle is equipped with a handle. In high-throughput immunohistochemistry experiments, reagent bottles often need to be frequently used and replaced. The handle design allows the experimenter to quickly remove or install the reagent bottle, greatly improving the smoothness and efficiency of the experimental operation. Attached Figure Description

[0021] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0022] Figure 1 This is a schematic diagram of the main structure of a reagent bottle suitable for high-throughput immunohistochemistry according to an embodiment of the present invention;

[0023] Figure 2 This is a second schematic diagram of a reagent bottle structure suitable for high-throughput immunohistochemistry according to an embodiment of the present invention;

[0024] Figure 3 This is a schematic diagram of a sealing assembly structure for a reagent bottle suitable for high-throughput immunohistochemistry according to an embodiment of the present invention;

[0025] Figure 4 This is one of the schematic diagrams of the interface structure of a reagent bottle suitable for high-throughput immunohistochemistry according to an embodiment of the present utility model;

[0026] Figure 5 This is the second schematic diagram of the interface structure of a reagent bottle suitable for high-throughput immunohistochemistry according to an embodiment of the present invention.

[0027] In the picture:

[0028] 1. Bottle body; 11. Bottle mouth; 12. Bottle body; 121. Handle; 13. Bottle bottom; 2. Screw cap; 3. Sealing assembly; 31. Sealing frame; 32. Sealing ring; 4. Top cover; 5. Interface; 51. Threaded interface; 52. Magnetic interface. Detailed Implementation

[0029] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0030] Example 1

[0031] A reagent bottle suitable for high-throughput immunohistochemistry, such as Figures 1-2 As shown, the reagent bottle includes a bottle body 1, a screw cap 2, and a sealing assembly 3. The bottle body 1 is integrally molded, ensuring the stability of the overall structure and providing good pressure resistance and deformation resistance. The screw cap 2 is rotatably connected to the bottle body 1. The screw cap 2 has a stepped structure with openings at both ends. The inner diameter of the upper opening of the screw cap 2 is smaller than that of the lower opening. The inner wall of the lower opening of the screw cap 2 has internal threads, and the outer circumference of the screw cap 2 has anti-slip textures. The rotatable connection between the screw cap and the bottle body makes the opening and closing of the reagent bottle very convenient and quick. A top cover 4 is provided at the upper opening of the screw cap 2. The top cover 4 is detachably connected to the screw cap 2 through a press-sealing structure. The top cover 4 is installed at the upper opening of the screw cap 2, which can further prevent external contaminants such as dust, water vapor, and microorganisms from entering the reagent bottle.

[0032] The bottle body 1 includes a bottle mouth 11, a bottle body 12, and a bottle bottom 13. The bottle body 12 is provided with an interface 5 for connecting to a high-throughput immunohistochemistry analyzer. The interface 5 is a threaded interface 51, used for quick connection and disconnection of the immunohistochemistry instrument. The surface of the interface 5 is coated with an anti-corrosion coating. The threaded interface 51 achieves a secure connection with the high-throughput immunohistochemistry analyzer by rotating and tightening the thread, ensuring that the reagent bottle will not loosen or fall off during the experiment, thus guaranteeing the stability and accuracy of the experiment.

[0033] like Figures 3-4 As shown, the sealing assembly 3 is installed on the bottle body 1. The sealing assembly 3 is used to prevent reagent leakage and is compatible with the automated sample dispensing system of the high-throughput immunohistochemistry analyzer. The sealing assembly 3 includes a sealing frame 31 and a sealing ring 32. The sealing ring 32 is located at the opening of the sealing frame 31. The sealing assembly is used to seal the connection between the bottle body 12 and the interface 5. By ensuring a tight seal between the bottle body 12 and the interface 5 through the sealing assembly 3, it is ensured that reagent leakage will not affect the actual dosage and the accuracy of experimental results during the automated sample dispensing process of the high-throughput immunohistochemistry analyzer, thus improving the reliability and reproducibility of experimental data.

[0034] The bottle body 12 is equipped with a handle 121 for easy gripping of the reagent bottle. A transparent observation window, made of corrosion-resistant glass or polycarbonate, is also provided on the bottle body 12 for observing the reagent's condition. Through real-time observation, laboratory personnel can promptly detect reagent abnormalities and take appropriate measures, preventing waste due to prolonged exposure or deterioration, thereby extending the actual lifespan of the reagents and reducing experimental costs.

[0035] Example 2

[0036] A reagent bottle suitable for high-throughput immunohistochemistry, such as Figure 5 As shown, the bottle body 1 is integrally formed and includes a bottle mouth 11, a bottle body 12, and a bottle bottom 13. The bottle body 12 is provided with an interface 5 for connecting to a high-throughput immunohistochemistry instrument. The interface 5 is a magnetic interface 52, used for quick connection and disconnection of the immunohistochemistry instrument. The magnetic interface 52 utilizes the principle of magnetic adsorption to achieve quick connection and disconnection of the reagent bottle and the high-throughput immunohistochemistry instrument. The experimenter only needs to bring the reagent bottle close to the instrument interface, and the magnetic force will automatically attract and fix it. Disconnection is as simple as pulling, greatly saving operation time and improving experimental efficiency, especially suitable for situations where reagent bottles are frequently changed in high-throughput experiments.

[0037] In summary, by utilizing the above-mentioned technical solution of this utility model, in practical use, this utility model, through the increased capacity of the integrated molded bottle 1 and the sealing component 3, adapts to the needs of high-throughput immunohistochemistry detection, significantly reduces the frequency of reagent addition, greatly reduces the time and manpower spent on reagent addition, and maintains more stable chemical properties and concentration of reagents in a sealed state for a long time, reducing reagent loss and meeting the ever-increasing clinical testing tasks. It solves the problem in existing technologies where, due to the large number of testing indicators and limited departmental space, it is impossible to add more instruments, and the testing indicators can only be completed by increasing the number of examination rounds. Currently, existing reagent bottles have small capacities, requiring frequent replacement and addition of reagents, which may introduce the risk of contamination and affect the accuracy and validity of test results.

[0038] The above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A reagent bottle suitable for high-throughput immunohistochemistry, characterized in that, The device includes a bottle body (1), a screw cap (2), and a sealing assembly (3). The bottle body (1) is integrally formed, the screw cap (2) is rotatably connected to the bottle body (1), and the sealing assembly (3) is installed on the bottle body (1). The sealing assembly (3) is used to prevent reagent leakage and is compatible with the automatic sample dispensing system of a high-throughput immunohistochemistry instrument.

2. The reagent bottle for high-throughput immunohistochemistry according to claim 1, characterized in that, The cap (2) has a stepped structure with openings at both ends. The inner diameter of the upper opening of the cap (2) is smaller than that of the lower opening. The inner wall of the lower opening of the cap (2) is provided with internal threads, and the outer circumference of the cap (2) is provided with anti-slip texture.

3. A reagent bottle suitable for high-throughput immunohistochemistry according to claim 2, characterized in that, The upper opening of the screw cap (2) is provided with an upper cover (4), and the upper cover (4) and the screw cap (2) are detachably connected by a press-sealing structure.

4. A reagent bottle suitable for high-throughput immunohistochemistry according to claim 1, characterized in that, The bottle body (1) includes a bottle mouth (11), a bottle body (12) and a bottle bottom (13), and the bottle body (12) is provided with an interface (5) for a high-throughput immunohistochemistry instrument.

5. A reagent bottle suitable for high-throughput immunohistochemistry according to claim 1, characterized in that, The reagent bottle also includes an interface (5), which is either a threaded interface (51) or a magnetic interface (52) for quick connection and disconnection.

6. A reagent bottle suitable for high-throughput immunohistochemistry according to claim 1, characterized in that, The sealing assembly (3) includes a sealing frame (31) and a sealing ring (32). The sealing ring (32) is located at the opening of the sealing frame (31). The sealing assembly is used to seal the connection between the bottle body (12) and the interface (5).

7. The reagent bottle according to claim 5, characterized in that, The surface of the interface (5) is coated with an anti-corrosion coating.

8. A reagent bottle suitable for high-throughput immunohistochemistry according to claim 1, characterized in that, The bottle body (12) is equipped with a handle (121) for easy gripping of the reagent bottle.

9. A reagent bottle suitable for high-throughput immunohistochemistry according to any one of claims 1-8, characterized in that, A transparent observation window is provided on the bottle body (12) for observing the state of the reagent.

10. A reagent bottle suitable for high-throughput immunohistochemistry according to claim 9, characterized in that, The transparent observation window is made of corrosion-resistant glass or polycarbonate.

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