An interference system comprising a radiation source that emits at least two radiation beams that interfere within a body part or area to be treated containing nanoparticles.

Abstract

The present invention provides a device that enables radiation heating or irradiation of lesion sites, such as tumors, at a lower intensity than the radiation used in HIFU. [Solution] A radiation heating system comprising at least two directional radiating elements that emit at least two radiation beams. A processing region exists due to the interference of at least two radiation beams emitted by the at least two radiating elements. The system also includes at least one nanoparticle included in the interference region.

Claims

1. A radiation heating system for treating a part of an individual's body, comprising: A first part comprising a radiating element, each radiating element emitting at least one radiation beam, Here, each radiating element is preferably positioned at a different relative position with respect to the horizontal support axis of the system, such that the position of the radiation source is different around the axis or in the radial or angular direction relative to the axis. Here, at least two different radiating elements have different directions defined by at least two different radiation angles measured with respect to a common reference axis, The radiating elements are arranged and oriented such that their beams intersect or overlap spatially, and the intersecting or overlapping region is a portion of the radiation region, focal region, or near-field region of at least one or each radiating element or piezoelectric element, and is contained within the far-field region of at least one or each individual radiating element or piezoelectric element, or within the near-field region of the collection of radiating elements or piezoelectric elements contained in the system. Here, the number of radiating elements is at least 3, 4, 5, 10, 20, 50, 60, 70, or 80, and at most 10 20 , 10 3 , or 100, Here, each radiating element belongs to the following group: i) The aperture angle or diffraction angle (T) of the beam emitted from the radiation source is greater than 0, 1, 2, 5, 25, or 45°, preferably measured between two opposing directions or points at the periphery of the beam at the radiation region level; ii) The diameter, width, thickness, or maximum dimension is less than half the diameter, width, or thickness of the body part to be treated, or the body part in which the system or at least part of the system is placed or inserted, or less than 100, 10, 1, or 0.5 cm; and iii) The frequency of the emitted beam is less than 100, 10, 5, 2, or 1.5 MHz; It is configured to have at least one characteristic selected from, and A second portion comprising at least one magnetic or metallic nanoparticle placed within the common region and / or exposed to intersecting or overlapping radiation beams, A system composed of the following.

2. The system according to claim 1, wherein the at least one nanoparticle or system does not contain, operate by generating, or has no function to generate at least 1, 2, 5, 10, or 100 nanobubbles, bubbles, or microbubbles.

3. A system according to claim 1, wherein the system does not include at least one phosphor.

4. The system according to claim 1, wherein at least one nanoparticle has at least one property selected from the following group: At least one nanoparticle forms an aggregate of at least two nanoparticles, and the at least two nanoparticles have at least one property selected from the following group: i) arranged in a chain, ii) arranged in a geometric figure, iii) bound or associated with each other via a binding or coating material, iv) the distance between them is less than 10, 1, 0.1 μm or less than the diameter of at least one nanoparticle, v) greater absorption, transmission, and / or reflection of a radiation beam emitted from the first part than a single nanoparticle, vi) greater motion, vibration, interaction, or internalization with or within cells or biological substances than a single nanoparticle, particularly under irradiation with a radiation beam emitted from the first component, and / or vii) greater than a single nanoparticle, particularly at least 0.1 × 10 -20 , 10 -5 , 10 -3 , or 10 -1 Heat only above a certain temperature. At least one nanoparticle has at least one magnetic property, which is selected from the group consisting of diamagnetic, paramagnetic, superparamagnetic, ferrimagnetic, and ferromagnetic properties. At least one nanoparticle contains at least 1, 2, 5, 10, 100 or 10 ３ A metal atom containing more than 1, 5, 10, 50, 75, 80, 90, or 99% by mass or volume of metal atoms, At least one nanoparticle is formed before, during, after, or as a result of irradiation with at least one or two radiation beams of Part 1. At least one nanoparticle is locally heated on a nanoparticle or nm scale, so that the temperature of the body part to be treated does not increase significantly by more than 0.1, 1, or 10°C, even under irradiation by at least one or two radiation beams of Part 1. At least one nanoparticle, individually or collectively, has a size smaller than 10 １０ , 10 ５ , 10 ４ , 10 ３ , 10 ２ , 10, 5, 2 or 1 nm in one, two or three dimensions, At least one nanoparticle has a size, either individually or collectively, in at least one, two, or three dimensions. 10 -3 , 10 -2 , 10 -1 , 0, 1, 2, 5, 10, 20, 50, 100, 10 3 or 10 5 Larger than nm, system.

5. The system described in claim 1 has the following features: A first part comprising at least two different radiating elements emits at least two different radiation beams, which interfere according to a first type of interference, that is, produce, are associated with, or include a partial or complete superposition of at least two radiation beams, or produce a coexistence in an interference region or common region that does not involve a partial or complete superposition of at least two radiation beams. Here, the superposition of at least two radiation beams means that at least two radiation beams exist or persist at the same location in the interference region or common region. The coexistence of at least two radiation beams without overlap means that at least two radiation beams exist or persist at at least two different locations within the interference region or common region. and At least one radiation beam of the first part emits at least one radiation beam which interferes with at least one nanoparticle of the second part by interference of the second kind, by generating, associating with, or encompassing the following: a) Absorption, transmission, reflection, and / or of at least one radiation beam by at least one nanoparticle b) Movement or vibration of at least one nanoparticle, and / or interaction or internalization of at least one nanoparticle by at least one cell or biological material, Dual interference system.

6. The system according to claim 1, wherein at least two different radiating elements emit at least two different radiating beams, and the following characteristics: a) At least two different radiation beams have at least one parameter having two different values ​​selected from the following group: The angle of propagation direction relative to the propagation direction or the horizontal or vertical axis (O1, O2), intensity (I １ , I ２ ), output (P １ , P ２ ), energy (E 1 , E 2 ), width (W 1 , W 2 ), penetration depth (D 1 , D 2 ), frequency (F 1 F 2 ), wavelength (W 1 , W 2 Having at least two different values ​​selected from ); and b) At least two radiations are at least two different types of radiation, Here, the first beam is O1, I 1 , P 1 , E 1 , W 1 , D 1 F 1 , and W 1 Having at least one parameter selected from the group consisting of, Here, the second beam is O 2 , I 2 , P 2 , E 2 , W 2 , D 2 F 2 and W 2 It has at least one parameter selected from the group consisting of; Here (O 1 - Oh 2 ) / (O 1 + Oh 2 ), (I 1 - I 2 ) / (I 1 + I 2 ), (I 1 - I 2 ) / I 1 , (I 1 -I (2 ) / I 2 、(P 1 -P 2 / (P 1 +P 2 )、(P 1 -P 2 / P 1 )、(P 1 -P (2) / P 2) (HAVE BEEN 1 -HAVE BEEN 2 ) / (HAVE BEEN 1 +E 2 ), (HAVE BEEN 1 -HAVE BEEN 2 ) / HAVE BEEN 1 , (HAVE BEEN 1 -HAVE BEEN 2 ) / HAVE BEEN 2 , (D 1 -D 2 ) / (D 1 +D 2 ), (D 1 -D 2 ) / D 1 , (D 1 -D 2 ) / D 2 , (F 1 -F 2 ) / (F 1 +F 2 ), (F 1 -F 2 ) / F 1 , (F 1 -F 2 ) / F 2 , (W 1 -W 2 ) / (W 1 +W 2 ), (W 1 -W 2 ) / W 1 , and / or (W 1 -W 2 ) / W 2 , whether it is an absolute value or not, 0, 10 -5 , 10 -3 , 10 -1 , 1, 5, 10, 50, 75, 100 or 10 4 Larger than, and Here, at least one parameter is preferably measured or present in at least one region selected from the following group: a) At least one emission region, b) At least one interference region or common region, and c) At least one region separating at least one emission region from at least one interference region or common region, A system having at least one characteristic selected from the following.

7. The system according to claim 1, characterized in that at least two different radiating elements emit at least two different radiation or radiation beams, and having the following characteristics: a) At least two different radiation beams have at least two similar or identical values ​​of parameters selected from the following group: In other words, the propagation direction or the angle between the propagation direction and the horizontal or vertical axis (O1, O2), intensity (I １ , I ２ ), power (P １ , P ２ ), energy (E 1 , E 2 ), width (W 1 , W 2 ), penetration depth (D 1 , D 2 ), frequency (F 1 F 2 ), wavelength (W 1 , W 2 At least two values ​​of the parameters selected from ) must be similar or identical; and b) At least two of the radiations are of the same or similar type; Note that the first beam is O 1 , I 1 , P 1 , E 1 , W 1 , D 1 F 1 , and W 1 Having at least one parameter selected from the group consisting of; The second beam is O 2 , I 2 , P 2 , E 2 , W 2 , D 2 F 2 , W 2 It has at least one parameter selected from the group consisting of; Here (O 1 - Oh 2 ) / (O 1 + Oh 2 ), (I 1 - I 2 ) / (I 1 + I 2 ), (I 1 - I 2 ) / I 1 , (I 1 -I (2 ) / I 2 、(P 1 -P 2 / (P 1 +P 2 )、(P 1 -P 2 / P 1 )、(P 1 -P (2) / P 2) (HAVE BEEN 1 -HAVE BEEN 2 ) / (HAVE BEEN 1 +E 2 ), (HAVE BEEN 1 -HAVE BEEN 2 ) / HAVE BEEN 1 , (HAVE BEEN 1 -HAVE BEEN 2 ) / HAVE BEEN 2 , (D 1 -D 2 ) / (D 1 +D 2 ), (D 1 -D 2 ) / D 1 , (D 1 -D 2 ) / D 2 , (F 1 -F 2 ) / (F 1 +F 2 )、(F 1 -F 2 ) / F 1 、(F 1 -F 2 ) / F 2 、 (W 1 -W 2 ) / (W 1 +W 2 )、(W 1 -W 2 ) / W 1 , and / or (W 1 -W 2 ) / W 2 Whether it is an absolute value or not, 10 20 , 10 10 , 10 5 , 10 3 , 100, 75, 50, 10, 5 or preferably less than 1%, Here, at least one of these parameters is measured or exists in at least one region selected from the following group: a) At least one emission region, b) At least one interference region or common region, and c) At least one region separating at least one emission region from at least one interference region or common region. A system in which at least one characteristic is selected.

8. The system according to claim 1, wherein the system, the first part or the second part partially or completely applies to the body part to be treated, continuously or discontinuously, at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or 100 times, for a sufficiently long period of at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or 100 seconds, preferably 0, 1, 2, 5, 10, or 100 seconds, to allow the first part and / or the second part to heal or heat the body part to be treated, preferably for a sufficiently short period of at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or 100 seconds, preferably 10 10 , 10 5 , 10 3 The system is set, managed, or applied to 10, 5, 2, or 1 minute intervals.

9. A system according to claim 1, wherein the system is used in combination with, includes, or is associated with a third part, the third part being an image element or device having the following features: a) The third part is selected from the following group: radiography, fluoroscopy, computed tomography (CT), mammography, dual-energy X-ray absorptiometry (DEXA), magnetic resonance imaging (MRI), functional MRI (fMRI), diffusion tensor imaging (DTI), MR spectroscopy, cardiac MRI, ultrasound imaging, Doppler ultrasound, 3D ultrasound, 4D ultrasound, elastography, contrast-enhanced ultrasound (CEUS), scintigraphy, single-photon emission computed tomography (SPECT), positron emission tomography (PET), PET / CT, PET / MRI, optical coherence tomography (OCT), fluorescence imaging, bioluminescence imaging (BLI), photoacoustic imaging, thermography, photoacoustic tomography (PAT), microwave imaging, electrical impedance imaging (EIT), and scanners, some or all of these. b) The third part includes software or artificial intelligence or fusion software that enables the fusion of at least one image of the body part to be treated, obtained from at least one first device (e.g., MRI) and at least one second device (e.g., ultrasound imaging), wherein the first device is preferably not included in the system, and the second device is included in the system. c) The third component includes at least one image sensor positioned in a region to receive, absorb, or be exposed to at least one radiation or radiation beam, the radiation or radiation beam preferably being partially or completely emitted, reflected, or diffracted by at least one nanoparticle or body part or interference or common region or part thereof. d) The third part includes at least two image sensors located in at least two different regions. These regions receive, absorb, or are exposed to at least two different radiations or two different radiation beams. These radiations or radiation beams are partially or completely emitted, reflected, or diffracted by at least two different nanoparticles, or two different sides or small planes of at least one nanoparticle, or two different parts of a body part, or two different parts of an interference region or common region. e) The third part is to receive, absorb, or be exposed to at least one radiation or radiation beam. f) A third part having at least one sensor, transducer, or piezoelectric element that detects at least one radiation or radiation beam, or has sufficient sensitivity, or has a sufficiently large number of sensors, transducers, or piezoelectric elements, to detect a difference in at least one value of at least one parameter between at least two different nanoparticles, two different sides or small planes of at least one nanoparticle, two different parts of a body part, or two different parts of an interference region or common region. g) The third part is positioned between at least two radiating elements of the first part, or within different regions thereof. h) The third part functions to partially or completely detect, or has sufficient imaging sensitivity, contrast intensity, or detection capability, at least one entity selected from the following groups: i) at least one nanoparticle of the second part, ii) at least one body part, iii) at least one interference region, iv) at least one emission region, and v) at least one region located between the emission region and the interference region or common region. i) The third part has imaging sensitivity or imaging intensity that is increased or enhanced by the presence of at least one nanoparticle of the second part. and j) The third part functions by detecting at least one beam emitted from at least one radiation source, or at least two different beams emitted from at least two different radiation beams, or has sufficient imaging sensitivity, contrast intensity, or detection capability. A system having at least one characteristic selected from the following.

10. The system according to claim 1, wherein the interference region or common region and / or body part to be treated are the following groups: Lesion site, Tumors, primary or metastatic tumors, cancer, cancerous lesions, Site of infection, particularly a site infected with at least one virus, bacterium, tumor cell or pathological biological material, Areas where pathological cells are more numerous than normal cells, and An area that includes at least one lesion site and is larger than at least one normal area, A system selected from the options.

11. The system according to claim 1, wherein the interference region or common region is larger than the treatment site, the size of the treatment site is measured by a third part of the system, and the interference region preferably includes at least one or two common regions, or the sum or aggregate of common regions, or is larger than at least one common region.

12. The system according to claim 1, wherein the radiating element is from the following group, i) X-ray sources such as X-ray tubes, ii) Radioisotope sources, iii) Accelerators such as linear accelerators (LINACs), iv) Gamma-ray sources, v) Particle accelerators, vi) Magnets such as superconducting magnets, vii) Coils such as high-frequency coils, viiii) Transducers or piezoelectric elements such as ultrasonic transducers and piezoelectric elements, ix) Lasers, x) LEDs, xi) Light sources, xii) Generators, injectors, or injectors for electric current or electromagnetic waves, xiii) Microwave emitters, xiv) Transmitters, sensors, generators, and generators for ultraviolet light, visible light, infrared light, electrons, particles, neutrons, positrons, X-rays, magnetic fields, radio waves, laser light, and ultrasound, xii) Positron emission tomography, xv) Magnetic resonance imaging, xvi) Photoacoustic imaging, A system selected from the options.

13. The system according to claim 1, wherein, Each emitting radiating element or radiating beam, under the operating conditions of the system, outside the interference region, has, is associated with, or generates any of the following: a) Temperatures below 100, 50, 10, 5, 2, 1, or 0.1 °C b) A temperature distribution of less than 100, 50, 10, 5, 2, 1 or 0.1 °C per meter, centimeter or millimeter in or outside the body part being treated. Here, at least two radiating elements or the radiating beams they emit, under the operating conditions of the system, associate, generate, or have the following in the interference region: a) Temperatures above 0, 0.1, 1.5, or 10°C b) A temperature distribution exceeding 0, 0.1, 1.5, or 10 °C per meter, centimeter, or millimeter in the body part being treated, or in at least one area outside the body part being treated, or in part or all of the body part being treated, This temperature is the thermal temperature of the radiation beam, and further The temperature distribution is the temperature or temperature change of a radiated beam within a predetermined region, such as an interference region. A system characterized by the following features.

14. The system according to claim 1, configured for use in a method of treating a body part, In the first step, the body part to be treated is imaged using a first device such as MRI, CT, or PET. In the second step, the body part to be treated is imaged by a second device, such as an ultrasound imaging probe, preferably attached to, embedded in, or associated with the first part of the system, and software or artificial intelligence is used to enable the integration of the image of the body part to be treated obtained by the first device into the second device, thereby enabling the second device to image and detect the body part to be treated. In the third step, under image guidance provided by the second device, at least one nanoparticle of the second part and / or thermometer is injected, administered, or activated on the body part to be treated. In the third step, at least two different radiation sources are placed in a region of the body under image guidance provided by the second apparatus. This region has at least one characteristic selected from the following group: 1) The region allows at least two different types of radiation beams to partially or completely cover, reach, target, or direct towards the body part to be treated. 2) The area in question is located below, above, or to the side of the body part to be treated. and 3) The region is divided into areas that separate the body part to be treated from the irradiation area (for example, a normal area and an area surrounding the body part to be treated), and is divided into 1, 10, and 10. ３ , 10 ６ or 10 ８ Distances of more than nm; In the fourth step, the system, at least two different radiating elements and / or a cooling unit are activated, and / or at least one parameter of the system and / or at least one parameter of the at least two different radiating elements, e.g., its intensity, frequency, is increased, and / or at least one parameter of the cooling unit, e.g., its temperature, is decreased, preferably resulting in the following: The treatment site is exposed to at least two different radiation beams and / or heated by at least 0, 0.1, 1, 5, or 10 °C. and At least one area other than the body part being treated is exposed to less radiation beam than the body part being treated, and / or receives a temperature increase of less than 0, 0.1, 1, 5, or 10 °C. In the fifth step, the thermometer is activated to measure the temperature of the body part to be treated, and at least one parameter of the radiating element is adjusted to maintain the temperature of the body part to be treated at the desired temperature. In the fifth step, the system, at least two different radiating elements and / or the cooling unit is turned off, and / or at least one parameter of the system and / or at least one parameter of the at least two different radiating elements, e.g., its intensity, frequency, temperature, and / or at least one parameter of the cooling unit, e.g., its temperature, is increased. This causes the body part being treated and / or at least one area outside the body part being treated to be at physiological temperature or 37°C, or from physiological temperature or 37°C to 100°C, 50°C, 10°C, 5°C, 2°C, 1°C, or 10°C. -1 It is possible to return to a temperature with a difference of less than ℃, In the seventh optional step, the size, contents, properties, or composition of the body part being treated is measured. This is done to determine whether there has been a decrease in the number or volume of lesions, cells, or biological material, and is preferably following at least one step of the method. Here, at least one step of the method, preferably the fourth step, is repeated 1, 2, 3, 4, 5, 6 or 10 or more times. Here, optionally, at least one step of the method, preferably the fifth step, is repeated more times than the other steps of the method, preferably the fourth step. Herein, the duration of at least one step of the method, preferably the fourth step, is sufficiently long, preferably longer than 0, 0.001, 0.1, 1, 2, 5, or 10 minutes, preferably so that the temperature of the body part being treated is maintained at the desired temperature for a sufficiently long period of time, in order for the treatment to be efficient. Here, depending on the case, the duration of at least one step of the method, preferably the fourth step, is sufficiently short, preferably 10 ２０ The duration is less than 100, 50, 20, or 10 minutes, in order to avoid overheating of the body part being treated and to avoid side effects. Here, at least two steps of the method precede or follow each other, and in any order, step 1 is preferably placed after or before steps 2, 3, 4, 5, 6, or 7, step 2 is preferably placed after or before steps 1, 3, 4, 5, 6, or 7, step 3 is preferably placed before or after steps 1, 2, 4, 5, 6, or 7, step 4 is preferably placed before or after steps 1, 2, 3, 5, 6, or 7, step 5 is preferably placed before or after steps 1, 2, 3, 4, 6, or 7, step 6 is preferably performed before or after steps 1, 2, 3, 4, 5, or 7, and / or step 7 is preferably performed before or after steps 1, 2, 3, 4, 5, or 6. A system characterized by being carried out in such a manner.

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