Cosmetics comprising a glycine derivative or a salt thereof

Abstract

The present invention provides a cosmetic composition containing a high concentration of a glycine derivative or a salt thereof, exhibiting excellent usability and stability. [Solution] (A) A glycine derivative having a specific structure or a salt thereof, (B) Monohydric lower alcohols, (C) Spherical powder, and (D)Water A cosmetic composition comprising, The content of component (A) is 0.3 to 5% by mass relative to the total amount of the cosmetic. A cosmetic product in which the content of component (B) is 3% by mass or more relative to the total amount of the cosmetic product.

Description

[Technical Field]

[0001] The present invention relates to a cosmetic composition comprising a glycine derivative or a salt thereof. [Background technology]

[0002] Traditionally, young women in particular have been concerned about the appearance of visible pores, and there has been a demand for cosmetics that can improve this. However, because the mechanism by which pores become visible is not fully understood, the common approach has been to use astringent lotions or remove blackheads. Alternatively, foundation is often used to improve the appearance. However, astringent lotions, for example, aim to tighten the skin by temporarily lowering the skin surface temperature with alcohol or by coagulating proteins with organic acids. As a result, they place a heavy burden on the skin and do not provide a fundamental solution to visible pores, and their effects have not been sufficient.

[0003] The applicant has already revealed that incomplete keratinization caused by sebum is one of the mechanisms contributing to the visibility of pores, and that by improving incomplete keratinization in the pore area, the area recognized as a pore decreases, thereby improving the visibility of pores. Based on these findings, the applicant has identified effective inhibitors of incomplete keratinization and pore-reducing agents (for example, Patent Document 1).

[0004] To more strongly express the effects of inhibiting incomplete keratinization and reducing pore size, it is conceivable to use higher doses of the incomplete keratinization inhibitor and pore-reducing agent. However, our research has shown that simply increasing the content of glycylglycine, a type of pore-reducing agent, in a lotion tends to cause problems such as a decrease in the lotion's feel and gelation. To resolve this problem, there is a need to develop a cosmetic product that can achieve excellent feel and stability even with a high content of glycine derivatives or their salts. [Prior art documents] [Patent Documents]

[0005] [Patent Document 1] Japanese Patent Publication No. 2005-179342 [Overview of the Initiative]

[0006] The present invention provides a cosmetic composition comprising a glycine derivative or a salt thereof.

[0007] The inventors have found that a cosmetic composition containing a specific powder, a glycine derivative or a salt thereof, exhibits excellent usability and stability even at high concentrations of the glycine derivative or salt. This invention is based on these findings.

[0008] The present invention provides the following: (1)(A) Below formula (1): [ka] (In the formula, R 1 and R 2 Each of these is independently a hydrogen atom, an alkyl group, an alkenyl group, an aryl group, an aralkyl group, an aminomethylcarbonyl group, an amidino group, an alkylcarbonyl group, an alkenylcarbonyl group, an arylcarbonyl group, or an aralkylcarbonyl group. R 3 These are a hydrogen atom, an alkyl group, an alkenyl group, an aryl group, or an aralkyl group. However, R 1 , R 2 , and R 3 (They cannot simultaneously become hydrogen atoms.) A glycine derivative or salt thereof represented by (B) Monohydric lower alcohols, (C) Spherical powder, and (D)Water A cosmetic composition comprising, The content of component (A) is 0.3 to 5% by mass relative to the total amount of the cosmetic. A cosmetic product wherein the content rate of the component (B) is 3 mass% or more based on the total amount of the cosmetic product. (2) The cosmetic product according to (1), wherein the component (C) is at least one selected from the group consisting of spherical resin powder, spherical silica, spherical starch powder, and spherical cellulose powder. (3) The cosmetic product according to (1) or (2), wherein the component (A) is glycylglycine or a salt thereof. (4) The cosmetic product according to any one of (1) to (3), further comprising niacin or a derivative thereof. (5) The cosmetic product according to any one of (1) to (4), further comprising a water-swelling clay mineral. (6) The cosmetic product according to any one of (1) to (5), which is an aqueous cosmetic product.

[0009] According to the present invention, there is provided a cosmetic product containing a glycine derivative or a salt thereof at a high content rate, which exhibits excellent usability and stability. Detailed description of the invention

[0010] According to one embodiment of the present invention, (A) the following formula (1):

Chemical formula

[0011] Component (A) in the present invention is a glycine derivative represented by formula (1) or a salt thereof (hereinafter, may be referred to as component (A). The same applies to other components).

Chemical formula

[0012] Component (A) may be a salt of the glycine derivative represented by formula (1). The type of salt is not particularly limited as long as it is a pharmacologically acceptable salt. For example, hydrochloride, sulfate, phosphate, hydrobromide, sodium salt, potassium salt, magnesium salt, calcium salt, magnesium salt, ammonium salt, etc. can be mentioned. Examples of organic salts include acetate, lactate, maleate, fumarate, tartrate, methanesulfonate, p-toluenesulfonate, triethanolamine salt, amino acid salt, etc. According to one preferred embodiment of the present invention, component (A) is glycylglycine or a salt thereof, preferably glycylglycine.

[0013] (A) The component may be one type or two or more types. The content of component (A) is not particularly limited as long as it is within the range of 0.3 to 5% by mass relative to the total amount of the cosmetic, but is preferably 0.75 to 4.5% by mass, and more preferably 1.2 to 3.5% by mass.

[0014] In the present invention, component (B) is a monohydric lower alcohol. In this specification, "monohydric lower alcohol" means a monohydric alcohol having 1 to 10 carbon atoms. Component (B) is not particularly limited as long as it is commonly used in cosmetics, quasi-drugs, etc., and examples of usable components include ethanol, propanol, isopropanol, menthol, etc. According to one preferred embodiment of the present invention, component (B) comprises ethanol or menthol, preferably ethanol, and more preferably ethanol.

[0015] (B) Component may be one type or two or more types. The content of component (B) is not particularly limited as long as it is 3% by mass or more relative to the total amount of cosmetic, but is preferably 5% by mass or more, and more preferably 7% by mass or more. Furthermore, there is no particular upper limit to the content of component (B), but is preferably 40% by mass or less, and more preferably 30% by mass or less.

[0016] Component (C) in the present invention is a spherical powder. Such a spherical powder is not particularly limited, but is a spherical powder commonly used in cosmetics, quasi-drugs, etc., and is preferably hydrophilic. The spherical powder to which hydrophilicity is imparted may be one whose surface has been treated to make it hydrophilic. The method for treating the spherical powder to make it hydrophilic is not particularly limited and can be carried out by methods such as polyethylene glycolation treatment. The spherical powder to which hydrophilicity is imparted may have a porous or non-porous surface. Examples of spherical powders include spherical resin powder, spherical silica, spherical starch powder, spherical cellulose powder, etc.

[0017] According to one preferred embodiment of the present invention, component (C) is a spherical resin powder, preferably a methyl methacrylate crosspolymer.

[0018] According to another preferred embodiment of the present invention, component (C) is spherical starch powder, preferably corn starch.

[0019] According to another preferred embodiment of the present invention, component (C) comprises one or more selected from the group consisting of spherical resin powder, spherical silica, spherical starch powder, and spherical cellulose powder, preferably one or more selected from the group consisting of spherical resin powder, spherical silica, spherical starch powder, and spherical cellulose powder.

[0020] (C) Component may be one type or two or more types. The content of component (C) is not particularly limited, but is preferably 0.01 to 5% by mass, and more preferably 0.05 to 3% by mass, relative to the total amount of the cosmetic.

[0021] In this invention, component (D) is water. Any water commonly used in cosmetics and quasi-drugs can be used, such as purified water, deionized water, or tap water. The content of component (D) may be, for example, 40% by mass or more, 50% by mass or more, or 95% by mass or less, or 90% by mass or less, based on the total amount of the cosmetic.

[0022] The cosmetic composition of the present invention may further contain niacin or a derivative thereof. Examples of such niacin or derivatives include niacin (nicotinic acid), nicotinic acid esters, nicotinic acid amides, and nicotinic acid salts (such as sodium salts).

[0023] According to one preferred embodiment of the present invention, the cosmetic composition of the present invention further comprises niacin or a derivative thereof. Such niacin or a derivative thereof is preferably niacin(nicotinic acid) or niacin(nicotinic acid)amide, and more preferably niacin(nicotinic acid)amide.

[0024] The content of niacin or its derivatives is not particularly limited, but is preferably 1 to 10% by mass, more preferably 3 to 7% by mass, and even more preferably 4 to 6% by mass, relative to the total amount of the cosmetic.

[0025] The cosmetic composition of the present invention may further contain water-swellable clay minerals. In this specification, water-swellable clay minerals are those that swell to form a gel when mixed with water, thereby imparting viscosity to the cosmetic composition of the present invention. Examples of such water-swellable clay minerals include silt, marine silt, tanakura clay, smectite clay minerals, kaolin clay minerals, antigolite clay minerals, pyrophyllite clay minerals, mica clay minerals, vermiculite clay minerals, chlorite clay minerals, silicate minerals, etc., and may be one type or two or more types. Examples of smectite clay minerals include montmorillonite, beidelite, nontronite, saponite, hectorite, souconite, stevensite, etc. The water-swellable clay minerals may be of natural origin or synthesized.

[0026] According to one preferred embodiment of the present invention, the cosmetic further comprises a water-swellable clay mineral. Such a water-swellable clay mineral is preferably a smectite-type clay mineral, and more preferably a hectorite.

[0027] The content of water-swellable clay minerals is not particularly limited, but is preferably 0.01 to 3% by mass, and more preferably 0.03 to 1.5% by mass, relative to the total amount of the cosmetic.

[0028] The cosmetic composition of the present invention may, if necessary, further contain optional additives commonly used in cosmetics and quasi-drugs, to the extent that they do not impair the effects of the present invention. Examples of such additives include oils, surfactants, humectants, powders, alcohol-based solvents, water-soluble polymers, oil-soluble polymers, film-forming agents, UV absorbers, preservatives, antibacterial agents, fragrances, salts, antioxidants, pH adjusters, chelating agents, cooling agents, anti-inflammatory agents, and skin-beautifying ingredients.

[0029] The cosmetic composition of the present invention is not particularly limited, but is preferably in the form of an aqueous cosmetic or an oil-in-water emulsion cosmetic, and more preferably an aqueous cosmetic. The cosmetic composition of the present invention may be, for example, a skincare cosmetic (e.g., lotion, emulsion, cream, serum, pack, mask, etc.), a makeup cosmetic (e.g., foundation, makeup base, etc.), a skin cleansing product (e.g., facial cleanser, makeup remover, etc.), a sunscreen cosmetic, etc.

[0030] The cosmetic composition according to the present invention can be manufactured by conventional methods. [Examples]

[0031] The present invention will be specifically described based on the following examples, but the present invention is not limited to these examples. Unless otherwise specified, the content is expressed in mass percent.

[0032] The cosmetic compositions of Comparative Examples 1-7 and Examples 1-6 were prepared by conventional methods using the formulations shown in Table 1. The usability (freshness, non-stickiness) and stability (base stability) of the prepared cosmetic compositions of Comparative Examples 1-7 and Examples 1-6 were evaluated according to the following procedure.

[0033] How to evaluate freshness Each prepared cosmetic product was applied to the skin by a panel of 10 trained professionals, and the refreshing feeling of each cosmetic product was evaluated according to the following criteria. Here, refreshing feeling refers to the refreshing sensation that remains after application of each cosmetic product. <Evaluation Criteria> A: 8 to 10 people rated it as having a refreshing aftertaste. B: 6-7 people rated it as having a refreshing aftertaste. C: 3 to 5 people rated it as having a refreshing aftertaste. D: 0-2 people rated it as having a refreshing aftertaste.

[0034] How to evaluate non-stickiness Each prepared cosmetic product was applied to the skin by a panel of 10 trained professionals, and the non-stickiness of each cosmetic product was evaluated according to the following criteria. <Evaluation Criteria> A: 8 to 10 people rated it as not feeling sticky. B: 6-7 people rated it as not feeling sticky. C: 3 to 5 people rated it as not feeling sticky. D: 0-2 people rated it as not feeling sticky.

[0035] Method for evaluating the stability of the base A panel of 10 trained professionals visually inspected each cosmetic product to check for the presence or absence of crystals and evaluated the base stability according to the following criteria. <Evaluation Criteria> A: 8 to 10 people assessed that no crystals were found in the cosmetic product. B: 6-7 people evaluated that no crystals were found in the cosmetics. C: 3 to 5 people evaluated that no crystals were found in the cosmetic product. D: 0-2 people evaluated that no crystals were found in the cosmetic product.

[0036] The results are shown in Tables 1 and 2.

[0037] [Table 1]

[0038] [Table 2]

[0039] The results in Tables 1 and 2 demonstrate that the cosmetic composition of the present invention possesses both good usability and stability.

Claims

1. (A) The following formula (1): 【Chemistry 1】 (In the formula, R １ and R ２ Each of these is independently a hydrogen atom, an alkyl group, an alkenyl group, an aryl group, an aralkyl group, an aminomethylcarbonyl group, an amidino group, an alkylcarbonyl group, an alkenylcarbonyl group, an arylcarbonyl group, or an aralkylcarbonyl group. R ３ These are a hydrogen atom, an alkyl group, an alkenyl group, an aryl group, or an aralkyl group. However, R １ , R ２ , and R ３ (They cannot simultaneously become hydrogen atoms.) A glycine derivative or salt thereof represented by (B) Monohydric lower alcohols, (C) Spherical powder, and (D) Water A cosmetic composition comprising, The content of component (A) is 0.3 to 5% by mass relative to the total amount of the cosmetic. A cosmetic product in which the content of component (B) is 3% by mass or more relative to the total amount of the cosmetic product.

2. The cosmetic composition according to claim 1, wherein component (C) is one or more selected from the group consisting of spherical resin powder, spherical silica, spherical starch powder, and spherical cellulose powder.

3. The cosmetic composition according to claim 1, wherein component (A) is glycylglycine or a salt thereof.

4. A cosmetic composition according to any one of claims 1 to 3, further comprising niacin or a derivative thereof.

5. A cosmetic composition according to any one of claims 1 to 3, further comprising a water-swellable clay mineral.

6. A cosmetic composition according to any one of claims 1 to 3, which is an aqueous cosmetic composition.

Images