Liquid cleaning agent composition for medical devices

Abstract

The present invention provides a liquid cleaning agent composition for medical devices that maintains a neutral to weakly alkaline pH while providing sufficient cleaning power against oils and fats derived from blood, protein stains, and bacterial stains, as well as low foaming, scale formation inhibition, and re-adhesion prevention, and exhibiting excellent system stability of the cleaning agent composition. [Solution] A liquid cleaning agent composition for medical devices containing the following components (A) to (E) and not containing an aminocarboxylic acid-based chelating agent. (A) Alkaline agent: 10-25% by mass (B) Polyelectrolyte polymer: 0.6 to 16% by mass, (C) Enzyme stabilizer (D) Enzyme (E) Nonionic surfactant: Less than 1.0% by mass

Description

Technical Field

[0001] The present invention relates to a liquid cleaning agent composition for medical instruments, and more particularly to a liquid cleaning agent composition for medical instruments used when cleaning medical instruments such as dialysis equipment.

Background Art

[0002] Various kinds of dirt adhere to medical instruments such as dialysis equipment and dialysis fluid pipes. For example, in addition to fats and oils and protein dirt derived from blood and the like, calcium components (calcium carbonate) contained in the dialysis fluid may form scale (hereinafter sometimes referred to as "calcium scale") and deposit on the dialysis equipment and dialysis fluid pipes. If the deposited calcium scale is left as it is, bacteria may grow through the scale, causing problems such as deterioration of the dialysis equipment itself and reduction of equipment performance. Therefore, at the site where medical instruments such as dialysis equipment are used, the medical instruments are cleaned.

[0003]

[0004]

[0005] For this reason, various cleaning agent compositions for cleaning medical instruments such as dialysis equipment have been proposed. For example, Patent Document 1 proposes a cleaning agent for a dialysis machine that can be cleaned without feeling an unpleasant irritating odor, can be directly drained into the sewer without the need for neutralization treatment of the drained liquid, and can further remove calcium scale, which contains a chelating agent, a pH adjuster, and water. In addition, Patent Document 2 enhances the ability to remove mineral components such as calcium and magnesium, metals or their ions, and when a water-soluble organic solvent is blended, it has high solubility in organic acid salts, bactericides or other added salts and is unlikely to cause precipitation. As a cleaning agent for an artificial dialysis device, it contains a water-soluble surfactant, a bactericide and its water-soluble organic solvent, an organic acid salt having a metal ion exchange ability such as a chelating action, and solubilizers such as urea, sodium aromatic sulfonate, polyhydric alcohol, and a lower alcohol having 1 to 5 carbon atoms.

[0005] Furthermore, Patent Document 3 proposes a one-solution antibacterial cleaning agent containing an alkaline agent, a silicate, and a chelating agent, which is stable, odorless, easy to handle, and capable of simultaneously performing sterilization and removal of calcium carbonate.

[0006] Furthermore, Patent Document 4 proposes a disinfectant cleaning agent for medical devices such as artificial dialysis machines that contains hypochlorite, polymerized phosphate, and silicate in specific ratios, which suppresses the precipitation of calcium carbonate, has excellent storage stability of the cleaning agent raw material, especially the cleaning agent concentrate, and has excellent rust prevention properties. [Prior art documents] [Patent Documents]

[0007] [Patent Document 1] Japanese Patent Publication No. 2021-25057 [Patent Document 2] Japanese Patent Publication No. 2001-161811 [Patent Document 3] Japanese Patent Publication No. 2009-249499 [Patent Document 4] Japanese Patent Publication No. 2004-315648 [Overview of the project] [Problems that the invention aims to solve]

[0008] However, while Patent Document 1 mentions the removal of calcium scale, the examples only show the dissolution of calcium scale, and the removal performance is insufficient. Furthermore, there is no mention of its cleaning power against oils and protein stains derived from blood, etc. Patent Document 2 contains a large amount of water-soluble surfactant, and a large amount of this water-soluble surfactant has the problem of easily clogging the endotoxin filter, which is necessary to remove endotoxins when blood flows through the dialysis machine. Patent Document 3 describes the cleaning power and bactericidal properties due to strong alkali, but does not mention the balance between chelating power and alkali in relation to the suppression of calcium scale. In addition, when the wastewater after cleaning dialysis equipment is discharged into the public sewer system, the hydrogen ion concentration (pH) is generally stipulated by laws and ordinances, but the antibacterial cleaning agent in Patent Document 3 uses a strong alkali, so the pH is relatively high, which is problematic. Patent Document 4 demonstrates that scale formation can be suppressed by using phosphates, metal corrosion can be prevented by combining phosphates and silicates, and the overall system stability is excellent by using sodium hypochlorite. However, there are issues regarding the safety of sodium hypochlorite and the environmental impact of using phosphates. Furthermore, pH is not mentioned.

[0009] Therefore, against this background, the present invention aims to provide a liquid cleaning agent composition for medical devices that has a pH of neutral to weakly alkaline, while providing sufficient cleaning power against oils and fats derived from blood, protein stains, and bacterial stains, as well as low foaming, scale formation inhibition, and re-adhesion prevention, and exhibiting excellent system stability of the cleaning agent composition. [Means for solving the problem]

[0010] However, in view of these circumstances, the inventors have conducted extensive research and have found that by combining an alkaline agent and an enzyme, it is possible to maintain a neutral to weakly alkaline pH in the liquid cleaning agent composition while enhancing its cleaning power against oils and protein stains derived from blood, etc. Furthermore, by incorporating a polymer electrolyte, it is possible to prepare a liquid cleaning agent composition for medical devices that can suppress scale formation and prevent re-adhesion by dispersing dirt, even without containing a chelating agent.

[0011] In other words, the present invention has the following aspects. [1] A liquid cleaning agent composition for medical devices containing the following components (A) to (E) and not containing an aminocarboxylic acid-based chelating agent. (A) Alkaline agent: 10-25% by mass (B) Polymer electrolyte polymer: 0.6~16% by mass (C) Enzyme stabilizer (D) Enzyme (E) Nonionic surfactant: Less than 1.0% by mass [2] A liquid cleaning agent composition for medical devices according to [1], wherein the pH at 25°C is 7.0 or higher and less than 9.0. [3] A liquid cleaning agent composition for medical devices according to [1] or [2], which does not contain a chelating agent, or if it does contain one, the amount of the chelating agent is 1% by mass or less. [4] The liquid cleaning agent composition for medical devices according to any one of [1] to [3], wherein the (E) nonionic surfactant comprises at least one selected from the group consisting of (E1), (E2), and (E3) below. (E1) A nonionic surfactant consisting of a polyoxyalkylene alkyl ether. (E2) A nonionic surfactant consisting of a mixture of polyoxyalkylene alkyl ether and polyalkylene glycol. (E3) A nonionic surfactant consisting of alkyl polyglucoside. [5] The liquid cleaning agent composition for medical instruments according to any one of [1] to [4], wherein the (A) alkali agent is an alkanolamine. [6] The (B) polyelectrolyte polymer contains the following (B1) and (B2), The liquid cleaning agent composition for medical instruments according to any one of [1] to [5], wherein the contents of the following (B1) and (B2) are set in the following ranges respectively with respect to the whole liquid cleaning agent composition for medical instruments. (B1) A polyelectrolyte polymer having a carboxy group with a pH at 25 °C of 4 or less and a weight average molecular weight of 1,000 to 500,000: 0.5 to 10% by mass. (B2) A potassium salt and / or a sodium salt of a polyelectrolyte polymer having a carboxy group with a weight average molecular weight of 1,000 to 100,000: 0.1 to 6.0% by mass. [7] The liquid cleaning agent composition for medical instruments according to any one of [1] to [6], wherein the (D) enzyme is at least one selected from the group consisting of amylase, protease, lipase, cellulase, phosphodiesterase, and glycoside hydrolase. [8] The liquid cleaning agent composition for medical instruments according to any one of [1] to [7], wherein the liquid cleaning agent composition for medical instruments contains (F) a rust inhibitor and (G) water. [9] A method for cleaning a dialysis device using the liquid cleaning agent composition for medical instruments according to any one of [1] to [8], A step of diluting the liquid cleaning agent composition for medical instruments with water to prepare a cleaning liquid having a content of the liquid cleaning agent composition of 0.01 to 5% by mass, A step of cleaning the dialysis device with the cleaning liquid, and a method for cleaning a dialysis device having the above steps.

Advantages of the Invention

[0012] The present invention contains (A) an alkaline agent, (B) a polyelectrolyte polymer, (C) an enzyme stabilizer, (D) an enzyme, and (E) a nonionic surfactant. By combining (A) the alkaline agent and (D) the enzyme, the pH of the liquid detergent composition can be made neutral to weakly alkaline, and the detergency against oils, fats, and protein stains derived from blood and the like can be enhanced. Further, by blending (B) the polyelectrolyte polymer, the ability to suppress scale formation and reattachment due to dispersion of dirt can be suppressed without containing a chelating agent. Therefore, the present invention has detergency against various stains in the use of detergents for medical instruments, particularly dialysis instruments, and also has excellent effects on storage stability, enzyme activity stability, low foaming property, scale formation suppression ability, and reattachment prevention property, so it is convenient for cleaning medical instruments.

Embodiments for Carrying Out the Invention

[0013] The present invention will be described below based on examples of embodiments for carrying out the present invention. However, the present invention is not limited to the embodiments described below.

[0014] In this specification, “x and / or y (x and y are arbitrary configurations or components)” means three combinations: only x, only y, and x and y. When expressed as “X~Y” (X and Y are arbitrary numbers), unless otherwise specified, it includes the meaning of “X or more and Y or less” and also the meaning of “preferably exceeding X” or “preferably less than Y”. When expressed as “X or more” (X is an arbitrary number) or “Y or less” (Y is an arbitrary number), it also includes the meaning of “preferably exceeding X” or “preferably less than Y”. Regarding the numerical ranges described stepwise in this specification, the upper limit value or lower limit value of a numerical range at a certain step can be arbitrarily combined with the upper limit value or lower limit value of a numerical range at another step. Also, in the numerical ranges described in this specification, the upper limit value or lower limit value of the numerical range can be replaced with the values shown in the examples.

[0015] The liquid cleaning agent composition for medical instruments according to an embodiment of the present invention (hereinafter, may be referred to as "this cleaning agent composition") is a liquid cleaning agent composition for medical instruments containing (A) an alkaline agent, (B) a polymer electrolyte polymer, (C) an enzyme stabilizer, (D) an enzyme, and (E) a nonionic surfactant. Hereinafter, each component will be described.

[0016] <Component (A): Alkaline agent> Examples of the alkaline agent as the component (A) used in this embodiment include inorganic alkaline agents such as alkali metal hydroxides such as sodium hydroxide and potassium hydroxide, silicates such as sodium silicate and potassium silicate, and carbonates such as sodium carbonate and potassium carbonate, and organic alkaline agents such as alkanolamines such as monoethanolamine, diethanolamine, and triethanolamine. These can be used alone or in combination of two or more. Among them, organic alkaline agents are preferable from the viewpoint of detergency, and triethanolamine is particularly preferable.

[0017] As the alkanolamine, for example, a compound having a hydroxy group and an amino group in an alkane skeleton can be used. Examples of such compounds include monoethanolamine, diethanolamine, triethanolamine, monopropanolamine, dipropanolamine, tripropanolamine, monoisopropanolamine, diisopropanolamine, triisopropanolamine, N-ethyldiethanolamine, N-ethylethanolamine, N-methyldiethanolamine, and N-methylethanolamine. Among them, triethanolamine, diethanolamine, monoethanolamine, monoisopropanolamine, N-ethyldiethanolamine, N-methyldiethanolamine, and N-methylethanolamine are preferably used. More preferably, triethanolamine, diethanolamine, and monoethanolamine. These can be used alone or in combination of two or more.

[0018] The content of the alkali agent in the component (A) is 10 to 25% by mass, preferably set within the range of 10 to 22% by mass, and more preferably within the range of 10 to 20% by mass, based on the total amount of the present detergent composition. That is, if the content of the component (A) is too small, the detergency for protein stains tends to be poor. Conversely, if the content of the component (A) is too large, the rinsability deteriorates, the balance of each performance of the detergent composition worsens, it becomes difficult to obtain a synergistic effect with other components, and there is also a tendency to be disadvantageous in terms of cost.

[0019] <Component B: Polyelectrolyte polymer> The polyelectrolyte polymer of the component (B) used in the present embodiment means a polymer having a molecular weight of several thousand to several hundred thousand, having a dissociating group in the polymer chain, and dissociating in water to become a polymer ion.

[0020] As the polyelectrolyte polymer of the component (B), from the viewpoint of the scale formation inhibitory effect and the balance with other components, for example, polyacrylic acid or its alkali metal salt, methyl vinyl copolymer of ether and maleic acid or its alkali metal salt, copolymer of acrylic acid and maleic acid or its alkali metal salt, copolymer of olefin having 5 carbon atoms and maleic acid or its alkali metal salt, copolymer of styrene sulfonic acid and maleic acid or its alkali metal salt, copolymer of styrene sulfonic acid and acrylic acid or its alkali metal salt, copolymer of acrylic acid and 2-hydroxy-3-allyloxypropanesulfonic acid or its alkali metal salt, etc. can be mentioned. Among them, polyacrylic acid or its alkali metal salt, copolymer of acrylic acid and maleic acid or its alkali metal salt, copolymer of styrene sulfonic acid and maleic acid or its alkali metal salt, copolymer of styrene sulfonic acid and acrylic acid or its alkali metal salt are preferable. When the polyelectrolyte polymer is an alkali metal salt, the alkali metal salt may be a partial neutral product. And these may be used alone or in combination of two or more.

[0021] The average molecular weight of the polymer electrolyte polymer of component (B) is preferably 1,000 to 400,000, and more preferably 2,000 to 200,000, in the case of polyacrylic acid or its alkali metal salt, from the viewpoint of scale formation suppression ability.

[0022] In this specification, "average molecular weight" in polyelectrolyte polymers refers to "weight-average molecular weight," which is measured and converted using gel permeation chromatography (GPC).

[0023] Furthermore, the content of the polymer electrolyte polymer of component (B) is in the range of 0.6 to 16% by mass of the entire detergent composition, and is preferably in the range of 0.8 to 12% by mass in order to maintain balance with other components. In other words, if the content of component (B) is too low, it tends to be difficult to obtain the desired anti-re-adhesion effect, cleaning performance, and scale formation suppression effect, and if the content of component (B) is too high, the overall balance deteriorates, storage stability decreases, and it tends to be difficult to obtain further synergistic effects with other components. Component (B) can also be used for pH adjustment.

[0024] Furthermore, it is preferable that the polymer electrolyte polymer of component (B) contains the following (B1) and (B2). (B1) A polyelectrolyte polymer having a carboxyl group and a weight-average molecular weight of 1,000 to 500,000, with a pH of 4 or less at 25°C. (B2) Potassium salts and / or sodium salts of polyelectrolyte polymers having a carboxyl group and a weight-average molecular weight of 1,000 to 100,000. The combination of components (B1) and (B2) tends to improve the stability of the system.

[0025] Examples of component (B1) include acrylic acid polymers, maleic acid polymers, acrylic acid-maleic acid copolymers, poly-α-hydroxyacrylic acid, acrylic acid-maleic acid-polyethylene glycol copolymers, olefin-maleic acid copolymers, and acrylic acid-sulfonic acid copolymers, with maleic acid polymers, acrylic acid-maleic acid copolymers, and polyacrylic acid being more preferably used. These can be used individually or in combination of two or more.

[0026] The average molecular weight of component (B1) is 1,000 to 500,000 as described above, but is preferably 1,500 to 250,000, and more preferably 1,800 to 150,000, from the viewpoint of increasing the viscosity of the detergent composition. By using the average molecular weight range of component (B1) mentioned above, excellent effects are achieved. Using a component with an average molecular weight of less than 10,000 tends to result in water softening, excellent scale formation suppression, and excellent re-adhesion prevention, while using a component with an average molecular weight of 10,000 or more tends to result in excellent re-adhesion prevention and dispersibility.

[0027] The content of component (B1) is set within the range of 0.5 to 10% by mass relative to the total mass of the detergent composition, and is preferably set within the range of 1.0 to 8.0% by mass, considering the decrease in pH and the storage stability of the detergent composition as a whole.

[0028] The aforementioned component (B1) is typically used as an aqueous solution, and its pH in its natural state is 4 or less at a temperature of 25°C, preferably pH 1.0 to 4.0, and more preferably pH 1.5 to 3.5.

[0029] Examples of component (B2) include salts of acrylic acid polymers, salts of maleic acid polymers, salts of acrylic acid-maleic acid copolymers, salts of poly-α-hydroxyacrylic acid, salts of acrylic acid-maleic acid-polyethylene glycol copolymers, salts of olefin-maleic acid copolymers, and salts of acrylic acid-sulfonic acid copolymers. Examples of these salts include sodium salts, potassium salts, ammonium salts, and ethanolamine salts, with sodium polyacrylate, sodium acrylic acid-sulfonic acid copolymers, sodium acrylic acid-maleic acid copolymers, and sodium olefin-maleic acid copolymers being more preferably used. These can be used individually or in combination of two or more.

[0030] The average molecular weight of component (B2) is 1,000 to 100,000 as described above, but from the viewpoint of compositional balance of the detergent composition, it is preferably 1,500 to 80,000, more preferably 2,000 to 60,000, and even more preferably 3,000 to 40,000. By using the average molecular weight range of component (B2) mentioned above, excellent effects are achieved. Using a component with an average molecular weight of less than 10,000 tends to result in water softening, excellent scale formation suppression, and excellent re-adhesion prevention, while using a component with an average molecular weight of 10,000 or more tends to result in excellent re-adhesion prevention and dispersibility.

[0031] The content of component (B2) is set within the range of 0.1 to 6.0% by mass relative to the total mass of the detergent composition, and is preferably set within the range of 0.2 to 5.0% by mass, from the viewpoint of storage stability of the detergent composition as a whole.

[0032] It is preferable that the total mass of (B1) and (B2) is set within the range of 70 to 100% by mass with respect to the total mass of the (B) component, more preferably set within the range of 85 to 100% by mass, and even more preferably set to 100% by mass. That is, when the total mass of (B1) and (B2) is set within the above range, the ability to sequester metal ions, the threshold effect, the dispersibility of water-insoluble substances, the effect of preventing reattachment of dirt, and the detergency tend to be excellent in the balance with other components.

[0033] In addition, the mixing ratio (A / B) of the (A) component and the (B) component is selected within the range of 0.6 to 42, and it is preferably set within the range of 0.7 to 35. When set within the above range, the pH of this detergent composition can be set within the range of neutral to weakly alkaline without using a pH adjuster.

[0034] <C component: enzyme stabilizer> Examples of the enzyme stabilizer of the (C) component used in this embodiment include alcohols having 1 to 4 carbon atoms, polyhydric alcohols having 2 to 6 carbon atoms, glycol ethers having 3 to 8 carbon atoms, water-soluble calcium salts such as calcium chloride and calcium lactate, boric acid, sodium borate, potassium borate, sodium tetraborate, potassium tetraborate, acetamide, glycine, and maltodextrin. Among these, calcium chloride is preferable from the viewpoint of enzyme stability. These may be used alone or in any combination of two or more.

[0035] And the content of the enzyme stabilizer of the (C) component is not particularly limited, but it is preferably in the range of 0.1 to 5.0% by mass with respect to the entire detergent composition. Among them, from the balance with other components, it is more preferably in the range of 0.1 to 3.0% by mass. That is, when the content of the (C) component is set within the above range, the degradability of various protein stains tends to be high, and the reattachment prevention property also tends to be high.

[0036] <D component: enzyme> Examples of the enzyme as the component (D) used in the present embodiment include amylase, protease, lipase, cellulase, glycoside hydrolase, phosphodiesterase, and the like. These enzymes may be used alone or in combination of two or more. The component (D) is used to obtain a cleaning effect on specific stains that are difficult to compensate for with other detergent components by its enzyme activity, and is particularly effective for removing biofilms.

[0037] Among them, from the viewpoint of the cleaning effect, it is preferably included at least one selected from the group consisting of amylase, protease, lipase, cellulase, phosphodiesterase, and glycoside hydrolase, and protease, phosphodiesterase, and glycoside hydrolase are more preferable.

[0038] The content of the component (D) is preferably in the range of 0.1 to 5.0% by mass, more preferably 0.1 to 4.0% by mass, based on the total amount of the detergent composition. That is, when the content of the component (D) is set within the above range, the decomposability of various protein stains is increased, and the tendency to prevent redeposition is also increased. In addition, if the content of the component (D) is too small, the improvement in detergency will be poor due to the balance with other components. Conversely, if the content of the component (D) is too large, not only is it difficult to obtain a synergistic effect with other components, but it also tends to be disadvantageous in terms of cost.

[0039] <Component E: Nonionic surfactant> Examples of nonionic surfactants that are component (E) used in this embodiment include polyoxyalkylene alkyl ethers, polyoxyalkylene alkenyl ethers, polyoxyethylene alkylphenyl ethers, higher fatty acid alkanolamides or their alkylene oxide adducts, sucrose fatty acid esters, alkyl glycosides, fatty acid glycerol monoesters, alkylamine oxides, and the like. The alkyl and alkenyl groups in these nonionic surfactants (E) may be branched alkyl groups such as methyl groups. These can be used individually or in combination of two or more.

[0040] The content of the nonionic surfactant in component (E) is less than 1% by mass relative to the detergent composition, with a lower limit of preferably 0.1% by mass or more, and preferably 0.4% by mass or more. In other words, when the content of the nonionic surfactant in component (E) is set within the aforementioned range, there is a tendency for low foaming, cleaning ability, and re-adhesion prevention to be enhanced.

[0041] Furthermore, it is preferable that the nonionic surfactant, which is component (E), contains at least one selected from the group consisting of (E1), (E2), and (E3) below. (E1) A nonionic surfactant consisting of a polyoxyalkylene alkyl ether. (E2) A nonionic surfactant consisting of a mixture of polyoxyalkylene alkyl ether and polyalkylene glycol. (E3) A nonionic surfactant consisting of alkyl polyglucoside.

[0042] The above (E1) to (E3) can be used individually or in combination of two or more types, preferably in combination of two or more types, and more preferably in combination of two types. When using two or more of the above (E1) to (E3) in combination, it is preferable to include at least (E1).

[0043] Examples of (E1) include polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene polyoxybutylene alkyl ether, polyoxyethylene polyoxypropylene polyoxybutylene alkyl ether, and polyoxyethylene polyoxypropylene decyl ether, which can be used alone or in combination of two or more. Among these, polyoxyethylene alkyl ether and polyoxyalkylene branched decyl ether are preferred in terms of low foaming properties. Furthermore, the addition polymerization of the polyoxyalkylene may take the form of a random or block copolymer of two or three monomers.

[0044] The number of carbon atoms in the alkyl group of the polyoxyalkylene alkyl ether is preferably 8 to 22, more preferably 10 to 20, and even more preferably 12 to 18. It is believed that by using these surfactants in amounts below a certain level as (E1), the cleaning properties and low foaming properties can be better exhibited.

[0045] Furthermore, the cloud point of the 1% by mass aqueous solution of (E1) is usually 50°C or lower, and preferably 45°C or lower.

[0046] The content of (E1) is preferably less than 1.0% by mass of the total detergent composition, more preferably 0.8% by mass or less, and even more preferably 0.5% by mass or less.

[0047] The aforementioned (E2) is, for example, a polyoxyethylene-polyoxypropylene alkyl ether obtained by adding 1 to 40 moles of ethylene oxide (hereinafter "ethylene oxide" is abbreviated as "EO") and 1 to 50 moles of propylene oxide (hereinafter "propylene oxide" is abbreviated as "PO") to a linear or branched alcohol having 6 to 24 carbon atoms in the alkyl group. Preferably, the product is one in which 1 to 20 moles of EO and 1 to 20 moles of PO are added to a linear or branched alcohol having 6 to 18 carbon atoms, with an EO / PO weight ratio in the range of 0.5 to 5, or one in which 1 to 15 moles of EO and 1 to 50 moles of PO are added to a linear or branched alcohol having 6 to 18 carbon atoms, with an EO / PO weight ratio in the range of 0.05 to 1. Furthermore, the polyalkylene glycol mixed with the polyoxyalkylene alkyl ether is a polymer in which hydrocarbons are linked by ether bonds, and examples include polyethylene glycol, polypropylene glycol, and polytetramethylene glycol. These can be used individually or in combination of two or more. They may also be random or block copolymers of two or more of these. The average molecular weight of the polyalkylene glycol is not particularly limited, but from the viewpoint of dispersion uniformity, those with a molecular weight of 500 to 100,000 are preferably used.

[0048] The cloud point of the 1% by mass aqueous solution of (E2) is usually 45°C or lower, preferably 40°C or lower.

[0049] The content of (E2) is preferably less than 1.0% by mass of the total detergent composition, more preferably 0.8% by mass or less, and even more preferably 0.5% by mass or less.

[0050] Examples of alkyl polyglucosides used in (E3) above include decyl glucoside, lauryl glucoside, cocoyl glucoside, and octyl glucoside. Among these, decyl glucoside is preferred in terms of its low foaming properties.

[0051] The content of the above (E3) is preferably less than 1.0% by mass of the whole detergent composition, more preferably 0.9% by mass or less, and even more preferably 0.8% by mass or less.

[0052] In addition, the total mass of the above (E1) to (E3) is preferably set within the range of 70 to 100% by mass with respect to the total mass of the (E) component, more preferably set within the range of 85 to 100% by mass, and even more preferably set to 100% by mass. That is, when the total mass of the above (E1) to (E3) is set within the above range, the detergency and the prevention of redeposition tend to be enhanced. In addition, when the total mass of the above (E1) to (E3) is too large, not only does the balance as a whole tend to deteriorate, but also the synergistic effect with other components causes the cleaning performance to saturate and becomes disadvantageous in terms of cost. On the contrary, when it is too small, the low foaming property and solubilization ability tend not to be sufficiently exhibited.

[0053] <Component F: Rust inhibitor> In addition, this detergent composition is adjusted with the above (A) to (E) components as essential components, but in order to suppress the metal corrosion of medical instruments such as dialysis equipment and dialysis fluid pipes, a rust inhibitor as the (F) component can be used. Examples of the rust inhibitor as the above (F) component include nitrites such as sodium nitrite, inorganic rust inhibitors such as molybdates and tungstates, organic rust inhibitors such as t-butyl benzoate, azelate, 1-hydroxybenzotriazole salt, benzotriazole, tolyltriazole, and 2-mercaptobenzothiazole. These can be used alone or in combination of two or more. Among them, it is preferable to combine an inorganic rust inhibitor and an organic rust inhibitor, and more preferably a combination of sodium nitrite and an organic acid.

[0054] And the content of the rust inhibitor of the component (F) is not particularly limited, but it is preferably in the range of 0.1 to 5.0% by mass, more preferably in the range of 0.5 to 4.0% by mass from the balance with other components, with respect to the whole of this cleaning composition. That is, when the content of the component (F) is set within the above range, a tendency to be excellent in the effect of suppressing metal corrosion of medical instruments is observed.

[0055] <Component (G): Water> In addition, this cleaning composition is adjusted with the components (A) to (E) as essential components, but water as the component (G) can also be used. Examples of the component (G) include pure water, ion-exchanged water, soft water, distilled water, tap water, etc. These can be used alone or in combination of two or more. Note that the "water" is the sum of the water contained in the form of crystal water or aqueous solution derived from each component constituting the cleaning composition and the water added from the outside, and is contained as a balance so that the whole cleaning composition becomes 100% by mass.

[0056] This cleaning composition is prepared with the essential components (A) to (E) and the optional components (F) to (G), but can further appropriately contain various optional components other than the components (F) to (G). Examples of such optional components include water-soluble solvents, neutralizing components, preservatives, fragrances, thickeners, bactericides, etc. These can be used alone or in combination of two or more.

[0057] The content of the optional components other than the components (F) to (G) is preferably 5% by mass or less, more preferably 1% by mass or less, and even more preferably not contained, with respect to the whole of this cleaning composition.

[0058] Furthermore, since the pH of this detergent composition can be adjusted with (A) an alkaline agent and (B) a polymer electrolyte, a pH adjuster is usually not necessary. In other words, from the standpoint of reducing storage stability and being costly, it is preferable not to include a pH adjuster. Even if a pH adjuster is included, it is preferable that it be 1.0% by mass or less of the total detergent composition, more preferably 0.5% by mass or less, and even more preferably not included at all.

[0059] Furthermore, this detergent composition does not contain aminocarboxylic acid-based chelating agents in order to exhibit properties that prevent the re-adhesion of oily and protein stains. In addition, it is preferable that this detergent composition does not contain chelating agents. That is, it is preferable that it does not contain chelating agents in order to avoid deterioration of storage stability and to reduce environmental risks from wastewater, and even if a chelating agent is contained, it is preferable that it be 1.0% by mass or less of the total detergent composition, more preferably 0.1% by mass or less, and even more preferably that it is not contained at all.

[0060] This detergent composition can be prepared using the essential components (A) to (E), the optional components (F) to (G), and other optional components as needed, in accordance with the usual method for preparing detergent compositions.

[0061] The detergent composition obtained in this manner preferably has a pH of 7.0 or higher and less than 9.0 at 25°C, and more preferably in the range of 7.5 or higher and less than 9.0. That is, a higher pH can be expected to result in higher cleaning power, but if the pH becomes too high, it tends to have adverse effects on the environment and safety. However, when the pH of the detergent composition of the present invention is set within the above range, it is possible to exhibit high cleaning performance while taking into consideration the environment and safety. The pH value mentioned above was measured from the undiluted detergent composition before dilution.

[0062] This cleaning agent composition allows for a neutral to weakly alkaline pH while enhancing cleaning power against oils and protein stains derived from blood, etc. Furthermore, by incorporating a polymer electrolyte, it can exhibit scale formation suppression and prevention of re-adhesion of various stains without the need for a chelating agent, making it convenient for use as a cleaning agent for medical devices such as dialysis equipment.

[0063] Examples of medical devices include dialysis equipment (including peripheral equipment), endoscopes and endoscopic instruments such as biopsy forceps, as well as scissors, tweezers, forceps, needle holders, speculums, retractors, tubing, catheters, carts, etc. This cleaning agent composition is particularly suitable for use with dialysis equipment.

[0064] A method for cleaning the dialysis equipment includes, for example, the steps of: diluting the liquid cleaning agent composition for medical devices with water to prepare a cleaning solution containing 0.01 to 5% by mass of the liquid cleaning agent composition for medical devices; and cleaning the dialysis equipment using the cleaning solution.

[0065] When diluting the aforementioned liquid cleaning agent composition for medical devices with water, the content of the liquid cleaning agent composition for medical devices varies depending on what is being cleaned, but is usually 0.01 to 5% by mass, preferably 0.01 to 3% by mass, and more preferably 0.1 to 3% by mass. [Examples]

[0066] The present invention will be described in more detail below with reference to examples, but the present invention is not limited to the following examples unless it exceeds the gist of the invention. In the examples, "parts" and "%" refer to mass.

[0067] [Examples 1-22, Comparative Examples 1-12] Detergent compositions with the compositions shown in Tables 1-6 below were prepared, and their performance was evaluated in the following tests: Detergent Test 1 (detergent performance against egg yolk stains), Detergent Test 2 (detergent performance against blood stains), Detergent Test 3 (biofilm removal performance), storage stability, enzyme activity stability, low foaming, scale formation inhibition ability, and re-adhesion prevention ability. pH (undiluted solution, 25°C) was also measured. These results are shown in Tables 1-6 below. The testing methods and evaluation criteria for each item are as follows.

[0068] [Washing Test 1 (Washing performance against egg yolk stains)] To evaluate the cleaning performance against egg yolk stains, the following tests and evaluations were conducted. • Test method The prepared cleaning agent composition was prepared under the following conditions. Slide glasses with egg yolk stains were immersed in the composition for cleaning. After immersion, the mixture was rinsed with distilled water and visually evaluated. The slide glasses were cleaned in sets of three, and their cleaning performance was evaluated according to the evaluation criteria described below. *Soaking conditions Detergent concentration: 1% by mass Soaking temperature: 40℃ Immersion time: 30 minutes Dilution should be performed using distilled water. Egg stain: Use a microscope slide (26mm x 76mm: white-edged) with 0.4g of chicken egg yolk per slide, dried at room temperature for 24 hours. • Evaluation criteria Regarding egg yolk stains, the degree of stain removal was evaluated visually according to the following criteria. ◎: Removes over 90% of dirt. ○: Removes 70% or more of dirt but less than 90%. △: Removes 50% or more but less than 70% of dirt. ×: Removes less than 50% of dirt.

[0069] [Washing Test 2 (Washing performance against bloodstains)] To evaluate the cleaning ability against blood stains, the following tests and evaluations were conducted. • Test method TOSI (manufactured by PEREG, bovine blood purified product: albumin, hemoglobin, fibrinogen, thrombin) washing indicators were used. The plastic part of the TOSI washing indicator was removed and immersed in the washing solution for cleaning. After immersion cleaning, it was rinsed with distilled water and air-dried for 24 hours, and the level of contamination after cleaning was visually evaluated. Three TOSI washing indicators were washed together, and their cleaning performance was evaluated according to the evaluation criteria described below. *Soaking conditions Detergent concentration: 1% by mass Soaking temperature: 40℃ Immersion time: 30 minutes Dilution should be performed using distilled water. • Evaluation criteria Regarding the blood stains on the TOSI, the degree of stain removal was evaluated visually according to the following criteria. ◎: Removes over 90% of dirt. ○: Removes 70% or more of dirt but less than 90%. △: Removes 50% or more but less than 70% of dirt. ×: Removes less than 50% of dirt.

[0070] [Washing Test 3 (Biofilm Removal Performance)] To evaluate the biofilm removal performance, the following tests and evaluations were conducted. • Test method A microscope slide (26mm x 76mm: white-edged polished) is immersed in a bacterial suspension (biofilm-forming bacterial species: Staphylococcus epidermidis ATCC35984) and cultured under the following conditions. The cultured Staphylococcus epidermidis is 10 6 This is a bacterial suspension with CFU / mL, which is diluted 100-fold with culture medium and 10 4 The bacteria were cultured using a CFU / mL bacterial suspension. The cultured slides were washed with distilled water to remove any unattached cells and excess culture medium. During this process, the slides were washed by rinsing them five times in distilled water at a rate of 3 cm / s. The prepared cleaning agent composition was prepared under the following conditions. The treated slide glass was immersed in it for cleaning. After immersion, it was rinsed again with distilled water and dried. After drying, it was stained with a 0.1% methylene blue solution and visually evaluated. Three slide glass were washed in sets of three up to the following limits, and their cleaning performance was evaluated according to the evaluation criteria described below. *Culture conditions Culture temperature: 37℃ Culture time: 48 hours *Soaking conditions Detergent concentration: 1% by mass Soaking temperature: 40℃ Immersion time: 20 minutes Dilution should be performed using distilled water. • Evaluation criteria The cleaning and removal performance of biofilms was evaluated by visually inspecting stained glass slides according to the following criteria. ◎: Removes over 90% of dirt. ○: Removes 70% or more of dirt but less than 90%. △: Removes 50% or more but less than 70% of dirt. ×: Removes less than 50% of dirt.

[0071] [Storage stability] • Test method The prepared cleaning agent composition was placed in a 100 ml glass bottle and stored in a constant temperature bath (SLI-4S, manufactured by Sunaka Rika Kogyo Co., Ltd.) at 40°C, and simultaneously in an incubator (MTH-2400, manufactured by Sanyo Corporation) under a programmed temperature control of -5°C to 5°C. The bottle was stored in this condition for one month. Its appearance was then observed visually and evaluated according to the following evaluation criteria. • Evaluation criteria ◎: After one month, there were absolutely no changes in appearance such as turbidity, separation, or precipitation. ○: After one month, slight changes in appearance such as turbidity, separation, and precipitation were observed. △: After two weeks, slight changes in appearance such as turbidity, separation, or precipitation were observed. ×: Immediately after mixing, there was a change in appearance such as turbidity, separation, or precipitation.

[0072] [Enzyme activity stability] • Test method For α-amylase and protease, the enzyme activity values ​​were determined in the detergent composition after 2 weeks at 40°C. For lipase and cellulase, the remaining percentage was calculated from the enzyme activity values ​​in the detergent composition after 4 weeks at room temperature, and evaluated as follows. However, the enzyme activity values ​​were determined as follows. *How to determine α-amylase activity levels A tablet containing an indicator that develops color upon decomposition of starch, along with starch (Fadebas tablet), was added to an aqueous solution of a detergent, and the concentration of the dye was measured after a predetermined time. * How to determine protease activity levels A detergent aqueous solution and a casein solution were mixed, and after a predetermined time, trichloroacetic acid solution was added, followed by the addition of Folin-Ciocalten reagent dropwise, and the color development of the solution was measured. * How to determine lipase activity levels An emulsified olive oil solution was prepared, and after adding a detergent aqueous solution and stirring for a specified time, a few drops of phenolphthalein indicator were added, and the solution was titrated with sodium hydroxide solution. * How to determine cellulase activity levels CMC solution was added to the detergent aqueous solution and heated. After a predetermined time, dinitrosalicylic acid reagent was added, and the solution was heated to 100°C for a predetermined time. The resulting color was then measured. * How to determine phosphodiesterase activity levels Adenosine-3'-monophosphate was reacted with the resulting phosphoric acid, and the resulting phosphate was reduced with an amidol reagent under perchloric acid conditions. The color development of the resulting molybdenum blue was then measured. * How to determine glycoside hydrolase activity levels The reaction was carried out by reacting with 4-nitrophenyl α-glucoside, releasing the chromogenic group (4-nitrophenol). The reaction solution was made alkaline, and the resulting yellow color was measured. • Evaluation criteria ◎: Survival rate 70% or more. ○: Survival rate of 40% or more but less than 70%. △: Survival rate of 25% or more but less than 40%. ×: Remaining rate less than 25%.

[0073] [Low foaming] • Test method A detergent composition diluted with tap water and 30g of chicken eggs (whole eggs) thoroughly mixed were placed in a commercial automatic dishwasher (JWE-680UB-G, manufactured by Hoshizaki Corporation) and operated under the following operating conditions. The foaming of the washing solution was then visually evaluated according to the evaluation criteria described below. *Driving conditions Detergent concentration: 0.10% by mass Washing temperature: 40℃ Washing course: Standard washing cycle (Wash: 43 seconds, Rinse: 15 seconds) Tap water hardness: (as CaCO3) 50-60 mg / L • Evaluation criteria ◎: During operation, the foam is less than 50mm above the liquid surface, and the foam disappears quickly after operation ends. ○: During operation, the bubbles are less than 50 mm above the liquid surface, and the bubbles disappear within 1 minute after the end of operation. △: During operation, bubbles are 50mm or more above the liquid surface, but disappear within 1 minute after the end of operation. ×: Regardless of the foam height during operation, the foam remains even 1 minute after the end of operation.

[0074] [Scale generation suppression ability] • Test method The detergent composition was diluted to 0.05% using artificial hard water (total hardness: 150 mg / L), 50 ml was poured into a 100 ml colorimetric tube, and after being held at 60°C for 4 hours, the amount of scale formed was visually evaluated according to the following criteria. • Evaluation criteria ◎: No scale was generated. ○: There was almost no scaling. △: Scale generation occurred. ×: Severe scale buildup was observed.

[0075] [Re-deposition prevention] • Test method Add 1 g of salad oil colored with oil red to the prepared cleaning agent composition and stir well. While stirring under the following conditions, immerse a polystyrene test piece in the mixture and visually evaluate the degree of dirt adhering to the test piece according to the following criteria. * Immersion washing conditions Detergent concentration: 1% by mass Washing temperature: 40℃ Washing time: 5 minutes Stirring speed: 500 rpm Dilution was performed using distilled water. • Evaluation criteria ◎: No dirt was found on the test piece. ○: There was almost no dirt attached to the test piece. △: Dirt was found on the test piece. ×: The test piece had a considerable amount of dirt on it.

[0076] [pH: undiluted solution, 25℃] ·Measurement method Using a pH meter (pH METER F-12, manufactured by Horiba, Ltd.), the pH value of the undiluted detergent composition prepared in accordance with JIS Z-8802:1984 was measured at 25°C and evaluated according to the following criteria. • Evaluation criteria ◎: 7.0 or higher and less than 9.0. ×: Less than 7.0 or greater than 9.0.

[0077] The details of the components shown in Tables 1-6 below are as follows; unless otherwise specified, the values ​​in each table represent the effective concentration.

[0078] [Component A: Alkaline agent] Alkaline agent 1: (Triethanolamine) Product name: Triethanolamine S (manufactured by Nippon Shokubai Co., Ltd.) Alkaline agent 2: (Monoethanolamine) Product name: Monoethanolamine (manufactured by Nippon Shokubai Co., Ltd.) • Alkaline agent 3: (Potassium bicarbonate) Product name: Potassium bicarbonate (manufactured by Showa Chemical Co., Ltd.) • Alkaline agent 4: (Potassium hydroxide) Product Name: 48% Caustic Potassium (manufactured by AGC Corporation) [Component B: Polyelectrolyte polymer] (B1) ·Polyelectrolyte polymer 1: (Maleic acid polymer, average molecular weight 2000, purity 50%) Product name: Non-Pole PMA-50W, manufactured by NOF Corporation (pH: 1.0) ·Polyelectrolyte polymer 2: (Acrylic acid / maleic acid copolymer, average molecular weight 3000, purity 50%) Product name: SokalanCP 12 S, manufactured by BASF (pH1.5) ·Polyelectrolyte polymer 3: (Polyacrylic acid, average molecular weight 4500, purity 48%) Product name: Acusol 445, manufactured by Dow Chemical (pH 3.5) ·Polyelectrolyte polymer 4: (Polyacrylic acid, average molecular weight 10,000, purity 45%) Product name: Aqualic HL-415, manufactured by Nippon Shokubai Co., Ltd. (pH 2.0) ·Polyelectrolyte polymer 5: (Polyacrylic acid, average molecular weight 100,000, purity 35%) Product name: SokalanPA80S, manufactured by BASF (pH2.0) (B2) ·Polyelectrolyte polymer 6: (Sodium polyacrylate, average molecular weight 3500, purity 44%) Product name: Aqualic DL-40S, manufactured by Nippon Shokubai Co., Ltd. ·Polyelectrolyte polymer 7: (Na salt of acrylic acid-sulfonic acid copolymer, average molecular weight 3000, purity 50%) Product name: Aqualic GL-246, manufactured by Nippon Shokubai Co., Ltd. ·Polyelectrolyte polymer 8: (Na salt of acrylic acid-maleic acid copolymer, average molecular weight 60,000, purity 40%) Product name: Aqualic TL-200, manufactured by Nippon Shokubai Co., Ltd. ·Polyelectrolyte polymer 9: (Na salt of olefin-maleic acid copolymer, average molecular weight 12000, purity 25%) Product name: SokalanCP9, manufactured by BASF

[0079] [Component C: Enzyme stabilizer] • Enzyme stabilizer: Calcium chloride (74.3% as anhydrous) Product Name: Calcium Chloride Granules, manufactured by Central Glass Co., Ltd.

[0080] [Component D: Enzyme] • Enzyme 1: (α-amylase) Product name: Everis Act (manufactured by Novozymes Japan) • Enzyme 2: (Protease) Product name: Everis Precise (manufactured by Novozymes Japan) • Enzyme 3: (Lipase) Product name: Everis Link (manufactured by Novozymes Japan) • Enzyme 4: (Cellulase) Product Name: Celluclean 5000L (Manufactured by Novozymes Japan) • Enzyme 5: (glycoside hydrolase) Product name: Everis Guard (manufactured by Novozymes Japan) • Enzyme 6: (Phosphodiesterase) Product name: Everis Next (manufactured by Novozymes Japan)

[0081] [Component E: Nonionic surfactant] (E1) • Nonionic surfactant 1: (Polyoxyethylene alkyl ether, 1% by mass aqueous solution, cloud point 43°C) Product name: Adekanol B-714 (manufactured by Adeka) (E1) Nonionic surfactant 2: (Polyoxyalkylene branched decyl ether, 1% by mass aqueous solution, cloud point 43°C) Product name: Neugen LF-60X (manufactured by Daiichi Kogyo Seiyaku Co., Ltd.) (E2) • Nonionic surfactant 3: (A mixture of polyoxyalkylene alkyl ether and polyalkylene glycol) (Cloud point of 33°C in a 1% by mass aqueous solution) Product name: Neugen LF-202N (manufactured by Daiichi Kogyo Seiyaku Co., Ltd.) (E3) • Nonionic surfactant 4: (Decyl glucoside (active ingredient amount 65%)) Product Name: ALKYL POLYGLYCOSIDES APG 0810 65% (Manufactured by Azelis Japan Co., Ltd.)

[0082] [Nonionic surfactants other than components (E1) to (E3)] • Nonionic surfactant 5: (Polyoxyethylene polyoxypropylene block polymer (pull-lock type block polymer), cloud point 60°C in 1% by mass aqueous solution) Product name: Epan 740 (manufactured by Daiichi Kogyo Seiyaku Co., Ltd.) • Nonionic surfactant 6: (Polyoxyethylene polyoxypropylene block polymer (reverse pluronic type block polymer), cloud point 50°C in 1% by mass aqueous solution) Product name: Pluronic RPE1740 (manufactured by BASF)

[0083] [Component F: Rust inhibitor] • Rust inhibitor: (Sodium nitrite and organic acids) Product name: VERZONE IFC-30, manufactured by Yamato Kasei Co., Ltd.

[0084] [G component: water] ·water

[0085] [others] • Water-soluble solvents: (Glycerin, 99% active ingredient) Product name: Food additive glycerin, manufactured by Miyoshi Oil & Fat Co., Ltd. Chelatives (Citrate monohydrate, 91% active ingredient) Product name: Purified citric acid (crystalline), manufactured by Fuso Chemical Industry Co., Ltd.

[0086] [Table 1]

[0087] [Table 2]

[0088] [Table 3]

[0089] [Table 4]

[0090] [Table 5]

[0091] [Table 6]

[0092] From the results described above, it can be seen that in Examples 1 to 22, generally excellent evaluations were obtained for all evaluation items. On the other hand, Comparative Examples 1 to 12, which fall outside the scope defined in the present invention, received evaluations of "△" and "×", indicating that there are problems in one or more of the following: washing test 1, washing test 2, washing test 3, storage stability, enzyme activity stability, low foaming, scale formation inhibition ability, or re-adhesion prevention ability. [Industrial applicability]

[0093] The liquid cleaning agent composition for medical devices of the present invention maintains a neutral to weakly alkaline pH while providing sufficient cleaning power against oils and fats derived from blood, protein stains, and bacterial stains, as well as low foaming, scale formation inhibition, and re-adhesion prevention properties. Furthermore, the cleaning agent composition exhibits excellent system stability, making it an excellent cleaning agent for medical devices such as dialysis equipment, and therefore highly promising.

Claims

1. A liquid cleaning agent composition for medical devices containing the following components (A) to (E) and not containing an aminocarboxylic acid-based chelating agent. (A) Alkaline agent: 10-25% by mass (B) Polymer electrolyte polymer: 0.6 to 16% by mass (C) Enzyme stabilizer (D) Enzyme (E) Nonionic surfactant: Less than 1.0% by mass

2. The liquid cleaning agent composition for medical devices according to claim 1, wherein the pH at 25°C is 7.0 or higher and less than 9.

0.

3. A liquid cleaning agent composition for medical devices according to claim 1, which does not contain a chelating agent, or if it does contain one, the amount of the chelating agent is 1% by mass or less.

4. The liquid cleaning agent composition for medical devices according to claim 1, wherein the (E) nonionic surfactant comprises at least one selected from the group consisting of (E1), (E2), and (E3) below. (E1) A nonionic surfactant consisting of a polyoxyalkylene alkyl ether. (E2) A nonionic surfactant consisting of a mixture of polyoxyalkylene alkyl ether and polyalkylene glycol. (E3) A nonionic surfactant consisting of alkyl polyglucoside.

5. The liquid cleaning agent composition for medical devices according to claim 1, wherein the (A) alkaline agent is an alkanolamine.

6. The (B) polymer electrolyte polymer contains the following (B1) and (B2): The liquid cleaning agent composition for medical devices according to claim 1, wherein the content of (B1) and (B2) below is set to the following ranges with respect to the entire liquid cleaning agent composition for medical devices. (B1) A polyelectrolyte polymer having a carboxyl group and a weight-average molecular weight of 1,000 to 500,000, with a pH of 4 or less at 25°C: 0.5 to 10% by mass. (B2) Potassium salt and / or sodium salt of a polyelectrolyte polymer having a carboxyl group and a weight-average molecular weight of 1,000 to 100,000: 0.1 to 6.0% by mass.

7. The liquid cleaning agent composition for medical devices according to claim 1, wherein the enzyme (D) is at least one selected from the group consisting of amylase, protease, lipase, cellulase, phosphodiesterase, and glycoside hydrolase.

8. The liquid cleaning agent composition for medical devices according to claim 1, wherein the liquid cleaning agent composition for medical devices contains (F) a rust inhibitor and (G) water.

9. A method for cleaning a dialysis machine using a liquid cleaning agent composition for medical devices according to any one of claims 1 to 8, A step of diluting the aforementioned liquid cleaning agent composition for medical devices with water to prepare a cleaning solution having a content of 0.01 to 5% by mass of the aforementioned liquid cleaning agent composition for medical devices, A method for cleaning a dialysis machine, comprising the step of cleaning the dialysis machine using the cleaning solution.

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