Small animal colon medicine lavage device with negative pressure suction auxiliary function

Abstract

The utility model discloses a small -size animal colon traditional chinese medicine irrigation device with negative pressure suction auxiliary function relates to traditional chinese medicine irrigation technical field, the utility model discloses a irrigation device, the irrigation device has the medicine storage tube and storage mechanism composition, the storage mechanism installs at the medicine storage tube bottom end, and the storage mechanism and reflux mechanism are connected with the hose, the inside push -plate of medicine storage tube is slidably installed, the inside push -plate one side position of medicine storage tube is installed with the propulsion mechanism, the medicine storage tube front end connector other side is installed with one -way air inlet valve, one -way air inlet valve is connected with the storage mechanism through the hose, the hose is installed in the position of the front of medicine storage tube front end connector, and the front of medicine storage tube front end connector is provided with the hose the front end of hose is provided with the insertion mechanism. The utility model discloses through the fixed mechanism replacement different size insertion mechanism mode, not only can to different animals carry out irrigation test while can, carry out the abdominal pressure suction auxiliary, has increased the use range of irrigation device.

Description

Technical Field

[0001] This utility model belongs to the field of traditional Chinese medicine irrigation, specifically, it relates to a small animal colonic traditional Chinese medicine irrigation device with negative pressure suction auxiliary function. Background Technology

[0002] Colonic herbal lavage is a treatment method that combines traditional Chinese medicine theory with enema techniques. It primarily involves injecting a herbal solution into the colon through the anus, allowing the solution to act directly on the intestinal mucosa to treat diseases or regulate bodily functions. Herbal lavage devices are required during animal experiments.

[0003] Chinese Patent No. 202220238385.5 discloses an experimental animal intestinal dilation and irrigation device, relating to the field of medical device technology. The device includes an enema syringe, an intestinal irrigation head, a mercury manometer, a four-way connector, and a reservoir. The pressure measuring port of the mercury manometer is connected to the upper end of the reservoir via a flexible tube. The intestinal irrigation head is connected to the first port of the four-way connector via a flexible tube. The lower end of the reservoir is connected to the second port of the four-way connector via a flexible tube. The injection port of the enema syringe is connected to the third port of the four-way connector via a flexible tube. The fourth port of the four-way connector is equipped with a drain valve for controlling the opening and closing of the port.

[0004] When using this invention, the size of the intestinal perfusion head cannot be changed according to the animal species, and it cannot perform auxiliary negative pressure suction during use. When the drug enters the animal's body, it cannot be expelled naturally due to its high viscosity, and other equipment is required.

[0005] In view of this, this utility model is proposed. Utility Model Content

[0006] The technical problem to be solved by this utility model is to overcome the shortcomings of the existing technology and provide a small animal colonic irrigation device with negative pressure suction auxiliary function.

[0007] To solve the above-mentioned technical problems, the basic concept of the technical solution adopted by this utility model is as follows:

[0008] A small animal colonic irrigation device with negative pressure suction assistance includes an irrigation device; the irrigation device consists of a medicine storage cylinder and a storage mechanism. The storage mechanism is installed at the bottom of the medicine storage cylinder. The storage mechanism and the return mechanism are connected to a hose. A push plate is slidably installed inside the medicine storage cylinder. A rubber pad is attached to the front end of the push plate with adhesive. A propulsion mechanism is installed inside the medicine storage cylinder on one side of the push plate. A suction pipe is installed on one side of the front connector of the medicine storage cylinder. A control valve is installed on the upper side of the suction pipe. A one-way air inlet valve is installed on the other side of the front connector of the medicine storage cylinder. The one-way air inlet valve is connected to the storage mechanism through a hose. A hose is installed in front of the front connector of the medicine storage cylinder. A one-way discharge valve is installed at the rear end of the hose. An insertion mechanism is provided at the front end of the hose. The insertion mechanism and the hose are connected by a fixing mechanism.

[0009] Optionally, the outside of the medicine storage cylinder is wrapped with a friction pad, and a scale is provided in the middle of the medicine storage cylinder.

[0010] Optionally, the storage mechanism consists of a threaded cap and a storage barrel. The storage barrel is installed inside the threaded cap by rotating it with threads, and the upper end of the threaded cap is installed on one side of the bottom of the storage barrel.

[0011] Optionally, the reflux mechanism consists of a reflux pipe and a control valve. The control valve is installed in the middle of the reflux pipe, one end of the reflux pipe is installed on the upper side of the threaded cap, and the other end of the reflux pipe is installed in the middle of the hose.

[0012] Optionally, the propulsion mechanism consists of a threaded cylinder, a threaded rod, and a handle. The threaded cylinder is installed on one side of the medicine storage cylinder, the threaded rod is rotatably installed inside the threaded cylinder, one end of the threaded rod is rotatably installed on one side of the push plate, and the handle is welded to the other end of the threaded rod.

[0013] Optionally, the insertion mechanism consists of a limiting plate and a insertion tube, wherein the insertion tube is a silicone flexible tube, and the limiting plate is welded to the front end of the insertion tube.

[0014] Optionally, the fixing mechanism consists of a fixing sleeve, a baffle, a plug, and a threaded connector. The threaded connector is installed at the rear end of the insertion mechanism, the fixing sleeve is fitted on the upper side of the hose, the baffle is installed at the end of the hose, the plug is installed at the front end of the baffle, the plug is inserted into the threaded connector, and the fixing sleeve is rotatably installed on the upper side of the threaded connector.

[0015] By adopting the above technical solution, the present invention has the following beneficial effects compared with the prior art. Of course, any product implementing the present invention does not necessarily need to achieve all of the following advantages at the same time:

[0016] 1. By changing the insertion mechanism of different sizes through the fixed mechanism, not only can irrigation experiments be carried out on different animals, but also abdominal pressure suction can be assisted, which increases the application range of the irrigation device.

[0017] 2. When using the propulsion mechanism, the operator can hold the handle and rotate the threaded rod. When the threaded rod rotates, it can move the push plate forward or backward through the threaded action with the threaded cylinder, thus facilitating the slow movement of the push plate and making it easy to control the movement speed of the push plate.

[0018] 3. When in use, the insertion mechanism inserts a cannula into the colon. Different diameters and lengths of cannulas can be selected for different animal experiments. The limiting plate restricts the insertion of the cannula.

[0019] 4. When using the fixing mechanism, insert the plug into the threaded connector. The insertion depth of the plug into the threaded connector is limited by the limiting plate. Then, install the fixing sleeve on the upper side of the threaded connector by rotating the screw. The fixing sleeve presses and fixes the baffle, i.e. the plug, on the upper side of the threaded connector, thus completing the connection between the hose and the insertion mechanism.

[0020] The specific embodiments of this utility model will be described in further detail below with reference to the accompanying drawings. Attached Figure Description

[0021] The accompanying drawings described below are merely some embodiments. Those skilled in the art can obtain other drawings based on these drawings without any creative effort. In the drawings:

[0022] Figure 1 This is a schematic diagram of the structure of an embodiment of the present utility model;

[0023] Figure 2 This is a side view of an embodiment of the present invention.

[0024] Figure 3 This is a schematic diagram of the internal structure of an embodiment of the present utility model;

[0025] Figure 4 This is a schematic diagram of the insertion mechanism structure according to an embodiment of the present invention;

[0026] The attached diagram lists the components represented by each number as follows:

[0027] 1. Irrigation device; 2. Medicine storage cylinder; 3. Storage mechanism; 4. Hose; 5. Threaded cap; 6. Storage tank; 7. Return pipe; 8. One-way air inlet valve; 9. One-way liquid outlet valve; 10. Propulsion mechanism; 11. Threaded rod; 12. Threaded cylinder; 13. Handle; 14. Friction pad; 15. Scale; 16. Control valve; 17. Return mechanism; 18. Insertion mechanism; 19. Insertion tube; 20. Limiting plate; 21. Threaded connector; 22. Fixing mechanism; 23. Fixing sleeve; 24. Baffle; 25. Plug; 26. Rubber pad; 27. Liquid extraction tube; 28. Push plate.

[0028] It should be noted that these accompanying drawings and textual descriptions are not intended to limit the scope of the present invention in any way, but rather to illustrate the concept of the present invention to those skilled in the art by referring to specific embodiments. Detailed Implementation

[0029] The present invention will now be described in further detail with reference to the accompanying drawings.

[0030] Chronic kidney disease (CKD) has a high prevalence, and delaying renal failure is of great significance. Reducing renal interstitial fibrosis (RIF) is key to delaying renal failure. Gut-derived microinflammation can promote the progression of RIF, while short-chain fatty acids (SCFAs), metabolites of gut microbiota, can inhibit gut-derived microinflammation by regulating the ROS / NLRP3 pathway. Our previous work found that colonic dialysis with the Gubenxiezhuo formula can improve gut microbiota dysbiosis in CKD patients, upregulate SCFAs, downregulate serum inflammatory factors and NLRP3 inflammasome expression, and reduce the severity of RIF. Therefore, we hypothesize that colonic dialysis with the Gubenxiezhuo formula reduces RIF by regulating gut microbiota distribution, upregulating SCFA levels, and inhibiting NLRP3 inflammasome activation. This research aims to explore the deep-seated mechanism by which the Gubenxiezhuo formula regulates the gut microbiota of a RIF animal model from the perspective of the gut-kidney axis, using pseudo-sterile and fecal microbiota transplantation techniques. Combining in vivo nlrp3 gene knockout and in vitro cell experiments to intervene in ROS / NLRP3, this study seeks to investigate the mechanism by which the Gubenxiezhuo formula regulates SCFAs through colonic dialysis to inhibit ROS / NLRP3 activation and improve RIF. The goal is to elucidate the modern scientific connotation of the Gubenxiezhuo formula in treating RIF, thereby leveraging the advantages of traditional Chinese medicine in the prevention and treatment of RIF.

[0031] The colonic mucosa is a layer of tissue lining the colon, composed of a single layer of columnar epithelium, the lamina propria, and the muscularis mucosae. The epithelial cells are tightly packed, with tight junctions between them, ensuring the mucosal barrier function. Microvilli at the apex of the epithelial cells increase their surface area, facilitating absorption and secretion. The lamina propria contains abundant capillaries, lymphatic vessels, nerve fibers, and numerous immune cells, such as lymphocytes and plasma cells. These immune cells play a crucial role in defending against pathogen invasion and maintaining intestinal immune homeostasis. Furthermore, the lamina propria contains numerous intestinal glands composed of various cell types, including goblet cells and Paneth cells. The muscularis mucosae is composed of a thin layer of smooth muscle; its contraction facilitates minute movements of the mucosa, promoting absorption and the expulsion of intestinal gland secretions.

[0032] As the first line of defense for the intestines, the colonic mucosa prevents harmful substances such as bacteria, viruses, and toxins from invading the body, while also preventing digestive juices from eroding the intestinal wall. The colonic mucosa absorbs water, electrolytes (such as sodium, potassium, and chloride), and some vitamins (such as vitamin K and B vitamins), further concentrating the food residue after digestion and absorption in the small intestine to form feces. Goblet cells in the intestinal glands secrete mucus, which lubricates the intestines and protects the mucosa from mechanical damage and chemical irritation. Simultaneously, the colonic mucosa also secretes immunoglobulins and cytokines, participating in intestinal immune defense and regulation, and maintaining microbial homeostasis: a large number of symbiotic microorganisms exist on the surface of the colonic mucosa, interacting with mucosal cells to form a complex ecosystem. The mucosa provides a habitat and nutrients for microorganisms, which in turn help maintain normal intestinal function, such as aiding digestion, synthesizing vitamins, and resisting pathogens.

[0033] The following are some diseases related to the colon:

[0034] Inflammatory bowel disease, including ulcerative colitis and Crohn's disease, can cause inflammation, ulceration, bleeding and other lesions in the colonic mucosa. Patients often experience symptoms such as abdominal pain, diarrhea and bloody stools.

[0035] Colonic polyps are raised lesions that protrude from the surface of the colonic mucosa into the intestinal lumen. Most polyps are benign, but some polyps may become malignant and lead to colon cancer.

[0036] Colorectal cancer is a malignant tumor originating from the epithelial cells of the colonic mucosa. Its occurrence is related to a variety of factors, such as genetic factors, dietary habits, and intestinal microbial imbalance. Early-stage colorectal cancer may not have obvious symptoms, but as the disease progresses, symptoms such as rectal bleeding, abdominal pain, abdominal mass, and intestinal obstruction may appear.

[0037] The colonic mucosa plays a vital role in human digestion, absorption, and immune defense. Maintaining the health of the colonic mucosa is of great significance for maintaining overall human health.

[0038] The colon is an important site for the excretion and accumulation of toxins in patients with chronic kidney disease. Based on the "gut-kidney axis" theory of traditional Chinese medicine, the colon can be used as a target for RIF (Respiratory Inflammation of the Intestine) treatment, and the method of clearing the bowels and eliminating turbidity is an important means. The representative method is to administer compound decoctions or traditional Chinese medicine preparations with rhubarb as the main ingredient via the colon. Clinical studies [6.11] have shown that administration of traditional Chinese medicine via the colon can improve the poisoning symptoms of patients with chronic kidney disease, reduce the levels of toxins such as blood urea nitrogen (BUN), creatinine (Scr), uric acid (UA), and middle molecular weight substances (MMS) in the blood, and improve the symptoms of internal accumulation of turbid toxins in patients.

[0039] Small animal colonic lavage experiments are conducted because the following can be achieved during the experiment:

[0040] 1. Simulating Human Diseases and Treatments: Small animals such as rats and mice share certain physiological and pathological similarities with humans. By administering medication via colonic enema to small animals, the drug treatment process for human colon-related diseases can be simulated, providing important reference data for the research and treatment of human diseases.

[0041] 2. Studying drug action mechanisms: The colon is one of the important sites for drug absorption and metabolism. Colonic enema allows for direct delivery of drugs to the colon, enabling the study of drug absorption, distribution, metabolism, and excretion within the colon, as well as the mechanisms of drug action on colonic tissues and cells.

[0042] 3. Drug Development and Screening: In the process of new drug development, it is necessary to evaluate the efficacy and safety of the drug. Small animal colonic administration experiments can provide preliminary observation of the therapeutic effects and adverse reactions of the drug in animal models, providing important experimental data for further drug development and screening.

[0043] The purpose of the small animal colonic lavage experiment is:

[0044] 1. Treatment of colonic diseases: Research on drug treatment methods for diseases such as colonic inflammation, ulcers, and tumors. By administering drugs through instillation, observe the drug's effects on disease relief and cure, as well as its influence on pathological changes in colonic tissue, to provide experimental evidence for clinical treatment.

[0045] 2. Observe drug absorption characteristics: Understand the absorption characteristics of drugs in the colon, including absorption rate, absorption amount, and factors affecting absorption. This helps optimize drug formulations and dosing regimens, improving drug bioavailability and therapeutic efficacy.

[0046] 3. Research on the interaction between gut microbiota and drugs: In recent years, the role of gut microbiota in disease development and drug treatment has received increasing attention. Colonic enema experiments can be used to study the effects of drugs on the structure and function of the gut microbiota community, and how gut microbiota influence drug metabolism and efficacy.

[0047] Small animal colonic lavage experiments have the following advantages:

[0048] 1. High operability: Small animals are relatively small in size, making operation relatively simple. It is easy to perform anesthesia, fixation and surgery, and drugs can be delivered to the colon relatively accurately. In addition, the source of animals is relatively easy and the cost is relatively low, making it suitable for large-scale experimental research.

[0049] 2. Controllable experimental conditions: Experimental conditions, such as drug dosage, administration time, animal diet, and environment, can be strictly controlled, reducing experimental errors and improving the accuracy and reliability of experimental results. Furthermore, grouped control experiments can be conducted on animals as needed to better observe the drug's effects.

[0050] 3. Less Ethical Controversy: Compared to large animals, the use of small animals in experiments raises relatively fewer ethical controversies. When animal welfare principles are followed, the reasonable use of small animals in experimental research can contribute to the advancement of medicine and biology, and ultimately to human health, without violating ethical standards.

[0051] Please see Figure 1-4 As shown, this embodiment provides a small animal colonic herbal irrigation device with negative pressure suction assistance, including an irrigation device 1; the irrigation device 1 consists of a medicine storage cylinder 2 and a storage mechanism 3. The storage mechanism 3 is installed at the bottom of the medicine storage cylinder 2. The storage mechanism 3 and the return mechanism 17 are connected to the hose 4. A push plate 28 is slidably installed inside the medicine storage cylinder 2. A rubber pad 26 is glued to the front end of the push plate 28 with adhesive. A propulsion mechanism 10 is installed inside the medicine storage cylinder 2 on one side of the push plate 28. A suction pipe 27 is installed on one side of the front connector of the medicine storage cylinder 2. A control valve 16 is installed on the upper side of the suction pipe 27. A one-way air inlet valve 8 is installed on the other side of the front connector of the medicine storage cylinder 2. The one-way air inlet valve 8 is connected to the storage mechanism 3 through the hose 4. A hose 4 is installed in front of the front connector of the medicine storage cylinder 2. A one-way discharge valve 9 is installed at the rear end of the hose 4. An insertion mechanism 18 is provided at the front end of the hose 4. The insertion mechanism 18 and the hose 4 are connected by a fixing mechanism 22.

[0052] One application of this embodiment is as follows: First, open the control valve 16 on the upper side of the suction tube 27 and close the control valve 16 on the upper side of the reflux mechanism 17. Insert the suction tube 27 into the drug storage dish. Move the push plate 28 backward via the push mechanism 10. At this time, a negative pressure is formed inside the drug storage cylinder 2, which will draw the traditional Chinese medicine in through the suction tube 27. After the drawing is complete, close the control valve 16 on the upper side of the suction tube 27. Then, fix the insertion mechanism 18 at one end of the tubing 4 to the tubing 4 via the fixing mechanism 22. The fixing mechanism 22 allows for the replacement of the insertion mechanism 18 according to different animals, increasing the applicability of the irrigation device 1. After the insertion mechanism 18 is inserted into the animal's colon, it is pushed back by the push mechanism 10... Pushing the push plate 28 forward allows the traditional Chinese medicine inside the medicine storage cylinder 2 to be injected into the insertion mechanism 18 through the hose 4. The medicine is then injected into the animal's colon through the insertion mechanism 18. After the medicine has been in the colon for a period of time, when manual removal is required, simply open the control valve 16 on the upper side of the return mechanism 17. The push plate 28 is then moved backward by the push mechanism 10. At this time, the one-way outlet valve 9 at the end of the hose 4 near the medicine storage cylinder 2 is closed, and the removed liquid will enter the storage mechanism 3 through the return mechanism 17. By changing the insertion mechanism 18 to different sizes through the fixing mechanism 22, not only can different animals be subjected to irrigation experiments, but abdominal pressure suction can also be assisted, increasing the application range of the irrigation device 1.

[0053] In this embodiment, the outside of the medicine storage cylinder 2 is wrapped with a friction pad 14, and a scale 15 is provided in the middle of the medicine storage cylinder 2. The friction pad 14 is provided to increase the friction between the user's hand and the medicine storage cylinder 2 to avoid the phenomenon of hand slippage. At the same time, the scale 15 can display the solution content inside the medicine storage cylinder 2.

[0054] In this embodiment, the storage mechanism 3 consists of a threaded cap 5 and a storage bucket 6. The storage bucket 6 is installed inside the threaded cap 5 by rotating it with a thread. The upper end of the threaded cap 5 is installed on one side of the bottom of the medicine storage cylinder 2. When in use, the storage mechanism 3 installs the storage bucket 6 at the bottom of the threaded cap 5 by rotating it with a thread, which facilitates the installation and removal of the storage bucket 6 and makes it easier to clean the inside of the storage bucket 6.

[0055] In this embodiment, the reflux mechanism 17 consists of a reflux pipe 7 and a control valve 16. The control valve 16 is installed in the middle of the reflux pipe 7. One end of the reflux pipe 7 is installed on the upper side of the threaded cap 5, and the other end of the reflux pipe 7 is installed in the middle of the hose 4. When the reflux mechanism 17 is in use, when a negative pressure is generated inside the drug storage cylinder 2, the air inside the storage mechanism 3 will be introduced into the drug storage cylinder 2, and the air pressure inside the storage mechanism 3 will decrease. The reflux pipe 7 can be opened by controlling the control valve 16. At this time, the drug in the animal body will enter the reflux pipe 7 through the hose 4, and the reflux pipe 7 will introduce the drug into the storage mechanism 3 for storage.

[0056] In this embodiment, the propulsion mechanism 10 consists of a threaded cylinder 12, a threaded rod 11, and a handle 13. The threaded cylinder 12 is installed on one side of the medicine storage cylinder 2, and the threaded rod 11 is rotatably installed inside the threaded cylinder 12. One end of the threaded rod 11 is rotatably installed on one side of the push plate 28, and the handle 13 is welded to the other end of the threaded rod 11. When the propulsion mechanism 10 is in use, the operator can hold the handle 13 and rotate the threaded rod 11. When the threaded rod 11 rotates, it can move the push plate 28 forward or backward through the threaded action with the threaded cylinder 12, thereby facilitating the slow movement of the push plate 28 and making it easy to control the movement speed of the push plate 28.

[0057] In this embodiment, the insertion mechanism 18 consists of a limiting plate 20 and a cannula 19. The cannula 19 is a silicone flexible tube, and the limiting plate 20 is welded to the front end of the cannula 19. When in use, the insertion mechanism 18 is inserted into the colon through the cannula 19. Different diameters and lengths of cannulas 19 can be selected for different animal experiments. The limiting plate 20 can restrict the insertion of the cannula 19.

[0058] In this embodiment, the fixing mechanism 22 consists of a fixing sleeve 23, a baffle 24, a plug 25, and a threaded connector 21. The threaded connector 21 is installed at the rear end of the insertion mechanism 18. The fixing sleeve 23 is fitted onto the upper side of the hose 4. The baffle 24 is installed at the end of the hose 4. The plug 25 is installed at the front end of the baffle 24. The plug 25 is inserted into the threaded connector 21. The fixing sleeve 23 is rotated and installed on the upper side of the threaded connector 21. When the fixing mechanism 22 is in use, the plug 25 is inserted into the threaded connector 21. The depth of insertion of the plug 25 into the threaded connector 21 is limited by the limiting plate 20. The fixing sleeve 23 is then rotated and installed on the upper side of the threaded connector 21. The fixing sleeve 23 presses and fixes the baffle 24, i.e., the plug 25, on the upper side of the threaded connector 21, thereby completing the connection between the hose 4 and the insertion mechanism 18.

[0059] This utility model is not limited to the above-described embodiments. Anyone should know that structural changes made under the guidance of this utility model, and any technical solutions that are the same as or similar to this utility model, fall within the protection scope of this utility model. Technical aspects, shapes, and structures not described in detail in this utility model are all publicly known technologies.

Claims

1. A small animal colonic irrigation device with negative pressure suction assistance, characterized in that, The device includes a rinsing apparatus (1); the rinsing apparatus (1) consists of a medicine storage cylinder (2) and a storage mechanism (3). The storage mechanism (3) is installed at the bottom of the medicine storage cylinder (2). The storage mechanism (3) and the return mechanism (17) are connected to a hose (4). A push plate (28) is slidably installed inside the medicine storage cylinder (2). A rubber pad (26) is glued to the front end of the push plate (28). A propulsion mechanism (10) is installed inside the medicine storage cylinder (2) on one side of the push plate (28). A connector is installed on the front end of the medicine storage cylinder (2). A liquid extraction tube (27) is provided, and a control valve (16) is installed on the upper side of the liquid extraction tube (27). A one-way air inlet valve (8) is installed on the other side of the front end connector of the medicine storage cylinder (2). The one-way air inlet valve (8) is connected to the storage mechanism (3) through a hose (4). A hose (4) is installed in front of the front end connector of the medicine storage cylinder (2). A one-way liquid outlet valve (9) is installed at the rear end of the hose (4). An insertion mechanism (18) is provided at the front end of the hose (4). The insertion mechanism (18) and the hose (4) are connected by a fixing mechanism (22).

2. The small animal colonic irrigation device with negative pressure suction assistance function according to claim 1, characterized in that, The outside of the medicine storage cylinder (2) is wrapped with a friction pad (14), and a scale (15) is provided in the middle of the medicine storage cylinder (2).

3. The small animal colonic irrigation device with negative pressure suction assistance function according to claim 1, characterized in that, The storage mechanism (3) consists of a threaded cap (5) and a storage barrel (6). The storage barrel (6) is installed inside the threaded cap (5) by rotating the threaded cap. The upper end of the threaded cap (5) is installed on one side of the bottom of the medicine storage cylinder (2).

4. The small animal colonic irrigation device with negative pressure suction assistance function according to claim 3, characterized in that, The reflux mechanism (17) consists of a reflux pipe (7) and a control valve (16). The control valve (16) is installed in the middle of the reflux pipe (7). One end of the reflux pipe (7) is installed on the upper side of the threaded cap (5), and the other end of the reflux pipe (7) is installed in the middle of the hose (4).

5. The small animal colonic irrigation device with negative pressure suction assistance function according to claim 1, characterized in that, The propulsion mechanism (10) consists of a threaded cylinder (12), a threaded rod (11), and a handle (13). The threaded cylinder (12) is installed on one side of the medicine storage cylinder (2). The threaded rod (11) is rotatably installed inside the threaded cylinder (12). One end of the threaded rod (11) is rotatably installed on one side of the push plate (28). The handle (13) is welded to the other end of the threaded rod (11).

6. The small animal colonic irrigation device with negative pressure suction assistance function according to claim 1, characterized in that, The insertion mechanism (18) consists of a limiting plate (20) and a tube (19), wherein the tube (19) is a silicone flexible tube and the limiting plate (20) is welded to the front end of the tube (19).

7. The small animal colonic irrigation device with negative pressure suction assistance function according to claim 1, characterized in that, The fixing mechanism (22) consists of a fixing sleeve (23), a baffle (24), a plug (25), and a threaded connector (21). The threaded connector (21) is installed at the rear end of the insertion mechanism (18). The fixing sleeve (23) is fitted on the upper side of the hose (4). The baffle (24) is installed at the end of the hose (4). The plug (25) is installed at the front end of the baffle (24). The plug (25) is inserted into the threaded connector (21). The fixing sleeve (23) is rotatably installed on the upper side of the threaded connector (21).

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