Ranmodulin orthologs with improved rare earth separation performance

JP2025532059A5Pending Publication Date: 2026-09-25THE PENN STATE RES FOUND INC +1
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Patent Information

Application Number
JP2025515981
Authority / Receiving Office
JP · JP
Patent Type
Applications
Current Assignee / Owner
Priority Date
2023-05-30
Filing Date
2023-09-18
Publication Date
2026-09-25

AI Technical Summary

Technical Problem

The inefficient separation of rare earth elements (REEs) in traditional hydrometallurgical methods, which require numerous steps and toxic solvents, and the need for greener, more selective processes to address the similar physicochemical properties of lanthanides.

Method used

Development of proteins, such as Hansschlegelia quercus LanM (Hans-LanM), with enhanced selectivity for light rare earth elements (LREs) over heavy REEs, capable of binding and separating REEs through conformational changes and dimerization, facilitated by EF-hand motifs.

Benefits of technology

Hans-LanM proteins provide high selectivity and efficiency in separating LREs from HREs in a single step, reducing the number of processing steps and eliminating the use of toxic solvents, thus offering a more environmentally friendly and effective REE separation method.

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Abstract

A protein that binds to rare earth metals is provided. The protein may have improved rare earth metal / rare earth metal selectivity. The protein may have four EF-hand motifs, each having 11, 12, or 13 amino acid residues. Each EF-hand motif is separated by 12 or 13 amino acid residues, each amino acid residue is any canonical amino acid residue, and at least one amino acid residue is a hydrophobic amino acid residue. When the EF-hand motif has 12 amino acid residues, the motif may have the following sequence: X 1 -X 2 -X 3 -X 4 -X 5 -X 6 -X 7 -X 8 -X 9 -X 10 -X 11 Also provided are devices and kits comprising the proteins of the present disclosure. Methods of using the proteins and devices are also provided.
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