Novel piperazine derivatives or salts thereof and pharmaceutical compositions
JP2026098108APending Publication Date: 2026-06-16FUJIFILM CORP +1
Patent Information
- Authority / Receiving Office
- JP · JP
- Patent Type
- Applications
- Current Assignee / Owner
- FUJIFILM CORP
- Filing Date
- 2026-03-23
- Publication Date
- 2026-06-16
AI Technical Summary
Benefits of technology
【0010】 本発明の化合物又はその塩は、薬剤排出ポンプを産生する細菌、たとえば、薬剤排出ポンプを産生する腸内細菌又はグラム陰性菌及びそれらの薬剤耐性菌などに対し、強い薬剤排出ポンプ阻害活性を示し、他の抗菌剤と併用することで医薬として有用である。 本発明の医薬組成物は、薬剤排出ポンプを産生する細菌、たとえば、薬剤排出ポンプを産生する腸内細菌又はグラム陰性菌及びそれらの薬剤耐性菌などに対し、強い薬剤排出ポンプ阻害活性を示し、他の抗菌剤と併用することで医薬として有用である。
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Abstract
To provide compounds and pharmaceutical compositions that have inhibitory activity on the drug efflux pump of drug-resistant bacteria and can restore the antibacterial activity of other drugs when used in combination with other drugs. [Solution] According to the present invention, the general formula [1] Compounds represented by the formula "In the formula, each symbol is as described in the specification" or salts thereof, and pharmaceutical compositions containing them are provided.
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