Dual-action PDE5 inhibitor / organic nitrate transdermal dosage forms for enhancing local blood flow
By developing a dual-acting drug, using NO release and PDE5 inhibition to promote local blood flow, and achieving more efficient hair loss treatment through transdermal administer of microinjection, the problems of inefficiency and side effects in the prior art are solved.
JP2025507886AInactive Publication Date: 2025-03-21IND ACADEMIC COOP FOUND YONSEI UNIV +2
2 Cites 0 Cited by
Patent Information
- Application Number
- JP2024552117
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2022-03-02
- Filing Date
- 2023-03-02
- Publication Date
- 2025-03-21
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
Technical Problem
The prior art has problems of inefficiency in the treatment and prevention of hair loss, the need for frequent application and the potential for systemic side effects.
Method used
A dual-acting drug was developed to promote local blood flow by releasing nitric oxide (NO) and inhibiting phosphorus odiesterase type 5 (PDE5) to achieve more efficient treatment by transdermal administration of microinjection.
Benefits of technology
This approach significantly improves the efficacy of hair loss treatment in a single application, reduces the risk of systemic drug exposure, avoids side effects, and shows low dose effectiveness in female hair loss patterns.
✦ Generated by Eureka AI based on patent content.
Abstract
The present invention relates to a transdermal dosage form of a dual-acting PDE5 inhibitor / organic nitrate ester for enhancing local blood flow, more particularly to the use of a compound or a pharma- ceutically acceptable salt thereof, which acts dually as a soluble guanylate cyclase activator and a phosphodiesterase inhibitor to enhance local blood flow, for preventing or treating hair loss and various symptoms or diseases, and the transdermal dosage form thereof. The compound enhances local blood flow, thereby exerting excellent effects on preventing and treating hair loss and various other diseases caused by reduced local blood flow without side effects, and when injected intradermally using a microneedle, it exerts significantly improved effects on preventing and treating hair loss and various other diseases caused by reduced local blood flow, even with less frequent treatment, compared to treatment by application.
Need to check novelty before this filing date? Find Prior Art