A chromatographic column

Abstract

This utility model relates to the field of chromatographic column technology, and in particular to a chromatographic column, including column tube A, column tube B, drive assembly A, filter screen, and drive assembly B. A guide sleeve coaxially mounted on the outside of column tube A is provided; an externally threaded sleeve coaxially mounted on column tube B is provided, inserted into the guide sleeve and slidably connected to both the outer wall of column tube A and the inner wall of the guide sleeve. A connector is provided at the end of column tube B away from column tube A; drive assembly A is mounted on the guide sleeve, and in the working state, drive assembly A drives the externally threaded sleeve to slide along the axial direction of column tube A and guide sleeve; the filter screen is mounted inside column tube A and slidably connected to its inner wall; drive assembly B is mounted on the connector, and drive assembly B drives the filter screen to slide along the axial direction of column tube A. This utility model allows for adjustment of the chromatographic column capacity as needed, and by providing a movable and adjustable filter screen, it achieves positioning of the stationary phase in the chromatographic column, preventing the stationary phase from being dislodged when liquid phase or mixed solutions are added.

Description

Technical Field

[0001] This utility model relates to the field of chromatography column technology, and in particular to a chromatography column. Background Technology

[0002] The chromatographic column is the core component of a chromatographic analysis system. It is mainly used for the separation, purification, and analysis of mixtures. It separates different components in a mixture according to their physicochemical properties (such as polarity, molecular size, adsorption, etc.) by the difference in interaction between the stationary phase and the mobile phase, so that each component flows out at a different rate.

[0003] Chinese patent CN221771591U discloses a chromatographic column. This column utilizes an extended sleeve and a plug, allowing the plug to move up and down within the extended sleeve. This adjustment controls the overlap between the extended sleeve and the plug, thus regulating the actual capacity of the extended sleeve. By changing the capacity of the extended sleeve, the overall capacity of the chromatographic column can be adjusted, thereby improving its applicability.

[0004] However, the device still has shortcomings: after the plug extends to an appropriate length inside the extended sleeve, the upper end of the threaded groove of the extended sleeve is exposed, which can easily cause the stationary phase to get stuck in the threaded groove, making cleaning troublesome. In addition, the chromatographic column lacks a structure to assist in limiting the stationary phase. When adding liquid phase or mixed solution, the stationary phase is easily dislodged. Therefore, a filter paper needs to be added during actual operation, which is time-consuming and laborious. Utility Model Content

[0005] The purpose of this invention is to address the problems existing in the background art by proposing a chromatographic column.

[0006] The technical solution of this utility model is: a chromatographic column, including a column tube A, and a guide sleeve coaxial with the column tube A is disposed on the outside of the column tube A;

[0007] Column tube B, with an external threaded sleeve coaxial with it, the external threaded sleeve is inserted into the guide sleeve and is slidably connected to both the outer wall of column tube A and the inner wall of the guide sleeve, and a joint is provided at the end of column tube B away from column tube A.

[0008] Drive component A is mounted on the guide sleeve. In the working state, drive component A drives the external threaded sleeve to slide along the axial direction of the column tube A and the guide sleeve.

[0009] A filter screen is installed inside column tube A and is slidably connected to its inner wall.

[0010] And drive component B, which is installed on the connector, drives the filter screen to slide along the axial direction of the column tube A when in operation.

[0011] Preferably, the guide sleeve is provided with a cylindrical groove coaxial with it, and a guide rail is provided on the inner wall of the cylindrical groove along its axial direction. The external threaded sleeve is inserted into the cylindrical groove, and a guide groove is provided on the outer arc surface of the external threaded sleeve along its axial direction. The guide rail is inserted into the guide groove and slidably connected with its inner wall.

[0012] Preferably, the drive assembly A includes a knob A, which is coaxially rotatably connected to one end of the guide sleeve near the column tube B. A threaded groove is provided on the inner wall of the knob A, and the knob A is threadedly connected to the external threaded sleeve.

[0013] Preferably, the outer and inner diameters of column tube A and column tube B are the same, and the guide sleeve, knob A and external threaded sleeve are all transparent.

[0014] Preferably, the connector is threaded to the column tube A, and a guide tube coaxial with it is provided on the connector. A slide rod that slides along its axial direction is provided inside the guide tube, and the filter screen is connected to one end of the slide rod that extends out of the guide tube.

[0015] Preferably, a through hole is provided on the slide rod, and a positioning block is provided in the opening of the guide tube near the filter screen. The positioning block is inserted into the through hole and slidably connected to its inner wall.

[0016] Preferably, the drive assembly B includes an externally threaded tube and a knob B. One end of the externally threaded tube is inserted into the guide tube and rotatably connected to the positioning block. The lower end of the externally threaded tube passes through the positioning block. The externally threaded tube is threadedly connected to the slide rod. The knob B is rotatably connected to the connector on the same axis. The upper end of the externally threaded tube is coaxially connected to the knob B. A guide groove that communicates with the externally threaded tube is provided on the knob B.

[0017] Preferably, a discharge pipe is provided at the end of column tube B away from column tube A, and a control valve is provided on the discharge pipe to control the opening and closing of its internal channels.

[0018] Compared with the prior art, the present invention has the following beneficial technical effects:

[0019] By setting up a mating structure of column tube A, column tube B, guide sleeve, knob A, and external threaded sleeve, rotating knob A causes the guide sleeve to slide down, thereby moving column tube B away from column tube A, thus achieving the purpose of adjusting the column capacity. Furthermore, the external threaded sleeve remains in contact with column tube A, preventing the solid phase from entering the threaded groove, making subsequent cleaning of the column interior simple and convenient. By setting up a connector, filter screen, and drive assembly B that drives the filter screen to slide along the axial direction of column tube A, it is easy to use the filter screen to press down the top of the solid phase. At this time, even if liquid phase or mixed solution is injected rapidly, the solid phase will not be pushed up, ensuring that the top surface of the solid phase is always flush. Attached Figure Description

[0020] Figure 1 This is a schematic diagram of the structure of one embodiment of the present utility model;

[0021] Figure 2 This is a schematic diagram of the connection structure between column tube B, column tube A, and guide sleeve.

[0022] Figure 3 This is a schematic diagram of the connection structure of the various components on column tube A;

[0023] Figure 4 This is a schematic diagram of the connection structure between the slide rod, the guide tube, and knob B.

[0024] Reference numerals in the attached drawings: 1. Column tube A; 2. Guide sleeve; 201. Guide rail; 3. Knob A; 4. Column tube B; 5. External threaded sleeve; 501. Guide groove; 6. Discharge tube; 7. Control valve; 8. Connector; 9. Guide tube; 901. Positioning block; 10. Slide rod; 1001. Through hole; 11. Filter screen; 12. External threaded tube; 13. Knob B; 131. Guide groove. Detailed Implementation

[0025] Example 1

[0026] like Figures 1-4As shown, the present invention proposes a chromatographic column, comprising a column tube A1, a column tube B4, a drive assembly A, a filter screen 11, and a drive assembly B. A guide sleeve 2, coaxial with the column tube A1, is provided on the outside of the column tube A1, with the lower opening of the guide sleeve 2 flush with the lower opening of the column tube A1. A column groove, coaxial with the guide sleeve 2, is provided on the guide sleeve 2, and a guide rail 201 is provided along the axial direction of the inner wall of the column groove. An external threaded sleeve 5, coaxial with the column tube B4, is provided on the column tube B4, and is inserted into the guide sleeve 2, slidingly connected to both the outer wall of the column tube A1 and the inner wall of the guide sleeve 2. A connector 8 is provided at the end of the column tube B4 away from the column tube A1, and is threadedly connected to the column tube A1. A guide tube 9, coaxial with the connector 8, is provided on the guide tube 9, and a sliding rod 10, sliding along its axial direction, is provided inside the guide tube 9. A through hole 1001 is provided on the sliding rod 10. A positioning block 901 is provided in the opening of the guide tube 9 near the filter screen 11, and is inserted into the through hole 1001 and slidingly connected to its inner wall. An external threaded sleeve 5 is inserted into a cylindrical groove, and a guide groove 501 is provided along its axial direction on the outer arc surface of the external threaded sleeve 5. A guide rail 201 is inserted into the guide groove 501 and slidably connected to its inner wall. A filter hole is provided at the end of the column tube B4 away from the column tube A1. A drive assembly A is provided on the guide sleeve 2. The drive assembly A includes a knob A3, which is coaxially rotatably connected to the end of the guide sleeve 2 near the column tube B4. A threaded groove is provided on the inner wall of the knob A3, and the knob A3 is threadedly connected to the external threaded sleeve 5. In the working state, the drive assembly A drives the external threaded sleeve 5 to slide along the axial direction of the column tube A1 and the guide sleeve 2. The outer diameter and inner diameter of the column tube A1 and the column tube B4 are the same. The guide sleeve 2, the knob A3, and the external threaded sleeve 5 are all transparent. A filter screen 11 is provided inside the column tube A1, and the filter screen 11 is connected to the end of the slide rod 10 that extends out of the guide tube 9. Drive assembly B is mounted on connector 8. Drive assembly B includes an external threaded tube 12 and a knob B13. One end of the external threaded tube 12 is inserted into the guide tube 9 and rotatably connected to the positioning block 901. The lower end of the external threaded tube 12 passes through the positioning block 901. The external threaded tube 12 is threadedly connected to the slide rod 10. The knob B13 is rotatably connected to connector 8 on the same axis. The upper end of the external threaded tube 12 is coaxially connected to the knob B13. The knob B13 is provided with a guide groove 131 that communicates with the external threaded tube 12. When in operation, drive assembly B drives the filter screen 11 to slide along the axial direction of the column tube A1.

[0027] In this embodiment, the capacity of the chromatographic column is first increased according to actual needs. During operation, one hand holds the column tube A1, and the other hand rotates the knob A3. The knob A3 drives the external threaded sleeve 5 to gradually extend out of the guide sleeve 2, but the inner wall of the external threaded sleeve 5 is always in contact with the outer wall of the column tube A1. After the chromatographic column capacity is adjusted, the connector 8 is opened, the stationary phase is added, and the upper end face of the stationary phase is leveled. Then the connector 8 is connected, and the knob B13 is rotated. The knob B13 drives the external threaded tube 12 to rotate, thereby pushing the slide rod 10 to gradually slide down. The slide rod 10 drives the filter screen 11 to slide down until the upper end face of the stationary phase is pressed against it. Then the liquid phase is injected along the feed channel 131. The liquid phase enters the internal channel of the external threaded tube 12 along the feed channel 131 and goes down. After the liquid phase permeates the filter screen 11 and the stationary phase, the mixed solution is added, and the permeation rate of the single component in the mixed solution is increased by pressurization.

[0028] Example 2

[0029] like Figure 1 and Figure 2 As shown, the chromatographic column proposed in this utility model, compared with Embodiment 1, has an outlet pipe 6 at the end of column tube B4 away from column tube A1, and a control valve 7 is provided on the outlet pipe 6 to control the switching of its internal channels. The control valve 7 is, but is not limited to, a ball valve, and a knob C for driving the ball valve to rotate is provided on the outlet pipe 6.

[0030] In this embodiment, when it is necessary to remove excess liquid solution, the ball valve is opened, and the ball valve is closed when the upper liquid level of the liquid phase is flush with the upper surface of the stationary phase. Moreover, when separating and outputting the components in the mixed solution, the flow of the solution can be controlled by opening and closing the ball valve.

[0031] The embodiments of the present invention have been described in detail above with reference to the accompanying drawings. However, the present invention is not limited thereto. Various changes can be made within the scope of knowledge possessed by those skilled in the art without departing from the spirit of the present invention.

Claims

1. A chromatographic column, characterized in that, include: Column tube A(1), and a guide sleeve (2) coaxial with it is provided on the outside of column tube A(1); Column tube B (4), with an external threaded sleeve (5) coaxial with it. The external threaded sleeve (5) is inserted into the guide sleeve (2) and is slidably connected to the outer wall of column tube A (1) and the inner wall of guide sleeve (2). A connector (8) is provided at the end of column tube B (4) away from column tube A (1). Drive component A is set on guide sleeve (2). When in working state, drive component A drives the external threaded sleeve (5) to slide along the axial direction of column tube A (1) and guide sleeve (2). Filter screen (11) is installed inside column tube A (1) and is slidably connected to its inner wall; And drive component B, which is set on connector (8), and drive component B drives filter screen (11) to slide along column tube A (1) in working state.

2. A chromatographic column according to claim 1, characterised in that A cylindrical groove coaxial with the guide sleeve (2) is provided on the guide sleeve (2). A guide rail (201) is provided on the inner wall of the cylindrical groove along its axial direction. The external threaded sleeve (5) is inserted into the cylindrical groove, and a guide groove (501) is provided on the outer arc surface of the external threaded sleeve (5) along its axial direction. The guide rail (201) is inserted into the guide groove (501) and slidably connected to its inner wall.

3. A chromatographic column according to claim 1, characterized in that, The drive assembly A includes a knob A (3), which is coaxially rotatably connected to the end of the guide sleeve (2) near the column tube B (4). A threaded groove is provided on the inner wall of the knob A (3), and the knob A (3) is threadedly connected to the external threaded sleeve (5).

4. A chromatographic column according to claim 3, characterised in that The outer and inner diameters of the tube A (1) and the tube B (4) are the same. The guide sleeve (2), the knob A (3) and the external thread sleeve (5) are all transparent.

5. A chromatographic column according to claim 1, wherein The connector (8) is threaded to the column tube A (1). A guide tube (9) coaxial with it is provided on the connector (8). A slide rod (10) that slides along its axis is provided inside the guide tube (9). The filter screen (11) is connected to one end of the slide rod (10) that extends out of the guide tube (9).

6. A chromatographic column according to claim 5, characterised in that A through hole (1001) is provided on the slide rod (10), and a positioning block (901) is provided in the opening of the guide tube (9) near the filter screen (11). The positioning block (901) is inserted into the through hole (1001) and slidably connected to its inner wall.

7. A chromatographic column according to claim 6, characterised in that The drive assembly B includes an external threaded tube (12) and a knob B (13). One end of the external threaded tube (12) is inserted into the guide tube (9) and rotatably connected to the positioning block (901). The lower end of the external threaded tube (12) passes through the positioning block (901). The external threaded tube (12) is threadedly connected to the slide rod (10). The knob B (13) is rotatably connected to the connector (8) on the same axis. The upper end of the external threaded tube (12) is coaxially connected to the knob B (13). A guide groove (131) that communicates with the external threaded tube (12) is provided on the knob B (13).

8. A chromatographic column according to claim 1, wherein, A discharge pipe (6) is provided at the end of column tube B (4) away from column tube A (1), and a control valve (7) is provided on the discharge pipe (6) to control the switch of its internal channel.

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