Stirred reaction kettle for synthesis of levofloxacin

Abstract

The utility model discloses a stirring type reaction kettle for levofloxacin acid synthesis, including stirring type reaction kettle main part and absorption tank. The utility model discloses a processing cavity, plugging disc has been adopted, and the acid waste gas produced when levofloxacin acid synthesis can enter the absorption tank in the pipeline, because the absorption tank is internally provided with multiple groups of independent processing cavities through the partition board, therefore, the acid waste gas can be treated independently through the processing cavity, and the processing cavity is internally provided with multiple groups of plugging discs, and the through -flow hole is staggered and arranged on the plugging disc, guarantees its full reaction with lye, and the independent setting of processing cavity can guide the waste gas into other chamber inside when the use of lye inside one group of chambers is completed, thereby guaranteeing the continuity of tail gas treatment, while not delaying the waste liquid discharge and recharging of the corresponding chamber, avoiding shutdown maintenance, reducing the influence on the operation, with good waste gas treatment effect, small maintenance influence, short operation delay advantage.

Description

Technical Field

[0001] This utility model relates to the field of levofluorocarboxylic acid synthesis technology, and more specifically, to a stirred reactor for the synthesis of levofluorocarboxylic acid. Background Technology

[0002] Ofofluorocarboxylic acid is an intermediate of levofloxacin. Levofloxacin is a quinolone antibiotic with broad-spectrum antibacterial activity and strong antibacterial properties. It has strong antibacterial activity against most Enterobacteriaceae, such as Escherichia coli, Klebsiella spp., Proteus spp., Salmonella spp., Shigella spp., and Gram-negative bacteria like Haemophilus influenzae, Legionella pneumophila, and Neisseria gonorrhoeae. It also has antibacterial activity against Gram-positive bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus pyogenes, as well as Mycoplasma pneumoniae and Chlamydia pneumoniae, but its activity against anaerobic bacteria and Enterococci is relatively poor.

[0003] During the synthesis of levofluorocarboxylic acid, acidic waste gas is generated in the stirred hydrolysis reactor. Direct discharge of this acidic waste gas will cause environmental pollution. Therefore, the tail gas (the main components of the acidic waste gas include hydrogen fluoride (HF), hydrogen chloride (HCl), sulfur dioxide (SO2), etc.) needs to be treated to meet emission standards. Traditionally, the treatment is carried out in a single chamber. Once the internal alkaline solution (such as NaOH) is depleted, the machine needs to be shut down for discharge and replenishment, which has a significant impact on the continuity of operation, resulting in reduced operating efficiency. Furthermore, the contact time between the tail gas and the alkaline solution is short, resulting in insufficient treatment and reduced treatment quality. Overall, the performance is not ideal.

[0004] No effective solutions have yet been proposed to address the problems in the relevant technologies. Utility Model Content

[0005] (a) Technical problems to be solved

[0006] To address the shortcomings of existing technologies, this invention provides a stirred reactor for the synthesis of levofluorocarboxylic acid, which has the advantages of good waste gas treatment effect, minimal maintenance impact, and short operation delay, thereby solving the problems mentioned in the background technology.

[0007] (II) Technical Solution

[0008] To achieve the advantages of good waste gas treatment effect, minimal maintenance impact, and short operation delay, the specific technical solution adopted by this utility model is as follows:

[0009] A stirred reactor for the synthesis of levofluorocarboxylic acid includes a stirred reactor body and an absorption tank. The absorption tank is located on one side of the stirred reactor body. A sealing plate is welded to the top of the absorption tank. Several processing chambers are located on the top of the sealing plate via a partition plate. Several sets of sealing plates are evenly installed inside each processing chamber. Flow holes are staggered on the surface of the sealing plates at different locations. A gas guide pipe is installed through and sealed on one side of each sealing plate. The top of the gas guide pipe passes through the sealing plate and connects to a second multi-port pipe. The bottom of the gas guide pipe is located at the bottom of the processing chamber and connects to a distribution pipe. Several dispersion tubes are located on the surface of the distribution pipe. The inlet of the second multi-port pipe penetrates one side of the absorption tank and connects to the second exhaust pipe. A second solenoid valve is installed at the outlet of the second multi-port pipe. A liquid supply pipe is installed at the top of one side surface of the absorption tank. A flow valve is installed on the liquid supply pipe. The outlet of the liquid supply pipe is connected to the first multi-port pipe. The branch pipes on the first multi-port pipe are connected to the processing chambers at different locations. A first solenoid valve is installed at the outlet of the first multi-port pipe. A multi-port pipe is also installed on the inner surface of one side of the first multi-port pipe within the processing chamber. The multi-port pipes are centrally connected to the exhaust gas discharge pipe, and a solenoid valve is also installed on the multi-port pipe. The exhaust gas discharge pipe is located at the top of the absorption tank.

[0010] Furthermore, a first exhaust pipe is installed on one side of the top of the stirred reactor body, and the outlet of the first exhaust pipe is connected to the condenser.

[0011] Furthermore, a baffle is installed at an angle on one side of the condenser, and an opening is provided at the top of the baffle surface. A refrigerant coil is installed on one side of the baffle inside the condenser. The two ends of the refrigerant coil are connected to the refrigerant inlet and the refrigerant outlet, respectively. The condenser outlet is connected to the second exhaust pipe.

[0012] Furthermore, the bottom of one side surface of the condenser is connected to the main body of the stirred reactor via a liquid reflux pipe.

[0013] Furthermore, support legs are symmetrically installed at the bottom of the absorption tank.

[0014] Furthermore, several sets of waste liquid discharge pipes are installed at the bottom of the absorption tank corresponding to the position of the treatment chamber.

[0015] Furthermore, a pH meter is installed inside the processing chamber.

[0016] Furthermore, the pH meter and the solenoid valve are both connected to the control panel via wires, and the control panel is located on one side of the absorption tank.

[0017] (III) Beneficial Effects

[0018] Compared with the prior art, this utility model provides a stirred reactor for the synthesis of levofluorocarboxylic acid, which has the following advantages:

[0019] This invention employs a treatment chamber and sealing discs. Acidic waste gas generated during the synthesis of levofluorocarboxylic acid enters the absorption tank through a pipeline. The absorption tank has multiple independently existing treatment chambers separated by partitions, allowing for independent treatment of the acidic waste gas. Each treatment chamber contains multiple sealing discs with staggered flow holes, effectively extending the waste gas retention time and ensuring sufficient reaction with the alkaline solution, thus improving the treatment quality. Furthermore, the independent design of the treatment chambers allows waste gas to be transferred to other chambers when the alkaline solution in one chamber is depleted, ensuring continuous tail gas treatment without interrupting the discharge and replenishment of waste liquid in the corresponding chamber, avoiding downtime for maintenance, and minimizing operational disruption. This invention offers advantages such as good waste gas treatment effect, minimal maintenance impact, and short operational downtime. Attached Figure Description

[0020] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0021] Figure 1 This is a schematic diagram of the stirred reactor for the synthesis of levofluorocarboxylic acid proposed in this utility model;

[0022] Figure 2 This is a schematic diagram of the sealing disc of this utility model;

[0023] Figure 3 This is a schematic diagram of the distribution structure of the processing cavity of this utility model;

[0024] Figure 4 This is a schematic diagram of the distribution tube and dispersion tube of this utility model.

[0025] In the picture:

[0026] 1. Stirred reactor body; 2. First exhaust pipe; 3. Baffle; 4. Condenser; 5. Refrigerant coil; 6. Refrigerant inlet; 7. Refrigerant outlet; 8. Liquid reflux pipe; 9. Absorption tank; 10. Second exhaust pipe; 11. Sealing plate; 12. First solenoid valve; 13. Second multi-way pipe; 14. Waste gas discharge pipe; 15. Second solenoid valve; 16. Control panel; 17. First multi-way pipe; 18. Gas guide pipe; 19. Flow hole; 20. Sealing plate; 21. pH meter; 22. Dispersion pipe; 23. Distribution pipe; 24. Support leg; 25. Waste liquid discharge pipe; 26. Partition plate; 27. Processing chamber; 28. Flow valve; 29. ​​Liquid supply pipe. Detailed Implementation

[0027] To further illustrate the various embodiments, the present invention provides accompanying drawings, which are part of the disclosure of the present invention. These drawings are mainly used to illustrate the embodiments and can be used in conjunction with the relevant descriptions in the specification to explain the operating principles of the embodiments. With reference to these contents, those skilled in the art should be able to understand other possible implementation methods and the advantages of the present invention. The components in the figures are not drawn to scale, and similar component symbols are usually used to represent similar components.

[0028] According to an embodiment of the present invention, a stirred reactor for the synthesis of levofluorocarboxylic acid is provided.

[0029] The present invention will now be further described in conjunction with the accompanying drawings and specific embodiments, such as... Figure 1-4As shown, the stirred reactor for the synthesis of levofluorocarboxylic acid according to an embodiment of the present invention includes a stirred reactor body 1 and an absorption tank 9. The absorption tank 9 is located on one side of the stirred reactor body 1. A sealing plate 11 is welded to the top of the absorption tank 9. Several processing chambers 27 are provided on the top of the sealing plate 11 via a partition plate 26. Several blocking plates 20 are evenly installed inside the processing chambers 27. Flow holes 19 are staggered on the surface of the blocking plates 20 at different positions. A gas guide pipe 18 is installed through and sealed on one side of the blocking plate 20. The top of the gas guide pipe 18 passes through one side of the sealing plate 11 and connects to a second multi-port pipe 13. The bottom end of the gas guide pipe 18 is located at the bottom of the inner side of the processing chamber 27 and connects to a distribution pipe 23. The surface of the distribution pipe 23 is provided with... Several sets of dispersion pipes 22 are provided. The inlet of the second multi-port pipe 13 passes through one side of the absorption tank 9 and is connected to the second exhaust pipe 10. The outlet of the second multi-port pipe 13 is equipped with a second solenoid valve 15. A liquid supply pipe 29 is installed at the top of one side surface of the absorption tank 9. A flow valve 28 is installed on the liquid supply pipe 29. The outlet of the liquid supply pipe 29 is connected to the first multi-port pipe 17. The branch pipes on the first multi-port pipe 17 are connected to the processing chambers 27 at different positions. A first solenoid valve 12 is installed at the outlet of the first multi-port pipe 17. A multi-port pipe is also provided on one side of the first multi-port pipe 17 at the inner surface of the processing chamber 27. The multi-port pipes are connected to the exhaust pipe 14. A solenoid valve is also provided on the multi-port pipe. The exhaust pipe 14 is located at the top of the absorption tank 9.

[0030] In one embodiment, a first exhaust pipe 2 is installed on one side of the top of the stirred reactor body 1. The outlet of the first exhaust pipe 2 is connected to the condenser 4. The first exhaust pipe 2 is set up to discharge the acidic waste gas generated during the synthesis of levofluorocarboxylic acid, so that it can enter the treatment chamber 27 through the second exhaust pipe 10 for corresponding purification, thereby ensuring the treatment quality of the waste gas and facilitating its subsequent qualified discharge.

[0031] In one embodiment, a baffle 3 is installed at an angle on one side of the condenser 4, and an opening is provided at the top of the surface of the baffle 3. A refrigerant coil 5 is installed on one side of the baffle 3 inside the condenser 4. The two ends of the refrigerant coil 5 are connected to the refrigerant inlet 6 and the refrigerant outlet 7, respectively. The outlet of the condenser 4 is connected to the second exhaust pipe 10. The refrigerant inside the condenser 4 can be adjusted according to the requirements, such as liquid nitrogen, cooling water, coolant, etc., which will not be elaborated in detail here.

[0032] In one embodiment, the bottom of one side surface of the condenser 4 is connected to the main body 1 of the stirred reactor via a liquid return pipe 8. The liquid return pipe 8 is provided to return the liquid condensed by the condenser 4 for reuse.

[0033] In one embodiment, support legs 24 are symmetrically installed at the bottom of the absorption tank 9. The support legs 24 are provided to support and fix the entire device for better use.

[0034] In one embodiment, several sets of waste liquid discharge pipes 25 are installed at the bottom of the absorption tank 9 corresponding to the processing chamber 27. The waste liquid discharge pipes 25 are provided to facilitate the discharge of waste liquid after use, so as to facilitate the subsequent addition of alkali solution.

[0035] In one embodiment, a pH meter 21 is installed inside the processing chamber 27. The pH meter 21 is an industrial online pH meter, MIK-PH6.0, used to detect the pH value inside the processing chamber 27, thereby determining whether the alkali solution can continue to be used, facilitating timely discharge of waste liquid and replenishment of alkali solution.

[0036] In one embodiment, the pH meter 21 and the solenoid valve are both connected to the control panel 16 via wires, and the control panel 16 is located on one side of the absorption tank 9. The control panel 16 integrates a PLC (Siemens S7-1200) and an HMI (10-inch touch screen). The solenoid valve is made of corrosion-resistant and acid-alkali resistant material used by Kaiborui Chemical Pharmaceutical Co., Ltd., and is used to control various components.

[0037] Working principle: In actual use, the absorption tank 9 contains alkaline solution, which is added to the absorption tank 9 through the supply pipe 29. The saturated waste liquid after use is discharged through the waste liquid discharge pipe 25. The acidic gas generated in the stirred reactor body 1 enters the condenser 4 through the first exhaust pipe 2. After being condensed by the condenser 4, the liquid accumulates in the condenser 4, and the gas enters the absorption tank 9 through the second exhaust pipe 10. After absorption and filtration in the absorption tank 9, it is discharged through the waste gas discharge pipe 14, which can effectively reduce environmental pollution. The design of the baffle 3 prevents the liquid from flowing back to the stirred reactor body 1 directly from the first exhaust pipe 2. Moreover, the absorption tank 9 has a multi-chamber design formed by the partition plate 26, and each processing chamber 27 is independent. The processing chambers 27 are configured such that each chamber is connected to a corresponding pipe on a second multi-port pipe 13 connected to the bottom of the second exhaust pipe 10. This allows the acidic gas to be processed to be introduced into the corresponding processing chamber 27. A second solenoid valve 15 is installed on the pipe; by controlling the opening and closing of the second solenoid valve 15 at different positions, the acidic gas can be smoothly introduced to a designated location for subsequent processing. Due to the independent design of the chambers, after the alkali solution in one set of chambers is used up, the gas can be introduced into other processing chambers 27 by opening and closing the second solenoid valve 15. The used processing chamber 27 can discharge waste liquid through the waste liquid discharge pipe 25 at the bottom, while new alkali solution is supplied through the liquid supply pipe 29. During the introduction process, the introduced alkali solution enters the cavity through a designated pipe on the first multi-port pipe 17 at one end of the supply pipe 29, thus replenishing the alkali solution. The supply pipe 29 is equipped with a flow valve 28 to control the amount of alkali solution added, ensuring a stable addition and guaranteeing the subsequent treatment quality. During tail gas treatment, the introduced tail gas flows through the distribution pipe 23 at the bottom of the treatment chamber 27 into the corresponding dispersion pipe 22 and exits through openings on the surface of the dispersion pipe 22. The exited tail gas smoothly enters the alkali solution, reacting with it to purify the tail gas. Furthermore, the treatment chamber 27 has multiple sets of sealing discs 20 arranged longitudinally inside, and the sealing discs 20... The device is provided with staggered flow holes 19. The flow holes 19 at different positions can increase the retention time of the exhaust gas, thereby allowing the exhaust gas to come into more complete contact with the alkaline solution, thus improving the overall treatment quality. At the same time, the side of the first multi-port pipe 17 is located at the top of the inside of the treatment chamber 27 and is equipped with a multi-port pipe (not shown). All multi-port pipes (not shown) are connected to the exhaust gas discharge pipe 14 and are equipped with solenoid valves (not shown). Therefore, the direction of exhaust gas discharge can be controlled by opening and closing the solenoid valves (not shown), so that the treated exhaust gas inside the corresponding treatment chamber 27 can be discharged, thereby ensuring the normal use of the device. The device as a whole has the advantages of good exhaust gas treatment effect, low maintenance impact, and short operation delay.

[0038] In this utility model, unless otherwise explicitly specified and limited, the terms "installation", "setting", "connection", "fixing", "screw connection", etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal connection of two components or the interaction between two components. Unless otherwise explicitly limited, those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0039] The above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A stirred reactor for the synthesis of levofluorocarboxylic acid, comprising a stirred reactor body (1) and an absorption tank (9), characterized in that, The main body (1) of the stirred reactor is provided with an absorption tank (9) on one side. A sealing plate (11) is welded to the top of the absorption tank (9). The top of the sealing plate (11) is provided with several processing chambers (27) through a partition plate (26). Several sets of sealing plates (20) are evenly installed inside the processing chambers (27). The surface of the sealing plates (20) at different positions is provided with flow holes (19) in an alternating manner. A gas guide pipe (18) is installed through and sealed on one side of the sealing plate (20). The top of the gas guide pipe (18) passes through the sealing plate (11) and is connected to the second multi-port pipe (13). The bottom end of the gas guide pipe (18) is located at the bottom of the processing chamber (27) and is connected to the distribution pipe (23). Several sets of dispersion pipes (22) are provided on the surface of the distribution pipe (23). The inlet of the second multi-port pipe (13) is located at... A second exhaust pipe (10) is connected to one side of the absorption tank (9). A second solenoid valve (15) is provided at the outlet of the second multi-port pipe (13). A liquid supply pipe (29) is installed at the top of one side of the absorption tank (9). A flow valve (28) is installed on the liquid supply pipe (29). The outlet of the liquid supply pipe (29) is connected to the first multi-port pipe (17). The branch pipes on the first multi-port pipe (17) are connected to the processing chambers (27) at different positions. A first solenoid valve (12) is provided at the outlet of the first multi-port pipe (17). A multi-port pipe is also provided on one side of the first multi-port pipe (17) at the inner surface of the processing chamber (27). The multi-port pipes are connected to the exhaust pipe (14). A solenoid valve is also provided on the multi-port pipe. The exhaust pipe (14) is located at the top of the absorption tank (9).

2. The stirred reactor for the synthesis of levofluorocarboxylic acid according to claim 1, characterized in that, The first exhaust pipe (2) is installed on one side of the top of the stirred reactor body (1), and the outlet of the first exhaust pipe (2) is connected to the condenser (4).

3. The stirred reactor for the synthesis of levofluorocarboxylic acid according to claim 2, characterized in that, A baffle (3) is installed at an angle on one side inside the condenser (4), and an opening is provided at the top of the surface of the baffle (3). A refrigerant coil (5) is installed on one side of the baffle (3) inside the condenser (4). The two ends of the refrigerant coil (5) are connected to the refrigerant inlet (6) and the refrigerant outlet (7) respectively. The outlet of the condenser (4) is connected to the second exhaust pipe (10).

4. The stirred reactor for the synthesis of levofluorocarboxylic acid according to claim 2, characterized in that, The bottom of one side surface of the condenser (4) is connected to the main body (1) of the stirred reactor via a liquid return pipe (8).

5. The stirred reactor for the synthesis of levofluorocarboxylic acid according to claim 1, characterized in that, Support legs (24) are symmetrically installed at the bottom of the absorption tank (9).

6. The stirred reactor for the synthesis of levofluorocarboxylic acid according to claim 1, characterized in that, Several sets of waste liquid discharge pipes (25) are installed at the bottom of the absorption tank (9) and at the corresponding position of the treatment chamber (27).

7. The stirred reactor for the synthesis of levofluorocarboxylic acid according to claim 1, characterized in that, A pH meter (21) is provided inside the processing chamber (27).

8. The stirred reactor for the synthesis of levofluorocarboxylic acid according to claim 7, characterized in that, The pH meter (21) and the solenoid valve are connected to the control panel (16) via wires, and the control panel (16) is located on one side of the surface of the absorption tank (9).

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