A sub-assembly of a medicament delivery device

Abstract

A sub-assembly of a medicament delivery device, the sub-assembly comprising: an outer cap, an inner cap, a retainer, a front sleeve, and a biasing member; wherein the retainer comprises a body extending along a longitudinal axis between a proximal end and a distal end; wherein a channel is arranged in the body of the retainer along the longitudinal axis; wherein the inner cap comprises a cap body attached to the retainer such that the inner cap is configured to be disengaged from the first fastener of the retainer by a rotation of the inner cap around the longitudinal axis relative to the retainer; wherein the outer cap comprises a body at least partially surrounding the cap body of the inner cap; wherein the outer cap comprises is engaged with the inner cap such that the inner cap and the outer cap is axially immovable in the proximal direction relative to the retainer; wherein the front sleeve comprises a proximal wall extending in a direction transverse to the longitudinal axis and a sleeve body extending in the direction of the longitudinal axis from proximal wall; wherein the cap body of the inner cap is at least partially positioned within the sleeve body; wherein the proximal wall is adjacent to the outer cap; and wherein the biasing member is positioned between the proximal wall of the front sleeve and the retainer.

Description

[0001] TITLE

[0002] A sub-assembly of a medicament delivery device

[0003] TECHNICAL FIELD

[0004] The present disclosure generally relates to a sub-assembly of a medicament delivery device, and particularly to a sub-assembly of a medicament delivery device comprising a front sleeve.

[0005] BACKGROUND

[0006] Medicament delivery devices such as pen-type manual injectors or auto-injectors are generally known for the self-administration of a medicament by patients without formal medical training. For example, patients suffering from diabetes may require repeated injections of insulin, or patients may require regular injections of other types of medicaments, such as growth hormones.

[0007] It is an advantage when the medicament delivery devices for self-administration comprise automatic functions so that even if users are without professional training or are in an emergency, the users can easily and properly use the medicament delivery devices.

[0008] Even though many of the devices on the market, as well as the ones described above, have their respective advantages, there is still room for improvement.

[0009] SUMMARY

[0010] The invention is defined by the appended claims, to which reference should now be made.

[0011] In the present disclosure, when the term “distal direction” is used, this refers to the direction pointing away from the dose delivery site during use of the medicament delivery device. When the term “distal part / end” is used, this refers to the part / end of the delivery device, or the parts / ends of the members thereof, which under use of the medicament delivery device is / are located furthest away from the dose delivery site. Correspondingly, when the term “proximal direction” is used, this refers to the direction pointing towards the dose delivery site during use of the medicament delivery device. When the term “proximal part / end” is used, this refers to the part / end of the delivery device, or the parts / ends of the members thereof, which under use of the medicament delivery device is / are located closest to the dose delivery site.

[0012] Further, the term “longitudinal”, “longitudinally”, “axially” or “axial” refer to a direction extending from the proximal end to the distal end, typically along the device or components thereof in the direction of the longest extension of the device and / or component.

[0013] Similarly, the terms “transverse”, “transversal” and “transversally” refer to a direction generally perpendicular to the longitudinal direction.

[0014] Further, the terms “circumference”, “circumferential”, or “circumferentially” refer to a circumference or a circumferential direction relative to an axis, typically a central axis extending in the direction of the longest extension of the device and / or component. Similarly, “radial” or “radially” refer to a direction extending radially relative to the axis, and “rotation”, “rotational” and “rotationally” refer to rotation relative to the axis.

[0015] There is hence provided a sub-assembly of a medicament delivery device, the sub-assembly comprising: an outer cap, an inner cap, a retainer, a front sleeve, and a biasing member. The retainer comprises a body extending along a longitudinal axis between a proximal end and a distal end. A channel is arranged in the body of the retainer along the longitudinal axis; wherein the body of the retainer comprises a first fastener; and the retainer comprises a proximally directed surface. The inner cap comprises a cap body having a counter first fastener engaged with the first fastener of the retainer. The first fastener of the inner cap is configured to be disengaged from the first fastener of the retainer by a rotation of the inner cap around the longitudinal axis relative to the retainer, and the inner cap comprises a distally directed surface. The outer cap comprises a body at least partially surrounding the cap body of the inner cap. The outer cap comprises a proximally directed surface engaged with the distally directed surface of the inner cap; wherein the outer cap comprises a distally directed surface. The front sleeve comprises a proximal wall extending in a direction transverse to the longitudinal axis and a sleeve body extending in the direction of the longitudinal axis from the proximal wall. The cap body of the inner cap is at least partially positioned within the sleeve body. The proximal wall is adjacent to the distally directed surface of the outer cap. The biasing member is positioned between the proximal wall of the front sleeve and the proximally directed surface of the retainer.

[0016] The sub-assembly can provide more design flexibility to the medicament delivery device. For example, the front sleeve serves as a front part of a medicament delivery member guard that is configured to be in contact with the medicament delivery site. Thus, the front sleeve can be customized easily, e.g., comprising different sensation structures or being wider given triggering issues of obesity patients. Furthermore, as the biasing member is a part of the sub-assembly, there is more design flexibility to the medicament delivery device to position a distal part of the medicament delivery member guard.

[0017] Preferably, according to another embodiment, the biasing member extends along the longitudinal axis between a first end and a second end.

[0018] Preferably, according to another embodiment, the biasing member is in contact with the proximal wall of the front sleeve at the first end and is in contact with the proximally directed surface of the retainer at the second end.

[0019] Preferably, according to another embodiment, a distal end of the outer cap comprises the distally directed surface of the outer cap.

[0020] Preferably, according to another embodiment, the first fastener of the body of the retainer and the counter first fastener of the inner cap formed a threaded fastener.

[0021] Preferably, according to another embodiment, the first fastener of the body of the retainer and the counter first fastener of the inner cap formed a bayonet fastener. Preferably, according to another embodiment, the outer cap and the inner cap are rotationally immovable in at least one rotation direction around the longitudinal axis such that the inner cap is configured to be rotated via the outer cap.

[0022] Preferably, according to another embodiment, the cap body of the inner cap is engaged with the body of the outer cap to form an interface having a non-circular cross-section when observes along the longitudinal axis.

[0023] Preferably, according to another embodiment, the sub-assembly comprises a clutch positioned between the cap body of the inner cap and the body of the outer cap in the direction transverse to the longitudinal axis.

[0024] Preferably, according to another embodiment, the clutch is engaged with the cap body of the inner cap to form an interface having a non-circular cross-section when observes along the longitudinal axis.

[0025] Preferably, according to another embodiment, the clutch is engaged with the body of the outer cap to form an interface having a non-circular cross-section when observes along the longitudinal axis.

[0026] Preferably, according to another embodiment, the sub-assembly comprises ratchet teeth and a flexible arm extending in the direction transverse to the longitudinal axis towards the ratchet teeth. The ratchet teeth are attached to one of the body of the outer cap and the cap body of the inner cap.

[0027] Preferably, according to another embodiment, the flexible arm is attached to the other one of the body of the outer cap and the cap body of the inner cap; such that an audible and / or tactile indication is generated when the flexible arm is rotated relative to the ratchet teeth.

[0028] Preferably, according to another embodiment, the sub-assembly comprises a medicament delivery hub received within the channel of the retainer and a medicament delivery member attached to the medicament delivery member hub. The medicament delivery hub and the delivery member are both at least partially surrounded by the sleeve body of the front sleeve.

[0029] Preferably, according to another embodiment, the delivery member hub comprises a first interaction member engaged with a counter interaction member of the cap body of the inner cap.

[0030] Preferably, according to another embodiment, the delivery member hub comprises a second interaction member engaged with a counter interaction member in the channel of the retainer such that the rotation of the cap body relative to the channel of the retainer results in a movement of the medicament delivery hub in the direction of the longitudinal axis towards the distal end of the retainer.

[0031] Preferably, according to another embodiment, the first interaction member and the second interaction member are a protrusion extending from the delivery member hub in the direction transverse to the longitudinal axis. Preferably, according to another embodiment, the counter interaction member of the inner cap is a helical track extending in the cap body.

[0032] Preferably, according to another embodiment, the counter interaction member of the retainer is a slot extending along the longitudinal axis in the body of the retainer.

[0033] Preferably, according to another embodiment, the protrusion of the delivery member hub is positioned both in the helical track of the cap body and the slot of the retainer.

[0034] Preferably, according to another embodiment, the first interaction member comprises a surface facing in the direction transverse to the longitudinal axis.

[0035] Preferably, according to another embodiment, the second interaction member comprises a helical protrusion extending from the delivery member hub.

[0036] Preferably, according to another embodiment, the counter interaction member of the inner cap is a surface adjacent to the surface of the first interaction member.

[0037] Preferably, according to another embodiment, the counter interaction member of the retainer is a thread at least partially around an inner surface of the channel.

[0038] Preferably, according to another embodiment, the helical protrusion is configured to move along the thread of the retainer.

[0039] Preferably, according to another embodiment, the proximal wall of the front sleeve comprises a flange extending in the direction transverse to the longitudinal axis beyond the sleeve body.

[0040] Preferably, according to another embodiment, the flange is configured to be in contact with a medicament delivery site during a medicament delivery operation of the medicament delivery device.

[0041] Preferably, according to another embodiment, the front sleeve comprises a fastener configured to be attached to a component of the medicament delivery device to thereby form a medicament delivery member guard of the medicament delivery device.

[0042] Preferably, according to another embodiment, the retainer comprises a second fastener configured to be operably attached to a housing of the medicament delivery device such that the sub-assembly is attached to the housing of the medicament delivery device via the retainer.

[0043] Another aspect of the invention provides a medicament delivery device comprising the sub-assembly as mentioned in any embodiment above.

[0044] Preferably, according to another embodiment, the medicament delivery device comprises a housing extending along the longitudinal axis between a proximal end and a distal end, and a medicament delivery member guard movably arranged in the housing. Preferably, according to another embodiment, the medicament delivery member guard is formed by the front sleeve attached to a distal sleeve; and wherein the front sleeve is telescopic to the proximal end of the housing.

[0045] Preferably, according to another embodiment, the biasing member is configured to move the front sleeve further in the proximal direction relative to the housing when the inner cap and the outer cap are removed from the retainer.

[0046] Preferably, according to another embodiment, the fastener of the front sleeve is configured to snap fit to a counter fastener of the distal sleeve of the medicament delivery device to form the medicament delivery member guard.

[0047] Preferably, according to another embodiment, the medicament delivery device comprises a container carrier within the housing.

[0048] Preferably, according to another embodiment, the container carrier is configured to contain a medicament container containing a medicament.

[0049] Preferably, according to another embodiment, the second fastener of the retainer is configured to be attached to a counter fastener of the container carrier.

[0050] Preferably, according to another embodiment, the container carrier comprises a proximal opening lined up with the channel of the retainer in the direction of the longitudinal axis when the retainer is attached to the container carrier.

[0051] Preferably, according to another embodiment, the second fastener of the retainer is configured to snap fit to the counter fastener of the container carrier.

[0052] Preferably, according to another embodiment, the sub-assembly is used in a medicament delivery device.

[0053] Preferably, according to another embodiment, the medicament delivery device comprises a medicament container.

[0054] Preferably, according to another embodiment, the medicament container is a multiple-chamber medicament container.

[0055] Preferably, according to another embodiment, the medicament container is made of glass material or plastic material.

[0056] Preferably, according to another embodiment, the medicament container is a syringe, a cartridge or a collapsible bag.

[0057] Preferably, according to another embodiment, the medicament container comprises an integral medicament delivery member. Preferably, according to another embodiment, the medicament container doesn’t comprise an integral medicament delivery member. In this embodiment, the medicament container is configured to be fluidly communicated with a medicament delivery member before use of the medicament delivery device.

[0058] Preferably, according to another embodiment, the medicament container is axially fixed to the container carrier.

[0059] Preferably, according to another embodiment, the medicament container is axially movable to the container carrier.

[0060] Preferably, according to another embodiment, the medicament delivery device comprises a rotator.

[0061] Preferably, according to another embodiment, the rotator comprises a rotator body having at least one retaining member on its inner surface.

[0062] Alternatively, or additionally, according to another embodiment, the rotator comprises a rotator body having a first and a second retaining member on its inner surface.

[0063] Preferably, according to another embodiment, the medicament delivery device comprises a plunger rod.

[0064] Alternatively, or additionally, according to another embodiment, the plunger rod comprises a counter retaining element configured to interact with the at least one retaining member or selectively with each of the first, the second and the third retaining members.

[0065] Preferably, according to another embodiment, the plunger rod comprises a first and a second counter retaining elements, the first and the second counter retaining elements is configured to interact selectively with the retaining member of the rotator.

[0066] Preferably, according to another embodiment, the retaining member is a radially inward protruding rib.

[0067] Preferably, according to another embodiment, the first and the second retaining members are ledges.

[0068] Preferably, according to another embodiment, the counter retaining member is a radially outward protruding arm.

[0069] Preferably, according to another embodiment, the first and the second counter retaining members are grooves.

[0070] Preferably, according to another embodiment, the body of the rotator is tubular.

[0071] Preferably, according to another embodiment, the plunger rod comprises a hollow body.

[0072] Preferably, according to another embodiment, the container carrier comprises a dose stop arranged on its distal end. Preferably, according to another embodiment, the plunger rod further comprises an interaction member configured to interact with a counter interaction member on the distal end of the container carrier.

[0073] Preferably, according to another embodiment, the interaction between the interaction member and the counter interaction member is configured to provide feedback to a user of the medicament delivery device.

[0074] Preferably, according to another embodiment, the distal sleeve comprises a guide element; and the rotator comprises a rotator body arranged with a guide track on its outer surface; wherein the guide element is configured to interact with the guide track such that an axial movement of the distal sleeve causes the rotator to rotate.

[0075] Preferably, according to another embodiment, the medicament delivery device is in an initial state when the rotator is in an initial position which is defined as when the plunger rod is in an initial position in which the counter retaining element is engaged with the second retaining member.

[0076] Preferably, according to another embodiment, the medicament delivery device is in a ready-to-be-used state when the rotator is in a first rotational position which is defined as when the plunger rod is in a prefiring position in which the counter retaining element is engaged with the retaining member.

[0077] Preferably, according to another embodiment, the plunger rod is configured to move from the pre-firing position to a final position in which the counter retaining element is disengaged from the retaining member such that the medicament contained in the medicament container is thereby delivered to a user of the medicament delivery device.

[0078] Preferably, according to another embodiment, the rotator comprises a ramp surface arranged between the second and the retaining members; wherein the counter retaining element is configured to move along the ramp surface from the second retaining member to the retaining member.

[0079] Preferably, according to another embodiment, the medicament container comprises a medicament delivery member attached at a proximal end of the medicament container.

[0080] Preferably, according to another embodiment, the medicament delivery device comprises a medicament delivery member attached at the proximal end of the housing.

[0081] Preferably, according to another embodiment, the medicament delivery device comprises a medicament delivery member isolated assembly attached at the proximal end of the housing.

[0082] Preferably, according to another embodiment, the medicament delivery device is an injection device, an inhalation device, or a medical sprayer.

[0083] Preferably, according to another embodiment, the medicament delivery device is an auto-injector. Preferably, according to another embodiment, the delivery member is an injection needle or a spray nozzle.

[0084] Furthermore, all terms used in the claims are to be interpreted according to their ordinary meaning in the technical field, unless explicitly defined otherwise herein. All references to "a / an / the element, apparatus, component, means, etc.” are to be interpreted openly as referring to at least one instance of the element, apparatus, component, means, etc., unless explicitly stated otherwise.

[0085] BRIEF DESCRIPTION OF THE DRAWINGS

[0086] Embodiments of the inventive concept will now be described, by way of example only, with reference to the accompanying drawings, in which:

[0087] Fig. 1 schematically shows a perspective view of a sub-assembly of the invention;

[0088] Fig. 2 schematically shows a perspective view of components of the sub-assembly of Fig. 1 in one example;

[0089] Figs 3A-3B schematically show perspective views of an outer cap and an inner cap of the sub-assembly of Fig. 1 ;

[0090] Fig. 4 schematically shows a perspective view of the inner cap of the sub-assembly of Figs 3A-3B;

[0091] Fig. 5 schematically shows a perspective view of a clutch of the sub-assembly of Fig. 2;

[0092] Fig. 6 schematically shows a perspective view of the outer cap of Figs 3A-3B and the clutch of Fig. 5;

[0093] Fig. 7 schematically shows a perspective view of a front sleeve of a sub-assembly of Fig. 1 ;

[0094] Fig. 8 schematically shows a perspective view of the sub-assembly of the Fig. 1 when the outer cap and the inner cap are removed;

[0095] Fig. 9 schematically shows a perspective view of a delivery member hub and a delivery member of a subassembly of Fig. 2;

[0096] Fig. 10 schematically shows a perspective view of a retainer of the sub-assembly of Fig. 1 ;

[0097] Fig. 11 schematically shows a perspective view of the inner cap of the sub-assembly of Fig. 1 ;

[0098] Fig. 12 schematically shows a perspective view of an inner cap of the sub-assembly of Fig. 1 in another example, a delivery member and a delivery member hub of the sub-assembly of Fig. 1 in another example, and a retainer of the sub-assembly of Fig. 1 in another example;

[0099] Fig. 13 schematically shows a perspective view of the inner cap, the medicament delivery member hub, the medicament delivery member and the retainer of the sub-assembly of Fig. 12; Fig. 14 schematically shows a perspective view of a medicament delivery device comprising the subassembly of Fig. 1 ;

[0100] Fig. 15 schematically shows a perspective view of the components of the medicament delivery device of Fig. 14;

[0101] Fig. 16 schematically shows a perspective view of the assembling steps of the medicament delivery device of Fig. 14;

[0102] Fig. 17 schematically shows a perspective view of the retainer of the sub-assembly of Fig. 1 and a container carrier of Fig. 14;

[0103] Fig. 18 schematically shows a perspective view of the front sleeve of Fig. 1 and a distal sleeve of Fig. 14;

[0104] Fig. 19 schematically shows a perspective view of a distal portion of the distal sleeve of Fig. 14 with a rotator of Fig. 14;

[0105] Fig. 20 schematically shows a perspective view of the rotator of Fig. 19 and a plunger rod of Fig. 14;

[0106] Figs 21-22 schematically show perspective views of interactions of the distal portion of the distal sleeve of Fig. 14 with the rotator of Fig. 14 in different examples.

[0107] DETAILED DESCRIPTION

[0108] Figs 1-16 illustrate a sub-assembly 2 of a medicament delivery device. The sub-assembly 2 comprises an outer cap 21 , an inner cap 22; 22’, a retainer 23; 23’, a front sleeve 24, and a biasing member 25. The retainer 23; 23’ comprises a body 230 extending along a longitudinal axis L between a proximal end and a distal end. A channel 232; 232’ is arranged in the body 230 of the retainer 23; 23’ along the longitudinal axis L. The body 230 of the retainer 23; 23’ comprises a first fastener 233, as shown in Fig. 10. The retainer 23; 23’ comprises a proximally directed surface 230a. The inner cap 22; 22’ comprises a cap body 220 having a counter first fastener 221 engaged with the first fastener 233 of the retainer 23; 23’, as shown in Fig. 11 . The counter first fastener 221 of the inner cap 22; 22’ is configured to be disengaged from the first fastener 233 of the retainer 23; 23’ by a rotation of the inner cap 22; 22’ around the longitudinal axis L relative to the retainer 23; 23’. The inner cap 22; 22’ comprises a distally directed surface 222a. The outer cap 21 comprises a body 210 at least partially surrounding the cap body 220 of the inner cap 22; 22’. The outer cap 21 comprises a proximally directed surface 210a engaged with the distally directed surface 222a of the inner cap 22; 22’, as shown in Fig. 3B. The outer cap 21 comprises a distally directed surface 210b. The front sleeve 24 comprises a proximal wall 241 extending in a direction transverse to the longitudinal axis L and a sleeve body 240 extending in the direction of the longitudinal axis L from proximal wall 241 , as shown in Fig. 7. The cap body 220 of the inner cap 22; 22’ is at least partially positioned within the sleeve body 240. The proximal wall 241 is adjacent to the distally directed surface 210b of the outer cap 21 . The biasing member 25 is positioned between the proximal wall 241 of the front sleeve 24 and the proximally directed surface 230a of the retainer 23; 23’, as shown in Fig. 8. As a result, the when the outer cap 21 is attached to the retainer 23; 23’ via the engagement between the retainer 23; 23’ and the inner cap 22; 22’, the biasing member 25 is in a tensioned state, but being blocked from moving in the direction of the longitudinal axis L by the retainer 23; 23’ and the outer cap 21 , as shown in Fig. 1. Once the outer cap 21 and the inner cap 22; 22’ are removed from the retainer 23;

[0109] 23’, the biasing member 25 can move in the proximal direction relative to the retainer 23; 23’, as shown in Fig. 8. In a preferred example, the biasing member is a compression spring being compressible in the direction of the longitudinal axis L. In this example, the biasing member extends from a proximal end to a distal end along the longitudinal axis L. In a preferred example, the proximal end of the biasing member is adjacent to the proximal wall 241 of the front sleeve 24, and the distal end of the biasing member is adjacent to the proximally directed surface 230a of the retainer 23; 23’. Alternatively, or additionally, the biasing member is a flexible arm extending from the proximally directed surface of the retainer towards a proximal end. In this example, the proximal end of the flexible arm is adjacent to the proximal wall of the front sleeve. Alternatively, or additionally, the biasing member is a flexible arm extending from the proximal wall of the front sleeve towards a distal end. In this example, the distal end of the flexible arm is adjacent to the proximally directed surface of the retainer. In a preferred example, the biasing member 25 extends along the longitudinal axis L between a first end 25a and a second end 25b. The biasing member 25 is in contact with the proximal wall 241 of the front sleeve 24 at the first end 25a and is in contact with the proximally directed surface 230a of the retainer 23; 23’ at the second end 25b. Preferably, the biasing member is a compression spring configured to be compressible between the first end 25a and the second end 25b.

[0110] In a preferred example, a distal end of the outer cap 21 comprises the distally directed surface 210b of the outer cap 21 . In other words, the distal end of the outer cap 21 is configured to block the front sleeve from moving in the proximal direction relative to the retainer 23 when the outer cap 21 is attached to the retainer 23. Alternatively, or additionally, the outer cap comprises a protrusion extending from the body in the direction transverse to the longitudinal axis L. In this example, the protrusion comprises the distally directed surface of the outer cap.

[0111] In a preferred example, the outer cap 21 comprises a plurality of ribs extending from the outer surface of the body of the outer cap such that the user can easily grip the outer cap via the plurality of the ribs. In a preferred example, the ribs are inclined relative to the outer surface of the body of the outer cap in one rotational direction such that the user can get a tactile indication about the rotational direction that the inner cap and the outer cap can be detached by rotated in such direction. In a preferred example, the cap body of the inner cap is generally tubular. In a preferred example, a groove 222 is arranged in the cap body of the inner cap 22, as shown in Fig. 4. In this example, an edge of the groove 222 provides the distally directed surface 222a of the inner cap 22, as shown in Fig. 3B and Fig. 4. In this example, the body 210 of the outer cap 21 comprises a snaping arm configured to snap fit into the groove 222 of the inner cap 22, as shown in Fig. 3B. In this example, the snaping arm comprises the proximally directed surface 210a of the outer cap 21 . As a result, the inner cap 22 and the outer cap 21 are linearly immovable in the direction of the longitudinal axis L. In one example, the first fastener 233 of the body 230 of the retainer 23 and the counter first fastener 221 of the inner cap 22 formed a threaded fastener, as shown in Figs 10-11. Alternatively, the first fastener of the body of the retainer and the counter first fastener of the inner cap formed a bayonet fastener. In a preferred example, the outer cap 21 and the inner cap 22 are rotationally immovable in at least one rotation direction around the longitudinal axis L such that the inner cap 22 is configured to be rotated via the outer cap 21 . In this example, a user of the medicament delivery device having the sub-assembly 2 can hold and rotate the outer cap 21 to thus rotate the inner cap 22 relative to the retainer 23. Thus, a better user experience can be provided. In a preferred example, the cap body 220 of the inner cap 22 is engaged with the body 210 of the outer cap 21 to form an interface having a non-circular cross-section when observes along the longitudinal axis L. For example, the inner cap comprises a rib extending from the cap body in the direction transverse to the longitudinal axis towards a recess in the body of the outer cap; alternatively, or additionally, the body of the outer cap is formed with a triangle cross-section when observes along the longitudinal axis, and the cap body of the inner cap is also formed with a triangle cross-section when observes along the longitudinal axis and being snuggly fitted with the shape of the body of the outer cap. In another example, the sub-assembly 2 comprises a clutch 26 positioned between the cap body 220 of the inner cap 22 and the body 210 of the outer cap 21 in the direction transverse to the longitudinal axis L. The clutch 26 is engaged with the cap body 220 of the inner cap 22 to form an interface having a non-circular cross-section when observes along the longitudinal axis L. The clutch 26 is engaged with the body 210 and the outer cap 21 to form an interface having a non-circular cross-section when observes along the longitudinal axis L. In one example, the clutch 26 comprises an annular body 261 configured to enclose a section 223 of the cap body 220 of the inner cap 21 , as shown in Fig. 4. In this example, the annular body 261 of the clutch 26 is formed in polygon shape cross-section when observes along the longitudinal axis L, as shown in Fig. 5. Additionally, in a preferred example, the subassembly 2 comprises ratchet teeth 212 and a flexible arm 262 extending in the direction transverse to the longitudinal axis L towards the ratchet teeth 212. The ratchet teeth are attached to one of the body of the outer cap and the cap body of the inner cap, and the flexible arm is attached to the other one of the body of the outer cap and the cap body of the inner cap; such that an audible and / or tactile indication is generated when the flexible arm is rotated relative to the ratchet teeth. In one example where the subassembly 2 comprises the clutch 26, the flexible arm 262 can be provided by the clutch 26 as shown in Fig. 5. In this example, the flexible arm 262 is attached to the inner cap 22 via the clutch 26. In the example shown in Fig. 3A, the body 210 of the outer cap 21 comprises the ratchet teeth 212. In this example, the flexible arm 262 of the clutch 26 comprises a chamfered end 262a configured to be positioned between the ratchet teeth. As mentioned above, the clutch 26 is rotationally immovable and engaged with the inner cap 22, thus, when the user rotates the outer cap 21 relative to the retainer 23 in one rotational direction, e.g., counter-clockwise direction, the chamfered end 262a moves past each tooth of the ratchet teeth; thereby, the audible and / or tactile indication is generated. Furthermore, as the chamfered end 262a can move past the ratchet teeth, the rotation of the outer cap 21 cannot be converted into the rotation of the inner cap 22, as a result, the inner cap 22 cannot be detached from the retainer 23. The audible and / or tactile indication is thus an indication to indicate to the user that the outer cap 21 should be rotated in an opposite direction for the purpose of cap removal. Furthermore, the chamfered end 262a comprises a surface perpendicular to the annular body of the clutch, in this example, when the user rotates the outer cap 21 relative to the retainer 23 in the opposite rotational direction, e.g., clockwise direction, the perpendicular surface of the chamfered end 262a engages with one of the ratchet teeth 212 in the rotational direction. As a result, a rotation of the outer cap 21 relative to the retainer 23 also rotates the clutch 26 and the inner cap 22 relative to the retainer 23 around the longitudinal axis L. Thus, the inner cap 22 can be detached from the retainer 23.

[0112] In another example, the sub-assembly 2 comprises a medicament delivery hub 27; 27’ received within the channel 232; 232’ of the retainer 23; 23’ and a medicament delivery member 28 attached to the medicament delivery member hub 27; 27’, as shown in Fig. 10 and Fig. 12. The medicament delivery hub 27; 27’ and the delivery member 28 are both at least partially surrounded by the sleeve body 240 of the front sleeve 24. The inner cap 22; 22’ is configured to seal the medicament delivery member 28. In one example, the medicament delivery member is immovably attached to the retainer. Alternatively, in another example, the medicament delivery member 28 is movable relative to the retainer 23; 23’ in the direction of the longitudinal axis L. In this example, the delivery member hub 23; 23’ comprises a first interaction member 271 ; 270’ engaged with a counter interaction member 224; 224’ of the cap body 220 of the inner cap 22; 22’. The delivery member hub 27; 27’ comprises a second interaction member 272; 27T engaged with a counter interaction member 232a; 232a’ in the channel 232; 232’ of the retainer 23; 23’ such that the rotation of the cap body 220 relative to the channel 232; 232’ of the retainer 23; 23’ results in a movement of the medicament delivery hub 27; 27’ in the direction of the longitudinal axis L towards the distal end of the retainer 23; 23’. In this example, when the user removes the inner cap 22; 22’ from the retainer 23; 23’, the user also causes the medicament delivery member 28 to move in the direction of the longitudinal axis L. In a preferred example, the medicament delivery member is configured to be moved in towards the distal end of the retainer 23; 23’.

[0113] In one example, the first interaction member 27T and the second interaction member 27T are a protrusion extending from the delivery member hub 27’ in the direction transverse to the longitudinal axis L. In a preferred example, as shown in Fig. 12, the interaction member 271 ’ and the second interaction member 272’ are the same structure, e.g., the same protrusion of the delivery member hub 27’. In this example, the counter interaction member 224’ of the inner cap 22’ is a helical track 224’ extending in the cap body 220, as shown in Fig. 12. The counter interaction member 232a’ of the retainer 23’ is a slot 232a’ extending along the longitudinal axis L in the body 230 of the retainer 23’. The protrusion 27T of the delivery member hub 27’ is positioned both in the helical track 224’ of the cap body 220 and the slot 232a’ of the retainer 23’, as shown in Fig. 13. In this example, the slot 232a’ is configured to prevent the delivery member hub 27’ from rotating relative to the channel 232’ of the retainer 23’. Thus, when the inner cap 22’ is rotated relative to the retainer 23’ around the longitudinal axis L, the helical track 224’ moves the delivery member hub 27’ linearly in the direction of the longitudinal axis L. In a preferred example, the direction of the helical track 224’ is designed to move the delivery member hub 27’ towards the distal end of the retainer 23’ when the inner cap 22’ is rotated in a predetermined rotational direction. Alternatively, in another example, as shown in Figs 9-11 , the first interaction member 271 comprises a surface facing in the direction transverse to the longitudinal axis L. Preferably, the second interaction member 272 comprises a helical protrusion extending from the delivery member hub 27. In this example, the counter interaction member 224 of the inner cap 22 is a surface adjacent to the surface of the first interaction member 271. In a preferred example, the counter interaction member 232a of the retainer 23 is a thread 232a at least partially around an inner surface of the channel 232. In this example, the helical protrusion 272 is configured to move along the thread 232a’ of the retainer 23. In one example, cut-outs are arranged in the delivery member hub 27. In this example, the edges of cut-outs comprise the first interaction member 271 . Thus, when the inner cap 22 is rotated relative to the retainer 23 around the longitudinal axis L, the delivery member hub 27 is rotated relative to the channel 232 of the retainer 23. The interaction between the second interaction member 272 and the counter interaction member 232 causes the delivery member hub 27 to move in the direction of the longitudinal axis when the delivery member hub 27 is rotated. In a preferred example, the direction of the thread of the retainer 23 and / or the helical protrusion 271 of the delivery member hub 27 are designed to move the delivery member hub 27 towards the distal end of the retainer 23 when the inner cap 22 is rotated in a predetermined rotational direction. It should be noted that in the example where the delivery member hub 27 comprises the helical protrusion 271 , instead of having the thread, the counter interaction member can be a protrusion extending towards the longitudinal axis L; alternatively, in the example where the counter interaction member 232a of the retainer 23 is a thread 232a, instead of having a helical protrusion 272, the delivery member hub 27 can comprise a protrusion.

[0114] The front sleeve 24 of the sub-assembly 2 is configured to be used as a part of a medicament delivery guard of the medicament delivery device. The front sleeve 24 is configured to surround the medicament delivery member 28 of the medicament delivery device such that unintentional damage of the medicament delivery member and the injury of the user by the medicament delivery member can be avoided. In one example, the front sleeve 24 is configured to be in contact with the medicament delivery site during the use of the medicament delivery device. In one example, the proximal wall 241 of the front sleeve 24 comprises a flange 242 extending in the direction transverse to the longitudinal axis L beyond the sleeve body 241 . The flange 242 is configured to be in contact with a medicament delivery site during a medicament delivery operation of the medicament delivery device. In a preferred example, the front sleeve 24 comprises a fastener 243 configured to be attached to a component of the medicament delivery device to thereby form a medicament delivery member guard of the medicament delivery device. Furthermore, in another example, the retainer 23 comprises a second fastener 231 configured to be operably attached to a housing 10 of the medicament delivery device such that the sub-assembly 2 is attached to the housing 10 of the medicament delivery device via the retainer 23.

[0115] In one example, the fastener 243 of the front sleeve 24 is configured to be snap fitted to a component of the medicament delivery device to thereby form a medicament delivery member guard of the medicament delivery device. In one example, the second fastener 231 of the retainer 23 is configured to be snap fitted to a container carrier s of the medicament delivery device. In this example, the container carrier 6 of the medicament delivery device is configured to be attached to the housing 10 of the medicament delivery device.

[0116] Another aspect of the invention, as shown in Figs 14-22, provides a medicament delivery device comprising the sub-assembly 2 as mentioned in any example above. The medicament delivery device comprises the housing 10 extending along the longitudinal axis L between a proximal end and a distal end, and a medicament delivery member guard movably arranged in the housing 10. The medicament delivery member guard is formed by the front sleeve 24 attached to a distal sleeve 3. The front sleeve 24 is telescopic to the proximal end of the housing 10. The biasing member 25 is configured to move the medicament delivery member guard relative to the housing 10. In a preferred example, the housing 10 comprises a window 11 such that the user can observe the medicament via the window.

[0117] In a preferred example, the biasing member 25 is configured to move the front sleeve 24 further in the proximal direction relative to the housing 10 when the inner cap 22 and the outer cap 21 are removed from the retainer 23. In this example, the distal sleeve 3 is positioned in a distal position before the subassembly is attached to the housing 10 of the medicament delivery device. Once the front sleeve moves in the proximal direction relative to the housing, the front sleeve 24 pulls the distal sleeve to a proximal position. As mentioned above, in a preferred example, the fastener 234 of the front sleeve 24 is configured to snap fit to a counter fastener 34 of the distal sleeve 3 of the medicament delivery device to form the medicament delivery member guard. Furthermore, in another example, the medicament delivery device comprises the container carrier 6 within the housing 10. The container carrier 6 has a body 60 configured to contain a medicament container M containing a medicament. The second fastener 231 of the retainer 23 is configured to be attached to a counter fastener 61 of the body 60 of the container carrier 6. The container carrier 6 comprises a proximal opening lined up with the channel 232 of the retainer 23 in the direction of the longitudinal axis L when the retainer is attached to the container carrier 6. In a preferred example, the medicament delivery device further comprises a plunger rod 5 and an energy source 7. The plunger rod 5 is configured to be moved under the force of the energy source 7 into the medicament container to expel the medicament during the use of the medicament delivery device. In one example, the energy source 7 is a spring connected to the plunger rod 5. In a preferred example, the medicament delivery device comprises a guide rod 8 positioned within the spring 7 to prevent the spring from buckling. Alternatively, the energy source can be a gas canister containing pressurized gas. In one example, the medicament delivery device further comprises a rotator 4 configured to releasably hold the plunger rod 5 against the force from the energy source 7. In one example, as shown in Fig. 20, the rotator comprises a rotator body 40 having a retaining member 41 b, e.g., at least one ledge 41 b, extending from an inner surface of the rotator body 40. The plunger rod 5 comprises a plunger rod body 50 having a counter retaining member 51 , e.g., a ledge 51 extending from the plunger rod body 50. The counter ledge 51 of the plunger rod 5 is configured to engage with the ledge 41 b of the rotator 4 when the rotator 4 is in a first rotational position. In one example, the rotator 4 is axially immovable relative to the housing 10. For example, the housing 10 comprises a protrusion extending towards the longitudinal axis L. In this example, a proximal end of the rotator 4 is engaged with the protrusion of the housing 10. The rotator 4 is configured to be rotated around the longitudinal axis L from the first rotational position to a second rotational position where the counter ledge 51 of the plunger rod 5 is disengaged from the ledge of the rotator 4 such that the plunger rod 5 moves in the proximal direction relative to the housing 10. In one example, the rotator 4 is configured to be rotated by the distal sleeve 3 of the medicament delivery member guard. As shown in Fig. 19, the rotator 4 comprises a guiding track 40a comprising a helical surface. The distal sleeve 3 comprises a track follower 31 a configured to move along the guiding track 40a of the rotator 4 when the distal sleeve 3 is moved in the direction of the longitudinal axis L by the front sleeve 24. In one example, the track follower 31 a is a protrusion. In one example, the guiding track 40a of the rotator comprises a first helical surface 40b and a second helical surface 40c, as shown in Figs 21-22. In this example, the distal sleeve 3 is positioned in the distal position when the outer cap 21 is attached to the housing 10 via the retainer 23, as shown in Fig. 21 . When the outer cap 21 is removed, the front sleeve 24 moves the distal sleeve 3 to the proximal position, the track follower 31 a moves along the second helical surface 40c of the rotator 4, thus, rotates the rotator 4 from an initial position to the first rotational position, as shown in Fig. 22. When the user plans to carry out the medicament delivery operation, the user presses the proximal end, e.g., preferably, the flange 242 of the front sleeve 24 against the medicament delivery site. As a result, the front sleeve 24 and the distal sleeve 3 are moved in the distal direction relative to the housing 10. Thus, the track follower 31a moves along the first helical surface 40b of the rotator and thereby rotates the rotator 4 from the first rotational position to the second rotational position. As a result, the plunger rod 5 is released from the rotator 4.

[0118] In another example, the rotator 4 comprises a second retaining member 41 a, e.g., a second ledge 41a configured to engage with the counter ledge 51 of the plunger rod 5 when the rotator 4 is in the initial position. In this example, when the rotator 4 moves from the initial position to the first rotational position, the plunger rod 5 is disengaged from the second retaining member 41 a of the rotator 4 and moved in the proximal direction to engage with the retaining member 41 b of the rotator 4. This proximal movement of the plunger rod 5 can be used to perform a priming action, e.g., expel air from the medicament container; and / or mix medicament from one or more medicament containers within the container carrier 6.

[0119] In one example, the plunger rod 5 comprises an indication member 52 configured to interact with a counter indication member to provide an audible and / or tactile indication to the user about the start of the medicament delivery operation and / or the progress of the medicament delivery operation and / or the end of the medicament delivery operation. In one example, the counter indication member is a part of the rotator. Alternatively, or additionally, the counter indication member is a part of the container carrier. In a preferred example, the indication member is a set of ratchet teeth; and the counter indication member is a flexible arm.

[0120] In a preferred example, the housing 10, the distal sleeve 3, the rotator 4, the plunger rod 5, the container carrier 6, the energy source 7, the guide rod 8 (only when the energy source 7 is a spring) are configured to be assembled as a rear sub-assembly 1. In this example, the rear sub-assembly 1 and the subassembly 2 can be manufactured and assembled in different places and sent to a place that is closer to the end user to be assembled with the medicament container M. In a preferred example, as shown in Fig. 16, the medicament container M is configured to be linearly inserted (as shown with arrow X1) into the rear sub-assembly 1 , then the sub-assembly 2 can be linearly inserted (as shown with arrow X2) into the rear sub-assembly 1 to form the medicament delivery device.

[0121] Furthermore, the housing of the medicament delivery device, as mentioned in any example, may be provided with (i.e., molded in, molded with) a compound featuring persistently antimicrobial, antifungal, and / or antiviral properties. Alternatively, a compound featuring persistently antimicrobial, antifungal, and / or antiviral properties may be applied to the molded (i.e., finished) components through secondary processes (e.g., chemical vapor deposition), spraying, or dipping processes.

[0122] The medicament delivery devices described herein can be used for the treatment and / or prophylaxis of one or more of many different types of disorders. Exemplary disorders include, but are not limited to: rheumatoid arthritis, inflammatory bowel diseases (e.g. Crohn’s disease and ulcerative colitis), hypercholesterolaemia, diabetes (e.g. type 2 diabetes), psoriasis, migraines, multiple sclerosis, anaemia, lupus, atopic dermatitis, asthma, nasal polyps, acute hypoglycaemia, obesity, anaphylaxis and allergies. Exemplary types of medicaments that could be included in the medicament delivery devices described herein include, but are not limited to, small molecules, hormones, cytokines, blood products, antibodies, antibody-drug conjugates, bispecific antibodies, proteins, fusion proteins, peptibodies, polypeptides, pegylated proteins, protein fragments, protein analogues, protein variants, protein precursors, chimeric antigen receptor T cell therapies, cell or gene therapies, oncolytic viruses, or immunotherapies and / or protein derivatives. Exemplary medicaments that could be included in the medicament delivery devices described herein include, but are not limited to (with non-limiting examples of relevant disorders in brackets): etanercept (rheumatoid arthritis, inflammatory bowel diseases (e.g. Crohn’s disease and ulcerative colitis)), evolocumab (hypercholesterolaemia), exenatide (type 2 diabetes), secukinumab (psoriasis), erenumab (migraines), alirocumab (rheumatoid arthritis), methotrexate (amethopterin) (rheumatoid arthritis), tocilizumab (rheumatoid arthritis), interferon beta-1 a (multiple sclerosis), sumatriptan (migraines), adalimumab (rheumatoid arthritis), darbepoetin alfa (anaemia), belimumab (lupus), peginterferon beta-1 a' (multiple sclerosis), sarilumab (rheumatoid arthritis), semaglutide (type 2 diabetes, obesity), dupilumab (atopic dermatitis, asthma, nasal polyps, allergies), glucagon (acute hypoglycaemia), epinephrine (anaphylaxis), insulin (diabetes), atropine and vedolizumab (inflammatory bowel diseases (e.g. Crohn’s disease and ulcerative colitis)) , ipilimumab, nivolumab, pembrolizumab, atezolizumab, durvalumab, avelumab, cemiplimab, rituximab, trastuzumab, ado-trastuzumab emtansine, fam-trastuzumab deruxtecan-nxki, pertuzumab, transtuzumab-pertuzumab, alemtuzumab, belantamab mafodotin-blmf, bevacizumab, blinatumomab, brentuximab vedotin, cetuximab, daratumumab, elotuzumab, gemtuzumab ozogamicin, 90-Yttrium-ibritumomab tiuxetan, isatuximab, mogamulizumab, moxetumomab pasudotox, obinutuzumab, ofatumumab, olaratumab, panitumumab, polatuzumab vedotin, ramucirumab, sacituzumab govitecan, tafasitamab, or margetuximab. Pharmaceutical formulations including, but not limited to, any drug described herein are also contemplated for use in the medicament delivery devices described herein, for example, pharmaceutical formulations comprising a drug as listed herein (or a pharmaceutically acceptable salt of the drug) and a pharmaceutically acceptable carrier. Pharmaceutical formulations comprising a drug as listed herein (or a pharmaceutically acceptable salt of the drug) may include one or more other active ingredients, or may be the only active ingredient present. Exemplary medicaments that could be included in the medicament delivery devices described herein include, but are not limited to, an immuno-oncology or bio-oncology medications such as immune checkpoints, cytokines, chemokines, clusters of differentiation, interleukins, integrins, growth factors, enzymes, signaling proteins, pro-apoptotic proteins, anti-apoptotic proteins, T-cell receptors, B-cell receptors, or costimulatory proteins.

[0123] Exemplary medicaments that could be included in the medicament delivery devices described herein include, but are not limited to, those exhibiting a proposed mechanism of action, such as HER-2 receptor modulators, interleukin modulators, interferon modulators, CD38 modulators, CD22 modulators, CCR4 modulators, VEGF modulators, EGFR modulators, CD79b modulators, Trop-2 modulators, CD52 modulators, BCMA modulators, PDGFRA modulators, SLAMF7 modulators, PD-1 / PD-L1 inhibitors / modulators, B-lymphocyte antigen CD19 inhibitors, B-lymphocyte antigen CD20 modulators, CD3 modulators, CTLA-4 inhibitors, TIM-3 modulators, VISTA modulators, INDO inhibitors, LAG3 (CD223) antagonists, CD276 antigen modulators, CD47 antagonists, CD30 modulators, CD73 modulators, CD66 modulators, CDw137 agonists, CD158 modulators, CD27 modulators, CD58 modulators, CD80 modulators, CD33 modulators, APRIL receptor modulators, HLA antigen modulators, EGFR modulators, B-lymphocyte cell adhesion molecule modulators, CDw123 modulators, Erbb2 tyrosine kinase receptor modulators, mesothelin modulators, HAVCR2 antagonists, NY-ESO-1 0X40 receptor agonist modulators, adenosine A2 receptors, ICOS modulators, CD40 modulators, TIL therapies, or TCR therapies.

[0124] Exemplary medicaments that could be included in the medicament delivery devices described herein include, but are not limited to, a multi-medication treatment regimen such as AC, Dose-Dense AC, TCH, GT, EC, TAC, TC, TCHP, CMF, FOLFOX, mFOLFOX6, mFOLFOX7, FOLFCIS, CapeOx, FLOT, DCF, FOLFIRI, FOLFIRINOX, FOLFOXIRI, IROX, CHOP, R-CHOP, RCHOP-21 , Mini-CHOP, Maxi-CHOP, VR- CAP, Dose-Dense CHOP, EPOCH, Dose-Adjusted EPOCH, R-EPOCH, CODOX-M, IVAC, HyperCVAD, R-HyperCVAD, SC-EPOCH-RR, DHAP, ESHAP, GDP, ICE, MINE, CEPP, CDOP, GemOx, CEOP, CEPP, CHOEP, CHP, GCVP, DHAX, CALGB 8811 , HIDAC, MOpAD, 7 + 3, 5 +2, 7 + 4, MEC, CVP, RBAC500, DHA-Cis, DHA-Ca, DHA-Ox, RCVP, RCEPP, RCEOP, CMV, DDMVAC, GemFLP, ITP, VIDE, VDC, VAI, VDC-IE, MAP, PCV, FCR, FR, PCR, HDMP, OFAR, EMA / CO, EMA / EP, EP / EMA, TP / TE, BEP, TIP, VIP, TPEx, ABVD, BEACOPP, AVD, Mini-BEAM, IGEV, C-MOPP, GCD, GEMOX, CAV, DTPACE, VTD-PACE, DCEP, ATG, VAC, VelP, OFF, GTX, CAV, AD, MAID, AIM, VAC-IE, ADOC, or PE.

[0125] Exemplary medicaments that could be included in the medicament delivery devices described herein include, but are not limited to, those used for chemotherapy, such as an alkylating agent, plant alkaloid, antitumor antibiotic, antimetabolite, or topoisomerase inhibitor, enzyme, retinoid, or corticosteroid. Exemplary chemotherapy medicaments include, by way of example but not limitation, 5-fluorouracil, cisplatin, carboplatin, oxaliplatin, doxorubicin, daunorubicin, idarubicin, epirubicin, paclitaxel, docetaxel, cyclophosphamide, ifosfamide, azacitidine, decitabine, bendamustine, bleomycin, bortezomib, busulfan, cabazitaxel, carmustine, cladribine, cytarabine, dacarbazine, etoposide, fludarabine, gemcitabine, irinotecan, leucovorin, melphalan, methotrexate, pemetrexed, mitomycin, mitoxantrone, temsirolimus, topotecan, valrubicin, vincristine, vinblastine, or vinorelbine.

[0126] The inventive concept has mainly been described above with reference to a few examples. However, as is readily appreciated by a person skilled in the art, other embodiments than the ones disclosed above are equally possible within the scope of the inventive concept, as defined by the appended claims.

[0127] Some other aspects of the invention are defined by the following clauses.

[0128] 1 . A sub-assembly (2) of a medicament delivery device, the sub-assembly comprising: an outer cap (21), an inner cap (22; 22’), a retainer (23; 23’), a front sleeve (24), and a biasing member (25); wherein the retainer (23; 23’) comprises a body (230) extending along a longitudinal axis (L) between a proximal end and a distal end; wherein a channel (232; 232’) is arranged in the body of the retainer along the longitudinal axis; wherein the body (230) of the retainer (23; 23’) comprises a first fastener (233); wherein the retainer (23; 23’) comprises a proximally directed surface (230a); wherein the inner cap (22; 22’) comprises a cap body (220) having a counter first fastener (221) engaged with the first fastener (230a) of the retainer (23; 23’); wherein the counter first fastener (221) of the inner cap (22; 22’) is configured to be disengaged from the first fastener (233) of the retainer (23; 23’) by a rotation of the inner cap (22; 22’) around the longitudinal axis (L) relative to the retainer (23; 23’); wherein the inner cap (22; 22’) comprises a distally directed surface (222a); wherein the outer cap (21) comprises a body (210) at least partially surrounding the cap body (220) of the inner cap (22; 22’); wherein the outer cap (21) comprises a proximally directed surface (210a) engaged with the distally directed surface (222a) of the inner cap (22; 22’); wherein the outer cap (21) comprises a distally directed surface (210b); wherein the front sleeve (24) comprises a proximal wall (241) extending in a direction transverse to the longitudinal axis (L) and a sleeve body (240) extending in the direction of the longitudinal axis (L) from proximal wall (241); wherein the cap body (220) of the inner cap (22; 22’) is at least partially positioned within the sleeve body (240); wherein the proximal wall (241) is adjacent to the distally directed surface (210b) of the outer cap (21); and wherein the biasing member (25) is positioned between the proximal wall (241) of the front sleeve (24) and the proximally directed surface (230a) of the retainer (23; 23’).

[0129] 2. The sub-assembly according to clause 1 , wherein a distal end of the outer cap comprises the distally directed surface of the outer cap.

[0130] 3. The sub-assembly according to clause 1 or 2, wherein the first fastener of the body of the retainer and the counter first fastener of the inner cap formed a thread fastener. 4. The sub-assembly according to clause 1 or 2, wherein the first fastener of the body of the retainer and the counter first fastener of the inner cap formed a bayonet fastener.

[0131] 5. The sub-assembly according to any one of the preceding clauses, wherein the outer cap and the inner cap are rotationally immovable in at least one rotation direction around the longitudinal axis such that the inner cap is configured to be rotated via the outer cap.

[0132] 6. The sub-assembly according to clause 5, wherein the cap body of the inner cap is engaged with the body the outer cap to form an interface having a non-circular cross-section when observes along the longitudinal axis.

[0133] 7. The sub-assembly according to clause 5, wherein the sub-assembly comprises a clutch positioned between the cap body of the inner cap and the body of the outer cap in the direction transverse to the longitudinal axis; wherein the clutch is engaged with the cap body of the inner cap to form an interface having a non-circular cross-section when observes along the longitudinal axis; and wherein the clutch is engaged with the body the outer cap to form an interface having a non-circular cross-section when observes along the longitudinal axis.

[0134] 8. The sub-assembly according to any one of the preceding clauses, wherein the sub-assembly comprises ratchet teeth and a flexible arm extending in the direction transverse to the longitudinal axis towards the ratchet teeth; wherein the ratchet teeth are attached to one of the body of the outer cap and the cap body of the inner cap; wherein the flexible arm is attached to the other one of the body of the outer cap and the cap body of the inner cap; such that an audible and / or tactile indication is generated when the flexible arm is rotated relative to the ratchet teeth.

[0135] 9. The sub-assembly according to any one of the preceding clauses, wherein the sub-assembly comprises a medicament delivery hub received within the channel of the retainer and a medicament delivery member attached to the medicament delivery member hub; and wherein the medicament delivery hub and the delivery member are both at least partially surrounded by the sleeve body of the front sleeve.

[0136] 10. The sub-assembly according to clause 9, wherein the delivery member hub comprises a first interaction member engaged with a counter interaction member of the cap body of the inner cap; wherein the delivery member hub comprises a second interaction member engaged with a counter interaction member in the channel of the retainer such that the rotation of the cap body relative to the channel of the retainer results in a movement of the medicament delivery hub in the direction of the longitudinal axis towards the distal end of the retainer.

[0137] 11 . The sub-assembly according to clause 10, wherein the first interaction member and the second interaction member are a protrusion extending from the delivery member hub in the direction transverse to the longitudinal axis; wherein the counter interaction member of the inner cap is a helical track extending in the cap body; wherein the counter interaction member of the retainer is a slot extending along the longitudinal axis in the body of the retainer; and wherein the protrusion of the delivery member hub is positioned both in the helical track of the cap body and the slot of the retainer.

[0138] 12. The sub-assembly according to clause 10, wherein the first interaction member comprises a surface facing in the direction transverse to the longitudinal axis; wherein the second interaction member comprises a helical protrusion extending from the delivery member hub; wherein the counter interaction member of the inner cap is a surface adjacent to the surface of the first interaction member; wherein the counter interaction member of the retainer is a thread at least partially around an inner surface of the channel; and wherein the helical protrusion is configured to move along the thread of the retainer.

[0139] 13. The sub-assembly according to any one of the preceding clauses, wherein the proximal wall of the front sleeve comprises a flange extending in the direction transverse to the longitudinal axis beyond the sleeve body; and wherein the flange is configured to be in contact with a medicament delivery site during a medicament delivery operation of the medicament delivery device.

[0140] 14. The sub-assembly according to any one of the preceding clauses, wherein the front sleeve comprises a fastener configured to be attached to a component of the medicament delivery device to thereby form a medicament delivery member guard of the medicament delivery device.

[0141] 15. The sub-assembly according to any one of the preceding clauses, wherein the retainer comprises a second fastener configured to be operably attached to a housing of the medicament delivery device such that the sub-assembly is attached to the housing of the medicament delivery device via the retainer.

[0142] 16. The sub-assembly according to any one of the preceding claims, wherein the biasing member extends along the longitudinal axis between a first end and a second end; wherein the biasing member is in contact with the proximal wall of the front sleeve at the first end and is in contact with the proximally directed surface of the retainer at the second end.

[0143] 17. A medicament delivery device comprising the sub-assembly according to any one of the preceding clauses, wherein the medicament delivery device comprises a housing extending along the longitudinal axis between a proximal end and a distal end, and a medicament delivery member guard movably arranged in the housing; wherein the medicament delivery member guard is formed by the front sleeve attached to a distal sleeve; and wherein the front sleeve is telescopic to the proximal end of the housing.

[0144] 18. The medicament delivery device according to clause 17, wherein the biasing member is configured to move the front sleeve further in the proximal direction relative to the housing when the inner cap and the outer cap are removed from the retainer.

[0145] 19. The medicament delivery device according to clause 17 or 18 when dependent on clause 14, wherein the fastener of the front sleeve is configured to snap fit to a counter fastener of the distal sleeve of the medicament delivery device to form the medicament delivery member guard. 20. The medicament delivery device according to any one of clauses 17-19 when dependent on clause 15, wherein the medicament delivery device comprises a container carrier within the housing; wherein the container carrier is configured to contain a medicament container containing medicament; wherein the second fastener of the retainer is configured to be attached to a counter fastener of the container carrier; and wherein the container carrier comprises a proximal opening lined up with the channel of the retainer in the direction of the longitudinal axis when the retainer is attached to the container carrier.

[0146] 21 . The medicament delivery device according to clause 20, wherein the second fastener of the retainer is configured to snap fit to the counter fastener of the container carrier.

Claims

CLAIMS1 . A sub-assembly (2) of a medicament delivery device, the sub-assembly comprising: an outer cap (21), an inner cap (22; 22’), a retainer (23; 23’), a front sleeve (24), and a biasing member (25); wherein the retainer (23; 23’) comprises a body (230) extending along a longitudinal axis (L) between a proximal end and a distal end; wherein a channel (232; 232’) is arranged in the body of the retainer along the longitudinal axis; wherein the body (230) of the retainer (23; 23’) comprises a first fastener (233); wherein the retainer (23; 23’) comprises a proximally directed surface (230a); wherein the inner cap (22; 22’) comprises a cap body (220) having a counter first fastener (221) engaged with the first fastener (230a) of the retainer (23; 23’); wherein the counter first fastener (221) of the inner cap (22; 22’) is configured to be disengaged from the first fastener (233) of the retainer (23; 23’) by a rotation of the inner cap (22; 22’) around the longitudinal axis (L) relative to the retainer (23; 23’); wherein the inner cap (22; 22’) comprises a distally directed surface (222a); wherein the outer cap (21) comprises a body (210) at least partially surrounding the cap body (220) of the inner cap (22; 22’); wherein the outer cap (21) comprises a proximally directed surface (210a) engaged with the distally directed surface (222a) of the inner cap (22; 22’); wherein the outer cap (21) comprises a distally directed surface (210b); wherein the front sleeve (24) comprises a proximal wall (241) extending in a direction transverse to the longitudinal axis (L) and a sleeve body (240) extending in the direction of the longitudinal axis (L) from proximal wall (241); wherein the cap body (220) of the inner cap (22; 22’) is at least partially positioned within the sleeve body (240); wherein the proximal wall (241) is adjacent to the distally directed surface (210b) of the outer cap (21); and wherein the biasing member (25) is positioned between the proximal wall (241) of the front sleeve (24) and the proximally directed surface (230a) of the retainer (23; 23’).

2. The sub-assembly according to claim 1 , wherein a distal end of the outer cap comprises the distally directed surface of the outer cap.

3. The sub-assembly according to claim 1 or 2, wherein the first fastener of the body of the retainer and the counter first fastener of the inner cap formed a thread fastener.

4. The sub-assembly according to any one of the preceding claims, wherein the biasing member extends along the longitudinal axis between a first end and a second end; wherein the biasing member is in contact with the proximal wall of the front sleeve at the first end and is in contact with the proximally directed surface of the retainer at the second end.

5. The sub-assembly according to any one of the preceding claims, wherein the outer cap and the inner cap are rotationally immovable in at least one rotation direction around the longitudinal axis such that the inner cap is configured to be rotated via the outer cap.

6. The sub-assembly according to claim 5, wherein the sub-assembly comprises a clutch positioned between the cap body of the inner cap and the body of the outer cap in the direction transverse to the longitudinal axis; wherein the clutch is engaged with the cap body of the inner cap to form an interface having a non-circular cross-section when observes along the longitudinal axis; and wherein the clutch is engaged with the body the outer cap to form an interface having a non-circular cross-section when observes along the longitudinal axis.

7. The sub-assembly according to any one of the preceding claims, wherein the sub-assembly comprises ratchet teeth and a flexible arm extending in the direction transverse to the longitudinal axis towards the ratchet teeth; wherein the ratchet teeth are attached to one of the body of the outer cap and the cap body of the inner cap; wherein the flexible arm is attached to the other one of the body of the outer cap and the cap body of the inner cap; such that an audible and / or tactile indication is generated when the flexible arm is rotated relative to the ratchet teeth.

8. The sub-assembly according to any one of the preceding claims, wherein the sub-assembly comprises a medicament delivery hub received within the channel of the retainer and a medicament delivery member attached to the medicament delivery member hub; and wherein the medicament delivery hub and the delivery member are both at least partially surrounded by the sleeve body of the front sleeve.

9. The sub-assembly according to claim 8, wherein the delivery member hub comprises a first interaction member engaged with a counter interaction member of the cap body of the inner cap; wherein the delivery member hub comprises a second interaction member engaged with a counter interaction member in the channel of the retainer such that the rotation of the cap body relative to the channel of the retainer results in a movement of the medicament delivery hub in the direction of the longitudinal axis towards the distal end of the retainer.

10. The sub-assembly according to claim 9, wherein the first interaction member comprises a surface facing in the direction transverse to the longitudinal axis; wherein the second interaction member comprises a helical protrusion extending from the delivery member hub; wherein the counter interaction member of the inner cap is a surface adjacent to the surface of the first interaction member; wherein the counter interaction member of the retainer is a thread at least partially around an inner surface of the channel; and wherein the helical protrusion is configured to move along the thread of the retainer.11 . The sub-assembly according to any one of the preceding claims, wherein the proximal wall of the front sleeve comprises a flange extending in the direction transverse to the longitudinal axis beyond the sleeve body; and wherein the flange is configured to be in contact with a medicament delivery site during a medicament delivery operation of the medicament delivery device.

12. The sub-assembly according to any one of the preceding claims, wherein the front sleeve comprises a fastener configured to be attached to a component of the medicament delivery device to thereby form a medicament delivery member guard of the medicament delivery device.

13. The sub-assembly according to any one of the preceding claims, wherein the retainer comprises a second fastener configured to be operably attached to a housing of the medicament delivery device such that the sub-assembly is attached to the housing of the medicament delivery device via the retainer.

14. A medicament delivery device comprising the sub-assembly according to any one of the preceding claims, wherein the medicament delivery device comprises a housing extending along the longitudinal axis between a proximal end and a distal end, and a medicament delivery member guard movably arranged in the housing; wherein the medicament delivery member guard is formed by the front sleeve attached to a distal sleeve; and wherein the front sleeve is telescopic to the proximal end of the housing.

15. The medicament delivery device according to claim 16, wherein the biasing member is configured to move the front sleeve further in the proximal direction relative to the housing when the inner cap and the outer cap are removed from the retainer.

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