A sample delivery device for endocrine metabolic diseases

Abstract

This utility model belongs to the field of testing device technology. To solve the technical problem of temperature control for endocrine and metabolic disease specimens in existing technologies, it specifically relates to a specimen delivery device for endocrine and metabolic diseases. It includes a lid, a delivery box that fits with the lid, a buffer assembly inside the delivery box for buffering the specimens during delivery, and a cooling assembly inside the delivery box for temperature control during specimen delivery. By setting up partitions and installing cooling elements in different areas, different temperature controls are achieved, thereby ensuring the safety of specimen delivery for endocrine and metabolic diseases.

Description

Technical Field

[0001] This utility model belongs to the field of testing device technology, specifically relating to a testing device for endocrine and metabolic diseases. Background Technology

[0002] Syndromes that occur when the secretory function and / or structure of endocrine glands or endocrine tissues themselves are abnormal. This also includes syndromes arising from abnormal hormone sources, hormone receptor abnormalities, and physiological disorders caused by hormonal or metabolic disturbances.

[0003] For example, diabetes mellitus is a common endocrine-metabolic disease caused by defects in insulin secretion or action, or both, resulting in a metabolic disorder characterized by chronic hyperglycemia. It can involve chronic, progressive lesions in tissues such as the heart, brain, kidneys, lungs, bones, blood vessels, nerves, skin, eyes, ears, mouth, and feet, leading to functional impairment and failure. Severe cases or stress can cause acute metabolic disturbances such as ketoacidosis and hyperosmolar coma. For example, gout is a heterogeneous group of diseases characterized by long-term purine metabolism disorders and elevated blood uric acid. Its clinical features include hyperuricemia, urate crystal formation and deposition, and the resulting characteristic acute arthritis, tophi, and in severe cases, joint deformities and functional impairment. It often affects the kidneys, causing chronic interstitial nephritis and uric acid urinary tract stones.

[0004] In the field of endocrinology, blood tests are required for the aforementioned diseases, and patients sometimes need to send their blood to the laboratory for analysis after the blood draw. For example, the existing patent "CN 214863792 U" ("A Test Tube Delivery Fixing Device for Endocrinology and Metabolism") effectively protects the test tubes by providing a protective sleeve, reducing the risk of breakage due to accidental damage during delivery. Secondly, this invention effectively distinguishes patients by incorporating a name card holder in the middle of the side wall of the protective sleeve. Furthermore, this invention features a simple structure, convenient operation, and ingenious design, greatly improving work efficiency and offering significant social and economic benefits; it is a product that is easy to promote and use.

[0005] However, the device still has the following problems: First, ordinary blood test specimens should be placed at 22℃~25℃. For example, excessively high temperatures in summer can easily lead to deterioration and contamination. Second, specimens for endocrine disease tests such as insulin, pre-insulin, and C-peptide should be placed in an ice box immediately after sampling and sent for testing, and serum should be separated promptly at 4℃. Summary of the Invention

[0006] The purpose of this invention is to provide a sample delivery device for endocrine and metabolic diseases, which overcomes the technical problem in the prior art that the temperature cannot be controlled for endocrine and metabolic disease specimens. By setting up partitions and setting cooling pads in different areas, different temperature controls can be achieved, thereby ensuring the safety of sample delivery for endocrine and metabolic diseases.

[0007] To achieve the above-mentioned technical effects, the technical approach adopted by this utility model is as follows:

[0008] This invention features separate refrigeration components for the room temperature and refrigerated zones of the sample delivery box, allowing for different temperature settings. In the refrigerated zone, the refrigeration chamber and test tube placement hole are interconnected for better refrigeration; a sealing ring is included to secure and seal the endocrine metabolism specimen tubes. A buffer component is incorporated to prevent test tube movement and minimize damage to red blood cells.

[0009] Based on the above technical concept, the structure of this utility model is a test delivery device for endocrine and metabolic diseases, including a box cover, and further comprising:

[0010] The test box is installed in conjunction with the box lid.

[0011] A buffer assembly, located inside the sample delivery box, is used for buffering endocrine and metabolic disease specimens during the delivery process.

[0012] The cooling component, located inside the sample delivery box, is used for temperature control during the delivery of endocrine and metabolic disease specimens.

[0013] Preferably, the test chamber is divided into two areas: a room temperature area and a refrigerated area, both of which have test tube placement holes.

[0014] Preferably, both the ambient temperature zone and the refrigeration zone are provided with refrigeration chambers, and the refrigeration chamber in the refrigeration zone and the test tube placement hole are connected.

[0015] Preferably, the buffer component includes:

[0016] A buffer element is provided at the bottom inside the placement hole;

[0017] A sealing ring is installed on the inner wall of the placement hole.

[0018] Preferably, the refrigeration assembly includes two sets of power supplies and refrigeration plates, which are respectively located in the ambient temperature zone and the refrigeration zone.

[0019] Compared with the prior art, the beneficial effects of this utility model are:

[0020] 1. This utility model features refrigeration components for both the ambient temperature zone and the refrigerated zone of the sample delivery box. Routine blood test samples are placed in the ambient temperature zone, while samples for endocrine and metabolic diseases such as insulin, pre-insulin, and C-peptide are placed in the refrigerated zone. The refrigeration components allow for different temperature settings. Furthermore, the refrigeration chamber and test tube placement hole in the refrigerated zone are interconnected for better refrigeration performance.

[0021] 2. The sealing ring in this utility model has two effects: first, it fixes the endocrine metabolism specimen test tube; second, it can achieve a sealing effect. In the refrigeration area, since the refrigeration chamber and the test tube placement hole are connected, there is a risk of ice water leakage. The sealing ring can achieve a sealing effect and prevent water leakage.

[0022] 3. This utility model is equipped with a buffer component. Since the test tubes of different endocrine and metabolic disease specimens are of different heights, they will shake when placed in the same test tube rack, which will cause damage to red blood cells and lead to hemolysis. The buffer component can prevent the test tubes from shaking and reduce the damage to red blood cells. Attached Figure Description

[0023] The accompanying drawings are provided to further understand the present invention and form part of the specification. They are used together with the embodiments of the present invention to explain the present invention and do not constitute a limitation thereof.

[0024] In the attached diagram:

[0025] Figure 1 This is a schematic diagram of the endocrine and metabolic disease testing device of this utility model;

[0026] Figure 2 This is a schematic diagram of the structure of the test delivery box of this utility model;

[0027] Figure 3 This is a schematic diagram of the structure of the box cover of this utility model;

[0028] Figure 4 This is a cross-sectional view of the inspection box of this utility model;

[0029] Among them, 1. Box lid, 2. Test box, 21. Room temperature area, 22. Refrigerated area, 23. Test tube placement hole, 24. Water inlet, 25. Refrigeration chamber, 3. Buffer assembly, 31. Buffer component, 32. Sealing ring, 4. Refrigeration assembly, 41. Power supply, 42. Refrigeration chip. Detailed Implementation

[0030] In the description of this utility model, it should be understood that the terms "upper", "lower", "front", "rear", "left", "right", "front end", "rear end", "inner side", "outer side", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0031] In the description of this application, it should also be noted that, unless otherwise expressly specified and limited, the terms "set up," "install," "connect," and "link" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal communication between two components. Those skilled in the art can understand the specific meaning of the above terms in this application according to the specific circumstances.

[0032] The following is in conjunction with the appendix Figure 1-4 The preferred embodiments of the present invention will be described herein. It should be understood that the preferred embodiments described herein are for illustration and explanation only and are not intended to limit the present invention.

[0033] Endocrine and metabolic diseases, as an important branch of systems biology, require comprehensive and precise quantification of the dynamic changes of metabolites in organisms through detection technologies. This, in turn, reveals metabolic responses to environmental stimuli, pathophysiological changes, or genetic variations. In the exploration of metabolomics, the selection and processing of samples are the cornerstones of the research, and the sample delivery process is a crucial link that directly affects the accuracy and reliability of the measurement results.

[0034] Based on the above findings, this application provides a sample delivery device for endocrine and metabolic diseases, which solves the aforementioned problems through the following embodiments.

[0035] Example:

[0036] A sample delivery device for endocrine and metabolic diseases includes a lid 1. The inner wall of the lid 1 is bonded with an aluminum foil insulation film, which can completely block light, air, moisture and bacteria, and prevent heat loss through conduction or convection. A handle is provided on the upper surface of the lid 1 for easy carrying by medical personnel.

[0037] In addition, since the test box 2 is divided into sections, a baffle is installed at the center line of the inner part of the box cover 1 to achieve the same effect of partitioning.

[0038] Test box 2 has insulation material on all four sides and the west side, which can achieve the effect of heat preservation.

[0039] Furthermore, the lower edge of the cover 1 is narrower, and the upper edge of the test box 2 is provided with an installation groove that can be inserted into the lower edge of the cover 1, thereby enabling the test box 2 and the cover 1 to be installed together.

[0040] Furthermore, a matching lock is provided on the side wall of the inspection box 2 and the box cover 1. This lock is common knowledge in the field and will not be described in detail here.

[0041] The test box 2 is divided into two areas: a room temperature area 21 and a refrigerated area 22. Both the room temperature area 21 and the refrigerated area 22 are provided with test tube placement holes 23.

[0042] Both the ambient temperature zone 21 and the refrigeration zone 22 are provided with refrigeration chambers 25, and the refrigeration chamber 25 of the refrigeration zone 22 is connected to the test tube placement hole 23.

[0043] Furthermore, the side wall of the test chamber 2 is provided with a water inlet 24 that communicates with the refrigeration chamber 25. Water can be injected into the refrigeration chamber 25. If it is necessary to replace the water, it can be poured out through the water inlet 24, or a drain outlet is provided at the lower end of the refrigeration chamber 25.

[0044] Buffer assembly 3, located inside the sample delivery box 2, is used for buffering endocrine and metabolic disease specimens during delivery. Buffer assembly 3 includes: a buffer element 31, which is a buffer spring, fixedly installed at the bottom of the placement hole 23; a buffer plate 33, made of rubber, with an inner groove on its upper surface that mates with the bottom of the test tube; and a sealing ring 32, made of silicone, adhered to the inner wall of the placement hole 23.

[0045] In this application, two sealing rings 32 are provided to completely fix the test tube. Because the test tubes have different heights, a buffer 31 is provided to ensure that the bottom of the test tube has a certain degree of support after entering at different depths. It should be noted that the purpose of the buffer 31 in this application is not to reduce the cushioning when the specimen test tube shakes inside the test tube well, but rather to provide support at the bottom. This is because if the test tube is in a shaking state, it can easily lead to hemolysis.

[0046] A cooling assembly 4, located inside the sample delivery box 2, is used for temperature control during the delivery of endocrine and metabolic disease specimens. The cooling assembly 4 includes two power supplies 41 and cooling elements 42, respectively located in the ambient temperature zone 21 and the refrigerated zone 22. Specifically, one cooling element 42 is located in the cooling chamber 25 of the ambient temperature zone 21, and the other cooling element 42 is located in the cooling chamber 25 of the refrigerated zone 22. Each cooling element 42 is electrically connected to its corresponding power supply 41, and the power supply 41 is connected to a switch 43. The connections of the power supplies 41, cooling elements 42, and switches 43, as well as the temperature control technology, are common knowledge to those skilled in the art and will not be elaborated upon here.

[0047] Application Examples:

[0048] The following describes in detail the application of the endocrine and metabolic disease testing device of this application in the field of endocrine and metabolic diseases, with reference to specific application examples.

[0049] In a metabolomics study of a diabetic patient, collected blood was placed in a 4°C ice-water bath and centrifuged for 1 hour. The blood was then centrifuged at 2500g for 15 minutes at 4°C to obtain clear serum. Serum aliquoting and storage were also performed at -80°C to ensure long-term stability of its metabolic characteristics.

[0050] Strict adherence to submission requirements is crucial for ensuring sample quality. Improper handling leading to hemolysis or slight deterioration can introduce changes in metabolites or components within red blood cells, severely interfering with the accuracy of metabolomics data, necessitating the collection of new samples.

[0051] During testing, blood is collected from a diabetic patient into several test tubes to perform tests such as complete blood count, insulin, pre-insulin, and C-peptide. The test tubes are placed in the test tube placement hole 23 and secured tightly by a sealing ring. Water is filled into the cooling chamber 25 through the water inlet 24. Finally, the temperature of the ambient temperature zone 21 and the refrigerated zone 22 is controlled by the cooling element 42.

[0052] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of this utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claims. The scope of protection of this utility model is defined by the appended claims and their equivalents.

Claims

1. A sample delivery device for endocrine and metabolic diseases, comprising a lid (1), characterized in that, Also includes: The inspection box (2) is installed in conjunction with the box cover (1); The buffer component (3) is set inside the sample delivery box (2) and is used for buffering endocrine and metabolic disease specimens during the delivery process. The cooling component (4) is installed inside the sample delivery box (2) and is used for temperature control during the sample delivery process of endocrine and metabolic diseases.

2. The endocrine and metabolic disease testing device according to claim 1, characterized in that, The test box (2) is divided into two areas: a room temperature area (21) and a refrigerated area (22). Both the room temperature area (21) and the refrigerated area (22) have test tube placement holes (23).

3. The endocrine and metabolic disease testing device according to claim 2, characterized in that, Both the ambient temperature zone (21) and the refrigeration zone (22) are provided with refrigeration chambers (25), and the refrigeration chamber (25) of the refrigeration zone (22) and the test tube placement hole (23) are connected.

4. The endocrine and metabolic disease testing device according to claim 3, characterized in that, The buffer component (3) includes: A buffer (31) is provided at the bottom inside the placement hole (23); A sealing ring (32) is provided on the inner side wall of the placement hole (23).

5. The endocrine and metabolic disease testing device according to claim 4, characterized in that, The refrigeration component (4) includes two power supplies (41) and a refrigeration chip (42), which are respectively located in the ambient temperature zone (21) and the refrigeration zone (22).

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