Apparatus for thermal cycling and related methods - Patents.com

JP2024511359A5Active Publication Date: 2025-03-25BG RESEARCH LTD
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Patent Information

Application Number
JP2023557042
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2021-12-22
Filing Date
2022-03-18
Publication Date
2025-03-25
Estimated Expiration
2042-03-18

AI Technical Summary

Technical Problem

Existing thermal cyclers for direct RT-qPCR from crude samples face challenges in achieving rapid and uniform thermal cycling of large reaction volumes, leading to inefficiencies and prolonged processing times, especially when handling pathogenic samples without prior treatment.

Method used

A thermal conduction chamber (TCC) design using opposing Peltier cells to directly hold the reaction vessel, combined with a thermally conductive reaction vessel and a dual-purpose cap portion for sealing and independent heating, ensures rapid and uniform temperature control across the entire reaction volume.

Benefits of technology

This approach significantly reduces thermal cycle time and enhances temperature uniformity, allowing for faster and more reliable pathogen detection in crude samples, even in portable devices.

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Abstract

1. An apparatus comprising: first and second Peltier devices arranged substantially opposite one another; and a thermal conduction chamber defined substantially between the first and second Peltier devices and configured to surround a reaction vessel in use to facilitate transfer of heat between the reaction vessel and the Peltier devices.
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