Cyclic peptides for trapping interleukin-1β

JP2025084920A5Pending Publication Date: 2026-06-16MERCK SHARP & DOHME LLC
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
MERCK SHARP & DOHME LLC
Filing Date
2025-03-03
Publication Date
2026-06-16

AI Technical Summary

Technical Problem

Current treatments for atherosclerotic cardiovascular disease (ASCVD) primarily focus on cholesterol-lowering drugs, which while effective, do not adequately address the inflammatory component of the disease, particularly the role of interleukin-1β (IL-1β) in promoting vascular inflammation.

Method used

Development of specific cyclic peptides that bind to IL-1β, preventing its interaction with the IL-1 receptor and thereby inhibiting downstream inflammatory signaling pathways. These peptides can be administered orally and are designed to treat cardiovascular diseases such as atherosclerosis and inflammatory disorders.

Benefits of technology

The cyclic peptides effectively capture IL-1β, reducing downstream inflammatory markers like IL-6 and CRP, which can slow the progression of atherosclerotic disease and reduce the risk of major adverse cardiac events (MACE).

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Abstract

To provide additional, non-surgical therapeutic approaches beyond the standard of care cholesterol-lowering medications for slowing the progression of atherosclerosis and decreasing the risk of Major Adverse Cardiac Events (MACE).SOLUTION: The present disclosure provides cyclic peptides represented by a specific formula, which reduce inflammation by binding to an IL-1β cytokine and prevent binding to an IL-1 receptor, thereby inhibiting downstream pro-inflammatory signaling. These cyclic peptides can be pharmaceutically active compounds useful for the treatment of cardiovascular diseases and inflammatory disorders.SELECTED DRAWING: None
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