α-Synuclein binder and method of use

Abstract

This invention provides compounds useful for binding and imaging α-synuclein aggregates, as well as methods for imaging them. [Solution] The present invention relates to compounds represented by formula (I) or pharmaceutically acceptable salts thereof. Accordingly, these compounds or salts thereof are useful for binding and imaging α-synuclein aggregates in patients with Parkinson's disease. More specifically, the invention relates to a method of using them as tracers in positron emission tomography (PET) imaging to study α-synuclein in the brain in vivo to enable the diagnosis of Parkinson's disease and other neurodegenerative diseases characterized by α-synuclein pathology, and also to a method of measuring the clinical efficacy of therapeutic agents for Parkinson's disease and other neurodegenerative diseases characterized by α-synuclein pathology. TIFF2026094344000179.tif31126

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