Compositions containing isohexide diesters of C18 fatty acids and their use in methods for restoring epidermal integrity and function and for treating dermatological diseases
Patent Information
- Application Number
- DE602017092997
- Authority / Receiving Office
- DE · DE
- Patent Type
- Patents
- Current Assignee / Owner
- Priority Date
- 2016-09-27
- Filing Date
- 2017-08-22
- Publication Date
- 2025-12-03
- Estimated Expiration
- 2037-08-22
AI Technical Summary
Current therapies for skin conditions such as ichthyosis vulgaris and atopic dermatitis primarily address symptoms rather than the underlying barrier dysfunction, and there is a need for therapeutic agents that can enhance skin barrier function and repair epidermal integrity effectively and cost-effectively.
The use of certain C16 to C20 mono- and/or di-esters of isosorbide, which modulate gene expression and cellular pathways to improve skin health and restore barrier function, addressing the underlying causes of skin diseases like ichthyosis vulgaris and atopic dermatitis.
These esters enhance skin barrier repair, improve stratum corneum development, and provide therapeutic relief for skin diseases by up-regulating key proteins and genes, promoting skin health and integrity.