A device for the pre-treatment of solid samples of drugs

Abstract

The utility model relates to a drug processing device technical field especially, more particularly to a kind of drug solid sample pretreatment device including mounting frame, base, blocking frame, support plate, fixing frame, placement plate, electric push rod, push plate, electronic balance and discharge pipe, mounting frame lower surface is fixedly connected with base, blocking frame for limiting drug solid position is installed around in mounting frame left side cavity, placement plate for placing drug solid is installed in the lower end of blocking frame, fixing frame is installed in the lower end of placement plate in mounting frame side surface, support plate is vertically installed in the left side of fixing frame upper surface, electric push rod for pushing to next step after weighing is completed is installed in the center of support plate surface, push plate corresponding with placement plate interior is equipped in electric push rod piston end, electronic balance is installed in the placement plate interior, the utility model realizes through integrated electronic balance, electric push rod etc. Automatic assembly, ensure the accuracy and consistency of each sample processing.

Description

Technical Field

[0001] This utility model relates to the technical field of drug processing devices, and in particular to a drug solid sample pretreatment device. Background Technology

[0002] The main function of a drug solid sample pretreatment device is to pretreat drug solid samples for subsequent analysis and detection. This laboratory equipment is primarily used for pretreating drug solid samples, including steps such as sampling, processing, washing, concentration, extraction, and separation. Its purpose is to remove interfering substances from the sample, enhance the sensitivity and accuracy of the analysis, and thus improve the quality and reliability of the analytical results. Drug solid sample pretreatment devices are widely used in the field of drug detection, playing a particularly important role in confirming drug-related cases. By pretreating drug solid samples, matrix interference can be effectively removed, and sample concentration can be increased, thereby providing accurate data support for subsequent qualitative and semi-quantitative analyses.

[0003] Meanwhile, during manual processing, the operator's skill level, experience, and concentration will affect the sample processing results. Even slight differences in operation may lead to significant deviations in the final analysis results. Moreover, handling drug samples, especially highly toxic substances, poses a direct health threat to the operator. Exposure to these substances may cause acute poisoning or chronic health problems, such as respiratory diseases and skin irritation. Some drug samples are flammable and explosive, and careless handling during the process may cause fires or explosions. Utility Model Content

[0004] In order to overcome the inconsistencies and errors that may result from traditional manual processing methods, and given that safety is the primary consideration when processing drug samples, this utility model provides a drug solid sample pretreatment device.

[0005] The technical solution is as follows: A drug solid sample pretreatment device includes an installation frame, a base, a blocking frame, a support plate, a fixing frame, a placement plate, an electric push rod, a push plate, an electronic balance, and a discharge pipe. The base is fixedly connected to the lower surface of the installation frame. A blocking frame for limiting the position of the drug solid is installed around the cavity on the left side of the installation frame. A placement plate for placing the drug solid is installed at the lower end of the blocking frame. A fixing frame is installed on the side surface of the installation frame at the lower end of the placement plate. A support plate is vertically installed on the left side of the upper surface of the fixing frame. An electric push rod for pushing the sample to the next step after weighing is installed at the center of the support plate. The piston end of the electric push rod is provided with a push plate corresponding to the inside of the placement plate. An electronic balance is installed inside the placement plate. A discharge pipe is obliquely installed on the side of the placement plate away from the electric push rod.

[0006] Furthermore, a display screen for controlling electrical structures is installed at the corner of the mounting frame surface, and a methanol tank is provided on the upper surface of the base below the placement plate. A feed pipe is installed on the rear surface of the methanol tank near the corner, and a methanol inlet is installed at the top of the feed pipe.

[0007] Furthermore, a grinding frame connected to a methanol tank is provided on the upper surface of the base at the lower end of the discharge pipe. A solenoid valve is provided between the grinding frame and the methanol tank, and a grinding chamber is provided in the center of the grinding frame.

[0008] Furthermore, a cylinder is located at the center of the grinding chamber, and a pressure plate is installed around the outside of the piston end of the cylinder. A sleeve is installed at the end of the grinding frame away from the solenoid valve.

[0009] Furthermore, a precision pump is installed between the sleeve and the grinding frame, and a connecting pipe is vertically installed on the lower side of the sleeve, with a test tube installed at the lower end of the connecting pipe.

[0010] Furthermore, a support frame is fitted around the outside of the test tube, and a sealing plate is installed around the top of the support frame outside the connecting tube. A cabinet door is fastened to the outside of the support frame.

[0011] Furthermore, a sliding clamp connected to the test tube is installed on the inner side of the sealing plate, and a filter membrane is installed on the inner side of the top of the test tube.

[0012] Furthermore, a centrifugation module is installed at the lower end of the test tube, and a placement rack that is rotatably connected to the test tube is installed at the center of the upper surface of the centrifugation module.

[0013] The beneficial effects are as follows: This utility model achieves accurate measurement of sample weight by integrating precision measuring tools such as electronic balances, reducing errors caused by manual operation and improving the accuracy and reliability of experimental results. The device is designed with a blocking frame to limit the position of solid drugs and adopts an automated process to reduce manual intervention, thereby reducing the risk of operators coming into contact with harmful substances. In addition, the sealing design, such as the application of sealing plates, helps to prevent the leakage of toxic gases, further protecting the safety of operators. The integrated design of weighing, propulsion, dissolving, grinding, filtering and centrifugation simplifies the sample processing process, eliminates the need for multiple sample transfers, saves time, and improves overall work efficiency. Attached Figure Description

[0014] Figure 1 This is a three-dimensional structural diagram of a drug solid sample pretreatment device according to the present invention;

[0015] Figure 2 This is a three-dimensional structural diagram of the present invention;

[0016] Figure 3 This is a three-dimensional structural diagram of the present invention;

[0017] Figure 4 This is a three-dimensional structural diagram of the present invention;

[0018] Figure 5 This is a three-dimensional structural diagram of the present invention.

[0019] In the attached diagram, the following are the reference numerals: 1. Mounting frame; 2. Display screen; 3. Base; 4. Blocking frame; 5. Support plate; 6. Fixing frame; 7. Methanol tank; 8. Placement plate; 9. Electric push rod; 10. Push plate; 11. Electronic balance; 12. Discharge pipe; 13. Feed pipe; 14. Methanol inlet; 15. Grinding rack; 16. Grinding chamber; 17. Pressure plate; 18. Cylinder; 19. Precision pump; 20. Sleeve; 21. Connecting pipe; 22. Sealing plate; 23. Support frame; 24. Cabinet door; 25. Sliding clamp; 26. Test tube; 27. Placement rack; 28. Centrifuge module; 29. ​​Filter membrane; 30. Solenoid valve. Detailed Implementation

[0020] The present invention will now be described in detail with reference to the accompanying drawings and specific embodiments.

[0021] Among the currently discovered feasible technologies, the following are described:

[0022] The drug solid sample pretreatment device is a highly specialized and precise laboratory instrument designed to perform a series of complex pretreatment operations on drug solid samples to ensure the efficiency and accuracy of subsequent analysis and testing. Its design aims to provide a comprehensive and reliable solution for drug detection through a series of rigorous scientific steps, including but not limited to sampling, processing, cleaning, concentration, extraction, and separation. Through precise design and automated processes, the device can effectively remove various interfering substances in the sample, such as impurities and other non-target compounds, thereby improving the sensitivity and accuracy of the analysis. Enhanced analytical results: During sample processing, the device can separate drugs from complex matrices through various techniques such as dissolution, grinding, filtration, and centrifugation, and may concentrate them for subsequent qualitative and quantitative analysis. Improved result quality: Standardized sample pretreatment not only reduces errors caused by human factors but also improves the repeatability and reliability of experimental results, providing strong data support for forensic identification. Application areas and importance: The drug solid sample pretreatment device is widely used in the field of drug detection and plays a crucial role in confirming drug-related cases. It not only helps forensic toxicologists more accurately identify and quantify drug components, but also solves the matrix effect problem, effectively removing or reducing the influence of the sample matrix on the analysis process. This is especially crucial for the detection of trace drugs in complex matrices, providing data support. Samples that have undergone pretreatment are more suitable for use with high-sensitivity analytical instruments (such as GC-MS, LC-MS, etc.). These instruments can provide more accurate qualitative and semi-quantitative analysis results based on the pretreated samples. Furthermore, it provides legal evidence support. In judicial proceedings, accurate drug analysis results are one of the key bases for determining a case. High-quality pretreatment work is directly related to the credibility and authority of the final analysis report, helping to ensure judicial fairness. In short, the drug solid sample pretreatment device, through its carefully designed functional modules and rigorous operating procedures, significantly improves the quality and efficiency of drug detection, providing solid technical support for scientific research, public safety maintenance, and law enforcement. The application of this device is not limited to the field of forensic medicine, but is also suitable for drug surveillance, environmental monitoring, and many other occasions requiring highly accurate analysis.

[0023] In the manual handling of solid drug samples, the operator's skill level, experience, and concentration significantly affect the sample processing results. Even subtle differences in operation can lead to significant deviations in the final analytical results. This uncertainty not only reduces the reliability and repeatability of experimental data but may also mislead subsequent judicial decisions or scientific research. Each operator's professional skills and experience differ, directly impacting the consistency and accuracy of sample processing. For example, in critical steps such as weighing, dissolving, and filtering, subtle differences in manual operation can lead to inconsistent sample concentrations, thus affecting the accuracy of analytical results. Prolonged focus on meticulous operations can easily lead to fatigue, thereby reducing the operator's concentration. Especially when performing repeated operations, any brief distraction can lead to errors. Weighing is a crucial step in sample processing, directly related to the accuracy and repeatability of subsequent experimental results. Different operators may perform differently when using a balance for precise weighing due to differences in their professional skills and experience. For example, inexperienced operators may not fully grasp how to avoid the influence of external factors (such as airflow and temperature changes) on weighing accuracy, or may fail to strictly follow the standard operating procedures (SOPs), resulting in deviations in sample weight. Even minute differences in quality can be amplified in subsequent chemical reactions, affecting the overall experimental results and significantly impacting the final outcome. Handling drug samples, especially highly toxic substances, poses a direct health threat to operators. Exposure to these toxic substances can cause acute poisoning or chronic health problems, including but not limited to respiratory illnesses, skin irritation, and other long-term health effects. Lack of appropriate protective measures or improper operating procedures increase exposure risks, potentially endangering the lives of operators. Some drug samples are flammable and explosive, and careless handling in a laboratory environment can easily lead to fires or explosions. Such accidents not only cause personal injury to operators but also severely damage laboratory facilities and the environment. Therefore, ensuring strict adherence to safe operating procedures is crucial. Manual handling of drug samples involves many uncontrollable factors and technical limitations, restricting the quality and reliability of experimental data and creating serious health and safety hazards.

[0024] In contrast, a specially designed drug solid sample pretreatment device can effectively overcome the above problems. The automated process reduces human error and improves processing efficiency and consistency of results. At the same time, the closed system design protects operators from harmful substances to the greatest extent and greatly improves laboratory safety standards. In this way, not only can more accurate and reliable analytical data be obtained, but also a safer working environment can be provided for operators.

[0025] like Figures 1-5As shown, a drug solid sample pretreatment device includes an installation frame 1, a base 3, a blocking frame 4, a support plate 5, a fixing frame 6, a placement plate 8, an electric push rod 9, a push plate 10, an electronic balance 11, and a discharge pipe 12. The base 3 is fixedly connected to the lower surface of the installation frame 1. The blocking frame 4, which is used to limit the position of the drug solid, is installed around the cavity on the left side of the installation frame 1. The placement plate 8, which is used to place the drug solid, is installed at the lower end of the blocking frame 4. The fixing frame 6 is installed on the side surface of the installation frame 1 at the lower end of the placement plate 8. The support plate 5 is vertically installed on the left side of the upper surface of the fixing frame 6. The electric push rod 9, which is used to push the sample to the next step after weighing, is installed at the center of the surface of the support plate 5. The piston end of the electric push rod 9 is provided with a push plate 10 corresponding to the inside of the placement plate 8. The electronic balance 11 is installed inside the placement plate 8. The discharge pipe 12 is installed obliquely on the side of the placement plate 8 away from the electric push rod 9.

[0026] A display screen 2 for controlling electrical structures is installed at the corner of the mounting frame 1. A methanol tank 7 is located on the upper surface of the base 3 below the placement plate 8. A feed pipe 13 is installed on the rear surface of the methanol tank 7 near the corner. A methanol inlet 14 is installed at the top of the feed pipe 13. Through the integrated control interface, operators can easily monitor and adjust equipment parameters in real time, improving the convenience and accuracy of operation. A grinding rack 15 connected to the methanol tank 7 is located on the upper surface of the base 3 below the discharge pipe 12. A solenoid valve 30 is installed between the grinding rack 15 and the methanol tank 7. A grinding chamber 16 is opened in the center of the grinding rack 15, providing a centralized and convenient solvent management system to ensure the safety and accuracy of solvent addition and simplify the experimental preparation process.

[0027] First, the solid drug sample is placed on the placement plate 8 below the barrier frame 4. The barrier frame 4 is installed around the cavity on the left side of the mounting frame 1 to restrict the position of the solid drug. The placement plate 8 is equipped with an electronic balance 11 for accurately measuring the weight of the sample. The operator can monitor and adjust the equipment parameters in real time through the display screen 2 at the corner of the mounting frame 1 to ensure the accuracy and convenience of the weighing process. After weighing, the electric push rod 9 on the support plate 5 is activated, pushing the push plate 10 connected to its piston end to push the sample on the placement plate 8 toward the grinding frame 15. The cylinder 18 at the center of the grinding frame 15 drives the pressure plate 17 to crush the sample for subsequent analysis.

[0028] Please see Figures 3-4A cylinder 18 is located at the center of the grinding chamber 16. A pressure plate 17 is installed around the piston end of the cylinder 18. A sleeve 20 is installed at the end of the grinding frame 15 away from the solenoid valve 30, realizing automated sample processing. The solenoid valve 30 precisely controls the solvent flow rate, ensuring the accuracy of the solvent amount during grinding. A precision pump 19 is installed between the sleeve 20 and the grinding frame 15. A connecting pipe 21 is vertically installed on the lower side of the sleeve 20, and a test tube 26 is installed at the lower end of the connecting pipe 21. Mechanical force is used to efficiently complete sample pulverization, improving processing efficiency and ensuring that the sample particles are of uniform size, which is beneficial for subsequent analysis. The precision pump 19 accurately transfers liquid, reducing errors caused by manual operation and improving the reliability of experimental results. A support frame 23 is fitted on the outside of the test tube 26. A sealing plate 22 is installed around the outside of the connecting tube 21 at the top, and a cabinet door 24 is fastened to the outside of the support frame 23, which enhances the overall stability and safety of the device, protects the internal components from external contamination, and maintains a clean working environment. A sliding clamp 25 connected to the test tube 26 is installed inside the sealing plate 22, and a filter membrane 29 is installed inside the top of the test tube 26 to effectively prevent cross-contamination and ensure the independence of each sample. At the same time, the filter membrane 29 helps to remove unwanted particles and improve sample purity. A centrifuge module 28 is installed at the bottom of the test tube 26, and a placement rack 27 that is rotatably connected to the test tube 26 is installed at the center of the upper surface of the centrifuge module 28 to achieve rapid sample separation, providing a purer and more concentrated sample for subsequent analysis steps and improving work efficiency.

[0029] After initial weighing and propulsion steps, the solid drug sample to be processed is fed into the grinding chamber 16 of the grinding frame 15. A cylinder 18 is located at the center of the grinding chamber 16, with a pressure plate 17 surrounding its piston end. Activating the cylinder 18 causes the piston to push the pressure plate 17, applying pressure to the sample. This mechanical force efficiently completes the sample pulverization process, resulting in more uniform particle size, which is beneficial for subsequent analysis. A solenoid valve 30 precisely controls the flow rate of methanol from the methanol tank 7 to the grinding chamber 16, ensuring accurate solvent usage during the grinding process. This step is crucial for dissolving samples, cleaning, or other chemical treatments. A precision pump 19 is installed between the sleeve 20 and the grinding rack 15 to precisely transfer the solution containing the sample from the grinding chamber 16 to the test tube 26 at the end of the connecting tube 21 below. A sliding clamp 25 is installed inside the sealing plate 22, which can be adjusted to accommodate test tubes 26 of different sizes, effectively preventing cross-contamination between samples and ensuring the independence of each sample. A filter membrane 29 is installed inside the top of the tube to help remove unwanted particles and improve sample purity. Finally, the centrifuge module 28 installed at the lower end of the test tube 26 starts to work. The placement rack 27, which is rotatably connected to the center of the upper surface of the centrifuge module 28 and the test tube 26, allows the test tube 26 to rotate rapidly, achieving rapid sample separation.

[0030] The above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A pretreatment device for solid drug samples, characterized in that, The system includes an installation frame (1); it also includes a base (3), a blocking frame (4), a support plate (5), a fixing frame (6), a placement plate (8), an electric push rod (9), a push plate (10), an electronic balance (11), and a discharge pipe (12). The base (3) is fixedly connected to the lower surface of the installation frame (1). A blocking frame (4) for limiting the position of solid drugs is installed around the cavity on the left side of the installation frame (1). A placement plate (8) for placing solid drugs is installed at the lower end of the blocking frame (4). (1) A fixing frame (6) is installed on the side surface at the lower end of the placement plate (8). A support plate (5) is vertically installed on the left side of the upper surface of the fixing frame (6). An electric push rod (9) for pushing the weight to the next step is installed at the center of the surface of the support plate (5). The piston end of the electric push rod (9) is provided with a push plate (10) corresponding to the inside of the placement plate (8). An electronic balance (11) is installed inside the placement plate (8). A discharge pipe (12) is installed obliquely on the side of the placement plate (8) away from the electric push rod (9).

2. The drug solid sample pretreatment device according to claim 1, characterized in that, The mounting frame (1) has a display screen (2) for controlling electrical structures installed at the corner of the surface. The upper surface of the base (3) is provided with a methanol tank (7) located at the lower end of the placement plate (8). The rear surface of the methanol tank (7) is provided with a feed pipe (13) near the corner. The top of the feed pipe (13) is provided with a methanol inlet (14).

3. The drug solid sample pretreatment device according to claim 1, characterized in that, The upper surface of the base (3) is provided with a grinding frame (15) connected to the methanol tank (7) at the lower end of the discharge pipe (12). A solenoid valve (30) is provided between the grinding frame (15) and the methanol tank (7). A grinding chamber (16) is opened in the center of the grinding frame (15).

4. The drug solid sample pretreatment device according to claim 3, characterized in that, A cylinder (18) is provided in the center of the grinding chamber (16). A pressure plate (17) is installed around the piston end of the cylinder (18). A sleeve (20) is installed at the end of the grinding frame (15) away from the solenoid valve (30).

5. The drug solid sample pretreatment device according to claim 4, characterized in that, A precision pump (19) is installed between the sleeve (20) and the grinding frame (15). A connecting pipe (21) is vertically installed on the lower side of the sleeve (20), and a test tube (26) is installed at the lower end of the connecting pipe (21).

6. The drug solid sample pretreatment device according to claim 5, characterized in that, A support frame (23) is fitted on the outside of the test tube (26). A sealing plate (22) is installed around the top of the support frame (23) outside the connecting tube (21). A cabinet door (24) is fastened to the outside of the support frame (23).

7. The drug solid sample pretreatment device according to claim 6, characterized in that, A sliding clamp (25) connected to the test tube (26) is installed on the inner side of the sealing plate (22), and a filter membrane (29) is installed on the inner side of the top of the test tube (26).

8. A drug solid sample pretreatment device according to claim 5, characterized in that, A centrifuge module (28) is installed at the lower end of the test tube (26), and a placement rack (27) that is rotatably connected to the test tube (26) is installed at the center of the upper surface of the centrifuge module (28).

Images