Cosmetic composition with an anti-glycation effect to improve the skin's resistance to aging

Abstract

Cosmetic composition with an antiglycation effect to improve skin's resistance to aging. A cosmetic composition for combating skin aging, particularly on the neck, includes a mixture of skin actives comprising vitamin C, a vitamin C derivative, or a combination thereof; dandelion root extract; and at least one additional active ingredient selected from the group consisting of caffeine, vitamin E, lavender oil, and combinations thereof; and an aqueous carrier system comprising water, in which the cosmetic composition inhibits the glycation of peptides and proteins. The skin actives are provided in an aqueous carrier in the form of a monophase, a biphase, or an emulsion, in which the cosmetic composition is a leave-on treatment in the form of a cream, gel, lotion, toner, or serum. Figure for abbreviation: none

Description

Title of the invention: Cosmetic composition with an antiglycation effect to improve the skin's resistance to aging. FIELD OF THE INVENTION

[0001] This disclosure relates to a water-based cosmetic composition for combating skin aging which includes a mixture of skin actives that inhibit the glycation of peptides and proteins. CONTEXT OF THE INVENTION

[0002] Skin aging and the visible and textural changes associated with it are the primary targets of a wide variety of cosmetic products. The skin of the face and neck are particularly important targets for such treatments, especially the skin of the neck, which has different physical characteristics than the skin of the face and, consequently, exhibits specific signs of aging, which may include fine lines, wrinkles, sagging, and loss of firmness. Among skin cleansers, toners, moisturizers, and other forms of treatment, a wide variety of skincare products offer blends of ingredients that address the signs of aging.Although many ingredients in these products are known to have significant biological effects, it is difficult to develop cosmetic treatments that include sufficient quantities and combinations of these ingredients to be effective.

[0003] A particular aspect of skin aging is the accumulation of advanced glycation end products (sometimes referred to as "AGEs" in the cosmetic literature) in the skin, which is involved in the skin aging process linked to collagen degradation (correlated with loss of skin firmness) and melanogenesis (correlated with loss of skin tone uniformity). Active ingredients with antiglycation activity are known, including, for example, aminoguanidine (also known as gallic acid, extracted from hazelnut shells), alisine (extracted from garlic), and carnosine (also known as beta-alanyl-L-histidine, a dipeptide found in mammals); however, these active ingredients are not always suitable for all cosmetic vehicles due to ingredient incompatibility, cost, and the negative impact on the aesthetics of the cosmetic product.

[0004] The present invention proposes a novel combination of active ingredients exhibiting an unexpected antiglycation effect which is synergistic in nature, in which none of the individual active ingredients possesses antiglycation activity at practical use levels, but the combination demonstrates a statistically significant inhibition of peptide and protein glycation. BRIEF SUMMARY OF THE INVENTION

[0005] In a first embodiment, the disclosure proposes a cosmetic composition that includes a mixture of skin actives comprising vitamin C, a vitamin C derivative, or one of their combinations; a dandelion root extract; and at least one additional active selected from the group consisting of caffeine, vitamin E and its derivatives, lavender oil, and their combinations; and an aqueous support system comprising water, in which the cosmetic composition inhibits the glycation of peptides and proteins.

[0006] In some embodiments, vitamin C, vitamin C derivative or one of their combinations is present at a rate of about 0.2% to about 50%, dandelion root extract is present at a rate of about 0.05% to about 5%, and each of at least one additional active ingredient is present at a rate of about 0.01% to about 5%, all percentages being by weight, relative to the total weight of the cosmetic composition.

[0007] In some embodiments, vitamin C, vitamin C derivative or one of their combinations is present at a rate of about 0.2% to about 10%, dandelion root extract is present at a rate of about 0.08% to about 3%, and each of at least one additional active ingredient is present at a rate of about 0.01% to about 1%, all percentages being by weight, relative to the total weight of the cosmetic composition.

[0008] In some embodiments, at least one additional active ingredient comprises caffeine present at a rate of approximately 0.05% to approximately 0.5%, by weight, relative to the total weight of the cosmetic composition.

[0009] In some embodiments, at least one additional active ingredient comprises vitamin E present at a rate of approximately 0.05% to approximately 0.5%, by weight, relative to the total weight of the cosmetic composition.

[0010] In some embodiments, at least one additional active ingredient comprises lavender oil present at a rate of approximately 0.010% to approximately 0.020%, by weight, relative to the total weight of the cosmetic composition.

[0011] In some embodiments, vitamin C, vitamin C derivative or one of their combinations is selected from the group consisting of 1-ascorbic acid, acetyl-C (3-O-ethylascorbic acid), magnesium ascorbyl phosphate, sodium ascorbyl phosphate, tetrahexyldecyl ascorbate, ascorbyl glucoside, and their combinations.

[0012] In some embodiments, vitamin C, vitamin C derivative or one of their combinations includes acetyl-C, and at least one additional active ingredient includes caffeine, vitamin E and its derivatives, and lavender oil.

[0013] In some embodiments, the cosmetic composition is a monophase, a biphase or an emulsion, and wherein the cosmetic composition is a leave-on treatment in the form of a cream, a gel, a lotion, a toner or a serum.

[0014] In some embodiments, the cosmetic composition includes at least one additive selected from the group consisting of solvents, surfactants, thickeners, oils, waxes, preservatives, brighteners, effect pigments, essential oils, plant extracts, cosmetic actives, and combinations thereof.

[0015] In certain embodiments, the cosmetic composition includes: at least one water-soluble solvent selected from the group consisting of denatured alcohol, glycerin, propylene glycol, pentylene glycol, PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerin, propanediol, butylene glycol, and combinations thereof; at least one thickener selected from the group consisting of hydroxyethylcellulose, xanthan gum, hydroxypropylcellulose, sclerotium gum, guar gum, acacia gum, gellan gum, hydroxypropyl guar, and combinations thereof; at least one surfactant selected from the group consisting of PPG-6-decyltetradeceth-30, PEG-60 hydrogenated castor oil, laureth-23, polyglyceryl-2-oleate, polyglyceryl-4-caprate and their combinations;at least one cosmetic active ingredient chosen from the group consisting of adenosine, citric acid, hydroxypropyltetrahydropyrantriol, methyl dihydrojasmonate, phenoxyethanol, potassium hydroxide, salicylic acid, sodium citrate, tetrasodium glutamate diacetate, peptides, niacinamide, camosine, and combinations thereof.

[0016] In another embodiment, the disclosure proposes a cosmetic composition that includes vitamin C, a vitamin C derivative, or a combination thereof; dandelion root extract; caffeine; vitamin E and its derivatives; and lavender oil; an aqueous carrier system comprising water and at least one additive selected from the group consisting of: at least one water-soluble solvent selected from the group consisting of denatured alcohol, glycerin, propylene glycol, PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerin, pentylene glycol, propanediol, butylene glycol, and combinations thereof; at least one thickener including hydroxyethylcellulose; at least one surfactant selected from the group consisting of PPG-6-decyltetradeceth-30, PEG-60 hydrogenated castor oil, laureth-23, polyglyceryl-2-oleate, polyglyceryl-4-caprate and their combinations;at least one cosmetic active ingredient chosen from the group consisting of adenosine, citric acid, hydroxypropyltetrahydropyrantriol, methyl dihydrojasmonate, phenoxyethanol, potassium hydroxide, salicylic acid, sodium citrate, the; tetrasodium glutamate diacetate, peptides, niacinamide, camosin, and combinations thereof; and combinations thereof, wherein the cosmetic composition inhibits the glycation of peptides and proteins, and wherein the cosmetic composition is a monophase, a biphase or an emulsion, and wherein the cosmetic composition is a leave-on treatment in the form of a cream, gel, lotion, toner or serum.

[0017] In some embodiments, vitamin C, a vitamin C derivative or one of their combinations is acetyl-C.

[0018] In some embodiments, acetyl-C is present at a rate of approximately 0.2% to approximately 10% by weight, relative to the total weight of the cosmetic composition; dandelion root extract is present at a rate of approximately 0.08% to approximately 3% by weight, relative to the total weight of the cosmetic composition; caffeine is present at a rate of approximately 0.05% to approximately 1% by weight, relative to the total weight of the cosmetic composition; vitamin E is present at a rate of approximately 0.05% to approximately 1% by weight, relative to the total weight of the cosmetic composition; lavender oil is present at a rate of approximately 0.01% to approximately 1% by weight, relative to the total weight of the cosmetic composition.

[0019] In some embodiments, at least one water-soluble solvent comprises alcohol, glycerin, propylene glycol, PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerin, and pentylene glycol; at least one thickener comprises hydroxyethylcellulose; at least one surfactant comprises PPG-6-decyltetradeceth-30; at least one additional active ingredient comprises adenosine, citric acid, hydroxypropyltetrahydropyrantriol, methyl dihydrojasmonate, phenoxyethanol, potassium hydroxide, salicylic acid, sodium citrate, and tetrasodium glutamate diacetate.

[0020] In certain embodiments of the cosmetic composition, acetyl-C is present at a concentration of approximately 0.2% to approximately 1.5%, dandelion root extract is present at a concentration of approximately 0.08% to approximately 3%, caffeine is present at a concentration of approximately 0.05% to approximately 0.5%, vitamin E is present at a concentration of approximately 0.05% to approximately 0.5%, and lavender oil is present at a concentration of approximately 0.010% to approximately 0.020%, all percentages being by weight, relative to the total weight of the cosmetic composition, and wherein the cosmetic composition is offered in the form of an emulsion and is a leave-on treatment in the form of a cream, gel, lotion, toner, or serum, and wherein the cosmetic composition inhibits the glycation of peptides and proteins.

[0021] In certain embodiments of the cosmetic composition, acetyl-C is present at a concentration of approximately 1%, dandelion root extract is present at a concentration of approximately 0.13%, caffeine is present at a concentration of approximately 0.1%, vitamin E is present at a rate of approximately 0.1%, and lavender oil is present at a rate of approximately 0.015%, all percentages being by weight, relative to the total weight of the cosmetic composition, and wherein the cosmetic composition is offered in the form of an emulsion and is a leave-on treatment in the form of a cream, gel, lotion, toner or serum, and wherein the cosmetic composition inhibits the glycation of peptides and proteins.

[0022] In certain embodiments of the cosmetic composition, acetyl-C is present at approximately 5%, dandelion root extract is present at approximately 0.22%, caffeine is present at approximately 0.5%, vitamin E is present at approximately 0.5%, and lavender oil is present at approximately 0.08%, all percentages being by weight, relative to the total weight of the cosmetic composition, and wherein the cosmetic composition is offered in the form of an emulsion and is a leave-on treatment in the form of a cream, gel, lotion, toner, or serum, and wherein the cosmetic composition inhibits the glycation of peptides and proteins.

[0023] In certain embodiments of the cosmetic composition, acetyl-C is present at approximately 10%, dandelion root extract is present at approximately 1.3%, caffeine is present at approximately 1%, vitamin E is present at approximately 1%, and lavender oil is present at approximately 0.15%, all percentages being by weight, relative to the total weight of the cosmetic composition, and wherein the cosmetic composition is offered in the form of an emulsion and is a leave-on treatment in the form of a cream, gel, lotion, toner, or serum, and wherein the cosmetic composition inhibits the glycation of peptides and proteins.

[0024] In another embodiment, the disclosure proposes a method for improving a keratinous substrate, the method including the provision of a leave-on cosmetic composition which includes: vitamin C, a vitamin C derivative, or a combination thereof; dandelion root extract; caffeine; vitamin E; lavender oil; and an aqueous carrier system comprising water; and optionally, an additive selected from the group consisting of: a water-soluble solvent selected from the group consisting of denatured alcohol, glycerin, propylene glycol, PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerin, pentylene glycol, propanediol, butylene glycol, and combinations thereof;at least one thickener selected from the group consisting of hydroxyethylcellulose, xanthan gum, hydroxypropylcellulose, sclerotium gum, guar gum, acacia gum, gellan gum, hydroxypropyl guar, and combinations thereof; a surfactant selected from the group consisting of PPG-6-decyltetradeceth-30, PEG-60 hydrogenated castor oil, laureth-23, polyglyceryl-2-oleate, polyglyceryl-4-; caprate and their combinations; a cosmetic active ingredient selected from the group consisting of adenosine, citric acid, hydroxypropyltetrahydropyrantriol, methyl dihydrojasmonate, phenoxyethanol, potassium hydroxide, salicylic acid, sodium citrate, tetrasodium glutamate diacetate, peptides, niacinamide, carnosine, and their combinations; and their combinations; the application of the cosmetic composition to the keratinous substrate at least twice daily, for one or more days and, in some examples, for a period of at least 10 days; wherein the cosmetic composition inhibits the glycation of peptides and proteins, and wherein the cosmetic composition is a monophase, a biphase or an emulsion, and wherein the cosmetic composition is a leave-on treatment in the form of a cream, gel, lotion, toner or serum.

[0025] These aspects of the invention, as well as others, are set out in the attached claims and described in more detail in the detailed description of the invention.

[0026] This disclosure describes examples of embodiments according to the general inventive concepts and is not intended to limit the scope of the invention in any way. Indeed, the invention as described in the patent application goes beyond the examples of embodiments presented here and is not limited to them, and the terms used herein have their full ordinary meaning. DETAILED DESCRIPTION OF THE INVENTION

[0027] “Keratinous substrate”, as used herein, includes, but is not limited to, tissues keratinous, such as the skin of the face and body, hair and nails.

[0028] The disclosure relates to a cosmetic composition for combating skin aging which includes a mixture of skin actives comprising vitamin C, a vitamin C derivative, or one of their combinations; a dandelion root extract; and at least one additional active selected from the group consisting of caffeine, vitamin E and its derivatives, lavender oil, and their combinations; and an aqueous carrier system comprising water, in which the cosmetic composition inhibits the glycation of peptides and proteins. The skin actives are delivered in an aqueous carrier in the form of a monophase, a biphase, or an emulsion, in which the cosmetic composition is a leave-on treatment in the form of a cream, gel, lotion, toner, or serum.

[0029] The cosmetic composition demonstrates a statistically significant inhibition of peptide and protein glycation, as demonstrated in in vitro experiments. Since peptide and protein glycation has been shown to impact skin quality and contribute to signs of aging, the cosmetic composition is useful for combating skin aging, including wrinkles, fine lines, sagging, and loss of firmness, in which the benefits that benefits that may be conferred may include one or more of the following: increased firmness, increased elasticity, improved hydration, and a reduction in the presence of superficial adipose tissue.

[0030] In various embodiments, the cosmetic composition comprises the following ingredients and additional optional ingredients. COMPOSITIONS Vitamin C / Derivatives

[0031] In various embodiments, the cosmetic composition includes vitamin C, a vitamin C derivative, or one of their combinations.

[0032] In some embodiments, vitamin C, vitamin C derivative or one of their combinations is selected from the group consisting of 1-ascorbic acid, acetyl-C (3-O-ethylascorbic acid), magnesium ascorbyl phosphate, sodium ascorbyl phosphate, tetrahexyldecyl ascorbate, ascorbyl glucoside, and their combinations.

[0033] In some embodiments, vitamin C, a vitamin C derivative, or a combination thereof comprises a vitamin C derivative that includes acetyl-C (3-O-ethylascorbic acid). In some embodiments, vitamin C, a vitamin C derivative, or a combination thereof comprises the vitamin C derivative consisting of acetyl-C (3-O-ethylascorbic acid).

[0034] The cosmetic composition comprises vitamin C, a vitamin C derivative, or a combination thereof, in concentrations of approximately 0.2% to approximately 50%, or approximately 0.2% to approximately 10%, or approximately 0.5% to approximately 1.5%, or approximately 50%, or approximately 10%, or approximately 5%, or approximately 1%, or any suitable combination, subcombination, range, or subrange of these values ​​by weight relative to the weight of the cosmetic composition. However, those skilled in the art will understand that other ranges fall within the scope of the invention.

[0035] Thus, vitamin C or a vitamin C derivative, or one of their combinations, is present by weight, relative to the total weight of the cosmetic composition, at a rate of approximately 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 25, 30, 35, 40, 45, to approximately 50 percent, including increments and ranges intermediates. Dandelion root extract

[0036] In various embodiments, the cosmetic composition includes a dandelion root extract (TARAXACUM OFFICINALE (DANDELION) RHIZOME / ROOT EXTRACT). A commercially available example of a dandelion root extract is APOLLUSKIN GRV - supplied by Silab.

[0037] The cosmetic composition comprises a dandelion root extract in a concentration of approximately 0.05% to approximately 50%, or approximately 0.05% to approximately 5%, or approximately 0.08% to approximately 3%, or approximately 0.08% to approximately 1.5%, or approximately 0.08% to approximately 0.18%, or approximately 0.13%, or approximately 0.22%, or approximately 1.3%, or approximately 2.2%, or approximately 3%, or any suitable combination, sub-combination, range, or sub-range of these values ​​by weight, relative to the weight of the cosmetic composition. However, those skilled in the art will understand that other ranges fall within the scope of the invention.

[0038] Thus, the dandelion root extract is present, by weight, relative to the total weight of the cosmetic composition, at a rate of approximately 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 25, 30, 35, 40, 45, to about 50 percent, including intermediate increments and ranges. Additional additives

[0039] In various embodiments, the cosmetic composition includes at least one additional active ingredient selected from the group consisting of caffeine, vitamin E (and its derivatives, including tocopheryl acetate, tocopheryl glucoside, tocopheryl phosphate, tocopheryl succinate, alpha-, beta-, gamma-, and delta-tocopherol, and alpha-, beta-, gamma-, and delta-tocotrienol), lavender oil (LAVANDULA ANGUSTIFOLIA (LAVENDER) OIL), and combinations thereof. In some embodiments, the cosmetic composition includes caffeine, vitamin E, and lavender oil as additional active ingredients.

[0040] In various embodiments, the cosmetic composition comprises each of the additional active ingredients present in a range from about 0.01% to about 50%, or from about 0.01% to about 10%, or from about 0.01% to about 5%, or from about 0.01% to about 1%, or any appropriate combination, sub-combination, range or sub-range of these values ​​by weight, relative to the weight of the cosmetic composition.

[0041] In various embodiments, the cosmetic composition comprises caffeine, if applicable, in a range of about 0.01% to about 50%, or about 0.01% to about 10%, or about 0.01% to about 5%, or about 0.01% to about 1%, or about 0.05% to about 1%, or about 0.05% to about 0.5%, or at a rate of about 0.1%, or about 0.5%, or about 1%, or about any appropriate combination, subcombination, range or subrange of these values ​​by weight, relative to the weight of the cosmetic composition.

[0042] In various embodiments, the cosmetic composition comprises vitamin E or one of its derivatives, as appropriate, in a range of approximately 0.01% to approximately 50%, or approximately 0.01% to approximately 10%, or approximately 0.01% to approximately 5%, or approximately 0.01% to approximately 1%, or approximately 0.05% to approximately 1%, or from about 0.05% to about 0.5%, or about 0.1%, or about 0.5%, or about 1%, or about any appropriate combination, sub-combination, range or sub-range of these values ​​by weight, relative to the weight of the cosmetic composition.

[0043] In various embodiments, the cosmetic composition comprises lavender oil, where appropriate, in a range of about 0.01% to about 50%, or about 0.01% to about 10%, or about 0.01% to about 5%, or about 0.01% to about 1%, or about 0.05% to about 0.5%, or about 0.010% to about 0.020%, or at a rate of about 0.015%, or about 0.08%, or about 0.15%, or any appropriate combination, subcombination, range or subrange of these values ​​by weight, relative to the weight of the cosmetic composition.

[0044] Thus, each of the at least one additional active ingredient may be present by weight, relative to the total of the cosmetic composition, at a rate of approximately 0.01, 0.015, 0.02, 0.025, 0.03, 0.035, 0.04, 0.045, 0.05, 0.055, 0.06, 0.065, 0.07, 0.075, 0.08, 0.085, 0.09, 0.095, 0.1, 0.15, 0.2, 0.25, 0.3, 0.35, 0.4, 0.45, 0.5, 0.55, 0.6, 0.65, 0.7, 0.75, 0.8, 0.85, 0.9, 0.95, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 25, 30, 35, 40, 45, to about 50 percent, including intermediate increments and ranges. Aqueous support system Water

[0045] In various embodiments, the cosmetic composition includes water. The cosmetic composition comprises from approximately 1% to approximately 99% water, or from approximately 10% to approximately 95%, or from approximately 15% to approximately 90%, or from approximately 40% to approximately 80%, or from approximately 45% to approximately 65%, or from approximately 55% to approximately 70%, or approximately 60%, or any appropriate combination, subcombination, range, or subrange of these values ​​by weight relative to the weight of the cosmetic composition. However, those skilled in the art will understand that other ranges fall within the scope of the invention.

[0046] Thus, water is present by weight, relative to the total weight of the cosmetic composition, at a rate of approximately 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95 to approximately 99 percent, including intermediate increments and ranges.

[0047] The pH of the cosmetic composition is not limited, but is generally greater than or equal to about pH 6 and, in some embodiments, is one between 5 and 8, and between 5 and 7, and between 6 and 7, and, in some embodiments, is about 6. The pH can be adjusted to the desired value by adding a base (organic or inorganic) to the cosmetic composition, for example, ammonia or a primary, secondary, or tertiary (poly)amine, such as monoethanolamine, diethanolamine, triethanolamine, isopropanolamine or 1,3-propanediamine, or alternatively by the addition of an inorganic or organic acid, advantageously a carboxylic acid, such as, for example, citric acid. Water-soluble solvents

[0048] In some embodiments, the cosmetic composition may include at least one water-soluble solvent. The term "water-soluble solvent" is interchangeable with "water-miscible solvent" and refers to a compound that is liquid at 25 °C and atmospheric pressure (760 mmHg), and that has a solubility of at least 50% in water under these conditions. In some cases, the water-soluble solvent has a solubility of at least 60%, 70%, 80%, or 90% in water under these conditions. Non-limiting examples of water-soluble solvents include, for example, glycerin, alcohols (e.g., C1-C30, C1-C15, C1-C10, or C1-C4 alcohols), organic solvents, polyols, glycols, or mixtures thereof.

[0049] In certain particular embodiments as disclosed, if applicable, a water-soluble solvent may include alcohol (denatured alcohol), glycerin, propylene glycol and pentylene glycol, or combinations thereof.

[0050] By way of non-limiting examples of organic solvents, monoalcohols and polyols such as ethyl alcohol, isopropyl alcohol, propyl alcohol, benzyl alcohol, and phenylethyl alcohol may be cited, or glycols or glycol ethers such as, for example, monomethyl-, monoethyl-, and monobutyl ethers of ethylene glycol, propylene glycol, or their ethers such as, for example, monomethyl ether of propylene glycol, butylene glycol, hexylene glycol, dipropylene glycol, and alkyl ethers of diethylene glycol, for example, diethylene glycol monoethyl ether or monobutyl ether. Other suitable examples of organic solvents are ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, propanediol, and glycerin. Organic solvents can be volatile or non-volatile compounds.

[0051] Other non-limiting examples of water-soluble solvents include alkanols (polyhydric alcohols such as glycols and polyols) such as glycerin, 1,2,6-hexanetriol, trimethylolpropane, ethylene glycol, propylene glycol, diethylene glycol, butylene glycol, hexylene glycol, triethylene glycol, tetraethylene glycol, pentaethylene glycol, dipropylene glycol, 1,3-butanediol, 2,3-butanediol, 1,4-butanediol, 3-methyl-1,3-butanediol, 1,5-pentanediol, tetraethylene glycol, 1,6-hexanediol, 2-methyl-2,4-pentanediol, polyethylene glycol, 1,2,4-butanetriol, 1,2,6-hexanetriol, 2-butene-1,4-diol, 2-ethyl-1,3-hexanediol, 2-methyl-2,4-pentanediol, (caprylyl glycol), 1,2-hexanediol, 1,2-pentanediol and 4-methyl-1,2-pentanediol; alkyl alcohols having 1 to 4 carbon atoms such as ethanol, methanol, butanol, propanol and isopropanol; glycol ethers such as monomethyl ethylene glycol ether, monoethyl ethylene glycol ether, monobutyl ethylene glycol ether, monomethyl ethylene glycol ether acetate, monomethyl diethylene glycol ether, monoethyl diethylene glycol ether, mono-n-propyl diethylene glycol ether, mono-isopropyl ethylene glycol ether, mono-isopropyl diethylene glycol ether, mono-n-butyl ethylene glycol ether, mono-t-butyl ethylene glycol ether, mono-t-butyl diethylene glycol ether, 1-methyl-l-methoxybutanol, monomethyl propylene glycol ether, monoethyl propylene glycol ether, mono-t-butyl propylene glycol ether, mono-n-propyl propylene glycol ether, mono-isopropyl propylene glycol ether, monomethyl dipropylene glycol ether, monoethyl dipropylene glycol ether, mono-n-propyl dipropylene glycol ether and mono-isopropyl dipropylene glycol ether;2-pyrrolidone, N-methyl-2-pyrrolidone, 1,3-dimethyl-2-imidazolidinone, formamide, acetamide, dimethyl sulfoxide, sorbitol, sorbitan, acetin, diacetinate, triacetin, sulfolane, or mixtures thereof.

[0052] In various embodiments, the amount of at least one water-soluble solvent, if any, is from approximately 0.1% to approximately 25%, or from approximately 0.1% to approximately 2%, or from approximately 0.1% to approximately 1%, or from approximately 0.1% to approximately 0.8%, or from approximately 0.1% to approximately 0.5%, or from approximately 1% to approximately 20%, or from approximately 1% to approximately 10%, or from approximately 2% to approximately 8%, or any appropriate combination, subcombination, range, or subrange of these values ​​by weight, relative to the weight of the cosmetic composition. A person skilled in the art will, however, understand that other ranges fall within the scope of the invention. In some embodiments, the cosmetic composition includes more than one water-soluble solvent, each water-soluble solvent being present in such an amount as indicated above, in which each different water-soluble solvent can be present in one of the ranges chosen from the ranges indicated above.

[0053] Thus, each water-soluble solvent or combination of water-soluble solvents, as appropriate, may be present by weight, relative to the total weight of the cosmetic composition, at a rate of approximately 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24 to approximately 25 percent by weight, including intermediate increments and ranges. Additional ingredients / additives

[0054] In certain embodiments, the cosmetic composition may include at least one additive selected from the group consisting of solvents, thickeners, surfactants, cosmetic actives, preservatives, oils, waxes, essential oils, plant extracts, pH adjusters, chelating agents, Dispersants, brighteners, pigments, effect pigments, dyes and colorants, powders, opacifiers, and their combinations.

[0055] In certain particular embodiments, the cosmetic composition includes additives selected from the group consisting of a water-soluble solvent selected from the group consisting of denatured alcohol, glycerin, propylene glycol, PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerin, pentylene glycol, propanediol, butylene glycol, and combinations thereof; at least one thickener selected from the group consisting of hydroxyethylcellulose, xanthan gum, hydroxypropylcellulose, sclerotium gum, guar gum, acacia gum, gellan gum, hydroxypropyl guar, and combinations thereof; at least one surfactant selected from the group consisting of PPG-6-decyltetradeceth-30, PEG-60 hydrogenated castor oil, laureth-23, polyglyceryl-2-oleate, polyglyceryl-4-caprate and their combinations;at least one cosmetic active ingredient chosen from the group consisting of adenosine, citric acid, hydroxypropyltetrahydropyrantriol, methyl dihydrojasmonate, phenoxyethanol, potassium hydroxide, salicylic acid, sodium citrate, tetrasodium glutamate diacetate, peptides, niacinamide, camosine, and combinations thereof. Thickening

[0056] In some embodiments, the cosmetic composition may include one or more thickeners. The thickener may be synthetic, mineral, or organic in nature, and may comprise a particle of any shape.

[0057] In certain embodiments according to disclosure, where applicable, a thickener may be hydroxyethylcellulose.

[0058] More generally, by way of non-limiting example, thickeners may be selected from xanthan gum, cellulose gum, acacia gum from Senegal, guar gum, sclerotium gum, dehydroxanthan gum, gellan gum, agar, algin, talc, mica, silica, silica surface-treated with a hydrophobic agent, fumed silica, kaolin, clay / mineral smectite powders (Argilla extract), polyamide (NYLON) powders (e.g., Atochem's ORGASOL), polyurethane powders, poly-[3-alanine] powder and polyethylene powder, tetrafluoroethylene (TEFLON) polymer powders, lauroyllysine, starch, boron nitride, hydrophobic silica aerogel particles, hollow microspheres of polymers such as those made of polyvinylidene chloride / acrylonitrile,for example EXPANCEL (Nobel Industrie) or acrylic acid copolymers (POLYTRAP from Dow Corning) and silicone resin microbeads (TOSPEARLS from Toshiba, for example), polyorganosiloxane elastomer particles, precipitated calcium carbonate, magnesium carbonate, magnesium hydrogen carbonate, hydroxyapatite, the , hollow silica microspheres (SILICA BEADS from Maprecos), glass or ceramic microcapsules and metallic soaps derived from organic carboxylic acids containing 8 to 22 carbon atoms and preferably 12 to 18 carbon atoms, for example zinc stearate, magnesium stearate, lithium stearate, zinc laurate, magnesium myristate and their combinations.

[0059] In certain embodiments, one or more thickeners may be present in the cosmetic composition at concentrations ranging from approximately 0.01% to approximately 10%, or from approximately 0.01% to approximately 5%, or from approximately 0.01% to approximately 1%, or from approximately 0.01% to approximately 0.2%, or from approximately 0.01% to approximately 0.09%, or from approximately 0.02% to approximately 0.08%, or any appropriate combination, subcombination, range, or subrange of these values ​​by weight relative to the weight of the cosmetic composition. However, those skilled in the art will understand that other ranges fall within the scope of the invention. In certain embodiments, the cosmetic composition includes more than one thickener, each thickener being present in an amount as indicated above, in which each different thickener may be present in any of the ranges selected from those stated above.

[0060] Thus, each thickener or combination of thickeners, as appropriate, may be present by weight, relative to the total weight of the cosmetic composition, at a rate of approximately 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 2, 3, 4, 5, 6, 7, 8, 9, to approximately 10 percent, including intermediate increments and ranges. Surfactant

[0061] In some embodiments, the cosmetic composition may include one or more surfactants. In some particular embodiments, the cosmetic composition may comprise an emulsion that includes one or more surfactants, alone or in combination, with one or more oils (as described below).

[0062] In certain particular embodiments as disclosed, if applicable, a surfactant may include PPG-6-decyltetradeceth-30.

[0063] By way of non-limiting example, surfactants may be selected from glyceryl stearate (for example, glyceryl stearate SE), stearic acid, potassium cetyl phosphate, and combinations thereof.

[0064] The one or more surfactants in the cosmetic composition may be present in an amount ranging from approximately 0.1% to approximately 5%, or from approximately 0.1% to approximately 1%, or from approximately 0.2% to approximately 0.8%, or from approximately 0.3% to approximately 0.5%. In at least some embodiments, the surfactant is present in an amount less than approximately 1%, or less than approximately 0.8%. In some embodiments, the cosmetic composition includes more than one surfactant, each surfactant being present in an amount as indicated above, in which each A different surfactant may be present in one of the ranges chosen from the ranges stated above.

[0065] Thus, each surfactant or combination of surfactants, as appropriate, may be present by weight, relative to the total weight of the cosmetic composition, at a rate of approximately 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 3, 4, to approximately 5 percent, including intermediate increments and ranges. Oil

[0066] In some embodiments, the cosmetic composition may include one or more oils. In some embodiments, the cosmetic composition may include an emulsion comprising one or more oils, alone or in combination, with one or more surfactants (as described above).

[0067] In some embodiments, the cosmetic composition may include Cymbopogon Martini Oil essential oil, or lavender oil (as an additional active ingredient), or one of their combinations.

[0068] As used herein, oil refers to any nonpolar compound that is liquid at 25 °C and is hydrophobic and lipophilic. An oil suitable for this application may be volatile or non-volatile. The term "volatile oil" refers to an oil that can evaporate upon contact with skin or a keratin fiber in less than one hour at room temperature and atmospheric pressure. The volatile oil(s) is / are liquid at room temperature and has / are a non-zero vapor pressure at room temperature and atmospheric pressure, in particular from 0.13 Pa to 40,000 Pa (10⁻³ to 300 mmHg). The term "non-volatile oil" refers to an oil that remains on the skin or keratin fiber at room temperature and atmospheric pressure for at least several hours and has, in particular, a vapor pressure of less than 10⁻³ mmHg (0.13 Pa).

[0069] In certain embodiments, by way of non-limiting example, one or more oils in the cosmetic composition may be chosen from botanical and essential oils, such as Helianthus annuus seed oil, Mentha piperita oil, Rosmarinus officinalis (rosemary) leaf oil, Pelargonium graveolens flower oil, Citrus aurantium dulcis (orange) peel oil, Mentha viridis (spearmint) leaf oil, Citrus aurantifolia (lime) oil, Melaleuca alternifolia (tea tree) leaf oil, Citrus grandis (grapefruit) peel oil, Citrus medica limonum (lemon) peel oil, rose flower oil, Eucalyptus globulus leaf oil, and their combinations.

[0070] The term "silicone oil" refers to an oil comprising at least one silicon atom and, in particular, at least one Si-O group. The term "fluorinated oil" refers to an oil comprising at least one fluorine atom. The term "oil" "Hydrocarbon-based" refers to an oil composed primarily of hydrogen and carbon atoms. Hydrocarbon-based oil can be an animal hydrocarbon-based oil, a vegetable hydrocarbon-based oil, a mineral hydrocarbon-based oil, or a synthetic hydrocarbon-based oil. Furthermore, a suitable oil can be a mineral hydrocarbon-based oil, a vegetable hydrocarbon-based oil, or a synthetic hydrocarbon-based oil. Silicone oils

[0071] The composition may include one or more silicone oils. Non-limiting examples of silicone oils include dimethicone, cyclomethicone, polysilicone-11, phenyltrimethicone, trimethylsilylamodimethicone, and steaoxytrimethylsilane. In some cases, the cosmetic composition includes dimethicone and, optionally, additional oils, including additional silicone oils. Generally, the one or more silicone oils are non-volatile silicone oils.In some embodiments, the silicone oil is polydimethylsiloxanes (PDMS), polydimethylsiloxanes comprising alkyl or alkoxy groups which are pendant and / or at the end of the silicone chain, each of which groups contain from 2 to 24 carbon atoms, or phenyl silicones, such as phenyltrimethicones, phenyldimethicones, phenyl(trimethylsiloxy)diphenylsiloxanes, diphenyldimethicones, diphenyl(methyldiphenyl)trisiloxanes or (2-phenylethyl)trimethylsiloxysilicates.

[0072] Other examples of silicone oils that may be mentioned include linear or cyclic volatile silicone oils, in particular those having a viscosity of 8 centistokes (8 x 10⁶ m² / s) and containing, in particular, 2 to 7 silicon atoms, these silicones optionally comprising alkyl or alkoxy groups containing 1 to 10 carbon atoms. Volatile silicone oils that may be used in the invention include, in particular, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, heptamethylhexyltrisiloxane, heptamethyloctyltrisiloxane, hexamethyldisiloxane, octamethyltrisiloxane, decamethyltetrasiloxane, and dodecamethylpentasiloxane, and mixtures thereof. Fluoride oils

[0073] The cosmetic composition may comprise one or more fluorinated oils. For example, the one or more fluorinated oils may be selected from the group consisting of perfluoromethylcyclopentane, perfluoro-1,3-dimethylcyclohexane, dodecafluoropentane, tetradecafluorohexane, bromoperfluorooctyl, nonafluoromethoxybutane, nonafluoroethoxyisobutane, and 4-trifluoromethylperfluoromorpholine. Volatile fluorinated oils, such as nonafluoromethoxybutane, may be selected from the group consisting of perfluoromethylcyclopentane, perfluoro-1,3-dimethylcyclohexane, dodecafluoropentane, tetradecafluorohexane, bromoperfluorooctyl, nonafluoromethoxybutane, nonafluoroethoxyisobutane, and 4-trifluoromethylperfluoromorpholine. decafluoropentane, tetradecafluorohexane and dodecafluoropentane can also be used. Hydrocarbon-based oils

[0074] The composition may include one or more hydrocarbon-based oils. For example, the hydrocarbon-based oil may be a saturated hydrocarbon, an unsaturated hydrocarbon, lipids, triglycerides, a natural oil, and / or a synthetic oil. In some embodiments, the cosmetic composition may include a synthetic oil selected from the group consisting of a hydrogenated polyisobutene and a hydrogenated polydecene. A hydrocarbon-based oil may be a non-volatile hydrocarbon-based oil, such as: i. Oils based on vegetable hydrocarbons, such as glyceride triesters, which are generally triesters of fatty acids and glycerol, the fatty acids of which may have varying chain lengths from C4 to C24, these chains being saturated or unsaturated and linear or branched;These oils include, in particular, wheat germ oil, sunflower oil, grapeseed oil, sesame oil, corn oil, apricot oil, castor oil, shea butter, avocado oil, olive oil, soybean oil, sweet almond oil, palm oil, rapeseed oil, cottonseed oil, hazelnut oil, macadamia oil, jojoba oil, alfalfa oil, poppy oil, pumpkin seed oil, squash seed oil, blackcurrant oil, evening primrose oil, millet oil, barley oil, quinoa oil, rye oil, safflower oil, candlenut oil, passionflower oil, and rosehip oil. ii. synthetic ethers containing 10 to 40 carbon atoms; iii. linear or branched hydrocarbons of mineral or synthetic origin, such as petroleum jelly, polydecenes, hydrogenated polyisobutene such as Parleam and squalane 40; iv. Synthetic esters, for example, oils of the formula RCOOR' in which R represents a linear or branched fatty acid residue containing from 1 to 40 carbon atoms and R' represents a hydrocarbon chain that is particularly branched, containing from 1 to 40 carbon atoms, provided that R + R' equals 10, for example, Purcellin oil (cetearyl octanoate), isopropyl myristate, isopropyl palmitate, a C12-C15 alkyl benzoate, such as the product sold under the trade names Finsolv TN® or Witconol TN® by Witco or Tegosoft TN® by Evonik Goldschmidt, 2-ethylphenyl benzoate, such as the product sold under the trade name X-Tend 226 by ISP, isopropyl lanolate, hexyl laurate, adipate diisopropyl, isononyl isononanoate, oleyl erucate, 2-ethylhexyl palmitate, isostearyl isostearate, diisopropyl sebacate, such as the product sold under the name "Dub Dis" by Stearinerie Dubois, octanoates, decanoates or ricinoleates of alcohols or polyols, such as propylene glycol dioctanoate; hydroxylated esters, such as isostearyl lactate or diisostearyl malate; and pentaerythritol esters; citrates or tartrates, such as C12-C13 linear di(alkyl) tartrates, such as those sold under the name Cosmacol ETI® by Enichem Augusta Industriale, as well as C14-C15 linear di(alkyl) tartrates, such as those sold under the name Cosmacol ETL® by the same company; or acetates; v. fatty alcohols which are liquid at room temperature, containing a branched and / or unsaturated carbon-based chain containing 12 to 26 carbon atoms, for example octyldodecanol, isostearyl alcohol, oleyl alcohol, 2-hexyldecanol, 2-butyloctanol and 2-undecylpentadecanol; vi. higher fatty acids, such as oleic acid, linoleic acid, or linolenic acid; vii. carbonates, such as dicaprylyl carbonate, such as the product sold under the name Cetiol CC© by Cognis; viii. fatty amides, such as isopropyl N-lauroylsarcosinate, such as the product sold under the trade name Eldew SL 205© by Ajinomoto; and ix. The essential oils chosen from the group consisting of sunflower oil, sesame oil, peppermint oil, macadamia nut oil, tea tree oil, evening primrose oil, sage oil, rosemary oil, coriander oil, thyme oil, chili berry oil, rose oil, anise oil, balsam fir oil, bergamot oil, rosewood oil, cedarwood oil, chamomile oil, sage oil, clary sage oil, clove oil, cypress oil, eucalyptus oil, fennel oil, sea fennel oil, frankincense oil, geranium oil, ginger oil, grapefruit oil, jasmine oil, juniper oil, lavender oil, lemon oil, Indian verbena oil, lime oil, mandarin oil, marjoram oil, myrrh oil, oil of neroli, orange oil,Patchouli oil, pepper oil, black pepper oil, bitter orange petitgrain oil, pine oil, rose otto oil, rosemary oil, sandalwood oil, spearmint oil, spikenard oil, vetiver oil, wintergreen oil, and ylang-ylang.

[0075] Hydrocarbon-based oils may be glyceride triesters and in particular caprylic / capric acid triglycerides, synthetic esters and in particular isononyl isononanoate, oleyl erucate, a C12-C15 alkyl benzoate, 2-ethylphenyl benzoate and fatty alcohols, such as octyldodecanol. Examples of volatile hydrocarbon-based oils include hydrocarbon-based oils containing 8 to 16 carbon atoms, and in particular C8-C16 branched alkanes, such as petroleum-derived C8-C16 isoalkanes (also known as isoparaffins), such as isododecane (also known as 2,2,4,4,6-pentamethylheptane), isodecane or isohexadecane, oils sold under the trade names Isopar or Permethyl, C8-C16 branched esters, and isohexyl neopentanoate.

[0076] In some embodiments, the cosmetic composition may comprise one or more oils such as those described above, and oils that may be selected from a branched or linear liquid alkane with a carbon chain length in the range of C1 to C20. In various embodiments, the liquid alkanes may be selected from those having a carbon chain length in the range of C1 to C20. The liquid alkanes may be selected from those having a carbon chain length in the range of C1 to C20, or in the range of C15 to C19, or one in the range of C1, C12, C13, C14, C15, C16, C17, C18, or C19. In some embodiments, suitable liquid alkanes that may be used according to disclosure include hydrocarbon-based oils containing 8 to 16 carbon atoms, and in particular C8-C16 branched alkanes such as C8-C16 isoalkanes.

[0077] In some embodiments, the cosmetic composition may comprise one or more oils selected from among polar emollients chosen from esters, triglycerides, ethers, carbonates, alcohols, oils, butters, fatty acids, and combinations thereof. In various embodiments, the polar emollients may be chosen from those having a molecular weight of 400 g / mol or less. More generally, the polar emollient may have a molecular weight in the range of approximately 50 g / mol% to approximately 350 g / mol.

[0078] In some embodiments, the cosmetic composition may include polar emollients which include those derived from C12-C50 fatty acids, preferably from C16-C22 saturated fatty acids and monohydric alcohols. In some embodiments, these esters may be selected from isopropyl myristate, methyl palmitate, isopropyl laurate, isopropyl palmitate, ethylhexyl palmitate, ethylhexyl laurate, ethylhexyl oleate, ethylhexyl isononanoate, myristyle myristate, 2-ethylhexyl caprate / caprylate (or octyl caprate / caprylate), 2-ethylhexyl palmitate, isostearyl neopentanoate, isononyl isononanoate, hexyl laurate, acid esters lactic and fatty alcohols comprising 12 or 13 carbon atoms, dicaprylyl carbonate and mixtures thereof.

[0079] The one or more oils, as appropriate, may be present in the cosmetic composition in concentrations of approximately 0.0001% to approximately 20%, or approximately 0.001% to approximately 0.0010%, or approximately 0.003% to approximately 0.004%, or approximately 0.01% to approximately 0.1%, or approximately 0.1% to approximately 10%, or approximately 0.5% to approximately 20%, or approximately 1% to approximately 10%, or approximately 5% to approximately 10%, or approximately 2% to approximately 7%, or approximately 0.5% to approximately 2%, or approximately 0.008% to approximately 0.01%, or approximately 0.1% to approximately 0.2%, or approximately 0.5% to approximately 2%, or approximately any combination, sub-combination, range, or an appropriate sub-range of these values ​​by weight, relative to the weight of the cosmetic composition. However, those skilled in the art will understand that other ranges fall within the scope of the invention.In some embodiments, the cosmetic composition includes more than one oil, each oil being present in such quantity as indicated above, in which each different oil (such as, for example, vegetable oils and extracts with oils) may be present in one of the ranges selected from the ranges stated above.

[0080] Thus, each oil or combination of oils, as appropriate, may be present by weight, relative to the total weight of the cosmetic composition, at a rate of approximately 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 3, 4, 5, 6, 7, 8, 9 to approximately 10 percent, including intermediate increments and ranges. Additional cosmetic active ingredients

[0081] In some embodiments, the cosmetic composition may include one or more additional cosmetic active ingredients in addition to vitamin C, dandelion root extract, and one or more of caffeine, vitamin E, and lavender oil as described herein. In some embodiments, more than one additional cosmetic active ingredient may be present in the cosmetic composition, the active ingredient being chosen to provide one or more benefits, such as, but not limited to, brightening / whitening, improving skin tone, controlling or reducing blemishes, reducing redness, an anti-aging effect, and moisturizing. Some cosmetic activities may be antimicrobial or preservative in nature, or may include pH adjusters or chelating agents.

[0082] In certain embodiments, the cosmetic composition includes at least one cosmetic active ingredient selected from the group consisting of adenosine, citric acid, hydroxypropyltetrahydropyrantriol, methyl dihydrojasmonate, the phenoxyethanol, potassium hydroxide, salicylic acid, sodium citrate, tetrasodium glutamate diacetate, peptides, and their combinations.

[0083] In certain particular embodiments, the cosmetic composition includes adenosine, citric acid, rhydroxypropyltetrahydropyrantriol, methyl dihydrojasmonate, phenoxyethanol, potassium hydroxide, salicylic acid, sodium citrate and tetrasodium glutamate diacetate.

[0084] In certain embodiments, the active ingredients may be selected from anti-aging ingredients including hydroxypropyltetrahydropyrantriol, one or more humectants, such as methyl gluceth-20, and one or more vitamins or vitamin derivatives, or one of the following: sodium citrate, citric acid, dipotassium glycyrrhizate, Anogeissus Leiocarpus bark extract, hydrolyzed Rhodophycea extract, hydrolyzed linseed extract, Pseudoalteromonas ferment extract, Manilkara Multinervis leaf extract, Lavandula Hybrida oil, Grifola Frondosa fruiting body extract, Plantago Lanceolata leaf extract, Cyathea Medullaris leaf extract, hydrolyzed hyaluronic acid, Malus Domestica fruit cell culture extract, resveratrol, salicyloyl phytosphingosine, glaucine, retinol, retinoic acid, and their combinations.

[0085] In certain embodiments, the active ingredients may be selected from oily skin treatment ingredients including Lens esculenta (lentil) seed extract, sarcosine, Peumus Boldus leaf extract, Crithmum Maritimum extract, niacinamide, salicylic acid, hydroxyethylpiperazineethane sulfonic acid, Spiraea Ulmaria extract, pentaerythrityl tetra-di-t-butylhydroxyhydrocinnamate and combinations thereof.

[0086] In some embodiments, the active ingredients may be selected from the complexion-enhancing ingredients, including Ophiopogon Japonicus root extract, Chenopodium quinoa seed extract, Tamarindus indica seed gum, xylitylglucoside (and) anhydroxylitol (and) xylitol, ceramide derivatives, helianthus annuus (sunflower) seed oil unsaponifiables, myristyle malate phosphonic acid, mannose, 2-oleamido-l,3-octadecanediol and combinations thereof.

[0087] In certain embodiments, the active ingredients may be selected from among the anti-redness active ingredients including madecassoside, saccharide isomerate, palmitoyl tripeptide-8, panthenol, olea europaea (olive) leaf extract, Mentha piperita (peppermint) extract, Leontopodium alpinum extract, dipotassium glycyrrhizate, cetyl ester of acetyl dipeptide-1, acetyl tetrapeptide-15, Boswellia serrata extract, sodium palmitoyl proline (and) nymphaea alba flower extract, and combinations thereof.

[0088] In some embodiments, the active ingredients can be chosen from glycerin and glycols such as, for example, propylene glycol, butylene glycol, dipropylene glycol and diethylene glycol, glycol ethers such as monopropylene, dipropylene and tripropylene glycol alkyl (C1-C4) ethers, monoethylene, diethylene and triethylene glycol; salicylic acid and their combinations.

[0089] In certain embodiments, the active ingredients may be selected from algae and plankton extracts, enzymes and coenzymes, ceramides, antioxidant compounds, including phenolic compounds such as chalcones, flavones, flavanones, flavanols, flavonols, dihydroflavonols, isoflavonoids, neoflavonoids, catechins, anthocyanidins, tannins, lignans, aurones, stilbenoids, curcuminoids, alkylphenols, betacyanins, capsacinoids, hydroxybenzoketones, methoxyphenols, naphthoquinones, and phenolic terpenes, curcumin, pinoresinol, hydroxytyrosol, cinnamic acid, caffeic acid, p-coumaric acid, the Baicalin, and other extracts and their combinations.

[0090] In some embodiments, the active ingredients may be selected from anti-elastase and anti-collagenase agents, peptides, fatty acid derivatives, steroids; free radical scavengers, vitamins, and vitamin derivatives, phenylethylresorcinol, alpha- and beta-hydroxy acids, and hydrogen peroxide.

[0091] In some embodiments, the active ingredients can be selected from sunscreen agents (for example, an inorganic sunscreen agent, such as titanium dioxide and zinc oxide, and organic sunscreen agents, such as octocrylene, ethylhexyl salicylate, homosalate, and avobenzone); and their combinations.

[0092] In some embodiments, one or more additional optional cosmetic actives are water-soluble.

[0093] Although the optional active additives are given by way of examples, it shall be understood that other optional components compatible with known cosmetic applications in the art may be used.

[0094] In various embodiments, one or more additional cosmetic active ingredients, alone or in combination as appropriate, may be present in the cosmetic composition at concentrations of approximately 0.00001% to approximately 25%, or approximately 0.00005% to approximately 15%, or approximately 0.0001% to approximately 2%, or approximately 0.05% to approximately 1%, or approximately 0.02% to approximately 2%, or approximately 0.2% to approximately 1%, or any suitable combination, sub-combination, range, or sub-range of these values ​​by weight relative to the weight of the cosmetic composition. However, those skilled in the art will understand that other ranges fall within the scope of the invention. In some embodiments, the composition A cosmetic product comprises two, three, four, or more active ingredients, some or all of which may be water-soluble. In some embodiments, the cosmetic composition includes more than one additional cosmetic active ingredient, each additional cosmetic active ingredient being present in an amount as indicated above, in which each different additional cosmetic active ingredient may be present in one of the ranges selected from those stated above.

[0095] Thus, each additional cosmetic active ingredient or combination of additional cosmetic active ingredients, as appropriate, may be present by weight, relative to the total weight of the cosmetic composition, at a rate of approximately 0.00001, 0.00002, 0.00003, 0.00004, 0.00005, 0.00006, 0.00007, 0.00008, 0.00009, 0.0001, 0.0002, 0.0003, 0.0004, 0.0005, 0.0006, 0.0007, 0.0008, 0.0009, 0.001, 0.002, 0.003, 0.004, 0.005, 0.006, 0.007, 0.008, 0.009, 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, to approximately 25 percent, including intermediate increments and ranges. Optional additives

[0096] The cosmetic composition may also include one or more optional additives used in the cosmetic field which do not negatively affect the properties of the cosmetic composition according to the invention.

[0097] Optional additives may be selected from perfumes, pearlescent agents, fillers, powders, preservatives, proteins, protein hydrolysates, vitamins, silicones, odor absorbers and coloring materials; skin conditioners, moisturizing agents, antimicrobial components, including, but not limited to, phenoxyethanol, chlorphenesin, capryloyl glycol and sodium salicylate; thickeners and fillers, fruit extracts, for example Pyrus Malus (apple) fruit extract, and Aloe Barbadensis leaf juice powder; citric acid, sodium chloride; neutralizing or pH-correcting agents (for example, triethylamine (TEA) and sodium hydroxide), and combinations thereof.

[0098] In some embodiments, optional additives may be selected from fillers. The fillers may be of mineral or organic origin, natural or synthetic, to provide oil absorption or optical effects. Oil-absorbing fillers may impart a matte finish and a non-greasy feel to the skin. Optical effect fillers may give the skin an artistic blurring / veiling / blurring effect, make the skin appear more even, reduce the appearance of skin imperfections or discolorations, or minimize the visibility of pores.

[0099] Where appropriate, a filler may include a crosslinked vinyldimethicone / methicone silsesquioxane polymer, ammonium polyacryloyldimethyltaurate, a crosslinked methyl methacrylate polymer, silica silylate, mica, Zea starch maize (corn), magnesium oxide, nylon-12, nylon-66, cellulose, polyethylene, talc, talc (and) methicone, talc (and) dimethicone, perlite, sodium silicate, pumice, PTFE, ammonium polyacryloyldimethyltaurate, polymethyl methacrylate, rice starch, aluminum starch octenylsuccinate, modified potato starch, alumina, calcium sodium borosilicate, magnesium carbonate, hydrated silica, crosslinked dimethicone / vinyldimethicone polymer, sodium carboxymethyl starch, bismuth oxychloride, silica silylate, boron nitride, iron oxide, carbonate of calcium, calcium sulfate (and) iron oxides, sodium aluminum potassium silicate, silica, silica (and) methicone, silica (and) dimethicone, polysilicone-22, polysilicone-8, polysilicone-11,a crosslinked polymer of methyl methacrylate, polymethylsilsesquioxane, a crosslinked methylsilanol / silicate polymer, a crosslinked vinyldimethicone / methicone silsesquioxane polymer, a crosslinked diphenyldimethicone / vinyl diphenyldimethicone silsesquioxane polymer, and a styrene / acrylates copolymer.

[0100] Although the optional active additives are given by way of examples, it shall be understood that other optional components compatible with known cosmetic applications in the art may be used.

[0101] In various embodiments, where appropriate, the quantity of optional additives present in the cosmetic composition may range from about 0.001% to about 50%, or from about 0.01% to about 30%, or from about 1.5% to about 20%, and from about 5% to about 15%, or from about 0.005% to about 0.1%, or from about 0.05% to about 1%, or from about 0.06% to about 0.075%, or from about 0.1% to about 1%, or from about 0.25% to about 5%, and from about 0.5% to about 3.5%, or from about 0.2% to about 0.8%, or any appropriate combination, subcombination, range or subrange of these values ​​by weight, relative to the weight of the cosmetic composition. However, a person skilled in the art will understand that other beaches fall within the scope of the invention.In some embodiments, the cosmetic composition includes more than one optional component, each optional component being present in an amount as indicated above, in which each different optional component may be present in one of the ranges selected from the ranges stated above.

[0102] Thus, each optional component or combination of optional components, as appropriate, may be present by weight, relative to the total weight of the cosmetic composition, at a rate of approximately 0.001, 0.002, 0.003, 0.004, 0.005, 0.006, 0.007, 0.008, 0.009, 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 25, 30, 35, 40, 45 to approximately 50 percent, including intermediate increments and ranges. EXAMPLES

[0103] The following examples are provided for illustrative purposes only and are not intended to be limiting. Example 1#: Raw materials

[0104] The raw materials used in the example compositions include, in part, those listed in Table 1. Table 1#: Raw materials (partial list) RAW MATERIAL % of ACTIVE (IF LESS THAN 100%) 3-O-ETHYLASCORBIC ACID TARAXA CUM OFFICINALE (DANDELION) ROOT / RHIZOME EXTRACT 4.3 (the remainder being water, pentylene glycol) CAFFEINE TOCOPHERYL / TOCOPHERYL ACETATE LAVANDULA ANGUSTIFOLIA (LAVANDE) OIL HYDROXYPROPYL TETRAHYDROPYRANTIOL 35 (the remainder being water, propylene glycol) TETRASODIUM GLUTAMATE DIACETATE 47.5 (the remainder being water) Example 2#: Compositions

[0106] A representative example of a composition of the invention is shown in Table 2.

[0107] Table 2: Composition of invention A (a quantity in the table below reflects the final % by weight of active ingredient in the composition for active ingredients that are less than 100% in the MP) Composition of the invention A Ingredient Quantity 3-O-ETHYLASCORBIC ACID 1.00 ADENOSINE 0.04 ALCOHOL DENAT. 3.00 CAFFEINE 0.10 CITRIC ACID 0.12 CYMBOPOGON MARTINI OIL 0.02 GLYCERIN 5.00 HYDROXYETHYLCELLULOSE 0.40 HYDROXYPROPYL TETRAHYDROPYRANTRIOL 1.75 LAVANDULA ANGUSTIFOLIA (LAVENDER) OIL 0.015 METHYL DIHYDROJASMONATE 0.10 PEG / PPG / POLYBUTYLE GLYCOL-8 / 5 / 3 GLYCERIN 2.00 PHENOXYETHANOL 0.50 POTASSIUM HYDROXIDE 0.18 PPG-6-DECYLTETRADECETH-30 0.80 PROPYLENE GLYCOL 7.25 PENTYLENE GLYCOL 0.30 SALICYLIC ACID 0.45 SODIUM CITRATE 0.10 TARAXACUM OFFICINALE (DANDELION) ROOT / RHIZOME EXTRACT 0.13 TETRASODIUM GLUTAMATE DIACETATE 0.095 TOCOPHEROL / TOCOPHERYL ACETATE 0.10 WATER QS (-76)

[0108] In some embodiments, the cosmetic composition may include the following ingredients in total weight amounts of the cosmetic composition which include: 3-O-ethylascorbic acid (-1.00), adenosine (-0.04), alcohol denat. (-3.00), caffeine (-0.10), citric acid (-0.12), Cymbopogon Martini oil (-0.02), glycerin (-5.00), hydroxyethylcellulose (-0.40), hydroxypropyltetrahydropyrantriol (-1.75), Lavandula Angustifolia (lavender) oil (-0.015), methyl dihydrojasmonate (-0.10), PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerin (-2.00), phenoxyethanol (-0.50), potassium hydroxide (-0.18), PPG-6-decyltetradeceth-3 (-0.80), propylene glycol (-7.25), pentylene glycol (-0.30), salicylic acid (-0.45), sodium citrate (-0.10), extract of Taraxacum Officinale (dandelion) rhizome / root (-0.13), tetrasodium glutamate diacetate (-0.095), tocopherol / acetate tocopheryl (-0.10), water (-76), all present by weight relative to the weight of the cosmetic composition. Example 2#: In vitro glycation study.

[0109] A study was conducted in vitro / in tubo to evaluate whether the ingredients of the composition of the invention possess anti-glycation effects in an in tubo environment.

[0110] In tubo experiments were conducted to evaluate the glycation of BSA (bovine serum albumin) under control conditions and with exposure to an embodiment of the composition of the invention. Samples were prepared, including inventive, comparative, reference, and positive and negative controls.

[0111] A test plate was prepared with separate wells to receive each of the test compositions. Solutions representing the active ingredient concentrations listed under "Ingredient" in Table 3 below were added to a well containing BSA + D-ribose (the indicator solution) and PBS. The total amount of test solutions added for the compositions of the invention was always the same for all tests—25 microliters—5 microliters of each test solution (ingredient) per well. PBS was used as the solvent for the test solution. The plates were prepared in triplicate.

[0112] Compositions under test: Virgin: PBS + BSA, Negative control: PBS + BSA + D-ribose, Positive control: PBS + BSA + D-ribose + Aminoguanidine, five compositions of the invention

[0113] The concentrations listed in the table below represent the concentration of the active ingredient in the test solution added to each well - each ingredient other than the indicator solutions was added in quantities of 5 ml. For example, with reference to the composition Inv 4 in Table 3, five (5) microlitres of each of activated C (3-O-ETHYLASCORBIC ACID), dandelion extract, caffeine, lavender oil and vitamin E (tocopherol), (5 microlitres each -> 25 microlitres in total), each solution containing 50% of the active ingredient (activated C, dandelion extract, caffeine, lavender oil and vitamin E), in which each added ingredient had the initial concentration as indicated in the column corresponding to Inv 4, were added to wells containing the indicator solution.Inv 5 was tested in the same manner as Inv 4, except that each test solution contained 100% of the active ingredient (with the exception of caffeine, as shown in Table 3).

[0114] For compositions 1 to 5 of the invention: 5 x 5 microliters of each ingredient in the respective concentrations listed below were added to the [PBS + BSA + D-ribose] solution for a total volume of 250 microliters. In the 50% test combination, 2.5 microliters of each ingredient, except caffeine, were added. The caffeine was diluted separately with 5 microliters of PBS. to obtain a concentration of 1.5%. Then, the diluted caffeine was added to the remaining solution to obtain a total volume of 250 microliters. In the 100% test combination, 5 microliters of each ingredient, except caffeine, were added. The caffeine was separately diluted with 5 microliters of PBS to obtain a concentration of 2%. Then, the diluted caffeine was added to the remaining solution to obtain a total volume of 250 microliters.

[0115] The samples evaluated in the glycation study are presented in Table 3. The quantities of ingredients listed in the compositions of the invention below represent quantities of test solution as described above, and not the final concentration of active ingredient.

[0116] Table 3: Samples for the glycation study Ingredient Test Composition Ingredient Reference Negative Control Positive Control Inv 1 Inv 2 Inv 3 Inv 4 Inv 5 PBS + + + + + + + + BSA + + + + + + + D-Ribose + + + + + + + Aminoguanidine + Activated C (3-O-ETHYLASCORBIC ACID) 1 5 10 50 100 Dandelion Extract 3 15 30 50 100 CAFFEINE 0.1 0.5 1 1.5 2 Lavender Oil 0.01 5 0.08 0.15 50 100 Vitamin E (Tocopherol) 0.1 0.5 1 50 100 Protocol#:

[0117] The samples were placed on a plate in triplicate and the measurements were taken at the wavelength indicated on days 1 and 14.

[0118] Fluorescence intensity assessments were performed at ex 370 nm / em 440 nm

[0119] The samples were evaluated at intervals of 0 days, 3 days, 14 days, and 21 days. The main objective of incorporating time intervals is to have a Sufficient duration to capture the anti-glycation effect. It is essential to incorporate several time points to properly capture the anti-glycation effects, as they can vary depending on the specific ingredients used.

[0120] The amplitude of the fluorescence intensity is a positive indication of the extent of glycation. Glycation should be maximal with the negative control (BSA plus D-ribose), whereas glycation of the positive control with a known anti-glycation agent, aminoguanidine, should be reduced compared to the negative control.

[0121] The summary data of the glycation study are presented in Table 4, in which the results shown are those of the measurements on day 14. Table 4#: Summary Data Test Composition Fluorescence Intensity Percentage Glycation Reduction (%) Reference - - Negative Control 3.805 0 Positive Control 2.921 23 Inv 1 3.134 17 Inv 2 2.883 24 Inv 3 2.939 23 Inv 4 (50% of all active ingredients*) 2.964 22 Inv 5 (100% of all active ingredients*) 2.664 30

[0123] * all active ingredients include activated vitamin C (3-O-ethylascorbic acid), Dandelion extract, caffeine, vitamin E (tocopherol), lavender extract. Results#:

[0124] A significant anti-glycation effect was observed with the composition of the invention at all levels of components tested.

[0125] Evaluation of the anti-glycation effect of individual ingredients: each of activated carbon, dandelion extract, caffeine, lavender oil and vitamin E (quantities of 5 microliters) was introduced into a plate with 245 microliters of [PBS + BSA + D-ribose]. The concentrations of each ingredient added to the wells were as follows: activated carbon (100%, 50%, 10%, 5% and 1%), dandelion extract (100%, 50%, 30%, 15% and 3%), caffeine (2%, 1.5%, 1%, 0.5% and 0.1%), lavender oil (100%, 50%, 0.15%, 0.08% and 0.15%) and vitamin E (100%, 50%, 1%, 0.5% and 0.1%). The results with the individual ingredients (not shown) demonstrated that each of the activated carbon and dandelion extract only exhibited a glycation effect at high levels, and no glycation effect was observed with caffeine, lavender oil or vitamin E.

[0126] The key ingredients having concentrations in the final formula showed significant benefits on the reduction of glycation compared to the condition treated by D-ribose alone, demonstrating synergistic effects in combination when no significant effect was shown when each ingredient was tested individually at lower rates or at the rate of the final formula.

[0127] Embodiments of the composition of the invention have shown significant benefits in reducing glycation compared to the negative control (condition treated with D-ribose alone without an anti-glycation agent), and compared to the individual ingredients of the composition of the invention tested alone. Ascorbic acid and dandelion extract, respectively, when tested alone, demonstrated a reduction in glycation only at high doses, whereas each of caffeine, lavender oil, and vitamin E showed no significant reduction in glycation.

[0128] The data reveal that the embodiments of the composition of the invention exhibit statistically less glycation than with the active ingredients alone, which demonstrates synergistic effects in combination, and that the overall results with the compositions of the invention are comparable to those of the known anti-glycation ingredient, aminoguanidine.

[0129] The articles "a" and "an" as used herein mean one or more when applied to any particular feature in embodiments of the present invention described in the specification and claims. The articles "the," "a," or "them" preceding singular or plural nouns or noun phrases denote a specified particular feature or specific features and may have a singular or plural connotation depending on the context in which it is used. The adjectives "any" and "all" mean one, some, or all indiscriminately, regardless of quantity.

[0130] “One or more”, as used herein, means one or more and therefore includes individual components as well as mixtures / combinations.

[0131] The transitional terms “comprising,” “consisting essentially of,” and “consisting of,” when used in the appended claims, in their original and amended forms, define the scope of the claims with respect to any additional elements or steps not mentioned, which are excluded from the scope of the claim(s). The term “comprising” is intended to be inclusive or broad and does not exclude any additional, unmentioned element, process, step, or material. The term “consisting of” excludes any element, step, or material other than those specified in the claims and, in In the latter case, the impurities ordinarily associated with the specified material(s). The expression "consisting essentially of" limits the scope of a claim to the specified elements, steps, or material(s) and to those that do not materially affect the fundamental and innovative feature(s) of the claimed invention. All the processes and materials described herein that incorporate the present invention can, in alternative embodiments, be defined more specifically by any of the transitional expressions "comprising," "consisting essentially of," and "consisting of."

[0132] The terms "free" and "devoid" indicate that no reliably measurable excluded material is present in the cosmetic composition, typically 0% by weight, relative to the total weight of the cosmetic composition. The expression "essentially free" means that, although it is preferable that no excluded material be present in the cosmetic composition, it is possible to have very small amounts of the excluded material in the cosmetic composition of the invention, provided that such amounts do not materially affect the advantageous properties of the cosmetic composition. In particular, "essentially free" means that the excluded material may be present in the cosmetic composition in an amount of less than approximately 0.1% by weight, relative to the total weight of the cosmetic composition.

[0133] Apart from the operational examples, or unless otherwise indicated, it is understood that all numbers expressing quantities of ingredients and / or reaction conditions are modified in all cases by the term "about", meaning plus or minus 10% of the number indicated (for example, "about 10%" means 9% to 11% and "about 2%" means 1.8% to 2.2%).

[0134] All percentages and ratios are, unless otherwise stated, calculated by weight. All percentages are, unless otherwise stated, calculated relative to the total composition. In general, unless expressly stated otherwise herein, "weight" or "quantity" as used herein with respect to the percentage quantity of an ingredient refers to the quantity of raw material comprising the ingredient, the raw material being described herein as comprising less than and up to 100% of the ingredient's activity. Accordingly, the weight percentage of an active ingredient in a composition is represented as the quantity of raw material containing the active ingredient that is used and may or may not reflect the final percentage of the active ingredient, the final percentage of the active ingredient being dependent on the weight percentage of the active ingredient in the raw material.

[0135] All ranges and quantities given herein are intended to include subranges and quantities using any disclosed point as a boundary. Thus, a range of "1% to 10%, such as 2% to 8%, such as 3% to 5%", is intended to encompass the ranges from "1% to 8%", from "1% to 5%", from "2% to 10%", and so on. All figures, quantities, ranges, etc., are understood to be modified by the term "approximately", whether or not it is expressly stated. Similarly, a given range of "approximately 1% to 10%" is understood to have its 1% and 10% limits modified by the term "approximately". Furthermore, it is understood that when a quantity of a component is given, it is assumed to mean the quantity of the active ingredient, unless specifically stated otherwise.

[0136] Although the numerical ranges and parameters presenting the general scope of the disclosure are approximations, unless otherwise indicated, the numerical values ​​presented in the specific examples are reported as accurately as possible. However, every numerical value inherently contains some errors necessarily resulting from the standard deviation observed in their respective test measurements. The following example serves to illustrate embodiments of this disclosure but is not intended to be exhaustive.

[0137] Although the invention has been described with reference to one or more embodiments, a person skilled in the art will understand that various changes can be made and equivalents can replace elements without departing from the scope of the invention. Furthermore, numerous modifications can be made to adapt a particular situation or subject matter to the teachings of the invention without departing from its essential scope. Therefore, the invention is not limited to the particular embodiment disclosed as being the best envisaged embodiment for implementing this invention, but the invention will include all embodiments within the scope of the appended claims. In addition, all numerical values ​​identified in the detailed description are to be interpreted as if both the precise and approximate values ​​were expressly identified.

Claims

Demands

1. Cosmetic composition comprising: a. a mixture of skin actives including vitamin C, a vitamin C derivative, or a combination thereof; dandelion root extract; and at least one additional active selected from the group consisting of caffeine, vitamin E, lavender oil and combinations thereof; and b. an aqueous carrier system comprising water, in which the cosmetic composition inhibits the glycation of peptides and proteins.

2. Cosmetic composition according to claim 1, wherein the cosmetic composition includes at least one additive selected from the group consisting of solvents, surfactants, thickeners, oils, waxes, preservatives, brighteners, effect pigments, essential oils, plant extracts, cosmetic actives, and combinations thereof.

3. Cosmetic composition according to claim 1 or 2, wherein vitamin C, vitamin C derivative or combination thereof is present from about 0.2% to about 50%, dandelion root extract is present from about 0.05% to about 5%, and each of at least one additional active ingredient is present from about 0.01% to about 5%, all percentages being by weight, relative to the total weight of the cosmetic composition.

4. Cosmetic composition according to any one of the preceding claims, wherein vitamin C, vitamin C derivative or combination thereof is selected from the group consisting of 1-ascorbic acid, acetyl-C (3-O-ethylascorbic acid), magnesium ascorbyl phosphate, sodium ascorbyl phosphate, tetrahexyldecyl ascorbate, ascorbyl glucoside, and combinations thereof.

5. Cosmetic composition according to any one of the preceding claims, wherein vitamin C, vitamin C derivative or a combination thereof comprises acetyl-C.

6. Cosmetic composition according to claim 5, wherein at least one additional active ingredient comprises caffeine, vitamin E and lavender oil.

7. Cosmetic composition according to claim 6, wherein: a. Acetyl-C is present at a concentration of approximately 0.2% to approximately 10% by weight, relative to the total weight of the cosmetic composition; b. Dandelion root extract is present at a concentration of approximately 0.08% to approximately 1.5% by weight, relative to the total weight of the cosmetic composition; c. Caffeine is present at a concentration of approximately 0.05% to approximately 1% by weight, relative to the total weight of the cosmetic composition; d. Vitamin E is present at a concentration of approximately 0.05% to approximately 1% by weight, relative to the total weight of the cosmetic composition; e. Lavender oil is present at a concentration of approximately 0.01% to approximately 1% by weight, relative to the total weight of the cosmetic composition.

8. A cosmetic composition according to any one of claims 2 to 7, wherein the cosmetic composition comprises: a. at least one water-soluble solvent selected from the group consisting of denatured alcohol, glycerin, propylene glycol, pentylene glycol, PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerin, propanediol, butylene glycol, and combinations thereof; b. at least one thickener selected from the group consisting of hydroxyethylcellulose, xanthan gum, hydroxypropylcellulose, sclerotium gum, guar gum, acacia gum, gellan gum, hydroxypropyl guar, and combinations thereof; c. at least one surfactant selected from the group consisting of PPG-6-decyltetradeceth-30, PEG-60 hydrogenated castor oil, laureth-23, polyglyceryl-2-oleate, polyglyceryl-4-caprate and their combinations; d.at least one cosmetic active ingredient chosen from the group consisting of adenosine, citric acid, hydroxypropyltetrahydropyrantriol, methyl dihydrojasmonate, phenoxyethanol, potassium hydroxide, salicylic acid, sodium citrate, tetrasodium glutamate diacetate, peptides, niacinamide, camosine, and their combinations.

9. A cosmetic composition according to claim 8, wherein at least one water-soluble solvent comprises alcohol, glycerin, propylene glycol, pentylene glycol, and PEG / PPG / polybutylene glycol-8 / 5 / 3 glycerin; at least one thickener comprises hydroxyethylcellulose; at least one Surfactant includes PPG-6-decyltetradeceth-30; At least one additional active ingredient includes adenosine, citric acid, hydroxypropyltetrahydropyrantriol, methyl dihydrojasmonate, phenoxyethanol, potassium hydroxide, salicylic acid, sodium citrate, and tetrasodium glutamate diacetate.

10. Cosmetic composition according to any one of the preceding claims, wherein the cosmetic composition is a monophase, a biphase or an emulsion, and wherein the cosmetic composition is a leave-on treatment in the form of a cream, gel, lotion, toner or serum.