Glycation inhibitors

Abstract

This invention provides a glycation inhibitor consisting of effective ingredients and their mixing ratios that suppress the generation of AGEs. [Solution] The glycation inhibitor comprises an inhibitory component consisting of peony extract and celery extract in a 5:1 ratio, preferably with the inhibitory component present in the solvent at a concentration of 0.06% to 0.6%. Experiments have confirmed that the presence of this inhibitory component, consisting of peony extract and celery extract in a 5:1 ratio, is effective in inhibiting glycation.

Description

Technical Field

[0001] The present invention relates to a glycation inhibitor for suppressing glycation, particularly for suppressing the generation of advanced glycation end products (AGEs).

Background Art

[0002] It is known that suppressing oxidation in the human body and adjusting the environment of the skin (such as the scalp) can be achieved. This is because when reactive oxygen species are generated in the body, they damage the surrounding cells, leading to skin aging and deterioration. Glycation is also known as one of the factors that damage such skin. This is a phenomenon in which the proteins in the body bind to the sugars ingested from food and are altered by being warmed at body temperature.

[0003] If this is left as it is, it will change into advanced glycation end products (AGEs). It is very difficult to remove these AGEs from the body, and the method has not yet been established. If AGEs are generated and left as they are, it may cause diabetes, change the skin color to a yellowish color, or lead to skin aging and lesions. Therefore, it is necessary to suppress the generation of such AGEs, that is, to suppress the generation of AGEs by not causing glycation in the body.

[0004] In order to suppress the generation of such AGEs, inhibitors for suppressing the generation of advanced glycation end products are known (for example, see Patent Document 1). In Patent Document 1, an inhibitor for suppressing the generation of advanced glycation end products containing a xanthotoxol derivative as an active ingredient is provided, and the xanthotoxol derivative is preferably used for the prevention and / or treatment of diabetes or diabetic complications, and for the prevention and / or improvement of skin aging due to its action of suppressing the generation of advanced glycation end products.

Prior Art Documents

Patent Documents

[0005]

Patent Document 1

Summary of the Invention

[0006] However, it has not yet been considered which ingredients actually suppress the formation of AGEs, or, even if those ingredients are identified, what proportions of those ingredients are effective.

[0007] This invention takes into account the above-mentioned prior art and aims to provide a glycation inhibitor consisting of effective components and their mixing ratios for suppressing the generation of AGEs. [Means for solving the problem]

[0008] To achieve the above objective, the present invention provides a glycation inhibitor characterized by comprising an inhibitory component in which peony extract and celery extract are in a 5:1 ratio.

[0009] Preferably, the inhibitory component is present in the solvent at a concentration of 0.06% to 0.6%. [Effects of the Invention]

[0010] According to the present invention, the inhibitory component contains peony extract and celery extract in a 5:1 ratio, and experiments have confirmed that this is effective in inhibiting glycation.

[0011] Furthermore, experiments have confirmed that if this inhibitory component is present in the solvent at a concentration of 0.06% to 0.6%, it exhibits an even greater inhibitory effect on glycation. [Brief explanation of the drawing]

[0012] [Figure 1] This graph shows the effects of the glycation inhibitor according to the present invention. [Figure 2] This graph shows the effect of another glycation inhibitor according to the present invention. [Figure 3] This graph shows the effect of the glycation inhibitor one day after the state shown in Figure 2. [Figure 4] This graph shows the effect of the glycation inhibitor one day after the state shown in Figure 3. [Modes for carrying out the invention]

[0013] The inventors of this invention were aware that celery and rutin are effective in suppressing the formation of AGEs, but due to distribution issues and associated costs, they had been exploring alternatives. They focused on peony and concluded that a mixture of peony and celery might suppress glycation.

[0014] As shown in Figure 1, a glycation inhibitor containing 0.5% peony extract and 0.1% celery extract (i.e., peony extract:celery extract = 5:1) was prepared and compared with mixtures in other proportions. While various other active ingredients may be included as solvents for the glycation inhibitors, water is the primary solvent. For the experiment, albumin was used as the protein and 2 mM glyceraldehyde as the sugar. The glycation inhibitors, each containing peony extract and celery extract in their respective proportions, were added to these solutions and left for one day to observe the rate of AGEs development.

[0015] In the case where neither peony extract nor celery extract was included at all (0% for both), the incidence of AGEs was 100%. However, in the case where 0.1% of celery extract alone was added, 0.1% of peony extract alone was added, or 0.1% each of peony extract and celery extract was added (peony extract:celery extract = 1:1), some inhibitory effect on glycation was observed. However, the most effective result was observed with 0.5% peony extract and 0.1% celery extract added (peony extract:celery extract = 5:1).

[0016] Therefore, it was confirmed that a glycation inhibitor containing inhibitory components in a ratio of peony extract to celery extract of 5:1 was the most effective in inhibiting glycation. In order to further inhibit glycation, the inventors of this application investigated diluting the concentration while maintaining this 5:1 ratio.

[0017] As shown in Figures 2 to 4, the effect of glycation inhibitors on the generation of AGEs was investigated by reacting sugar (1 mM glyceraldehyde) and protein (albumin) at 37°C for 3 days. The concentrations of the glycation inhibitors used were 0.06%, 0.1%, and 0.6% of the inhibitory component consisting of peony extract and celery extract. For example, in the case of 0.06%, peony extract was present at 0.05% and celery extract at 0.01%. The solvent was mainly water. Figure 2 shows the generation rate of AGEs after 1 day after adding the respective concentrations of glycation inhibitors to the sugar and protein, Figure 3 shows the generation rate after 2 days, and Figure 4 shows the generation rate after 3 days.

[0018] As a result, good results were obtained at concentrations ranging from 0.06% to 0.6%. The inhibition rate of AGEs was 30% to 40%. In particular, since the raw material cost is high when the inhibitory component is greater than 0.1%, it is actually preferable to keep it at 0.1% or less. 0.1% is suitable for incorporation into hair growth products.

[0019] The peony extract used above consists of peony (root) extract (1.9%), water (49.05%), and 1,3-butylene glycol (49.05%). The celery extract consists of celery extract (24.2%), urea (1%), and 1,3-butylene glycol (74.8%). This composition is appropriate as a standard for inclusion in quasi-drugs. In particular, incorporating it into quasi-drug hair and scalp care products is expected to suppress scalp aging. Furthermore, using it in cosmetics in general is expected to suppress skin aging.

Claims

1. A glycation inhibitor characterized by containing an inhibitory component in which peony extract and celery extract are present in a 5:1 ratio.

2. The glycation inhibitor according to claim 1, characterized in that the inhibitory component is present in the solvent in a proportion of 0.06% to 0.6%.

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